Datasets:

electricsheepafrica
/

ssa-breast-immune-profiles

sample_id stringlengths 19 19	population stringclasses 7 values	region stringclasses 5 values	is_SSA bool 2 classes	is_reference_panel bool 2 classes	sex stringclasses 2 values	age int64 18 90	tme_cluster stringclasses 3 values	cd4_infiltration_category stringclasses 3 values	cd4_cells_per_mm2 float64 0 1.43k	cd8_infiltration_category stringclasses 3 values	cd8_cells_per_mm2 float64 0 1.55k	cd8_cd4_ratio float64 0 1.34M	macrophage_polarization stringclasses 3 values	macrophage_m2_m1_ratio float64 0.1 4	pdl1_expression stringclasses 3 values	pdl1_percent_positive float64 0 75.1	il6_category stringclasses 3 values	il6_level float64 0 51.2	tnf_alpha_category stringclasses 3 values	tnf_alpha_level float64 0 36.1	il10_category stringclasses 3 values	il10_level float64 0 26.1	ifng_category stringclasses 3 values	ifng_level float64 0 33.6	immune_hot bool 2 classes	cd8_high bool 2 classes	pdl1_high bool 2 classes	il6_high bool 2 classes	tnf_alpha_high bool 2 classes	il10_high bool 2 classes	ifng_high bool 2 classes
IMMUNE_SAMPLE_00001	SSA_West	West	true	false	Female	53	Immune_hot	Low	126.3	Intermediate	564.3	4.47	M1_dominant	0.41	Negative	1.2	Intermediate	6.34	High	22.2	Low	0.76	Low	1.01	true	false	false	false	true	false	false
IMMUNE_SAMPLE_00002	SSA_West	West	true	false	Female	39	Immune_intermediate	Low	200.1	High	552.2	2.76	Mixed	1.21	Low	13.6	Low	0.84	Low	1.59	High	3.98	Low	0.5	false	true	false	false	false	true	false
IMMUNE_SAMPLE_00003	SSA_West	West	true	false	Female	58	Immune_hot	Low	95.7	Low	105.4	1.1	M2_dominant	1.2	Negative	0	Low	1.1	Intermediate	6.83	High	11.8	Intermediate	4.7	true	false	false	false	false	true	false
IMMUNE_SAMPLE_00004	SSA_West	West	true	false	Female	60	Immune_intermediate	Intermediate	277.4	Low	148.1	0.53	Mixed	1.27	High	27.6	High	29.97	Intermediate	6.9	High	11.98	Low	1.56	false	false	true	true	false	true	false
IMMUNE_SAMPLE_00005	SSA_West	West	true	false	Female	29	Immune_hot	Low	130.4	Low	27	0.21	Mixed	0.68	Negative	0.3	Intermediate	4.49	Low	0.89	High	9.18	Intermediate	4.9	true	false	false	false	false	true	false
IMMUNE_SAMPLE_00006	SSA_West	West	true	false	Female	36	Immune_hot	Low	188.7	High	968.7	5.13	M1_dominant	0.26	Negative	0.5	Low	1.01	Intermediate	4.63	Intermediate	2.23	Intermediate	2.62	true	true	false	false	false	false	false
IMMUNE_SAMPLE_00007	SSA_West	West	true	false	Female	51	Immune_hot	Low	212.6	High	1,110.3	5.22	M2_dominant	3.29	Negative	2.5	Intermediate	1.49	Low	0.86	Low	1.01	High	14.51	true	true	false	false	false	false	true
IMMUNE_SAMPLE_00008	SSA_West	West	true	false	Female	47	Immune_hot	Low	230.1	High	728	3.16	Mixed	0.58	Negative	0.1	High	23.25	Intermediate	3.96	Low	1.4	Intermediate	4.63	true	true	false	true	false	false	false
IMMUNE_SAMPLE_00009	SSA_West	West	true	false	Female	50	Immune_hot	High	678.9	Intermediate	565.4	0.83	M2_dominant	1.89	High	53.2	High	27.05	Low	0.97	Intermediate	2.39	High	13.58	true	false	true	true	false	false	true
IMMUNE_SAMPLE_00010	SSA_West	West	true	false	Female	41	Immune_intermediate	High	903.2	High	1,167.9	1.29	M2_dominant	1.69	Negative	1.1	High	12.04	Intermediate	2.92	Intermediate	3.14	Low	0.57	false	true	false	true	false	false	false
IMMUNE_SAMPLE_00011	SSA_West	West	true	false	Female	60	Immune_hot	Low	215.2	High	921.1	4.28	Mixed	0.83	Low	6.7	High	30.78	High	16.92	High	20.08	Intermediate	3.83	true	true	false	true	true	true	false
IMMUNE_SAMPLE_00012	SSA_West	West	true	false	Female	59	Immune_cold	High	807.8	High	823.9	1.02	Mixed	0.54	Low	6.9	Low	0.96	High	20.25	Intermediate	4.68	Intermediate	3.7	false	true	false	false	true	false	false
IMMUNE_SAMPLE_00013	SSA_West	West	true	false	Female	51	Immune_cold	High	1,220.7	High	1,236.9	1.01	M1_dominant	0.38	Negative	0.9	High	21.49	High	6.09	High	4.87	High	10.1	false	true	false	true	true	true	true
IMMUNE_SAMPLE_00014	SSA_West	West	true	false	Female	62	Immune_cold	Intermediate	517.5	Low	189.2	0.37	M1_dominant	1	High	20.9	High	27.15	Intermediate	5.15	Intermediate	3.98	Intermediate	6.31	false	false	true	true	false	false	false
IMMUNE_SAMPLE_00015	SSA_West	West	true	false	Female	55	Immune_intermediate	High	652.7	High	1,153	1.77	Mixed	1.19	Negative	1.7	Intermediate	6.78	Low	0.7	High	14.15	Low	0.94	false	true	false	false	false	true	false
IMMUNE_SAMPLE_00016	SSA_West	West	true	false	Female	41	Immune_hot	Low	195.2	High	776.4	3.98	M2_dominant	2.08	Negative	0	Intermediate	6.59	Low	1.59	Intermediate	7.27	Low	1.19	true	true	false	false	false	false	false
IMMUNE_SAMPLE_00017	SSA_West	West	true	false	Female	54	Immune_hot	High	908.1	High	756.5	0.83	Mixed	1.41	Negative	0.1	High	19.46	Intermediate	5.69	Intermediate	1.99	Intermediate	5.96	true	true	false	true	false	false	false
IMMUNE_SAMPLE_00018	SSA_West	West	true	false	Female	39	Immune_intermediate	Intermediate	395.3	Intermediate	393.7	1	M1_dominant	0.8	Negative	0.5	High	31.16	Intermediate	3.33	Intermediate	4.58	High	4.04	false	false	false	true	false	false	true
IMMUNE_SAMPLE_00019	SSA_West	West	true	false	Female	60	Immune_intermediate	Intermediate	272.8	Low	166	0.61	M1_dominant	1	Low	10.4	High	8.28	Intermediate	6.78	High	10.57	Intermediate	2.92	false	false	false	true	false	true	false
IMMUNE_SAMPLE_00020	SSA_West	West	true	false	Female	49	Immune_intermediate	High	538.9	Low	36.8	0.07	M2_dominant	2.16	Negative	0	High	25.65	Intermediate	3.76	Intermediate	3.23	Low	1.57	false	false	false	true	false	false	false
IMMUNE_SAMPLE_00021	SSA_West	West	true	false	Female	48	Immune_cold	Low	83.9	Low	100.1	1.19	Mixed	1.89	Negative	3.4	Intermediate	3.5	High	29.19	High	7.74	Intermediate	4.65	false	false	false	false	true	true	false
IMMUNE_SAMPLE_00022	SSA_West	West	true	false	Female	43	Immune_cold	High	1,154.7	Intermediate	477.4	0.41	Mixed	0.85	High	10.4	High	21.8	Low	0.32	Low	1.57	High	12.1	false	false	true	true	false	false	true
IMMUNE_SAMPLE_00023	SSA_West	West	true	false	Female	63	Immune_intermediate	Low	256.2	Intermediate	253.9	0.99	Mixed	1.12	Negative	0	High	27.91	Intermediate	3.39	Intermediate	2.07	Low	0.48	false	false	false	true	false	false	false
IMMUNE_SAMPLE_00024	SSA_West	West	true	false	Female	48	Immune_cold	Low	113.1	Intermediate	308.9	2.73	M2_dominant	2.98	Negative	0.8	Low	1.68	High	12.34	Low	1.15	Intermediate	2.76	false	false	false	false	true	false	false
IMMUNE_SAMPLE_00025	SSA_West	West	true	false	Female	45	Immune_intermediate	Intermediate	700.6	High	998	1.42	M1_dominant	0.73	Negative	0	Intermediate	8.29	High	22.4	High	13.35	Intermediate	4.08	false	true	false	false	true	true	false
IMMUNE_SAMPLE_00026	SSA_West	West	true	false	Female	46	Immune_intermediate	Low	240.3	Low	170.1	0.71	M2_dominant	1.9	Low	2.2	Intermediate	2.53	Intermediate	3.76	High	6.82	Intermediate	5.54	false	false	false	false	false	true	false
IMMUNE_SAMPLE_00027	SSA_West	West	true	false	Female	56	Immune_cold	Intermediate	388.2	High	770.5	1.98	Mixed	1.3	Low	10.8	Intermediate	4.53	High	20.44	High	11.52	Intermediate	0.99	false	true	false	false	true	true	false
IMMUNE_SAMPLE_00028	SSA_West	West	true	false	Female	54	Immune_intermediate	High	865.6	Low	106.8	0.12	M2_dominant	2.52	Negative	0	High	18.26	Low	0.49	High	19.88	Low	1.09	false	false	false	true	false	true	false
IMMUNE_SAMPLE_00029	SSA_West	West	true	false	Female	55	Immune_intermediate	Low	177.6	Intermediate	473.7	2.67	Mixed	0.6	High	12.6	High	21.84	High	8.98	Low	0.86	Intermediate	5.78	false	false	true	true	true	false	false
IMMUNE_SAMPLE_00030	SSA_West	West	true	false	Female	55	Immune_hot	Low	229.8	High	900.4	3.92	M1_dominant	0.51	High	22.2	Low	1.53	High	18.59	High	9.27	Intermediate	5.49	true	true	true	false	true	true	false
IMMUNE_SAMPLE_00031	SSA_West	West	true	false	Female	74	Immune_cold	High	726.9	Low	177.4	0.24	M1_dominant	0.53	Negative	0.1	Low	1.91	High	9.45	Low	1.05	Low	1.02	false	false	false	false	true	false	false
IMMUNE_SAMPLE_00032	SSA_West	West	true	false	Female	46	Immune_hot	High	828.1	High	579.8	0.7	M2_dominant	1.18	Low	4.3	Intermediate	2.22	Intermediate	2.23	Intermediate	3.22	Intermediate	1.34	true	true	false	false	false	false	false
IMMUNE_SAMPLE_00033	SSA_West	West	true	false	Female	44	Immune_intermediate	Intermediate	464.1	High	783.8	1.69	M1_dominant	0.94	Low	5.8	Intermediate	4.5	Low	0.09	High	6.16	Low	2.13	false	true	false	false	false	true	false
IMMUNE_SAMPLE_00034	SSA_West	West	true	false	Female	41	Immune_intermediate	High	947.6	Low	117	0.12	M2_dominant	1.5	Negative	0	High	10.92	High	21.12	High	10.5	Low	1.47	false	false	false	true	true	true	false
IMMUNE_SAMPLE_00035	SSA_West	West	true	false	Female	57	Immune_intermediate	Intermediate	418.5	High	464.4	1.11	Mixed	1.24	Negative	2.3	Low	1.68	Low	1.37	High	7.98	High	5.66	false	true	false	false	false	true	true
IMMUNE_SAMPLE_00036	SSA_West	West	true	false	Female	62	Immune_intermediate	Low	30.7	High	731	23.77	M2_dominant	1.97	Low	8.6	Intermediate	4.88	High	17.93	Intermediate	2.25	Intermediate	4.69	false	true	false	false	true	false	false
IMMUNE_SAMPLE_00037	SSA_West	West	true	false	Female	49	Immune_cold	Low	55.3	Intermediate	463.3	8.38	M1_dominant	0.38	Negative	0.2	Low	0.91	Low	0.46	Intermediate	2.1	Intermediate	6.39	false	false	false	false	false	false	false
IMMUNE_SAMPLE_00038	SSA_West	West	true	false	Female	41	Immune_intermediate	Intermediate	452.3	High	889.1	1.97	Mixed	1.38	Negative	0.1	Low	0.85	Intermediate	7.15	Intermediate	0.56	Intermediate	5.61	false	true	false	false	false	false	false
IMMUNE_SAMPLE_00039	SSA_West	West	true	false	Female	41	Immune_cold	Low	233.7	Intermediate	575.8	2.46	Mixed	0.62	Low	7.9	Intermediate	4.92	Low	0.62	Low	0.93	High	6.62	false	false	false	false	false	false	true
IMMUNE_SAMPLE_00040	SSA_West	West	true	false	Female	57	Immune_cold	Intermediate	392.4	High	424.8	1.08	M2_dominant	1.7	Negative	0	Low	1.23	Intermediate	2.22	Low	1.22	Intermediate	4.1	false	true	false	false	false	false	false
IMMUNE_SAMPLE_00041	SSA_West	West	true	false	Female	58	Immune_hot	Intermediate	289.3	Intermediate	541.7	1.87	M2_dominant	1.85	High	28.4	Intermediate	4.35	Low	2.26	Intermediate	3.2	High	18.2	true	false	true	false	false	false	true
IMMUNE_SAMPLE_00042	SSA_West	West	true	false	Female	56	Immune_hot	High	796.7	Intermediate	373.1	0.47	M2_dominant	1.52	Negative	0	High	5.25	Low	1.16	High	8.75	Intermediate	6.03	true	false	false	true	false	true	false
IMMUNE_SAMPLE_00043	SSA_West	West	true	false	Female	43	Immune_hot	Intermediate	345.7	Intermediate	256.7	0.74	M2_dominant	2.48	Low	4.6	Intermediate	4.32	High	12.84	Intermediate	3.01	High	15.01	true	false	false	false	true	false	true
IMMUNE_SAMPLE_00044	SSA_West	West	true	false	Female	53	Immune_cold	Intermediate	531.8	High	929.3	1.75	M2_dominant	0.72	Negative	1.9	Intermediate	8.42	Low	1.01	Low	1.41	High	10.93	false	true	false	false	false	false	true
IMMUNE_SAMPLE_00045	SSA_West	West	true	false	Female	51	Immune_hot	Intermediate	433.7	High	828.9	1.91	M2_dominant	1.77	Negative	2.2	High	15.06	Intermediate	5.47	Intermediate	3.92	Intermediate	3.88	true	true	false	true	false	false	false
IMMUNE_SAMPLE_00046	SSA_West	West	true	false	Female	52	Immune_intermediate	High	600.3	Low	156.1	0.26	Mixed	0.59	High	34.2	Intermediate	3.78	High	15.57	High	11.4	Intermediate	4.46	false	false	true	false	true	true	false
IMMUNE_SAMPLE_00047	SSA_West	West	true	false	Female	60	Immune_intermediate	High	709.7	Low	133.7	0.19	M2_dominant	2.4	Low	7	Low	0.54	Intermediate	4.7	High	12.7	High	10.44	false	false	false	false	false	true	true
IMMUNE_SAMPLE_00048	SSA_West	West	true	false	Female	52	Immune_intermediate	Intermediate	412	Low	184.9	0.45	Mixed	0.8	Low	4.7	Intermediate	9.01	Low	0.57	Low	0.64	Intermediate	6.16	false	false	false	false	false	false	false
IMMUNE_SAMPLE_00049	SSA_West	West	true	false	Female	57	Immune_intermediate	Intermediate	466.2	Low	136.6	0.29	M1_dominant	0.63	High	10.9	High	14.4	Low	1.13	Intermediate	2.46	High	11.8	false	false	true	true	false	false	true
IMMUNE_SAMPLE_00050	SSA_West	West	true	false	Female	51	Immune_intermediate	Intermediate	319.9	High	736	2.3	Mixed	0.9	Negative	1.7	Intermediate	5.46	High	15.58	High	14.2	Low	0.33	false	true	false	false	true	true	false
IMMUNE_SAMPLE_00051	SSA_West	West	true	false	Female	53	Immune_intermediate	High	954.1	Low	108.1	0.11	M1_dominant	0.74	Low	5.7	High	27.59	Intermediate	2.87	Low	0.43	Intermediate	5.31	false	false	false	true	false	false	false
IMMUNE_SAMPLE_00052	SSA_West	West	true	false	Female	57	Immune_intermediate	Low	107.5	High	770.8	7.17	Mixed	0.91	Negative	0	High	20.2	Intermediate	3.03	Low	0.54	Intermediate	2.87	false	true	false	true	false	false	false
IMMUNE_SAMPLE_00053	SSA_West	West	true	false	Female	34	Immune_intermediate	High	744.1	Low	204.7	0.28	M1_dominant	0.92	Negative	0	High	24.04	High	11.2	Low	1.65	Intermediate	4.24	false	false	false	true	true	false	false
IMMUNE_SAMPLE_00054	SSA_West	West	true	false	Female	46	Immune_intermediate	High	948.2	Low	128.9	0.14	M1_dominant	0.57	High	7.1	Low	0.66	Intermediate	5.25	Low	0.69	Intermediate	5.07	false	false	true	false	false	false	false
IMMUNE_SAMPLE_00055	SSA_West	West	true	false	Female	45	Immune_hot	High	720.1	Intermediate	264.2	0.37	M1_dominant	0.59	Negative	1.2	Low	0.54	Low	1.41	Intermediate	3.25	High	8.2	true	false	false	false	false	false	true
IMMUNE_SAMPLE_00056	SSA_West	West	true	false	Female	43	Immune_intermediate	Low	156.6	High	1,014.5	6.48	M2_dominant	1.46	Low	3.9	Intermediate	1.34	Intermediate	6.81	High	6.74	Intermediate	3.23	false	true	false	false	false	true	false
IMMUNE_SAMPLE_00057	SSA_West	West	true	false	Female	47	Immune_cold	High	881.5	High	838.5	0.95	Mixed	0.88	Low	5.8	High	27.55	Low	1.06	Intermediate	0.45	Low	0.84	false	true	false	true	false	false	false
IMMUNE_SAMPLE_00058	SSA_West	West	true	false	Female	66	Immune_hot	Intermediate	296.3	Low	130.4	0.44	M2_dominant	2.23	Negative	0.5	Intermediate	5.85	Intermediate	3.96	Low	0.34	Intermediate	0.8	true	false	false	false	false	false	false
IMMUNE_SAMPLE_00059	SSA_West	West	true	false	Female	40	Immune_intermediate	Intermediate	93.4	Intermediate	472.5	5.06	M1_dominant	0.36	Negative	0.5	Intermediate	4.75	High	21.66	Low	0.91	Low	0.93	false	false	false	false	true	false	false
IMMUNE_SAMPLE_00060	SSA_West	West	true	false	Female	61	Immune_hot	Intermediate	572.2	Low	192.9	0.34	M2_dominant	1.42	Negative	0.5	Intermediate	7.99	Low	2.12	Intermediate	2.08	Intermediate	5.39	true	false	false	false	false	false	false
IMMUNE_SAMPLE_00061	SSA_West	West	true	false	Female	31	Immune_cold	Low	180.1	High	640.6	3.56	Mixed	0.75	Negative	0	Intermediate	3.24	Intermediate	3	High	14.27	High	12.15	false	true	false	false	false	true	true
IMMUNE_SAMPLE_00062	SSA_West	West	true	false	Female	46	Immune_intermediate	Intermediate	376.7	Intermediate	405.5	1.08	Mixed	0.98	Negative	0.6	High	16.98	Low	0.44	Intermediate	5.36	Intermediate	3.12	false	false	false	true	false	false	false
IMMUNE_SAMPLE_00063	SSA_West	West	true	false	Male	52	Immune_hot	Intermediate	300.4	High	714.6	2.38	M2_dominant	1.29	High	24.2	High	17.53	High	22.32	Intermediate	0.9	Intermediate	3.03	true	true	true	true	true	false	false
IMMUNE_SAMPLE_00064	SSA_West	West	true	false	Female	56	Immune_hot	Intermediate	439.2	Low	110.3	0.25	M2_dominant	2.23	Low	7.4	Intermediate	5.54	High	18.78	High	9.8	Intermediate	2.83	true	false	false	false	true	true	false
IMMUNE_SAMPLE_00065	SSA_West	West	true	false	Female	58	Immune_hot	Low	107.2	Low	146.9	1.37	Mixed	1.19	Negative	0	High	25.9	Low	1.85	Intermediate	4.14	Intermediate	4.88	true	false	false	true	false	false	false
IMMUNE_SAMPLE_00066	SSA_West	West	true	false	Female	59	Immune_cold	High	992.9	Low	86.4	0.09	M1_dominant	0.73	Low	6.3	Intermediate	2.98	Intermediate	2.46	Intermediate	3.58	Intermediate	4.91	false	false	false	false	false	false	false
IMMUNE_SAMPLE_00067	SSA_West	West	true	false	Female	46	Immune_hot	Low	172.5	Intermediate	508.8	2.95	M1_dominant	0.86	High	35.7	Intermediate	5.11	Low	0.53	High	14.52	High	14.93	true	false	true	false	false	true	true
IMMUNE_SAMPLE_00068	SSA_West	West	true	false	Female	45	Immune_cold	High	962.4	Low	141.7	0.15	M1_dominant	0.82	Negative	0.5	Low	1.29	Intermediate	3.61	Intermediate	2.74	Low	1.12	false	false	false	false	false	false	false
IMMUNE_SAMPLE_00069	SSA_West	West	true	false	Female	59	Immune_hot	Intermediate	291.5	High	847.8	2.91	M2_dominant	1.82	High	36.4	High	25.08	Intermediate	5.22	High	14.34	Low	1.15	true	true	true	true	false	true	false
IMMUNE_SAMPLE_00070	SSA_West	West	true	false	Female	48	Immune_cold	Intermediate	265.4	High	500.9	1.89	M1_dominant	0.3	High	14	Low	1.14	High	4.86	Low	0.81	Intermediate	2.93	false	true	true	false	true	false	false
IMMUNE_SAMPLE_00071	SSA_West	West	true	false	Female	36	Immune_intermediate	Low	130.2	High	1,229.3	9.44	M1_dominant	0.34	Low	7.6	Low	1.31	Intermediate	1.43	High	16.16	High	15.95	false	true	false	false	false	true	true
IMMUNE_SAMPLE_00072	SSA_West	West	true	false	Female	38	Immune_intermediate	Low	264.8	High	450.8	1.7	M2_dominant	3.11	Negative	1	High	9.19	Low	1.02	Intermediate	2.02	Low	1.35	false	true	false	true	false	false	false
IMMUNE_SAMPLE_00073	SSA_West	West	true	false	Female	40	Immune_cold	Intermediate	403.6	High	1,080.9	2.68	M2_dominant	1.68	Negative	0.5	Intermediate	5.11	Intermediate	5.55	Low	0.53	Low	1.23	false	true	false	false	false	false	false
IMMUNE_SAMPLE_00074	SSA_West	West	true	false	Female	55	Immune_hot	High	935.9	Low	41.3	0.04	Mixed	1.35	Negative	0.3	Intermediate	3.72	High	6.15	Low	1.73	Intermediate	4.31	true	false	false	false	true	false	false
IMMUNE_SAMPLE_00075	SSA_West	West	true	false	Female	52	Immune_hot	High	738.6	High	760.7	1.03	Mixed	1.14	Low	8.2	Intermediate	4.66	High	23.89	Intermediate	0.75	High	8.85	true	true	false	false	true	false	true
IMMUNE_SAMPLE_00076	SSA_West	West	true	false	Female	58	Immune_intermediate	High	771	Intermediate	632.2	0.82	Mixed	0.97	Negative	0.8	Intermediate	6.64	Intermediate	6.03	Low	0.16	Intermediate	3.62	false	false	false	false	false	false	false
IMMUNE_SAMPLE_00077	SSA_West	West	true	false	Female	45	Immune_cold	Low	105.8	High	941.5	8.9	Mixed	1.14	Negative	0	High	21.32	Low	0.98	Low	0.8	Intermediate	4.48	false	true	false	true	false	false	false
IMMUNE_SAMPLE_00078	SSA_West	West	true	false	Female	52	Immune_hot	Low	199.7	High	665.6	3.33	M2_dominant	1.72	Low	11.4	Intermediate	4.84	High	15.6	High	11.43	Intermediate	6.3	true	true	false	false	true	true	false
IMMUNE_SAMPLE_00079	SSA_West	West	true	false	Female	57	Immune_intermediate	Low	242.1	High	1,158.1	4.78	Mixed	1.45	Negative	0	Low	1.15	Intermediate	3.53	Low	0.73	Intermediate	5.33	false	true	false	false	false	false	false
IMMUNE_SAMPLE_00080	SSA_West	West	true	false	Female	47	Immune_intermediate	Intermediate	485.4	High	1,066.3	2.2	Mixed	1.4	Negative	1	High	13.13	High	20.33	Intermediate	3.86	Low	0.64	false	true	false	true	true	false	false
IMMUNE_SAMPLE_00081	SSA_West	West	true	false	Female	55	Immune_cold	Intermediate	359.5	Low	197.8	0.55	M2_dominant	1.16	Low	6.2	Low	0.21	High	17.68	Intermediate	2.13	Intermediate	1.94	false	false	false	false	true	false	false
IMMUNE_SAMPLE_00082	SSA_West	West	true	false	Female	43	Immune_cold	Low	165.7	Intermediate	273.1	1.65	M1_dominant	0.79	Low	7.4	Intermediate	4.5	Low	0.33	Intermediate	4.72	Intermediate	5.26	false	false	false	false	false	false	false
IMMUNE_SAMPLE_00083	SSA_West	West	true	false	Female	46	Immune_cold	Intermediate	286.2	High	1,283.1	4.48	M1_dominant	0.75	Negative	0.9	Low	1.21	Intermediate	2.2	Intermediate	4.54	Intermediate	1.2	false	true	false	false	false	false	false
IMMUNE_SAMPLE_00084	SSA_West	West	true	false	Female	46	Immune_cold	Low	196.1	High	616.2	3.14	Mixed	0.9	Negative	0	Low	1.47	High	19.25	Low	0	Intermediate	4.5	false	true	false	false	true	false	false
IMMUNE_SAMPLE_00085	SSA_West	West	true	false	Female	37	Immune_hot	Intermediate	189.5	Low	94.4	0.5	M2_dominant	2.12	High	35.8	Low	0.47	High	19.34	Intermediate	4.7	Low	1.52	true	false	true	false	true	false	false
IMMUNE_SAMPLE_00086	SSA_West	West	true	false	Female	55	Immune_intermediate	Intermediate	461.2	High	890.2	1.93	Mixed	1.21	Negative	0	High	16.67	High	12.73	High	13.49	Intermediate	4.68	false	true	false	true	true	true	false
IMMUNE_SAMPLE_00087	SSA_West	West	true	false	Female	45	Immune_intermediate	Low	179.2	Intermediate	406.4	2.27	M2_dominant	2.09	Negative	1.4	Low	0.91	High	18.37	High	8.9	Intermediate	4.9	false	false	false	false	true	true	false
IMMUNE_SAMPLE_00088	SSA_West	West	true	false	Male	50	Immune_hot	Low	256.4	Intermediate	427.9	1.67	M1_dominant	0.65	High	18.2	High	19.95	High	6.51	High	10.85	High	11.87	true	false	true	true	true	true	true
IMMUNE_SAMPLE_00089	SSA_West	West	true	false	Female	55	Immune_intermediate	High	617.6	High	902.1	1.46	M2_dominant	1.29	High	40.1	Intermediate	4.67	Intermediate	2.93	Low	0.91	High	13.94	false	true	true	false	false	false	true
IMMUNE_SAMPLE_00090	SSA_West	West	true	false	Female	55	Immune_intermediate	Low	272.8	Intermediate	245	0.9	Mixed	0.89	Negative	0	Low	1	Intermediate	2.86	Intermediate	3.11	Intermediate	3.73	false	false	false	false	false	false	false
IMMUNE_SAMPLE_00091	SSA_West	West	true	false	Female	57	Immune_hot	High	515.9	Low	118.9	0.23	M2_dominant	2.04	Negative	0	High	11.48	Intermediate	5.21	High	6.9	Low	0.3	true	false	false	true	false	true	false
IMMUNE_SAMPLE_00092	SSA_West	West	true	false	Female	49	Immune_intermediate	Intermediate	380.6	Low	11.4	0.03	M2_dominant	3	Negative	0.3	Intermediate	6.68	Low	1.24	Intermediate	3.11	High	17.33	false	false	false	false	false	false	true
IMMUNE_SAMPLE_00093	SSA_West	West	true	false	Female	45	Immune_hot	Low	0.1	Low	84.4	1,590.97	M1_dominant	0.53	Negative	1.3	Low	0.94	Intermediate	5.11	Low	0.65	Intermediate	4.3	true	false	false	false	false	false	false
IMMUNE_SAMPLE_00094	SSA_West	West	true	false	Female	49	Immune_intermediate	Intermediate	550.9	High	1,108.5	2.01	M2_dominant	2.84	High	33.5	High	5.36	High	18.11	Low	0.04	Low	1.32	false	true	true	true	true	false	false
IMMUNE_SAMPLE_00095	SSA_West	West	true	false	Female	31	Immune_intermediate	Low	175.9	Low	252.8	1.44	M2_dominant	1.91	Negative	1.1	High	31.4	Intermediate	4.63	High	9.06	High	11.7	false	false	false	true	false	true	true
IMMUNE_SAMPLE_00096	SSA_West	West	true	false	Female	34	Immune_cold	Intermediate	445	High	389.5	0.88	M2_dominant	2.22	High	31	Low	1.53	Intermediate	1.54	Intermediate	5.44	High	5.69	false	true	true	false	false	false	true
IMMUNE_SAMPLE_00097	SSA_West	West	true	false	Female	35	Immune_cold	High	571.5	Intermediate	394.3	0.69	M1_dominant	0.83	Negative	0	High	23.11	Low	0.8	High	6.65	Low	0.42	false	false	false	true	false	true	false
IMMUNE_SAMPLE_00098	SSA_West	West	true	false	Female	39	Immune_hot	High	921.6	Intermediate	353.3	0.38	Mixed	0.94	Negative	0.7	Intermediate	7.98	High	14.37	Low	0.1	Intermediate	4.37	true	false	false	false	true	false	false
IMMUNE_SAMPLE_00099	SSA_West	West	true	false	Female	54	Immune_hot	Low	141.4	High	641.3	4.54	Mixed	0.93	Negative	0	Intermediate	6.85	Intermediate	3.64	High	15.46	Low	1.13	true	true	false	false	false	true	false
IMMUNE_SAMPLE_00100	SSA_West	West	true	false	Female	40	Immune_cold	Low	161	Intermediate	213.9	1.33	Mixed	1.1	Negative	1.5	High	5.83	Intermediate	1.69	High	6.99	Intermediate	5.45	false	false	false	true	false	true	false

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SSA Breast Immune Profiles & Tumor Microenvironment Dataset (Women, Multi-ancestry, Synthetic)

Dataset summary

This dataset provides a synthetic cohort of invasive breast cancers in women across multiple ancestry groups, with emphasis on sub-Saharan Africa (SSA) and comparable reference populations.

Each tumour is annotated with a panel of immune microenvironment features:

Tumour microenvironment (TME) cluster – Immune_cold, Immune_intermediate, Immune_hot.
CD4+ and CD8+ T-cell infiltration – categorical levels and approximate densities (cells/mm²).
Macrophage polarization – M1_dominant, Mixed, M2_dominant with approximate M2:M1 ratios.
PD-L1 expression – Negative, Low, High with approximate % PD-L1–positive tumour cells.
Cytokine profiles – categories and approximate levels for IL-6, TNF-α, IL-10, and IFN-γ.

Distributions are loosely anchored to global and SSA-focused literature on TILs, macrophages, PD-L1, and cytokines in breast cancer, while ensuring that all records are fully synthetic.

Cohort design

Sample size and populations

Total N: 10,000 synthetic invasive breast cancers.
Populations:
- SSA_West: 2,000
- SSA_East: 2,000
- SSA_Central: 1,500
- SSA_Southern: 1,500
- AAW (African American women): 1,500
- EUR (European reference): 1,000
- EAS (East Asian reference): 500
Sex:
- Predominantly Female, with a small fraction of male breast cancers (~1%).
Age:
- 18–90 years.
- Older mean age in EUR/EAS/AAW vs somewhat younger ages in SSA clusters, reflecting registry patterns.

Immune and TME features

TME cluster

Variable:

tme_cluster – Immune_cold, Immune_intermediate, or Immune_hot.
Derived: immune_hot – True if tme_cluster == "Immune_hot".

Patterns:

Immune-cold tumours are more common in EUR/EAS reference groups.
Immune-hot tumours (high T-cell infiltration) are moderately more frequent in SSA and AAW populations, consistent with TNBC-enriched and high-grade disease.

CD4+ and CD8+ T-cell infiltration

Variables:

cd4_infiltration_category – Low, Intermediate, High.
cd8_infiltration_category – Low, Intermediate, High.
cd4_cells_per_mm2 – approximate CD4+ density.
cd8_cells_per_mm2 – approximate CD8+ density.
cd8_cd4_ratio – ratio of CD8 to CD4 density.
Derived: cd8_high – True if cd8_infiltration_category == "High".

Anchoring:

Based on studies of lymphocyte-predominant breast cancer, basal-like/TNBC, and HER2+ disease, where high CD8+ infiltration is enriched and associated with better outcomes.
SSA and AAW populations are modeled with higher fractions of High CD8+ infiltration and slightly higher CD8:CD4 ratios than EUR/EAS.

Macrophage polarization

Variables:

macrophage_polarization – M1_dominant, Mixed, M2_dominant.
macrophage_m2_m1_ratio – approximate M2:M1 ratio.

Anchoring:

Immunohistochemical and transcriptomic studies show that M2-like macrophages (CD163+, etc.) are common in aggressive and HR-negative tumours and associated with worse prognosis.
SSA and AAW populations, enriched for aggressive subtypes, are modeled with higher M2-dominant fractions than EUR/EAS reference cohorts.

PD-L1 expression

Variables:

pdl1_expression – Negative, Low, High.
pdl1_percent_positive – approximate % of PD-L1–positive tumour cells.
Derived: pdl1_high – True if pdl1_expression == "High".

Anchoring:

PD-L1 IHC and CPS distributions in TNBC and HER2+ breast cancer suggest positivity (by various cut-offs) in roughly 15–30% of cases.
The dataset reflects higher PD-L1 High fractions in SSA and AAW groups (TNBC-enriched) relative to EUR/EAS reference populations.

Cytokine profiles (IL-6, TNF-α, IL-10, IFN-γ)

Variables:

il6_category, il6_level
tnf_alpha_category, tnf_alpha_level
il10_category, il10_level
ifng_category, ifng_level

Each cytokine has:

Category – Low, Intermediate, High.
Approximate level – continuous value in arbitrary units on a pg/mL-like scale.
Derived flags – il6_high, tnf_alpha_high, il10_high, ifng_high (true for High category).

Anchoring:

Case–control and cohort biomarker studies in breast cancer show elevated IL-6 and TNF-α in roughly 25–40% of patients, particularly in advanced and TNBC disease and in settings with high inflammatory burden.
Anti-inflammatory/immunoregulatory cytokines (e.g., IL-10) and effector cytokines (IFN-γ) are modeled to vary by population and TME pattern.
SSA and AAW populations have slightly higher probabilities of High IL-6/TNF-α/IL-10/IFN-γ than EUR/EAS in line with literature.

File and schema

`immune_profiles_data.parquet` / `immune_profiles_data.csv`

Each row represents a synthetic invasive breast cancer with demographics and immune/TME annotations:

Demographics
- sample_id
- population
- region
- is_SSA
- is_reference_panel
- sex
- age
TME and T cells
- tme_cluster, immune_hot
- cd4_infiltration_category, cd4_cells_per_mm2
- cd8_infiltration_category, cd8_cells_per_mm2, cd8_cd4_ratio, cd8_high
Macrophages
- macrophage_polarization
- macrophage_m2_m1_ratio
PD-L1
- pdl1_expression
- pdl1_percent_positive
- pdl1_high
Cytokines
- il6_category, il6_level, il6_high
- tnf_alpha_category, tnf_alpha_level, tnf_alpha_high
- il10_category, il10_level, il10_high
- ifng_category, ifng_level, ifng_high

Generation

The dataset is generated using:

immune_profiles/scripts/generate_immune_profiles.py

with configuration in:

immune_profiles/configs/immune_profiles_config.yaml

and literature inventory in:

immune_profiles/docs/LITERATURE_INVENTORY.csv

Key steps:

Cohort sampling – construct a multi-ancestry invasive breast cancer cohort with age and sex distributions by population.
TME assignment – sample tme_cluster by population to define immune-cold, intermediate, and hot microenvironments.
T-cell infiltration – independently sample CD4+ and CD8+ infiltration categories by population and derive approximate densities and CD8:CD4 ratios.
Macrophage polarization – sample macrophage_polarization categories and derive approximate M2:M1 ratios.
PD-L1 assignment – sample pdl1_expression categories and assign approximate % PD-L1–positive tumour cells.
Cytokine profiles – sample category distributions for IL-6, TNF-α, IL-10, and IFN-γ by population, then draw approximate levels from category-specific distributions.
Derived indicators – compute immune_hot, cd8_high, pdl1_high, and cytokine-high flags for downstream modeling.

Validation

Validation is performed with:

immune_profiles/scripts/validate_immune_profiles.py

and summarized in:

immune_profiles/output/validation_report.md

Checks include:

C01–C02 – Sample size and population counts vs config.
C03 – TME cluster distributions by population.
C04 – CD4+ infiltration distributions by population.
C05 – CD8+ infiltration distributions by population.
C06 – Macrophage polarization distributions by population.
C07 – PD-L1 expression distributions by population.
C08–C11 – IL-6, TNF-α, IL-10, and IFN-γ category distributions by population.
C12 – Missingness in key variables (demographics, TME, T cells, macrophages, PD-L1, cytokines, derived flags).

The released version is configured so that all distributional deviations remain within a 10% absolute tolerance, yielding an overall validation status of PASS.

Intended use

This dataset is intended for:

Immune-oncology modeling in breast cancer, especially TNBC and HER2+ subtypes.
Integration with other Electric Sheep Africa synthetic modules (e.g., pathology & histology, IHC, comorbidities, environmental exposures) to build multi-modal disease models.
Educational use for understanding how TILs, macrophages, PD-L1, and cytokines interact across ancestries and tumour types.

It is not suitable for:

Estimating true prevalence of immune phenotypes in any specific country, registry, or institution.
Direct clinical decision-making or eligibility assessment for immunotherapy.

All records are synthetic and non-identifiable.

Ethical considerations

No patient-level data are used; all tumours and immune profiles are simulated.
Differences in immune phenotypes between populations are included for methodological realism and must not be used to stigmatize or essentialize groups.
Users should interpret patterns alongside high-quality clinical and molecular epidemiology data from the relevant settings.

License

License: CC BY-NC 4.0.
Free for non-commercial research, education, and methods development with attribution.

Citation

If you use this dataset, please cite:

Electric Sheep Africa. "SSA Breast Immune Profiles & Tumor Microenvironment Dataset (Women, Multi-ancestry, Synthetic)." Hugging Face Datasets.

and, as appropriate, key literature on TILs, macrophages, PD-L1, and cytokines in breast cancer, including work from sub-Saharan Africa and African-descended populations.