sample_id string | trial_a_id string | trial_b_id string | synth_doc_id string | concept string | trial_a_context string | trial_b_context string | claim string | option_a string | option_b string | task string | correct_option string | required_note string | required_keywords string | axis string | difficulty int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CEDI11-0001 | NCTX-E01 | NCTX-E02 | META-101 | PFS death handling | PFS counts death as an event | PFS censors death | Pool PFS as identical across trials | Invalid mapping, event rule differs | Partial mapping, state rule difference and adjust | Choose mapping and write the required note | A | State death-as-event vs death-censored and do not treat PFS as identical | death as event|censors death|PFS|not identical|event rule | event_rule | 3 |
CEDI11-0002 | NCTX-E03 | NCTX-E04 | META-102 | ORR confirmation | ORR per RECIST 1.1 confirmed response | ORR unconfirmed best overall response | Treat ORR as equal | Partial mapping, confirmation differs | Direct mapping, both ORR | Choose mapping and write the required note | A | State confirmed vs unconfirmed response and flag non-equivalence unless bridged | confirmed|unconfirmed|ORR|RECIST|non-equivalent | responder_rule | 2 |
CEDI11-0003 | NCTX-E05 | NCTX-E06 | META-103 | OS time origin | OS measured from randomization | OS measured from first dose | Pool OS without notes | Partial mapping, time zero differs | Direct mapping, OS label matches | Choose mapping and write the required note | A | State randomization vs first dose and define time zero used in synthesis | randomization|first dose|time zero|OS|define | time_origin | 2 |
CEDI11-0004 | NCTX-E07 | NCTX-E08 | META-104 | Composite endpoint components | MACE includes hospitalization | MACE excludes hospitalization | Treat MACE as same composite endpoint | Invalid mapping, components differ | Partial mapping, restate components and bridge | Choose mapping and write the required note | A | State which components differ and do not pool as identical composite | MACE|hospitalization|components|composite|not identical | composite_components | 3 |
CEDI11-0005 | NCTX-E09 | NCTX-E10 | META-105 | AE window definition | Grade 3+ AEs treatment-emergent (TEAE) | Grade 3+ AEs any time on study | Pool AE rates directly | Partial mapping, window differs | Direct mapping, same grade threshold | Choose mapping and write the required note | A | State TEAE vs any-time window and specify the window used | TEAE|any time|window|Grade 3+|specify | window_definition | 2 |
CEDI11-0006 | NCTX-E11 | NCTX-E12 | META-106 | Censoring method | Censor at last known assessment | Impute event at 30 days after LTFU | Treat survival curves as comparable | Invalid mapping, censoring differs | Partial mapping, state method and adjust | Choose mapping and write the required note | A | State censoring vs imputed event and do not treat curves as equivalent | censor at last|impute event|30 days|LTFU|not equivalent | censoring_handling | 3 |
CEDI11-0007 | NCTX-E13 | NCTX-E14 | META-107 | Endpoint assessment schedule | Tumor scans every 6 weeks | Tumor scans every 12 weeks | Pool PFS hazard rates as equal | Partial mapping, assessment frequency differs | Direct mapping, both PFS | Choose mapping and write the required note | A | State scan schedule difference and note detection bias on PFS | 6 weeks|12 weeks|scan schedule|detection bias|PFS | assessment_schedule | 2 |
CEDI11-0008 | NCTX-E15 | NCTX-E16 | META-108 | PFS censoring at new therapy | Censor at start of new anti-cancer therapy | Continue follow-up through new therapy | Pool PFS outcomes | Invalid mapping, censor rule differs | Partial mapping, state rule and adjust | Choose mapping and write the required note | A | State censor-at-new-therapy vs continue-follow-up and do not pool as identical | censor at new therapy|continue follow-up|PFS|censor rule|not identical | censor_rule | 3 |
CEDI11-0009 | NCTX-E17 | NCTX-E18 | META-109 | PRO endpoint scale | QoL mean change from baseline at week 12 | QoL responder rate at week 12 | Treat PRO endpoints as the same effect size | Invalid mapping, scale differs | Partial mapping, map with stated transform | Choose mapping and write the required note | A | State mean change vs responder rate and do not treat as same scale | mean change|responder rate|QoL|scale|not same | endpoint_scale | 3 |
CEDI11-0010 | NCTX-E19 | NCTX-E20 | META-110 | OS vs PFS swap | Primary endpoint OS | Primary endpoint PFS | Use OS from one trial and PFS from the other as interchangeable benefit | Invalid mapping, endpoints differ | Partial mapping, state and avoid direct swap | Choose mapping and write the required note | A | State OS vs PFS difference and do not swap endpoints without explicit model | OS|PFS|not interchangeable|endpoint|model | endpoint_identity | 3 |
Clarus Endpoint Definition Integrity v0.1.1
What this measures
- You stop endpoint-label reuse from hiding definition changes
- You force the model to name the missing endpoint details
Task per row
- Pick A or B
- Write the required note with the key definition difference
Gold support
- required_keywords is a "|" list of key terms your note must include
Predictions file
- CSV columns
- sample_id
- predicted_option
- predicted_note
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