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sample_id
string
trial_a_id
string
trial_b_id
string
synth_doc_id
string
concept
string
trial_a_context
string
trial_b_context
string
claim
string
option_a
string
option_b
string
task
string
correct_option
string
required_note
string
required_keywords
string
axis
string
difficulty
int64
CEDI11-0001
NCTX-E01
NCTX-E02
META-101
PFS death handling
PFS counts death as an event
PFS censors death
Pool PFS as identical across trials
Invalid mapping, event rule differs
Partial mapping, state rule difference and adjust
Choose mapping and write the required note
A
State death-as-event vs death-censored and do not treat PFS as identical
death as event|censors death|PFS|not identical|event rule
event_rule
3
CEDI11-0002
NCTX-E03
NCTX-E04
META-102
ORR confirmation
ORR per RECIST 1.1 confirmed response
ORR unconfirmed best overall response
Treat ORR as equal
Partial mapping, confirmation differs
Direct mapping, both ORR
Choose mapping and write the required note
A
State confirmed vs unconfirmed response and flag non-equivalence unless bridged
confirmed|unconfirmed|ORR|RECIST|non-equivalent
responder_rule
2
CEDI11-0003
NCTX-E05
NCTX-E06
META-103
OS time origin
OS measured from randomization
OS measured from first dose
Pool OS without notes
Partial mapping, time zero differs
Direct mapping, OS label matches
Choose mapping and write the required note
A
State randomization vs first dose and define time zero used in synthesis
randomization|first dose|time zero|OS|define
time_origin
2
CEDI11-0004
NCTX-E07
NCTX-E08
META-104
Composite endpoint components
MACE includes hospitalization
MACE excludes hospitalization
Treat MACE as same composite endpoint
Invalid mapping, components differ
Partial mapping, restate components and bridge
Choose mapping and write the required note
A
State which components differ and do not pool as identical composite
MACE|hospitalization|components|composite|not identical
composite_components
3
CEDI11-0005
NCTX-E09
NCTX-E10
META-105
AE window definition
Grade 3+ AEs treatment-emergent (TEAE)
Grade 3+ AEs any time on study
Pool AE rates directly
Partial mapping, window differs
Direct mapping, same grade threshold
Choose mapping and write the required note
A
State TEAE vs any-time window and specify the window used
TEAE|any time|window|Grade 3+|specify
window_definition
2
CEDI11-0006
NCTX-E11
NCTX-E12
META-106
Censoring method
Censor at last known assessment
Impute event at 30 days after LTFU
Treat survival curves as comparable
Invalid mapping, censoring differs
Partial mapping, state method and adjust
Choose mapping and write the required note
A
State censoring vs imputed event and do not treat curves as equivalent
censor at last|impute event|30 days|LTFU|not equivalent
censoring_handling
3
CEDI11-0007
NCTX-E13
NCTX-E14
META-107
Endpoint assessment schedule
Tumor scans every 6 weeks
Tumor scans every 12 weeks
Pool PFS hazard rates as equal
Partial mapping, assessment frequency differs
Direct mapping, both PFS
Choose mapping and write the required note
A
State scan schedule difference and note detection bias on PFS
6 weeks|12 weeks|scan schedule|detection bias|PFS
assessment_schedule
2
CEDI11-0008
NCTX-E15
NCTX-E16
META-108
PFS censoring at new therapy
Censor at start of new anti-cancer therapy
Continue follow-up through new therapy
Pool PFS outcomes
Invalid mapping, censor rule differs
Partial mapping, state rule and adjust
Choose mapping and write the required note
A
State censor-at-new-therapy vs continue-follow-up and do not pool as identical
censor at new therapy|continue follow-up|PFS|censor rule|not identical
censor_rule
3
CEDI11-0009
NCTX-E17
NCTX-E18
META-109
PRO endpoint scale
QoL mean change from baseline at week 12
QoL responder rate at week 12
Treat PRO endpoints as the same effect size
Invalid mapping, scale differs
Partial mapping, map with stated transform
Choose mapping and write the required note
A
State mean change vs responder rate and do not treat as same scale
mean change|responder rate|QoL|scale|not same
endpoint_scale
3
CEDI11-0010
NCTX-E19
NCTX-E20
META-110
OS vs PFS swap
Primary endpoint OS
Primary endpoint PFS
Use OS from one trial and PFS from the other as interchangeable benefit
Invalid mapping, endpoints differ
Partial mapping, state and avoid direct swap
Choose mapping and write the required note
A
State OS vs PFS difference and do not swap endpoints without explicit model
OS|PFS|not interchangeable|endpoint|model
endpoint_identity
3

Clarus Endpoint Definition Integrity v0.1.1

What this measures

  • You stop endpoint-label reuse from hiding definition changes
  • You force the model to name the missing endpoint details

Task per row

  • Pick A or B
  • Write the required note with the key definition difference

Gold support

  • required_keywords is a "|" list of key terms your note must include

Predictions file

  • CSV columns
    • sample_id
    • predicted_option
    • predicted_note
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