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MED-10
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Statin Use and Breast Cancer Survival: A Nationwide Cohort Study from Finland
|
Recent studies have suggested that statins, an established drug group in the prevention of cardiovascular mortality, could delay or prevent breast cancer recurrence but the effect on disease-specific mortality remains unclear. We evaluated risk of breast cancer death among statin users in a population-based cohort of breast cancer patients. The study cohort included all newly diagnosed breast cancer patients in Finland during 1995–2003 (31,236 cases), identified from the Finnish Cancer Registry. Information on statin use before and after the diagnosis was obtained from a national prescription database. We used the Cox proportional hazards regression method to estimate mortality among statin users with statin use as time-dependent variable. A total of 4,151 participants had used statins. During the median follow-up of 3.25 years after the diagnosis (range 0.08–9.0 years) 6,011 participants died, of which 3,619 (60.2%) was due to breast cancer. After adjustment for age, tumor characteristics, and treatment selection, both post-diagnostic and pre-diagnostic statin use were associated with lowered risk of breast cancer death (HR 0.46, 95% CI 0.38–0.55 and HR 0.54, 95% CI 0.44–0.67, respectively). The risk decrease by post-diagnostic statin use was likely affected by healthy adherer bias; that is, the greater likelihood of dying cancer patients to discontinue statin use as the association was not clearly dose-dependent and observed already at low-dose/short-term use. The dose- and time-dependence of the survival benefit among pre-diagnostic statin users suggests a possible causal effect that should be evaluated further in a clinical trial testing statins’ effect on survival in breast cancer patients.
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how many statins are used during a cancer diagnosis
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] |
MED-10
|
Statin Use and Breast Cancer Survival: A Nationwide Cohort Study from Finland
| "Recent studies have suggested that statins, an established drug group in the prevention of cardiova(...TRUNCATED)
|
do statins cause cancer
| [-0.0005331477732397616,-0.022766610607504845,0.020660698413848877,-0.023520754650235176,-0.04123602(...TRUNCATED)
| [-0.019627220928668976,-0.007432758342474699,-0.04652729257941246,0.0592251680791378,-0.004320475738(...TRUNCATED)
| [-0.030973339453339577,0.004436999559402466,-0.01599375531077385,0.05358662083745003,-0.001669442513(...TRUNCATED)
|
MED-10
|
Statin Use and Breast Cancer Survival: A Nationwide Cohort Study from Finland
| "Recent studies have suggested that statins, an established drug group in the prevention of cardiova(...TRUNCATED)
|
statins effect on survival
| [-0.005804538726806641,-0.01166380476206541,0.025708256289362907,-0.04468502849340439,-0.01799167506(...TRUNCATED)
| [0.011004122905433178,-0.009316479787230492,0.0025343350134789944,0.03083680011332035,0.013925926759(...TRUNCATED)
| [0.0030467240139842033,0.010787402279675007,-0.014273097738623619,0.03019777126610279,-0.01253459602(...TRUNCATED)
|
MED-14
|
Statin use after diagnosis of breast cancer and survival: a population-based cohort study.
| "BACKGROUND: Preclinical studies have shown that statins, particularly simvastatin, can prevent grow(...TRUNCATED)
|
which statin to use after cancer diagnosis
| [0.009852228686213493,-0.014859991148114204,0.0229023490101099,-0.03287705034017563,-0.0134311458095(...TRUNCATED)
| [-0.015232693403959274,-0.023748990148305893,-0.03706098720431328,0.024812016636133194,0.00109549157(...TRUNCATED)
| [-0.02002757415175438,0.0003313067427370697,-0.010731527581810951,0.02324443683028221,-0.00193919835(...TRUNCATED)
|
MED-14
|
Statin use after diagnosis of breast cancer and survival: a population-based cohort study.
| "BACKGROUND: Preclinical studies have shown that statins, particularly simvastatin, can prevent grow(...TRUNCATED)
|
is statins effective after cancer diagnosis
| [-0.021902207285165787,-0.011674965731799603,0.014792590402066708,-0.03672346472740173,-0.0242242999(...TRUNCATED)
| [-0.010705017484724522,-0.0166766494512558,-0.03737911581993103,0.030815811827778816,-0.015493301674(...TRUNCATED)
| [-0.014164809137582779,0.018600907176733017,-0.0164272990077734,0.014681949280202389,-0.006036002188(...TRUNCATED)
|
MED-14
|
Statin use after diagnosis of breast cancer and survival: a population-based cohort study.
| "BACKGROUND: Preclinical studies have shown that statins, particularly simvastatin, can prevent grow(...TRUNCATED)
|
how to determine if statin is used to treat cancer
| [0.02095925249159336,-0.018061216920614243,0.01915999874472618,-0.014929691329598427,-0.016413046047(...TRUNCATED)
| [-0.01914253830909729,-0.016654612496495247,-0.04253629222512245,0.037826139479875565,-0.01291064638(...TRUNCATED)
| [-0.03384648635983467,-0.0033312642481178045,-0.018360834568738937,0.013930358923971653,-0.019016578(...TRUNCATED)
|
MED-118
|
Alkylphenols in human milk and their relations to dietary habits in central Taiwan.
| "The aims of this study were to determine the concentrations of 4-nonylphenol (NP) and 4-octylphenol(...TRUNCATED)
|
what is the op concentration in human milk
| [0.03000395931303501,0.010593440383672714,-0.018540319055318832,-0.04479018598794937,0.0093996105715(...TRUNCATED)
| [0.026955651119351387,0.00012414754019118845,-0.0203991886228323,0.020057829096913338,-0.02202359028(...TRUNCATED)
| [-0.029006699100136757,-0.033314622938632965,0.0032174817752093077,0.029383642598986626,-0.016316268(...TRUNCATED)
|
MED-118
|
Alkylphenols in human milk and their relations to dietary habits in central Taiwan.
| "The aims of this study were to determine the concentrations of 4-nonylphenol (NP) and 4-octylphenol(...TRUNCATED)
|
what is the value of op in fish oil
| [0.021116290241479874,-0.0038276039995253086,-0.010587616823613644,-0.03568992018699646,-0.036397237(...TRUNCATED)
| [0.010427641682326794,0.02617485448718071,-0.015586985275149345,0.037224180996418,0.0255211237818002(...TRUNCATED)
| [-0.0026659127324819565,-0.008024264127016068,-0.003673919476568699,0.03423686325550079,0.0036142349(...TRUNCATED)
|
MED-118
|
Alkylphenols in human milk and their relations to dietary habits in central Taiwan.
| "The aims of this study were to determine the concentrations of 4-nonylphenol (NP) and 4-octylphenol(...TRUNCATED)
|
does cooking oil cause op
| [0.02562646195292473,-0.013852766714990139,-0.0015708529390394688,-0.04028775542974472,-0.0338503383(...TRUNCATED)
| [-0.020846784114837646,0.0208906102925539,-0.026661094278097153,-0.004342471249401569,0.005098477471(...TRUNCATED)
| [0.0018983607878908515,-0.027646172791719437,-0.005440587643533945,0.04695368558168411,0.01836259290(...TRUNCATED)
|
MED-301
|
Methylmercury: A Potential Environmental Risk Factor Contributing to Epileptogenesis
| "Epilepsy or seizure disorder is one of the most common neurological diseases in humans. Although ge(...TRUNCATED)
|
what is methylmercury used for
| [-0.0031462630722671747,0.0043988036923110485,-0.02050289884209633,-0.0304486695677042,-0.0368008390(...TRUNCATED)
| [0.026999205350875854,0.06289587914943695,0.004116356372833252,0.041393667459487915,-0.0041323360055(...TRUNCATED)
| [-0.028816666454076767,-0.037237897515296936,-0.012546437792479992,-0.02078831195831299,0.0028825206(...TRUNCATED)
|
End of preview. Expand
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