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int64
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1977-03-03 00:00:00
2024-12-03 00:00:00
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22
204
reference
stringlengths
38
40
citations
int64
12.2k
89.2k
11,846,609
2001-12-03 00:00:00
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
https://pubmed.ncbi.nlm.nih.gov/11846609
89,231
33,538,338
2021-05-03 00:00:00
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
https://pubmed.ncbi.nlm.nih.gov/33538338
63,310
25,516,281
2014-12-03 00:00:00
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.
https://pubmed.ncbi.nlm.nih.gov/25516281
59,613
30,207,593
2018-11-03 00:00:00
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
https://pubmed.ncbi.nlm.nih.gov/30207593
43,137
2,231,712
1990-10-05 00:00:00
Basic local alignment search tool.
https://pubmed.ncbi.nlm.nih.gov/2231712
41,839
19,505,943
2009-08-15 00:00:00
The Sequence Alignment/Map format and SAMtools.
https://pubmed.ncbi.nlm.nih.gov/19505943
39,608
22,743,772
2012-06-28 00:00:00
Fiji: an open-source platform for biological-image analysis.
https://pubmed.ncbi.nlm.nih.gov/22743772
38,053
24,695,404
2014-08-01 00:00:00
Trimmomatic: a flexible trimmer for Illumina sequence data.
https://pubmed.ncbi.nlm.nih.gov/24695404
37,436
16,199,517
2005-10-25 00:00:00
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.
https://pubmed.ncbi.nlm.nih.gov/16199517
37,326
21,376,230
2011-03-04 00:00:00
Hallmarks of cancer: the next generation.
https://pubmed.ncbi.nlm.nih.gov/21376230
36,248
23,104,886
2013-01-01 00:00:00
STAR: ultrafast universal RNA-seq aligner.
https://pubmed.ncbi.nlm.nih.gov/23104886
35,851
22,388,286
2012-03-04 00:00:00
Fast gapped-read alignment with Bowtie 2.
https://pubmed.ncbi.nlm.nih.gov/22388286
35,156
19,451,168
2009-07-15 00:00:00
Fast and accurate short read alignment with Burrows-Wheeler transform.
https://pubmed.ncbi.nlm.nih.gov/19451168
32,244
18,156,677
2008-01-03 00:00:00
A short history of SHELX.
https://pubmed.ncbi.nlm.nih.gov/18156677
30,540
9,254,694
1997-09-01 00:00:00
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
https://pubmed.ncbi.nlm.nih.gov/9254694
30,101
14,597,658
2003-11-03 00:00:00
Cytoscape: a software environment for integrated models of biomolecular interaction networks.
https://pubmed.ncbi.nlm.nih.gov/14597658
29,069
9,310,563
1997-09-13 00:00:00
Bias in meta-analysis detected by a simple, graphical test.
https://pubmed.ncbi.nlm.nih.gov/9310563
28,851
18,929,686
2009-04-03 00:00:00
Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.
https://pubmed.ncbi.nlm.nih.gov/18929686
28,450
22,930,834
2012-07-03 00:00:00
NIH Image to ImageJ: 25 years of image analysis.
https://pubmed.ncbi.nlm.nih.gov/22930834
28,203
19,910,308
2010-01-01 00:00:00
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.
https://pubmed.ncbi.nlm.nih.gov/19910308
27,564
15,264,254
2004-10-03 00:00:00
UCSF Chimera--a visualization system for exploratory research and analysis.
https://pubmed.ncbi.nlm.nih.gov/15264254
26,477
25,605,792
2015-04-20 00:00:00
limma powers differential expression analyses for RNA-sequencing and microarray studies.
https://pubmed.ncbi.nlm.nih.gov/25605792
26,023
30,178,033
2018-10-02 00:00:00
PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation.
https://pubmed.ncbi.nlm.nih.gov/30178033
25,083
17,701,901
2007-09-03 00:00:00
PLINK: a tool set for whole-genome association and population-based linkage analyses.
https://pubmed.ncbi.nlm.nih.gov/17701901
24,187
31,986,264
2020-02-15 00:00:00
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.
https://pubmed.ncbi.nlm.nih.gov/31986264
23,913
271,968
1977-12-03 00:00:00
DNA sequencing with chain-terminating inhibitors.
https://pubmed.ncbi.nlm.nih.gov/271968
23,556
19,131,956
2009-12-03 00:00:00
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
https://pubmed.ncbi.nlm.nih.gov/19131956
23,417
34,265,844
2021-08-03 00:00:00
Highly accurate protein structure prediction with AlphaFold.
https://pubmed.ncbi.nlm.nih.gov/34265844
23,275
23,329,690
2013-04-03 00:00:00
MAFFT multiple sequence alignment software version 7: improvements in performance and usability.
https://pubmed.ncbi.nlm.nih.gov/23329690
22,980
10,592,173
2000-01-01 00:00:00
KEGG: kyoto encyclopedia of genes and genomes.
https://pubmed.ncbi.nlm.nih.gov/10592173
22,823
15,572,765
2004-12-03 00:00:00
Coot: model-building tools for molecular graphics.
https://pubmed.ncbi.nlm.nih.gov/15572765
22,722
3,558,716
1987-12-03 00:00:00
A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.
https://pubmed.ncbi.nlm.nih.gov/3558716
22,568
11,556,941
2001-09-03 00:00:00
The PHQ-9: validity of a brief depression severity measure.
https://pubmed.ncbi.nlm.nih.gov/11556941
22,451
15,034,147
2004-12-03 00:00:00
MUSCLE: multiple sequence alignment with high accuracy and high throughput.
https://pubmed.ncbi.nlm.nih.gov/15034147
22,410
22,455,463
2012-05-03 00:00:00
clusterProfiler: an R package for comparing biological themes among gene clusters.
https://pubmed.ncbi.nlm.nih.gov/22455463
22,130
843,571
1977-03-03 00:00:00
The measurement of observer agreement for categorical data.
https://pubmed.ncbi.nlm.nih.gov/843571
21,940
17,695,343
2007-05-03 00:00:00
G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.
https://pubmed.ncbi.nlm.nih.gov/17695343
21,447
20,383,002
2010-04-03 00:00:00
Features and development of Coot.
https://pubmed.ncbi.nlm.nih.gov/20383002
21,032
3,802,833
1986-09-03 00:00:00
Meta-analysis in clinical trials.
https://pubmed.ncbi.nlm.nih.gov/3802833
20,670
7,984,417
1994-11-11 00:00:00
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
https://pubmed.ncbi.nlm.nih.gov/7984417
20,559
8,744,570
1996-02-03 00:00:00
VMD: visual molecular dynamics.
https://pubmed.ncbi.nlm.nih.gov/8744570
20,064
17,872,937
2007-12-03 00:00:00
Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.
https://pubmed.ncbi.nlm.nih.gov/17872937
19,325
20,110,278
2010-03-15 00:00:00
BEDTools: a flexible suite of utilities for comparing genomic features.
https://pubmed.ncbi.nlm.nih.gov/20110278
19,010
12,111,919
2002-06-15 00:00:00
Quantifying heterogeneity in a meta-analysis.
https://pubmed.ncbi.nlm.nih.gov/12111919
18,903
14,744,438
2004-01-23 00:00:00
MicroRNAs: genomics, biogenesis, mechanism, and function.
https://pubmed.ncbi.nlm.nih.gov/14744438
18,800
27,004,904
2016-07-03 00:00:00
MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.
https://pubmed.ncbi.nlm.nih.gov/27004904
18,220
25,741,868
2015-05-03 00:00:00
Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.
https://pubmed.ncbi.nlm.nih.gov/25741868
18,095
20,644,199
2010-09-03 00:00:00
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.
https://pubmed.ncbi.nlm.nih.gov/20644199
17,611
24,227,677
2014-04-01 00:00:00
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.
https://pubmed.ncbi.nlm.nih.gov/24227677
17,580
20,124,702
2010-02-03 00:00:00
PHENIX: a comprehensive Python-based system for macromolecular structure solution.
https://pubmed.ncbi.nlm.nih.gov/20124702
17,363
6,880,820
1983-06-03 00:00:00
The hospital anxiety and depression scale.
https://pubmed.ncbi.nlm.nih.gov/6880820
17,208
3,447,015
1987-07-03 00:00:00
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
https://pubmed.ncbi.nlm.nih.gov/3447015
17,135
21,296,855
2011-12-03 00:00:00
Global cancer statistics.
https://pubmed.ncbi.nlm.nih.gov/21296855
16,612
11,328,886
2001-05-01 00:00:00
A new mathematical model for relative quantification in real-time RT-PCR.
https://pubmed.ncbi.nlm.nih.gov/11328886
16,311
10,592,235
2000-01-01 00:00:00
The Protein Data Bank.
https://pubmed.ncbi.nlm.nih.gov/10592235
16,256
29,722,887
2018-06-01 00:00:00
MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.
https://pubmed.ncbi.nlm.nih.gov/29722887
16,248
19,097,774
2009-01-03 00:00:00
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).
https://pubmed.ncbi.nlm.nih.gov/19097774
16,123
27,214,047
2016-07-03 00:00:00
DADA2: High-resolution sample inference from Illumina amplicon data.
https://pubmed.ncbi.nlm.nih.gov/27214047
15,840
16,717,171
2006-05-22 00:00:00
A brief measure for assessing generalized anxiety disorder: the GAD-7.
https://pubmed.ncbi.nlm.nih.gov/16717171
15,755
22,506,599
2012-05-03 00:00:00
SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing.
https://pubmed.ncbi.nlm.nih.gov/22506599
15,699
24,451,623
2014-05-01 00:00:00
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.
https://pubmed.ncbi.nlm.nih.gov/24451623
15,694
19,114,008
2008-12-29 00:00:00
WGCNA: an R package for weighted correlation network analysis.
https://pubmed.ncbi.nlm.nih.gov/19114008
15,471
19,461,840
2007-08-01 00:00:00
Phaser crystallographic software.
https://pubmed.ncbi.nlm.nih.gov/19461840
15,460
2,748,771
1989-05-03 00:00:00
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.
https://pubmed.ncbi.nlm.nih.gov/2748771
15,419
25,651,787
2015-03-03 00:00:00
Global cancer statistics, 2012.
https://pubmed.ncbi.nlm.nih.gov/25651787
15,247
24,132,122
2013-12-03 00:00:00
MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.
https://pubmed.ncbi.nlm.nih.gov/24132122
15,174
23,193,283
2013-01-03 00:00:00
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools.
https://pubmed.ncbi.nlm.nih.gov/23193283
14,996
32,109,013
2020-04-30 00:00:00
Clinical Characteristics of Coronavirus Disease 2019 in China.
https://pubmed.ncbi.nlm.nih.gov/32109013
14,917
19,261,174
2009-12-03 00:00:00
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
https://pubmed.ncbi.nlm.nih.gov/19261174
14,891
32,171,076
2020-03-28 00:00:00
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
https://pubmed.ncbi.nlm.nih.gov/32171076
14,675
25,260,700
2015-01-15 00:00:00
HTSeq--a Python framework to work with high-throughput sequencing data.
https://pubmed.ncbi.nlm.nih.gov/25260700
14,628
21,546,353
2011-10-03 00:00:00
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.
https://pubmed.ncbi.nlm.nih.gov/21546353
14,493
2,440,339
1987-04-03 00:00:00
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
https://pubmed.ncbi.nlm.nih.gov/2440339
14,455
2,868,172
1986-02-08 00:00:00
Statistical methods for assessing agreement between two methods of clinical measurement.
https://pubmed.ncbi.nlm.nih.gov/2868172
14,422
30,423,086
2018-09-01 00:00:00
fastp: an ultra-fast all-in-one FASTQ preprocessor.
https://pubmed.ncbi.nlm.nih.gov/30423086
14,420
388,439
1979-09-03 00:00:00
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
https://pubmed.ncbi.nlm.nih.gov/388439
14,415
19,414,839
2009-05-05 00:00:00
A new equation to estimate glomerular filtration rate.
https://pubmed.ncbi.nlm.nih.gov/19414839
14,344
1,593,914
1992-06-03 00:00:00
The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.
https://pubmed.ncbi.nlm.nih.gov/1593914
14,214
25,220,842
2015-03-01 00:00:00
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
https://pubmed.ncbi.nlm.nih.gov/25220842
14,206
31,978,945
2020-02-20 00:00:00
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
https://pubmed.ncbi.nlm.nih.gov/31978945
14,171
38,572,751
2024-12-03 00:00:00
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
https://pubmed.ncbi.nlm.nih.gov/38572751
14,019
15,273,542
2004-08-03 00:00:00
Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
https://pubmed.ncbi.nlm.nih.gov/15273542
13,883
18,546,601
2008-12-03 00:00:00
Analyzing real-time PCR data by the comparative C(T) method.
https://pubmed.ncbi.nlm.nih.gov/18546601
13,612
18,798,982
2008-12-03 00:00:00
Model-based analysis of ChIP-Seq (MACS).
https://pubmed.ncbi.nlm.nih.gov/18798982
13,575
17,846,036
2007-11-01 00:00:00
Clustal W and Clustal X version 2.0.
https://pubmed.ncbi.nlm.nih.gov/17846036
13,494
3,899,825
1985-07-03 00:00:00
Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.
https://pubmed.ncbi.nlm.nih.gov/3899825
13,254
31,078,660
2019-07-03 00:00:00
The REDCap consortium: Building an international community of software platform partners.
https://pubmed.ncbi.nlm.nih.gov/31078660
13,236
25,751,142
2015-04-03 00:00:00
HISAT: a fast spliced aligner with low memory requirements.
https://pubmed.ncbi.nlm.nih.gov/25751142
13,202
26,903,338
2016-02-23 00:00:00
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
https://pubmed.ncbi.nlm.nih.gov/26903338
13,182
25,371,430
2015-01-03 00:00:00
IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies.
https://pubmed.ncbi.nlm.nih.gov/25371430
13,153
25,554,246
2015-01-01 00:00:00
Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement.
https://pubmed.ncbi.nlm.nih.gov/25554246
13,059
19,499,576
2010-01-30 00:00:00
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.
https://pubmed.ncbi.nlm.nih.gov/19499576
12,971
16,904,174
2006-08-25 00:00:00
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
https://pubmed.ncbi.nlm.nih.gov/16904174
12,963
27,919,275
2016-12-05 00:00:00
Rayyan-a web and mobile app for systematic reviews.
https://pubmed.ncbi.nlm.nih.gov/27919275
12,824
21,816,040
2011-08-04 00:00:00
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.
https://pubmed.ncbi.nlm.nih.gov/21816040
12,684
6,606,682
1983-12-16 00:00:00
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
https://pubmed.ncbi.nlm.nih.gov/6606682
12,630
16,204,405
2005-11-03 00:00:00
Three approaches to qualitative content analysis.
https://pubmed.ncbi.nlm.nih.gov/16204405
12,329
31,912,902
2020-01-03 00:00:00
Cancer statistics, 2020.
https://pubmed.ncbi.nlm.nih.gov/31912902
12,328
32,142,651
2020-04-16 00:00:00
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
https://pubmed.ncbi.nlm.nih.gov/32142651
12,261
15,817,019
2005-04-03 00:00:00
The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.
https://pubmed.ncbi.nlm.nih.gov/15817019
12,245

PubMed Highly Cited

Current as of December 4, 2025

This dataset is metadata (id, publication date, title, link, # citations) for the Top 100 most highly cited PubMed articles. It was created using paperetl and the PubMed Baseline.

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