geraldamasi/medmentions-ner · Datasets at Hugging Face

tokens listlengths 11 826	ner_tags listlengths 11 826
[ "DCTN4", "as", "a", "modifier", "of", "chronic", "Pseudomonas", "aeruginosa", "infection", "in", "cystic", "fibrosis", "Pseudomonas", "aeruginosa", "(", "Pa", ")", "infection", "in", "cystic", "fibrosis", "(", "CF", ")", "patients", "is", "associated", "with", "worse", "long-term", "pulmonary", "disease", "and", "shorter", "survival", ",", "and", "chronic", "Pa", "infection", "(", "CPA", ")", "is", "associated", "with", "reduced", "lung", "function", ",", "faster", "rate", "of", "lung", "decline", ",", "increased", "rates", "of", "exacerbations", "and", "shorter", "survival", ".", "By", "using", "exome", "sequencing", "and", "extreme", "phenotype", "design", ",", "it", "was", "recently", "shown", "that", "isoforms", "of", "dynactin", "4", "(", "DCTN4", ")", "may", "influence", "Pa", "infection", "in", "CF", ",", "leading", "to", "worse", "respiratory", "disease", ".", "The", "purpose", "of", "this", "study", "was", "to", "investigate", "the", "role", "of", "DCTN4", "missense", "variants", "on", "Pa", "infection", "incidence", ",", "age", "at", "first", "Pa", "infection", "and", "chronic", "Pa", "infection", "incidence", "in", "a", "cohort", "of", "adult", "CF", "patients", "from", "a", "single", "centre", ".", "Polymerase", "chain", "reaction", "and", "direct", "sequencing", "were", "used", "to", "screen", "DNA", "samples", "for", "DCTN4", "variants", ".", "A", "total", "of", "121", "adult", "CF", "patients", "from", "the", "Cochin", "Hospital", "CF", "centre", "have", "been", "included", ",", "all", "of", "them", "carrying", "two", "CFTR", "defects", ":", "103", "developed", "at", "least", "1", "pulmonary", "infection", "with", "Pa", ",", "and", "68", "patients", "of", "them", "had", "CPA", ".", "DCTN4", "variants", "were", "identified", "in", "24", "%", "(", "29/121", ")", "CF", "patients", "with", "Pa", "infection", "and", "in", "only", "17", "%", "(", "3/18", ")", "CF", "patients", "with", "no", "Pa", "infection", ".", "Of", "the", "patients", "with", "CPA", ",", "29", "%", "(", "20/68", ")", "had", "DCTN4", "missense", "variants", "vs", "23", "%", "(", "8/35", ")", "in", "patients", "without", "CPA", ".", "Interestingly", ",", "p.Tyr263Cys", "tend", "to", "be", "more", "frequently", "observed", "in", "CF", "patients", "with", "CPA", "than", "in", "patients", "without", "CPA", "(", "4/68", "vs", "0/35", ")", ",", "and", "DCTN4", "missense", "variants", "tend", "to", "be", "more", "frequent", "in", "male", "CF", "patients", "with", "CPA", "bearing", "two", "class", "II", "mutations", "than", "in", "male", "CF", "patients", "without", "CPA", "bearing", "two", "class", "II", "mutations", "(", "P", "=", "0.06", ")", ".", "Our", "observations", "reinforce", "that", "DCTN4", "missense", "variants", ",", "especially", "p.Tyr263Cys", ",", "may", "be", "involved", "in", "the", "pathogenesis", "of", "CPA", "in", "male", "CF", "." ]	[ "B-Biologically Active Substance", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Temporal Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Activity", "B-Activity", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "B-Organism Attribute", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "B-Population Group", "O", "B-Age Group", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "B-Health Care Related Organization", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Biologically Active Substance", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "B-Age Group", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Bacterium", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Biologically Active Substance", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Organism Attribute", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "B-Disease or Syndrome", "O", "B-Organism Attribute", "B-Disease or Syndrome", "O" ]
[ "Nonylphenol", "diethoxylate", "inhibits", "apoptosis", "induced", "in", "PC12", "cells", "Nonylphenol", "and", "short-chain", "nonylphenol", "ethoxylates", "such", "as", "NP2", "EO", "are", "present", "in", "aquatic", "environment", "as", "wastewater", "contaminants", ",", "and", "their", "toxic", "effects", "on", "aquatic", "species", "have", "been", "reported", ".", "Apoptosis", "has", "been", "shown", "to", "be", "induced", "by", "serum", "deprivation", "or", "copper", "treatment", ".", "To", "understand", "the", "toxicity", "of", "nonylphenol", "diethoxylate", ",", "we", "investigated", "the", "effects", "of", "NP2", "EO", "on", "apoptosis", "induced", "by", "serum", "deprivation", "and", "copper", "by", "using", "PC12", "cell", "system", ".", "Nonylphenol", "diethoxylate", "itself", "showed", "no", "toxicity", "and", "recovered", "cell", "viability", "from", "apoptosis", ".", "In", "addition", ",", "nonylphenol", "diethoxylate", "decreased", "DNA", "fragmentation", "caused", "by", "apoptosis", "in", "PC12", "cells", ".", "This", "phenomenon", "was", "confirmed", "after", "treating", "apoptotic", "PC12", "cells", "with", "nonylphenol", "diethoxylate", ",", "whereas", "the", "cytochrome", "c", "release", "into", "the", "cytosol", "decreased", "as", "compared", "to", "that", "in", "apoptotic", "cells", "not", "treated", "with", "nonylphenol", "diethoxylate", "s.", "Furthermore", ",", "Bax", "contents", "in", "apoptotic", "cells", "were", "reduced", "after", "exposure", "to", "nonylphenol", "diethoxylate", ".", "Thus", ",", "nonylphenol", "diethoxylate", "has", "the", "opposite", "effect", "on", "apoptosis", "in", "PC12", "cells", "compared", "to", "nonylphenol", ",", "which", "enhances", "apoptosis", "induced", "by", "serum", "deprivation", ".", "The", "difference", "in", "structure", "of", "the", "two", "compounds", "is", "hypothesized", "to", "be", "responsible", "for", "this", "phenomenon", ".", "These", "results", "indicated", "that", "nonylphenol", "diethoxylate", "has", "capability", "to", "affect", "cell", "differentiation", "and", "development", "and", "has", "potentially", "harmful", "effect", "on", "organisms", "because", "of", "its", "unexpected", "impact", "on", "apoptosis", ".", "©", "2015", "Wiley", "Periodicals", ",", "Inc.", "Environ", "Toxicol", "31", ":", "1389-1398", ",", "2016", "." ]	[ "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Activity", "B-Cell Function", "B-Functional Concept", "O", "B-Cell", "B-Cell", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Finding", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Environmental Effect of Humans", "B-Substance", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Organism", "B-Organism", "O", "O", "O", "O", "B-Cell Function", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "B-Element, Ion, or Isotope", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Cell Function", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "B-Element, Ion, or Isotope", "O", "O", "B-Cell", "B-Cell", "B-Cell", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Cell Function", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Quantitative Concept", "B-Molecular Function", "B-Molecular Function", "O", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "O", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Cell", "B-Cell", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Enzyme", "B-Enzyme", "O", "O", "O", "B-Cell Component", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "B-Functional Concept", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Conceptual Entity", "O", "B-Cell", "B-Cell", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Activity", "B-Cell Function", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "O", "O", "B-Chemical", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Finding", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Qualitative Concept", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Physiologic Function", "O", "O", "B-Qualitative Concept", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Organism", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Cell Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Prevascularized", "silicon", "membranes", "for", "the", "enhancement", "of", "transport", "to", "implanted", "medical", "devices", "Recent", "advances", "in", "drug", "delivery", "and", "sensing", "devices", "for", "in", "situ", "applications", "are", "limited", "by", "the", "diffusion", "-limiting", "foreign", "body", "response", "of", "fibrous", "encapsulation", ".", "In", "this", "study", ",", "we", "fabricated", "prevascularized", "synthetic", "device", "ports", "to", "help", "mitigate", "this", "limitation", ".", "Membranes", "with", "rectilinear", "arrays", "of", "square", "pores", "with", "widths", "ranging", "from", "40", "to", "200", "μm", "were", "created", "using", "materials", "(", "50", "μm", "thick", "double-sided", "polished", "silicon", ")", "and", "processes", "(", "photolithography", "and", "directed", "reactive", "ion", "etching", ")", "common", "in", "the", "manufacturing", "of", "microfabricated", "sensors", ".", "Vascular", "endothelial", "cells", "responded", "to", "membrane", "geometry", "by", "either", "forming", "vascular", "tubes", "that", "extended", "through", "the", "pore", "or", "completely", "filling", "membrane", "pores", "after", "4", "days", "in", "culture", ".", "Although", "tube", "formation", "began", "to", "predominate", "overgrowth", "around", "75", "μm", "and", "continued", "to", "increase", "at", "even", "larger", "pore", "sizes", ",", "tubes", "formed", "at", "these", "large", "pore", "sizes", "were", "not", "completely", "round", "and", "had", "relatively", "thin", "walls", ".", "Thus", ",", "the", "optimum", "range", "of", "pore", "size", "for", "prevascularization", "of", "these", "membranes", "was", "estimated", "to", "be", "75-100", "μm", ".", "This", "study", "lays", "the", "foundation", "for", "creating", "a", "prevascularized", "port", "that", "can", "be", "used", "to", "reduce", "fibrous", "encapsulation", "and", "thus", "enhance", "diffusion", "to", "implanted", "medical", "devices", "and", "sensors", ".", "©", "2015", "Wiley", "Periodicals", ",", "Inc.", "J", "Biomed", "Mater", "Res", "Part", "B", ":", "Appl", "Biomater", ",", "104B", ":", "1602-1609", ",", "2016", "." ]	[ "B-Functional Concept", "B-Biomedical or Dental Material", "B-Manufactured Object", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Health Care Activity", "O", "B-Functional Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Manufactured Object", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "B-Phenomenon or Process", "O", "B-Functional Concept", "O", "B-Manufactured Object", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "B-Phenomenon or Process", "O", "B-Occupational Activity", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Occupational Activity", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Spatial Concept", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "I-Activity", "B-Manufactured Object", "B-Spatial Concept", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "B-Manufactured Object", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "O", "B-Activity", "B-Natural Phenomenon or Process", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Seated", "maximum", "flexion", ":", "An", "alternative", "to", "standing", "maximum", "flexion", "for", "determining", "presence", "of", "flexion", "-", "relaxation", "?", "The", "flexion", "-", "relaxation", "phenomenon", "(", "FRP", ")", "in", "standing", "is", "a", "specific", "and", "sensitive", "diagnostic", "tool", "for", "low", "back", "pain", ".", "Seated", "flexion", "as", "an", "alternative", "could", "be", "beneficial", "for", "certain", "populations", ",", "yet", "the", "behavior", "of", "the", "trunk", "extensors", "during", "seated", "maximum", "flexion", "compared", "to", "standing", "flexion", "remains", "unclear", ".", "Compare", "FRP", "occurrences", "and", "spine", "angles", "between", "seated", "and", "standing", "flexion", "postures", "in", "three", "levels", "of", "the", "erector", "spinae", "muscles", ".", "Thirty-one", "participants", "free", "of", "back", "pain", "performed", "seated", "and", "standing", "maximum", "trunk", "flexion", ".", "Electromyographical", "signals", "were", "recorded", "from", "the", "bilateral", "lumbar", "(", "L3", ")", ",", "lower-thoracic", "(", "T9", ")", ",", "and", "upper-thoracic", "(", "T4", ")", "erector", "spinae", "and", "assessed", "for", "the", "occurrence", "of", "FRP", ".", "Spine", "angles", "corresponding", "to", "FRP", "onset", "and", "cessation", "were", "determined", ",", "and", "FRP", "occurrences", "and", "angles", "were", "compared", "between", "posture", "and", "muscle", ".", "FRP", "occurrence", "was", "similar", "in", "standing", "and", "seated", "maximum", "flexion", "across", "all", "muscles", ",", "with", "the", "lumbar", "muscles", "showing", "the", "greatest", "consistency", ".", "Standing", "FRP", "onset", "and", "cessation", "angles", "were", "consistently", "greater", "than", "the", "corresponding", "seated", "FRP", "angles", ".", "Considering", "the", "similar", "number", "of", "FRP", "occurrences", ",", "seated", "maximum", "flexion", "may", "constitute", "an", "objective", "criterion", "for", "low", "back", "pain", "diagnosis", ".", "Future", "work", "should", "seek", "to", "confirm", "the", "utility", "of", "this", "test", "in", "individuals", "with", "low", "back", "pain", "." ]	[ "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Conceptual Entity", "O", "B-Spatial Concept", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Organ or Tissue Function", "O", "B-Activity", "O", "O", "B-Organ or Tissue Function", "O", "B-Activity", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Spatial Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Spatial Concept", "O", "B-Finding", "O", "B-Spatial Concept", "B-Organ or Tissue Function", "B-Organism Attribute", "O", "O", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Population Group", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Finding", "O", "B-Spatial Concept", "B-Quantitative Concept", "B-Body Location or Region", "B-Organ or Tissue Function", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Activity", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Activity", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "B-Activity", "O", "B-Organism Attribute", "O", "B-Tissue", "O", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Tissue", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Phenomenon or Process", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Population Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O" ]
[ "The", "Relationship", "Between", "Distance", "and", "Post-operative", "Visit", "Attendance", "Following", "Medical", "Male", "Circumcision", "in", "Nyanza", "Province", ",", "Kenya", "To", "date", ",", "there", "is", "no", "research", "on", "voluntary", "medical", "male", "circumcision", "(", "VMMC", ")", "catchment", "areas", "or", "the", "relationship", "between", "distance", "to", "a", "VMMC", "facility", "and", "attendance", "at", "a", "post-operative", "follow-up", "visit", ".", "We", "analyzed", "data", "from", "a", "randomly", "selected", "subset", "of", "males", "self-seeking", "circumcision", "at", "one", "of", "16", "participating", "facilities", "in", "Nyanza", "Province", ",", "Kenya", "between", "2008", "and", "2010", ".", "Among", "1437", "participants", ",", "46.7", "%", "attended", "follow-up", ".", "The", "median", "distance", "from", "residence", "to", "utilized", "facility", "was", "2.98", "km", "(", "IQR", "1.31-5.38", ")", ".", "Nearly", "all", "participants", "(", "98.8", "%", ")", "lived", "within", "5", "km", "from", "a", "facility", ",", "however", ",", "26.3", "%", "visited", "a", "facility", "more", "than", "5", "km", "away", ".", "Stratified", "results", "demonstrated", "that", "among", "those", "utilizing", "fixed", "facilities", ",", "greater", "distance", "was", "associated", "with", "higher", "odds", "of", "follow-up", "non-attendance", "(", "OR", "5.01-10km", "vs.", "0-1km", "=", "1.71", ",", "95", "%", "CI", "1.08", ",", "2.70", ",", "p", "=", "0.02", ";", "OR", ">", "10km", "vs.", "0-1", "km", "=", "2.80", ",", "95", "%", "CI", "1.26", ",", "6.21", ",", "p", "=", "0.01", ")", ",", "adjusting", "for", "age", "and", "district", "of", "residence", ".", "We", "found", "5", "km", "marked", "the", "threshold", "distance", "beyond", "which", "follow-up", "attendance", "significantly", "dropped", ".", "These", "results", "demonstrate", "distance", "is", "an", "important", "predictor", "of", "attending", "follow-up", ",", "and", "this", "relationship", "appears", "to", "be", "modified", "by", "facility", "type", "." ]	[ "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Behavior", "B-Activity", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Individual Behavior", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Health Care Related Organization", "O", "B-Activity", "O", "O", "B-Finding", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Research Activity", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "B-Activity", "B-Classification", "O", "B-Population Group", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Functional Concept", "B-Health Care Activity", "O", "O", "B-Spatial Concept", "B-Quantitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "B-Behavior", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Health Care Activity", "B-Activity", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Health Care Activity", "B-Activity", "B-Idea or Concept", "B-Quantitative Concept", "O", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "O", "O", "B-Idea or Concept", "O", "B-Functional Concept", "B-Health Care Activity", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Health Care Related Organization", "B-Qualitative Concept", "O" ]
[ "Promoting", "lifestyle", "behaviour", "change", "and", "well-being", "in", "hospital", "patients", ":", "a", "pilot", "study", "of", "an", "evidence-based", "psychological", "intervention", "Lifestyle", "risk", "behaviours", "show", "an", "inverse", "social", "gradient", ",", "clustering", "in", "vulnerable", "groups", ".", "We", "designed", "and", "piloted", "an", "intervention", "to", "address", "barriers", "to", "lifestyle", "behaviour", "change", "among", "hospital", "patients", ".", "We", "designed", "our", "intervention", "using", "effective", "components", "of", "behaviour", "change", "interventions", "informed", "by", "psychological", "theory", ".", "Delivered", "by", "a", "health", "psychologist", "based", "at", "the", "Royal", "Free", "London", "NHS", "Foundation", "Trust", ",", "the", "4-week", "intervention", "included", "detailed", "baseline", "assessment", ",", "personalized", "goal", "setting", ",", "psychological", "skills", "development", ",", "motivation", "support", "and", "referral", "to", "community", "services", ".", "Primary", "outcomes", "were", "feasibility", "and", "patient", "acceptability", ".", "We", "also", "evaluated", "changes", "to", "health", "and", "well-being", ".", "From", "1", "July", "2013", "to", "31", "September", "2014", ",", "686", "patients", "were", "referred", ",", "338", "(", "49.3", "%", ")", "attended", "a", "first", "appointment", "and", "172", "(", "25.1", "%", ")", "completed", "follow-up", ".", "Furthermore", ",", "72.1", "%", "of", "attenders", "were", "female", "with", "the", "median", "age", "55", "years", "and", "poor", "self-reported", "baseline", "health", ".", "After", "4", "weeks", ",", "self-efficacy", ",", "health", "and", "well-being", "scores", "significantly", "improved", ":", "63", "%", "of", "lifestyle", "goals", "and", "89", "%", "of", "health", "management", "goals", "were", "fully", "achieved", ";", "58", "%", "of", "referrals", "to", "community", "lifestyle", "behaviour", "change", "services", "and", "79", "%", "of", "referrals", "to", "other", "services", "(", "e.g", ".", "Citizen", "'s", "Advice", "Bureau", ")", "were", "accepted", ";", "99", "%", "were", "satisfied", "/", "very", "satisfied", "with", "the", "service", ".", "Our", "hospital-based", "intervention", "was", "feasible", ",", "acceptable", "and", "showed", "preliminary", "health", "and", "well-being", "gains", "." ]	[ "B-Activity", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "B-Finding", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Individual Behavior", "B-Individual Behavior", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Self-help or Relief Organization", "B-Self-help or Relief Organization", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Patient or Disabled Group", "B-Qualitative Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "O", "B-Finding", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "B-Organism Attribute", "O", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Mental Process", "O", "B-Idea or Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Intellectual Product", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Self-help or Relief Organization", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Finding", "B-Finding", "O", "O", "B-Health Care Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O" ]
[ "The", "Impact", "of", "Deployment", "on", "Parental", ",", "Family", "and", "Child", "Adjustment", "in", "Military", "Families", "Since", "9/11", ",", "military", "service", "in", "the", "United", "States", "has", "been", "characterized", "by", "wartime", "deployments", "and", "reintegration", "challenges", "that", "contribute", "to", "a", "context", "of", "stress", "for", "military", "families", ".", "Research", "indicates", "the", "negative", "impact", "of", "wartime", "deployment", "on", "the", "well", "being", "of", "service", "members", ",", "military", "spouses", ",", "and", "children", ".", "Yet", ",", "few", "studies", "have", "considered", "how", "parental", "deployments", "may", "affect", "adjustment", "in", "young", "children", "and", "their", "families", ".", "Using", "deployment", "records", "and", "parent", "-", "reported", "measures", "from", "primary", "caregiving", "(", "N", "=", "680", ")", "and", "military", "(", "n", "=", "310", ")", "parents", ",", "we", "examined", "the", "influence", "of", "deployment", "on", "adjustment", "in", "military", "families", "with", "children", "ages", "0-10", "years", ".", "Greater", "deployment", "exposure", "was", "related", "to", "impaired", "family", "functioning", "and", "marital", "instability", ".", "Parental", "depressive", "and", "posttraumatic", "stress", "symptoms", "were", "associated", "with", "impairments", "in", "social", "emotional", "adjustment", "in", "young", "children", ",", "increased", "anxiety", "in", "early", "childhood", ",", "and", "adjustment", "problems", "in", "school-age", "children", ".", "Conversely", ",", "parental", "sensitivity", "was", "associated", "with", "improved", "social", "and", "emotional", "outcomes", "across", "childhood", ".", "These", "findings", "provide", "guidance", "to", "developing", "preventive", "approaches", "for", "military", "families", "with", "young", "children", "." ]	[ "O", "O", "O", "B-Activity", "O", "B-Family Group", "O", "B-Family Group", "O", "B-Age Group", "B-Individual Behavior", "O", "B-Family Group", "B-Family Group", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "B-Temporal Concept", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Family Group", "B-Family Group", "O", "B-Research Activity", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Activity", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Professional or Occupational Group", "B-Population Group", "O", "B-Professional or Occupational Group", "B-Family Group", "O", "O", "B-Age Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Family Group", "B-Activity", "O", "O", "B-Individual Behavior", "O", "B-Age Group", "B-Age Group", "O", "O", "B-Family Group", "O", "O", "I-Intellectual Product", "B-Intellectual Product", "O", "B-Family Group", "O", "B-Intellectual Product", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "B-Family Group", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Individual Behavior", "O", "B-Family Group", "B-Family Group", "O", "B-Age Group", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "B-Functional Concept", "B-Social Behavior", "B-Social Behavior", "O", "B-Finding", "B-Finding", "O", "B-Family Group", "B-Mental or Behavioral Dysfunction", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Functional Concept", "O", "B-Social Behavior", "B-Finding", "B-Individual Behavior", "O", "B-Age Group", "B-Age Group", "O", "O", "B-Finding", "O", "O", "B-Temporal Concept", "O", "O", "B-Individual Behavior", "O", "O", "B-Age Group", "B-Age Group", "O", "O", "O", "B-Family Group", "B-Mental Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Social Behavior", "O", "B-Finding", "B-Finding", "O", "B-Temporal Concept", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Family Group", "B-Family Group", "O", "O", "B-Age Group", "O" ]
[ "Combining", "electrostatic", "powder", "with", "an", "insecticide", ":", "effect", "on", "stored", "-", "product", "beetles", "and", "on", "the", "commodity", "The", "opportunity", "to", "reduce", "the", "amount", "of", "pirimiphos-methyl", "applied", "to", "grain", "by", "formulating", "it", "in", "an", "electrostatic", "powder", "was", "investigated", ".", "The", "insecticidal", "efficacy", "of", "pirimiphos-methyl", "in", "EC", "formulation", "or", "formulated", "using", "electrostatic", "powder", "(", "EP", ")", "as", "an", "inert", "carrier", "was", "investigated", "against", "Sitophilus", "oryzae", "(", "L.", ")", ",", "Oryzaephilus", "surinamensis", "(", "L.", ")", ",", "Rhyzopertha", "dominica", "(", "F.", ")", "and", "Tribolium", "confusum", "Jacquelin", "du", "Val", ".", "Furthermore", ",", "the", "adhesive", "properties", "of", "EP", "to", "rice", ",", "corn", "and", "wheat", ",", "together", "with", "the", "effect", "on", "bulk", "density", "and", "bread", "-", "and", "pasta", "-", "making", "properties", ",", "were", "investigated", ".", "The", "results", "showed", "that", "pirimiphos-methyl", "formulated", "with", "EP", "provided", "better", "efficacy", "against", "adults", "when", "compared", "with", "EC", "formulation", "for", "O.", "surinamensis", "and", "T.", "confusum", ",", "but", "there", "was", "no", "difference", "for", "R.", "dominica", ".", "Progeny", "production", "was", "consistently", "lower", "in", "grain", "treated", "with", "the", "EP", "formulation", "than", "in", "grain", "treated", "with", "the", "EC", ".", "Tests", "showed", "that", "EP", "adhered", "to", "the", "kernels", "for", "longer", "on", "hard", "wheat", "than", "on", "maize", "or", "rice", ".", "In", "most", "commodities", ",", "EP", "did", "not", "alter", "the", "bulk", "density", ".", "Finally", ",", "the", "addition", "of", "EP", "did", "not", "affect", "flour", "-", "and", "bread", "-", "making", "properties", ",", "nor", "the", "pasta", "-making", "properties", ".", "The", "results", "of", "the", "present", "study", "suggest", "that", "an", "EP", "could", "be", "used", "to", "reduce", "the", "amount", "of", "pirimiphos-methyl", "applied", "to", "grain", "for", "effective", "pest", "control", ",", "with", "no", "detrimental", "effects", "on", "grain", "quality", ".", "©", "2016", "Society", "of", "Chemical", "Industry", "." ]	[ "O", "B-Substance", "B-Substance", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Functional Concept", "O", "B-Entity", "B-Eukaryote", "O", "O", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Food", "O", "O", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Qualitative Concept", "O", "B-Pharmacologic Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Substance", "B-Substance", "O", "B-Substance", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Substance", "O", "B-Food", "O", "B-Food", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Food", "O", "O", "B-Food", "O", "B-Activity", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Substance", "O", "O", "B-Qualitative Concept", "O", "B-Eukaryote", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Family Group", "O", "O", "O", "O", "O", "B-Food", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Substance", "O", "O", "O", "B-Food", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "B-Substance", "B-Phenomenon or Process", "O", "O", "B-Food", "O", "O", "O", "O", "B-Food", "O", "O", "B-Food", "O", "B-Food", "O", "O", "O", "B-Food", "O", "B-Substance", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "B-Food", "O", "O", "B-Food", "O", "B-Activity", "B-Qualitative Concept", "O", "O", "O", "B-Food", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Food", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Food", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Radiofrequency", "ablation", "of", "posteroseptal", "accessory", "pathways", "associated", "with", "coronary", "sinus", "diverticula", "Posteroseptal", "accessory", "pathways", "may", "be", "associated", "with", "a", "coronary", "sinus", "(", "CS", ")", "diverticulum", ".", "Our", "purpose", "was", "to", "describe", "the", "clinical", "characteristics", ",", "mapping", "and", "ablation", "of", "these", "pathways", ".", "This", "was", "a", "retrospective", "study", "of", "all", "patients", "who", "underwent", "ablation", "of", "posteroseptal", "accessory", "pathways", "in", "a", "single", "centre", ".", "Patients", "with", "a", "diverticulum", "of", "the", "CS", "or", "one", "of", "its", "tributaries", "were", "included", "in", "group", "I", ",", "while", "the", "other", "patients", "formed", "group", "II", ".", "Clinical", "presentation", ",", "ablation", "procedure", "and", "outcome", "were", "compared", "between", "the", "two", "groups", ".", "A", "total", "of", "51", "patients", "were", "included", ",", "16", "in", "group", "I", "and", "35", "in", "group", "II", ".", "There", "were", "no", "significant", "differences", "in", "age", "or", "sex", "distribution", ".", "Atrial", "fibrillation", "(", "AF", ")", "and", "previous", "unsuccessful", "ablation", "were", "more", "common", "in", "group", "I", ".", "A", "negative", "delta", "wave", "in", "lead", "II", "was", "the", "ECG", "finding", "with", "best", "sensitivity", "and", "specificity", "for", "the", "presence", "of", "a", "diverticulum", ".", "A", "pathway", "potential", "was", "common", "at", "the", "successful", "site", "in", "group", "I", ",", "and", "the", "interval", "between", "local", "ventricular", "electrogram", "and", "delta", "wave", "onset", "was", "shorter", "(", "19.5", "±", "8", "vs", "33.1", "±", "7.6", "ms", ",", "p", "<", "0.001", ")", ".", "There", "was", "a", "trend", "toward", "lower", "procedural", "success", "rate", "and", "higher", "recurrence", "rate", "in", "group", "I", ",", "although", "this", "was", "not", "significant", ".", "CS", "diverticula", "should", "be", "suspected", "in", "patients", "with", "manifest", "posteroseptal", "accessory", "pathways", "who", "have", "a", "previous", "failed", "ablation", ",", "documented", "AF", "or", "typical", "electrocardiographic", "signs", ".", "A", "discrete", "potential", "is", "frequently", "seen", "at", "the", "successful", "site", ",", "but", "the", "local", "ventricular", "electrogram", "is", "not", "as", "early", "as", "in", "other", "accessory", "pathways", "." ]	[ "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Diagnostic Procedure", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Finding", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "B-Quantitative Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Disease or Syndrome", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O" ]
[ "Association", "of", "RBP4", "levels", "with", "increased", "arterial", "stiffness", "in", "adolescents", "with", "family", "history", "of", "type", "2", "diabetes", "The", "aim", "of", "this", "study", "was", "to", "explore", "the", "impact", "of", "family", "history", "of", "type", "2", "diabetes", "(", "FH2D", ")", "on", "arterial", "stiffness", "in", "young", "people", "and", "its", "relationship", "to", "adipocytokines", ".", "This", "case-control", "study", "included", "52", "adolescents", "(", "male", "/", "female", "28/24", ")", "with", "FH2D", "(", "FH2D+", ")", "and", "40", "adolescents", "(", "male", "/", "female", "21/19", ")", "without", "FH2D", "(", "FH2D-", ")", ".", "Anthropometric", "measurements", ",", "including", "height", ",", "weight", ",", "waist", "circumference", "(", "WC", ")", ",", "and", "blood", "pressure", ",", "were", "obtained", ".", "Blood", "samples", "were", "collected", ",", "fasting", "plasma", "glucose", "(", "FPG", ")", ",", "serum", "lipids", ",", "Retinol", "Binding", "Protein", "4", "(", "RBP4", ")", ",", "C", "reactive", "protein", "(", "CRP", ")", ",", "adiponectin", "and", "visfatin", "were", "examined", ".", "Brachial-ankle", "pulse", "wave", "velocity", "(", "baPWV", ")", "was", "used", "to", "evaluate", "arterial", "stiffness", ".", "Visceral", "fat", "area", "(", "VFA", ")", "was", "measured", "by", "computerized", "tomography", ".", "Compared", "with", "FH2D-", "group", ",", "FH2D+", "group", "had", "a", "significantly", "higher", "oral", "glucose", "tolerance", "test", "(", "OGTT", ")", "2-hour", "insulin", ",", "RBP4", "and", "baPWV", "levels", ",", "a", "lower", "adiponectin", "and", "glucose", "infusing", "rate", "(", "GIR", ")", "(", "P", "<", "0.05", ")", ".", "BaPWV", "was", "positively", "correlated", "with", "age", ",", "systolic", "blood", "pressure", "(", "SBP", ")", ",", "diastolic", "blood", "pressure", "(", "DBP", ")", ",", "2-hour", "(", "OGTT", ")", "insulin", ",", "RBP4", ",", "and", "VFA", ",", "and", "negatively", "correlated", "with", "GIR", "in", "FH2D+", "group", ".", "After", "multivariate", "analysis", ",", "age", ",", "SBP", ",", "RBP4", "and", "VFA", "maintained", "an", "independent", "association", "with", "baPWV", "in", "FH2D+", "group", "(", "P", "<", "0.05", ")", ",", "while", "only", "age", ",", "SBP", ",", "and", "VFA", "were", "independent", "predictors", "of", "baPWV", "in", "FH2D-", "group", "(", "P", "<", "0.05", ")", ".", "These", "findings", "led", "to", "the", "conclusion", "that", "RBP4", "level", "was", "associated", "with", "increased", "arterial", "stiffness", "in", "young", "subjects", "with", "family", "history", "of", "type", "2", "diabetes", "." ]	[ "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Age Group", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Temporal Concept", "B-Population Group", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Age Group", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "B-Finding", "O", "B-Finding", "O", "O", "O", "B-Age Group", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "B-Finding", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "B-Organism Function", "B-Organism Function", "O", "O", "O", "O", "B-Body Substance", "B-Body Substance", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Laboratory Procedure", "O", "B-Enzyme", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Finding", "B-Population Group", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Population Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "O", "B-Biologically Active Substance", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Clinical Attribute", "O", "O", "B-Idea or Concept", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Temporal Concept", "B-Population Group", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O" ]
[ "EZH2", "and", "ZFX", "oncogenes", "in", "malignant", "behaviour", "of", "parathyroid", "neoplasms", "Several", "studies", "reported", "somatic", "mutations", "of", "many", "genes", "(", "MEN1", ",", "CTNNB1", ",", "CDKIs", "and", "others", ")", "in", "parathyroid", "adenoma", ",", "although", "with", "different", "prevalence", ".", "Recently", ",", "activating", "mutations", "of", "the", "EZH2", "and", "ZFX", "oncogenes", "were", "identified", "in", "benign", "parathyroid", "adenoma", "by", "whole", "exome", "sequencing", ".", "The", "same", "mutations", "had", "been", "found", "in", "blood", "and", "ovary", "malignant", "tumours", ".", "On", "one", "hand", ",", "this", "result", "raised", "the", "hypothesis", "that", "these", "oncogenes", "may", "play", "a", "role", "in", "the", "onset", "of", "parathyroid", "tumour", ",", "but", "it", "would", "also", "suggest", "they", "may", "be", "involved", "in", "malignant", ",", "rather", "benign", ",", "parathyroid", "neoplasm", ".", "Our", "aim", "was", "to", "verify", "the", "occurrence", "of", "selected", "mutations", "of", "the", "EZH2", "and", "ZFX", "genes", "in", "an", "Italian", "cohort", "of", "23", "sporadic", "parathyroid", "carcinomas", ",", "12", "atypical", "and", "45", "typical", "adenomas", ".", "DNA", "was", "extracted", "from", "paraffin-embedded", "tissues", ",", "PCR", "amplified", "and", "directly", "sequenced", ".", "No", "mutations", "were", "detected", "in", "the", "coding", "sequence", "and", "boundaries", "of", "both", "genes", "in", "any", "of", "the", "samples", ".", "Two", "polymorphisms", "of", "the", "EZH2", "gene", "were", "identified", "with", "different", "prevalence", ":", "the", "rs2072407", "variant", "was", "present", "in", "the", "30", "%", "of", "the", "samples", ",", "in", "keeping", "with", "the", "overall", "frequency", "in", "larger", "populations", ",", "while", "the", "rs78589034", "variant", ",", "located", "close", "to", "the", "5", "'", "end", "of", "the", "exon", "16", ",", "was", "detected", "in", "only", "one", "proband", "with", "familial", "isolated", "hyperparathyroidism", ";", "we", "investigated", "the", "possible", "outcome", "on", "the", "splicing", "process", ".", "EZH2", "and", "ZFX", "genes", "do", "not", "seem", "to", "have", "an", "impact", "on", "the", "onset", "of", "most", "parathyroid", "tumours", ",", "both", "benign", "and", "malignant", ",", "though", "further", "studies", "on", "larger", "cohorts", "of", "different", "ethnicity", "are", "needed", "." ]	[ "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Research Activity", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Activity", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Body Substance", "O", "B-Body Part, Organ, or Organ Component", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Neoplastic Process", "O", "B-Biologically Active Substance", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Tissue", "B-Tissue", "O", "B-Molecular Biology Research Technique", "B-Phenomenon or Process", "O", "O", "B-Functional Concept", "O", "B-Finding", "B-Genetic Function", "O", "B-Finding", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Substance", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Temporal Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Finding", "O", "O", "O", "B-Family Group", "O", "B-Functional Concept", "B-Functional Concept", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Population Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O" ]
[ "The", "effect", "of", "total", "hip", "arthroplasty", "on", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "and", "low", "back", "pain", "in", "patients", "with", "severe", "hip", "osteoarthritis", "Sagittal", "spinopelvic", "malalignment", "has", "been", "reported", "in", "spinal", "disorders", "such", "as", "low", "back", "pain", "(", "LBP", ")", ",", "and", "restoration", "of", "normal", "alignment", "is", "targeted", "when", "treating", "these", "disorders", ".", "Abnormal", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "has", "been", "reported", "in", "patients", "with", "severe", "hip", "osteoarthritis", "(", "OA", ")", ",", "who", "have", "a", "high", "prevalence", "of", "associated", "LBP", ".", "This", "prospective", "longitudinal", "study", "aimed", "to", "investigate", "changes", "in", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "after", "total", "hip", "arthroplasty", "(", "THA", ")", "in", "patients", "with", "severe", "hip", "OA", ",", "and", "whether", "these", "changes", "contribute", "to", "LBP", "relief", ".", "Patients", "undergoing", "primary", "THA", "due", "to", "severe", "unilateral", "hip", "OA", "were", "recruited", ".", "Physical", "examination", "and", "X-ray", "films", "were", "taken", "to", "rule", "out", "any", "spinal", "disorder", ".", "Sagittal", "alignment", "of", "pelvis", ",", "hip", ",", "and", "spine", "was", "analyzed", "on", "lateral", "radiographs", "taken", "before", "(", "baseline", ")", "and", "1", "year", "after", "(", "follow-up", ")", "THA", ".", "Functional", "instruments", "were", "completed", "by", "patients", "including", ":", "visual", "analog", "scale", "(", "VAS", ")", "for", "LBP", ",", "Roland-Morris", "Disability", "Questionnaire", "(", "RMDQ", ")", ",", "and", "Harris", "Hip", "Score", "(", "HHS", ")", ".", "Comparisons", "were", "carried", "out", "at", "baseline", "and", "follow-up", ",", "and", "between", "patients", "with", "and", "without", "LBP", ".", "The", "recruited", "69", "patients", "showed", "significantly", "reduced", "hip", "flexion", "and", "improved", "global", "spinal", "balance", "at", "follow-up", "compared", "with", "baseline", ".", "LBP", "was", "reported", "by", "39", "patients", "(", "56.5", "%", ")", "before", "surgery", ";", "at", "follow-up", ",", "17", "reported", "complete", "resolution", ",", "while", "22", "reported", "significant", "relief", ".", "Significant", "decreases", "in", "VAS", "and", "RMDQ", "scores", "in", "lumbar", "spine", "and", "increase", "in", "hip", "HHS", "were", "observed", ".", "THA", "in", "patients", "with", "severe", "hip", "OA", "could", "help", "correct", "abnormal", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "and", "relieve", "comorbid", "LBP", ".", "Improvements", "in", "hip", "flexion", "and", "global", "spinal", "balance", "might", "be", "involved", "in", "the", "mechanism", "of", "LBP", "relief", "." ]	[ "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Body Location or Region", "B-Body Part, Organ, or Organ Component", "B-Pathologic Function", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "O", "B-Finding", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Sign or Symptom", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Sign or Symptom", "B-Finding", "O", "B-Patient or Disabled Group", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Body Location or Region", "B-Finding", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Health Care Activity", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "B-Sign or Symptom", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Health Care Activity", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Health Care Activity", "O", "O", "B-Quantitative Concept", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Clinical Attribute", "O", "B-Intellectual Product", "B-Quantitative Concept", "O", "B-Body Location or Region", "B-Body Location or Region", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "B-Finding", "B-Sign or Symptom", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "B-Sign or Symptom", "B-Finding", "O" ]
[ "Beyond", "neutral", "and", "forbidden", "links", ":", "morphological", "matches", "and", "the", "assembly", "of", "mutualistic", "hawkmoth", "-", "plant", "networks", "A", "major", "challenge", "in", "evolutionary", "ecology", "is", "to", "understand", "how", "co-evolutionary", "processes", "shape", "patterns", "of", "interactions", "between", "species", "at", "community", "level", ".", "Pollination", "of", "flowers", "with", "long", "corolla", "tubes", "by", "long-tongued", "hawkmoths", "has", "been", "invoked", "as", "a", "showcase", "model", "of", "co-evolution", ".", "Recently", ",", "optimal", "foraging", "models", "have", "predicted", "that", "there", "might", "be", "a", "close", "association", "between", "mouthparts", "'", "length", "and", "the", "corolla", "depth", "of", "the", "visited", "flowers", ",", "thus", "favouring", "trait", "convergence", "and", "specialization", "at", "community", "level", ".", "Here", ",", "we", "assessed", "whether", "hawkmoths", "more", "frequently", "pollinate", "plants", "with", "floral", "tube", "lengths", "similar", "to", "their", "proboscis", "lengths", "(", "morphological", "match", "hypothesis", ")", "against", "abundance", "-based", "processes", "(", "neutral", "hypothesis", ")", "and", "ecological", "trait", "mismatches", "constraints", "(", "forbidden", "links", "hypothesis", ")", ",", "and", "how", "these", "processes", "structure", "hawkmoth", "-", "plant", "mutualistic", "networks", "from", "five", "communities", "in", "four", "biogeographical", "regions", "of", "South", "America", ".", "We", "found", "convergence", "in", "morphological", "traits", "across", "the", "five", "communities", "and", "that", "the", "distribution", "of", "morphological", "differences", "between", "hawkmoths", "and", "plants", "is", "consistent", "with", "expectations", "under", "the", "morphological", "match", "hypothesis", "in", "three", "of", "the", "five", "communities", ".", "In", "the", "two", "remaining", "communities", ",", "which", "are", "ecotones", "between", "two", "distinct", "biogeographical", "areas", ",", "interactions", "are", "better", "predicted", "by", "the", "neutral", "hypothesis", ".", "Our", "findings", "are", "consistent", "with", "the", "idea", "that", "diffuse", "co-evolution", "drives", "the", "evolution", "of", "extremely", "long", "proboscises", "and", "flower", "tubes", ",", "and", "highlight", "the", "importance", "of", "morphological", "traits", ",", "beyond", "the", "forbidden", "links", "hypothesis", ",", "in", "structuring", "interactions", "between", "mutualistic", "partners", ",", "revealing", "that", "the", "role", "of", "niche-based", "processes", "can", "be", "much", "more", "complex", "than", "previously", "known", "." ]	[ "O", "B-Conceptual Entity", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "B-Phenomenon or Process", "B-Eukaryote", "O", "B-Plant", "B-Functional Concept", "O", "O", "O", "O", "B-Occupation or Discipline", "B-Occupation or Discipline", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Spatial Concept", "O", "B-Functional Concept", "O", "B-Classification", "O", "B-Group", "B-Qualitative Concept", "O", "B-Organism Function", "O", "B-Plant", "O", "B-Plant", "B-Plant", "B-Plant", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "O", "O", "B-Research Device", "O", "B-Genetic Function", "O", "O", "O", "O", "O", "B-Research Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Plant", "B-Spatial Concept", "O", "O", "O", "B-Plant", "O", "O", "O", "B-Organism Attribute", "B-Activity", "O", "B-Occupation or Discipline", "O", "B-Group", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Eukaryote", "O", "O", "B-Plant", "B-Plant", "O", "B-Classification", "B-Classification", "B-Quantitative Concept", "O", "O", "O", "B-Eukaryote", "B-Quantitative Concept", "O", "B-Spatial Concept", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "O", "B-Phenomenon or Process", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Qualitative Concept", "B-Occupational Activity", "O", "B-Conceptual Entity", "B-Conceptual Entity", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Spatial Concept", "B-Eukaryote", "O", "B-Plant", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Group", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "B-Activity", "O", "B-Spatial Concept", "B-Organism Attribute", "O", "O", "O", "B-Group", "O", "O", "O", "B-Functional Concept", "O", "B-Spatial Concept", "O", "O", "B-Eukaryote", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "B-Genetic Function", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Organism Attribute", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "B-Idea or Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Impact", "of", "totally", "laparoscopic", "combined", "management", "of", "colorectal", "cancer", "with", "synchronous", "hepatic", "metastases", "on", "severity", "of", "complications", ":", "a", "propensity-score", "-based", "analysis", "Thanks", "to", "widespread", "diffusion", "of", "minimally", "invasive", "approach", "in", "the", "setting", "of", "both", "colorectal", "and", "hepatic", "surgeries", ",", "the", "interest", "in", "combined", "resections", "for", "colorectal", "cancer", "and", "synchronous", "liver", "metastases", "(", "SCLM", ")", "by", "totally", "laparoscopic", "approach", "(", "TLA", ")", "has", "increased", ".", "Aim", "of", "this", "study", "was", "to", "compare", "outcome", "of", "combined", "resections", "for", "SCLM", "performed", "by", "TLA", "or", "by", "open", "approach", ",", "in", "a", "propensity-score-based", "study", ".", "All", "25", "patients", "undergoing", "combined", "TLA", "for", "SCLM", "at", "San", "Raffaele", "Hospital", "in", "Milano", "were", "compared", "in", "a", "case-matched", "analysis", "with", "25", "out", "of", "91", "patients", "undergoing", "totally", "open", "approach", "(", "TOA", "group", ")", ".", "Groups", "were", "matched", "with", "1:2", "ratio", "using", "propensity", "scores", "based", "on", "covariates", "representing", "disease", "severity", ".", "Main", "endpoints", "were", "postoperative", "morbidity", "and", "long-term", "outcome", ".", "The", "Modified", "Accordion", "Severity", "Grading", "System", "was", "used", "to", "quantify", "complications", ".", "The", "groups", "resulted", "comparable", "in", "terms", "of", "patients", "and", "disease", "characteristics", ".", "The", "TLA", "group", ",", "as", "compared", "to", "the", "TOA", "group", ",", "had", "lower", "blood", "loss", "(", "350", "vs", "600", "mL", ")", ",", "shorter", "postoperative", "stay", "(", "9", "vs", "12", "days", ")", ",", "lower", "postoperative", "morbidity", "index", "(", "0.14", "vs", "0.20", ")", "and", "severity", "score", "for", "complicated", "patients", "(", "0.60", "vs", "0.85", ")", ".", "Colonic", "anastomosis", "leakage", "had", "the", "highest", "fractional", "complication", "burden", "in", "both", "groups", ".", "In", "spite", "of", "comparable", "long-term", "overall", "survival", ",", "the", "TLA", "group", "had", "better", "recurrence-free", "survival", ".", "TLA", "for", "combined", "resections", "is", "feasible", ",", "and", "its", "indications", "can", "be", "widened", "to", "encompass", "a", "larger", "population", "of", "patients", ",", "provided", "its", "benefits", "in", "terms", "of", "reduced", "overall", "risk", "and", "severity", "of", "complications", ",", "rapid", "functional", "recovery", "and", "favorable", "long-term", "outcomes", "." ]	[ "O", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Diagnostic Procedure", "O", "B-Neoplastic Process", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Quantitative Concept", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "I-Population Group", "B-Population Group", "O", "O", "B-Finding", "B-Finding", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Temporal Concept", "B-Functional Concept", "O" ]
[ "Application", "of", "an", "Analytical", "Solution", "as", "a", "Screening", "Tool", "for", "Sea", "Water", "Intrusion", "Sea", "water", "intrusion", "into", "aquifers", "is", "problematic", "in", "many", "coastal", "areas", ".", "The", "physics", "and", "chemistry", "of", "this", "issue", "are", "complex", ",", "and", "sea", "water", "intrusion", "remains", "challenging", "to", "quantify", ".", "Simple", "assessment", "tools", "like", "analytical", "models", "offer", "advantages", "of", "rapid", "application", ",", "but", "their", "applicability", "to", "field", "situations", "is", "unclear", ".", "This", "study", "examines", "the", "reliability", "of", "a", "popular", "sharp-interface", "analytical", "approach", "for", "estimating", "the", "extent", "of", "sea", "water", "in", "a", "homogeneous", "coastal", "aquifer", "subjected", "to", "pumping", "and", "regional", "flow", "effects", "and", "under", "steady-state", "conditions", ".", "The", "analytical", "model", "is", "tested", "against", "observations", "from", "Canada", ",", "the", "United", "States", ",", "and", "Australia", "to", "assess", "its", "utility", "as", "an", "initial", "approximation", "of", "sea", "water", "extent", "for", "the", "purposes", "of", "rapid", "groundwater", "management", "decision", "making", ".", "The", "occurrence", "of", "sea", "water", "intrusion", "resulting", "in", "increased", "salinity", "at", "pumping", "wells", "was", "correctly", "predicted", "in", "approximately", "60", "%", "of", "cases", ".", "Application", "of", "a", "correction", "to", "account", "for", "dispersion", "did", "not", "markedly", "improve", "the", "results", ".", "Failure", "of", "the", "analytical", "model", "to", "provide", "correct", "predictions", "can", "be", "attributed", "to", "mismatches", "between", "its", "simplifying", "assumptions", "and", "more", "complex", "field", "settings", ".", "The", "best", "results", "occurred", "where", "the", "toe", "of", "the", "salt", "water", "wedge", "is", "expected", "to", "be", "the", "closest", "to", "the", "coast", "under", "predevelopment", "conditions", ".", "Predictions", "were", "the", "poorest", "for", "aquifers", "where", "the", "salt", "water", "wedge", "was", "expected", "to", "extend", "further", "inland", "under", "predevelopment", "conditions", "and", "was", "therefore", "more", "dispersive", "prior", "to", "pumping", ".", "Sharp-interface", "solutions", "remain", "useful", "tools", "to", "screen", "for", "the", "vulnerability", "of", "coastal", "aquifers", "to", "sea", "water", "intrusion", ",", "although", "the", "significant", "sources", "of", "uncertainty", "identified", "in", "this", "study", "require", "careful", "consideration", "to", "avoid", "misinterpreting", "sharp-interface", "results", "." ]	[ "B-Functional Concept", "O", "O", "B-Intellectual Product", "B-Conceptual Entity", "O", "O", "B-Health Care Activity", "B-Intellectual Product", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "O", "B-Finding", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Occupation or Discipline", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Quantitative Concept", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Natural Phenomenon or Process", "O", "O", "B-Functional Concept", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Qualitative Concept", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Functional Concept", "O", "B-Idea or Concept", "O", "B-Geographic Area", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Geographic Area", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Substance", "B-Substance", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Occupational Activity", "B-Mental Process", "B-Mental Process", "O", "O", "B-Temporal Concept", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "B-Quantitative Concept", "B-Laboratory or Test Result", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Finding", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "B-Spatial Concept", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "B-Intellectual Product", "O", "B-Health Care Activity", "O", "O", "B-Finding", "O", "B-Spatial Concept", "B-Natural Phenomenon or Process", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O" ]
[ "Patient", "-", "Physician", "Discordance", "in", "Global", "Assessment", "in", "Rheumatoid", "Arthritis", ":", "A", "Systematic", "Literature", "Review", "With", "Meta-Analysis", "The", "integration", "of", "the", "patient", "in", "therapeutic", "decision-making", "is", "important", "in", "the", "management", "of", "rheumatoid", "arthritis", "(", "RA", ")", ",", "but", "the", "patient", "opinion", "regarding", "disease", "status", "may", "differ", "from", "the", "physician", "'s", "opinion", ".", "The", "aim", "of", "this", "study", "was", "to", "assess", "in", "the", "published", "literature", "the", "frequency", "and", "drivers", "of", "patient", "-", "physician", "discordance", "in", "global", "assessment", "in", "RA", ".", "A", "systematic", "literature", "review", "of", "all", "articles", "published", "up", "to", "January", "2015", "in", "Medline", "or", "Embase", ",", "reporting", "discordance", "in", "RA", ",", "was", "conducted", "by", "2", "investigators", ".", 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";", "the", "weighted", "mean", "value", "was", "2.7", "cm", ".", "The", "pooled", "percentage", "of", "patients", "with", "discordance", "was", "43", "%", "(", "95", "%", "confidence", "interval", "36", "%", "-51", "%", ";", "range", "25", "%", "-76", "%", ")", ".", "PGA", "was", "usually", "higher", "than", "PhGA", ".", "The", "drivers", "of", "PGA", "were", "pain", "and", "functional", "incapacity", ",", "whereas", "drivers", "of", "PhGA", "were", "joint", "counts", "and", "acute-phase", "reactants", ".", "Discordance", "in", "global", "assessment", "was", "most", "frequently", "defined", "as", "a", "difference", "of", "3", "points", "or", "more", ";", "even", "with", "such", "a", "stringent", "definition", ",", "up", "to", "half", "the", "patients", "were", "found", "to", "be", "discordant", ".", "The", "long-term", "consequences", "of", "this", "discordance", "remain", "to", "be", "determined", "." ]	[ "B-Patient or Disabled Group", "O", "B-Professional or Occupational Group", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Research Activity", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "B-Mental Process", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Patient or Disabled Group", "B-Mental Process", "O", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Mental Process", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Activity", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Temporal Concept", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Professional or Occupational Group", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Occupational Activity", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Research Activity", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Intellectual Product", "O", "B-Research Activity", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "O", "B-Research Activity", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Sign or Symptom", "O", "B-Functional Concept", "B-Clinical Attribute", "O", "O", "O", "O", "B-Research Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O" ]
[ "Nosocomial", "pneumonia", "caused", "by", "methicillin-resistant", "Staphylococcus", "aureus", "treated", "with", "linezolid", "or", "vancomycin", ":", "A", "secondary", "economic", "analysis", "of", "resource", "use", "from", "a", "Spanish", "perspective", "Adopting", "a", "unique", "Spanish", "perspective", ",", "this", "study", "aims", "to", "assess", "healthcare", "resource", "utilization", "(", "HCRU", ")", "and", "the", "costs", "of", "treating", "nosocomial", "pneumonia", "(", "NP", ")", "produced", "by", "methicillin-resistant", "Staphylococcus", "aureus", "(", "MRSA", ")", "in", "hospitalized", "adults", "using", "linezolid", "or", "vancomycin", ".", "An", "evaluation", "is", "also", "made", "of", "the", "renal", "failure", "rate", "and", "related", "economic", "outcomes", "between", "study", "groups", ".", "An", "economic", "post", "hoc", "evaluation", "of", "a", "randomized", ",", "double-blind", ",", "multicenter", "phase", "4", "study", "was", "carried", "out", ".", "Nosocomial", "pneumonia", "due", "to", "MRSA", "in", "hospitalized", "adults", ".", "The", "modified", "intent", "to", "treat", "(", "mITT", ")", "population", "comprised", "224", "linezolid", "-", "and", "224", "vancomycin", "-", "treated", "patients", ".", "Costs", "and", "HCRU", "were", "evaluated", "between", "patients", "administered", "either", "linezolid", "or", "vancomycin", ",", "and", "between", "patients", "who", "developed", "renal", "failure", "and", "those", "who", "did", "not", ".", "Analysis", "of", "HCRU", "outcomes", "and", "costs", ".", "Total", "costs", "were", "similar", "between", "the", "linezolid", "-", "(", "€17,782±€9,615", ")", "and", "vancomycin", "-", "treated", "patients", "(", "€17,423±€9,460", ")", "(", "P=.69", ")", ".", "The", "renal", "failure", "rate", "was", "significantly", "lower", "in", "the", "linezolid", "-", "treated", "patients", "(", "4", "%", "vs.", "15", "%", ";", "P", "<", ".001", ")", ".", "The", "total", "costs", "tended", "to", "be", "higher", "in", "patients", "who", "developed", "renal", "failure", "(", "€19,626±€10,840", "vs.", "€17,388±€9,369", ";", "P=.14", ")", ".", "Among", "the", "patients", "who", "developed", "renal", "failure", ",", "HCRU", "(", "days", "on", "mechanical", "ventilation", ":", "13.2±10.7", "vs.", "7.6±3.6", "days", ";", "P=.21", ";", "ICU", "stay", ":", "14.4±10.5", "vs.", "9.9±6.6", "days", ";", "P=.30", ";", "hospital", "stay", ":", "19.5±9.5", "vs.", "16.1±11.0", "days", ";", "P=.26", ")", "and", "cost", "(", "€17,219±€8,792", "vs.", "€20,263±€11,350", ";", "P=.51", ")", "tended", "to", "be", "lower", "in", "the", "linezolid", "-", "vs.", "vancomycin", "-", "treated", "patients", ".", "There", "were", "no", "statistically", "significant", "differences", "in", "costs", "per", "patient", "-", "day", "between", "cohorts", "after", "correcting", "for", "mortality", "(", "€1000", "vs.", "€1,010", ";", "P=.98", ")", ".", "From", "a", "Spanish", "perspective", ",", "there", "were", "no", "statistically", "significant", "differences", "in", "total", "costs", "between", "the", "linezolid", "and", "vancomycin", "pneumonia", "cohorts", ".", "The", "drug", "cost", "corresponding", "to", "linezolid", "was", "partially", "offset", "by", "fewer", "renal", "failure", "adverse", "events", "." ]	[ "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Geographic Area", "O", "O", "O", "O", "B-Geographic Area", "O", "O", "O", "B-Research Activity", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Idea or Concept", "O", "O", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "B-Bacterium", "O", "O", "B-Finding", "B-Finding", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Research Activity", "O", "B-Research Activity", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Bacterium", "O", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Population Group", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "B-Quantitative Concept", "O", "B-Idea or Concept", "O", "O", "O", "B-Patient or Disabled Group", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Idea or Concept", "O", "B-Temporal Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "B-Temporal Concept", "O", "B-Population Group", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "B-Disease or Syndrome", "B-Population Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Quantitative Concept", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Pathologic Function", "B-Pathologic Function", "O" ]
[ "The", "Role", "of", "TRAF4", "and", "B3GAT1", "Gene", "Expression", "in", "the", "Food", "Hypersensitivity", "and", "Insect", "Venom", "Allergy", "in", "Mastocytosis", "Mastocytosis", "is", "an", "uncommon", "disease", "classified", "as", "a", "myeloproliferative", "neoplasm", ",", "however", ",", "its", "symptoms", "are", "broad", "and", "place", "patients", "at", "crossroads", "between", "dermatology", ",", "hematology", "and", "allergology", ".", "Patients", "with", "mastocytosis", "often", "suffer", "from", "symptoms", "resulting", "from", "the", "activation", "and", "release", "of", "mediators", "from", "the", "mast", "cells", ",", "such", "as", "generalized", "itching", ",", "redness", ",", "headache", ",", "abdominal", "cramps", ",", "diarrhea", ",", "bone", "pain", "or", "arthritis", ",", "hypotension", "and", "shock", ".", "The", "possible", "severe", ",", "fatal", "or", "near", "fatal", "reactions", "caused", "by", "food", "hypersensitivity", "are", "reasons", "for", "the", "research", "focused", "on", "marker", "identification", ".", "The", "aim", "of", "the", "study", "was", "to", "analyse", "the", "gene", "expression", "differences", "in", "mastocytosis", "patients", "with", "and", "without", "food", "and", "drug", "hypersensitivity", "and", "insect", "venom", "allergy", "(", "IVA", ")", ".", "A", "total", "of", "57", "Caucasian", "patients", "with", "mastocytosis", "were", "studied", "[", "median", "age", "41.8", ";", "range", "18-77", "years", ";", "15", "(", "26.3", "%", ")", "males", "and", "42", "(", "73.7", "%", ")", "females", "]", ".", "Quantitative", "RT-PCRs", "of", "11", "genes", "plus", "ribosomal", "18S", "RNA", "were", "run", ".", "Symptoms", "of", "food", "hypersensitivity", "were", "found", "in", "12", "patients", "(", "21", "%", ")", ",", "including", "3", "patients", "(", "13", "%", ")", "with", "cutaneous", "mastocytosis", "(", "CM", ")", ",", "and", "9", "(", "28", "%", ")", "with", "indolent", "systemic", "mastocytosis", "(", "ISM", ")", ".", "IVA", "was", "confirmed", "in", "13", "patients", "(", "22.8", "%", ")", "including", "6", "patients", "(", "10.5", "%", ")", "with", "CM", ",", "and", "7", "patients", "(", "12.3", "%", ")", "with", "ISM", ".", "Drug", "hypersensitivity", "was", "diagnosed", "in", "10", "patients", "(", "17.5", "%", ")", ".", "Significant", "differences", "in", "the", "gene", "expression", "were", "found", "for", "TRAF4", "(", "p", "=", "0.008", ")", "in", "the", "comparison", "of", "the", "mastocytosis", "patients", "with", "and", "without", "concomitant", "food", "hypersensitivity", ".", "Furthermore", "significant", "differences", "were", "found", "in", "gene", "expression", "for", "B3GAT1", "(", "p", "=", "0.003", ")", "in", "patients", "with", "IVA", "compared", "to", "patients", "without", "insect", "sting", "anaphylaxis", "in", "the", "medical", "history", ".", "The", "expression", "of", "studied", "genes", "did", "not", "differ", "according", "to", "the", "presence", "of", "drug", "hypersensitivity", ".", "The", "TRAF4", "expression", "was", "higher", "in", "mastocytosis", "patients", "with", "food", "hypersensitivity", "in", "their", "medical", "history", ",", "the", "B3GAT1", "expression", "was", "lower", "in", "mastocytosis", "patients", "with", "IVA", "in", "history", "." ]	[ "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Finding", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "B-Gene or Genome", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "B-Sign or Symptom", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "B-Pathologic Function", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Finding", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "O", "O", "B-Patient or Disabled Group", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "O", "O", "O" ]
[ "Generalized", "Weakness", "in", "a", "Transplant", "Patient", ":", "A", "Case", "Presentation", "Generalized", "weakness", "in", "transplant", "patients", "is", "a", "major", "complaint", "in", "tertiary", "rehabilitation", "hospitals", ".", "The", "diagnosis", "and", "management", "of", "generalized", "weakness", "in", "this", "population", "pose", "challenges", "for", "physicians", ".", "We", "present", "the", "case", "of", "a", "transplant", "patient", "with", "generalized", "weakness", "who", "was", "eventually", "diagnosed", "with", "calciphylaxis", "using", "a", "multidisciplinary", "diagnostic", "approach", "of", "electrodiagnostics", ",", "vascular", "study", ",", "and", "skin", "biopsy", ".", "Calciphylaxis", "is", "a", "rare", "cutaneous", "disorder", "that", "mimics", "other", "collagen", "vascular", "diseases", "in", "its", "presentation", "and", "fulminant", "course", ".", "Physiatrists", "should", "be", "cognizant", "of", "calciphylaxis", ",", "as", "it", "signals", "a", "poor", "prognosis", "if", "not", "correctly", "diagnosed", "and", "treated", "in", "a", "timely", "manner", ",", "with", "high", "incidence", "of", "sepsis", ",", "wound", "pain", ",", "and", "disability", ".", "V", "." ]	[ "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Finding", "B-Patient or Disabled Group", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Finding", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Population Group", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Patient or Disabled Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "O", "B-Finding", "O", "B-Disease or Syndrome", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Diagnostic Procedure", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Finding", "O", "O", "O" ]
[ "Use", "of", "ecoacoustics", "to", "determine", "biodiversity", "patterns", "across", "ecological", "gradients", "The", "variety", "of", "local", "animal", "sounds", "characterizes", "a", "landscape", ".", "We", "used", "ecoacoustics", "to", "noninvasively", "assess", "the", "species", "richness", "of", "various", "biotopes", "typical", "of", "an", "ecofriendly", "forest", "plantation", "with", "diverse", "ecological", "gradients", "and", "both", "nonnative", "and", "indigenous", "vegetation", ".", "The", "reference", "area", "was", "an", "adjacent", "large", "World", "Heritage", "Site", "protected", "area", "(", "PA", ")", ".", "All", "sites", "were", "in", "a", "global", "biodiversity", "hotspot", ".", "Our", "results", "showed", "how", "taxa", "segregated", "into", "various", "biotopes", ".", "We", "identified", "65", "singing", "species", ",", "including", "birds", ",", "frogs", ",", "crickets", ",", "and", "katydids", ".", "Large", ",", "natural", ",", "protected", "grassland", "sites", "in", "the", "PA", "had", "the", "highest", "mean", "acoustic", "diversity", "(", "14.1", "species", "/", "site", ")", ".", "Areas", "covered", "in", "nonnative", "timber", "or", "grass", "species", "were", "devoid", "of", "acoustic", "species", ".", "Sites", "grazed", "by", "native", "and", "domestic", "megaherbivores", "were", "fairly", "rich", "(", "5.1", ")", "in", "acoustic", "species", "but", "none", "were", "unique", "to", "this", "habitat", "type", ",", "where", "acoustic", "diversity", "was", "greater", "than", "in", "intensively", "managed", "grassland", "sites", "(", "0.04", ")", ".", "Natural", "vegetation", "patches", "inside", "the", "plantation", "mosaic", "supported", "high", "mean", "acoustic", "diversity", "(", "indigenous", "forests", "7.6", ",", "grasslands", "8.0", ",", "wetlands", "9.1", ")", ",", "which", "increased", "as", "plant", "heterogeneity", "and", "patch", "size", "increased", ".", "Indigenous", "forest", "patches", "within", "the", "plantation", "mosaic", "contained", "a", "highly", "characteristic", "acoustic", "species", "assemblage", ",", "emphasizing", "their", "complementary", "contribution", "to", "local", "biodiversity", ".", "Overall", ",", "acoustic", "signals", "determined", "spatial", "biodiversity", "patterns", "and", "can", "be", "a", "useful", "tool", "for", "guiding", "conservation", "." ]	[ "O", "O", "B-Occupational Activity", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "O", "B-Spatial Concept", "B-Animal", "B-Natural Phenomenon or Process", "B-Idea or Concept", "O", "B-Spatial Concept", "O", "O", "O", "B-Occupational Activity", "O", "O", "B-Functional Concept", "O", "B-Classification", "O", "O", "B-Quantitative Concept", "B-Geographic Area", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "B-Finding", "O", "B-Group Attribute", "B-Plant", "O", "O", "B-Conceptual Entity", "B-Geographic Area", "O", "O", "B-Spatial Concept", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Functional Concept", "O", "O", "B-Conceptual Entity", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "O", "B-Individual Behavior", "B-Classification", "O", "O", "B-Bird", "O", "B-Amphibian", "O", "B-Eukaryote", "O", "O", "B-Eukaryote", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Classification", "O", "B-Spatial Concept", "O", "O", "B-Spatial Concept", "O", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Classification", "O", "O", "O", "B-Classification", "B-Classification", "O", "B-Spatial Concept", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Animal", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Group Attribute", "B-Natural Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Plant", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Quantitative Concept", "O", "B-Group Attribute", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "B-Qualitative Concept", "B-Classification", "B-Classification", "B-Idea or Concept", "O", "O", "O", "O", "B-Activity", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O" ]
[ "A", "Randomized", "Controlled", "Noninferiority", "Trial", "of", "Single", "Dose", "of", "Oral", "Dexamethasone", "Versus", "5", "Days", "of", "Oral", "Prednisone", "in", "Acute", "Adult", "Asthma", "Oral", "dexamethasone", "demonstrates", "bioavailability", "similar", "to", "that", "of", "oral", "prednisone", "but", "has", "a", "longer", "half-life", ".", "We", "evaluate", "whether", "a", "single", "dose", "of", "oral", "dexamethasone", "plus", "4", "days", "of", "placebo", "is", "not", "inferior", "to", "5", "days", "of", "oral", "prednisone", "in", "treatment", "of", "adults", "with", "mild", "to", "moderate", "asthma", "exacerbations", "to", "prevent", "relapse", "defined", "as", "an", "unscheduled", "return", "visit", "for", "additional", "treatment", "for", "persistent", "or", "worsening", "asthma", "within", "14", "days", ".", "Adult", "emergency", "department", "patients", "(", "aged", "18", "to", "55", "years", ")", "were", "randomized", "to", "receive", "either", "a", "single", "dose", "of", "12", "mg", "of", "oral", "dexamethasone", "with", "4", "days", "of", "placebo", "or", "a", "5-", "day", "course", "of", "oral", "prednisone", "60", "mg", "a", "day", ".", "Outcomes", "including", "relapse", "were", "assessed", "by", "a", "follow-up", "telephone", "interview", "at", "2", "weeks", ".", "One", "hundred", "seventy-three", "dexamethasone", "and", "203", "prednisone", "subjects", "completed", "the", "study", "regimen", "and", "telephone", "follow-up", ".", "The", "dexamethasone", "group", "by", "a", "small", "margin", "surpassed", "the", "preset", "8", "%", "difference", "between", "groups", "for", "noninferiority", "in", "relapse", "rates", "within", "14", "days", "(", "12.1", "%", "versus", "9.8", "%", ";", "difference", "2.3", "%", ";", "95", "%", "confidence", "interval", "-4.1", "%", "to", "8.6", "%", ")", ".", "Subjects", "in", "the", "2", "groups", "had", "similar", "rates", "of", "hospitalization", "for", "their", "relapse", "visit", "(", "dexamethasone", "3.4", "%", "versus", "prednisone", "2.9", "%", ";", "difference", "0.5", "%", ";", "95", "%", "confidence", "interval", "-4.1", "%", "to", "3.1", "%", ")", ".", "Adverse", "effect", "rates", "were", "generally", "the", "same", "in", "the", "2", "groups", ".", "A", "single", "dose", "of", "oral", "dexamethasone", "did", "not", "demonstrate", "noninferiority", "to", "prednisone", "for", "5", "days", "by", "a", "very", "small", "margin", "for", "treatment", "of", "adults", "with", "mild", "to", "moderate", "asthma", "exacerbations", ".", "Enhanced", "compliance", "and", "convenience", "may", "support", "the", "use", "of", "dexamethasone", "regardless", "." ]	[ "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Age Group", "B-Disease or Syndrome", "B-Clinical Drug", "B-Clinical Drug", "B-Activity", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "B-Functional Concept", "O", "B-Temporal Concept", "O", "B-Biomedical or Dental Material", "O", "O", "B-Spatial Concept", "O", "O", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "B-Functional Concept", "O", "B-Age Group", "O", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Functional Concept", "B-Phenomenon or Process", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "O", "B-Temporal Concept", "O", "B-Age Group", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Patient or Disabled Group", "O", "B-Organism Attribute", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Research Activity", "O", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Temporal Concept", "O", "B-Biomedical or Dental Material", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "B-Functional Concept", "B-Phenomenon or Process", "O", "B-Activity", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Temporal Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Pharmacologic Substance", "O", "O", "B-Hormone", "B-Group", "B-Qualitative Concept", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Phenomenon or Process", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Health Care Activity", "O", "O", "B-Phenomenon or Process", "B-Health Care Activity", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Hormone", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Activity", "B-Qualitative Concept", "O", "B-Hormone", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Age Group", "O", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Activity", "B-Finding", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O", "O" ]
[ "Relationship", "between", "XspI", "Site", "Polymorphisms", "of", "LDL-R", "Gene", "and", "Serum", "IL-2", "and", "IL-10", "in", "Patients", "with", "Hypercholesterolemia", "Relationship", "has", "been", "identified", "in", "sporadic", "reports", "between", "polymorphisms", "and", "hypercholesterolemia", ".", "However", ",", "the", "relationship", "between", "inflammatory", "cytokines", "and", "polymorphism", "of", "low-density", "lipoprotein", "receptor", "(", "LDL-R", ")", "gene", "in", "hypercholesterolemia", "is", "unclear", ".", "This", "study", "aimed", "to", "explore", "the", "relationship", "and", "significance", "between", "polymorphisms", "of", "LDL-R", "gene", "and", "serum", "Interleukin-2", "(", "IL-2", ")", ",", "IL-10", "in", "patients", "with", "hypercholesterolemia", ".", "PCR-RFLP", "and", "direct", "DNA", "sequencing", "assay", "were", "employed", "to", "determine", "polymorphism", "of", "LDL-R", "gene", "in", "900", "patients", "with", "hypercholesterolemia", "and", "400", "healthy", "cases", ".", "ELISA", "was", "applied", "to", "assay", "serum", "concentration", "of", "IL-2", "and", "IL-10", ".", "Blood", "lipid", "indexes", "were", "tested", "in", "all", "cases", ".", "Compared", "with", "the", "healthy", "controls", ",", "level", "of", "IL-2", "increased", "significantly", ",", "while", "IL-10", "decreased", "significantly", "(", "P", "<", "0.05", ")", ".", "Correlation", "analysis", "showed", "that", "IL-2", "was", "positively", "correlated", "with", "total", "cholesterol", "(", "TC", ")", ",", "LDL-c", ",", "and", "genotype", "(", "r", "=", "0.542", ",", "0.410", ",", "0.598", ",", "P", "<", "0.05", ")", "and", "negatively", "correlated", "with", "HDL-c", "(", "r", "=", "-0.352", ",", "P", "<", "0.05", ")", ".", "Negative", "relationship", "also", "was", "found", "between", "TC", ",", "LDL-c", ",", "genotype", ",", "and", "IL-10", "(", "r", "=", "-0.452", ",", "-0.390", ",", "-0.613", ",", "P", "<", "0.05", ")", ",", "and", "positive", "correlation", "between", "HDL-c", "and", "IL-10", "(", "r", "=", "0.398", ",", "P", "<", "0.05", ")", ".", "Multiple", "linear", "regression", "showed", "that", "genotypes", "and", "TC", "were", "independent", "factors", "affecting", "the", "levels", "of", "IL-2", "and", "IL-10", "(", "P", "<", "0.05", ")", ".", "IL-2", "and", "IL-10", "were", "related", "to", "gene", "polymorphisms", "of", "LDL-R", ",", "which", "might", "be", "involved", "in", "the", "development", "and", "progress", "of", "hypercholesterolemia", "." ]	[ "B-Qualitative Concept", "O", "B-Enzyme", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Genetic Function", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Immunologic Factor", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Disease or Syndrome", "O", "B-Finding", "O", "O", "B-Research Activity", "B-Idea or Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "O", "B-Immunologic Factor", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Finding", "O", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "B-Laboratory Procedure", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Intellectual Product", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "B-Immunologic Factor", "B-Quantitative Concept", "B-Idea or Concept", "O", "O", "B-Immunologic Factor", "B-Quantitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Immunologic Factor", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "O", "O", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "O", "B-Organism Attribute", "O", "O", "B-Immunologic Factor", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Immunologic Factor", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "B-Organic Chemical", "O", "B-Idea or Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "I-Immunologic Factor", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Qualitative Concept", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O" ]
[ "HERG1", "potassium", "channel", "expression", "in", "potentially", "malignant", "disorders", "of", "the", "oral", "mucosa", "and", "prognostic", "relevance", "in", "oral", "squamous", "cell", "carcinoma", "HERG1", "potassium", "channel", "plays", "a", "critical", "role", "in", "the", "cell", "proliferation", ".", "HERG1", "protein", "expression", "was", "analyzed", "by", "immunohistochemistry", "(", "IHC", ")", "in", "62", "patients", "with", "oral", "leukoplakias", "and", "100", "patients", "with", "oral", "squamous", "cell", "carcinomas", "(", "OSCC", ")", ".", "HERG1", "mRNA", "levels", "were", "assessed", "by", "real-time", "reverse", "transcriptase-polymerase", "chain", "reaction", "(", "RT-PCR", ")", "in", "22", "patients", "with", "primary", "head", "and", "neck", "squamous", "cell", "carcinoma", "(", "HNSCC", ")", ".", "Statistically", "significant", "associations", "were", "found", "between", "HERG1", "expression", "and", "tobacco", "consumption", ",", "disease", "stage", ",", "tumor", "differentiation", ",", "tumor", "recurrence", ",", "and", "reduced", "survival", ".", "There", "was", "no", "association", "between", "HERG1", "expression", "and", "the", "risk", "of", "progression", "from", "oral", "leukoplakia", "to", "OSCC", ".", "In", "addition", ",", "a", "high", "proportion", "of", "tumors", "(", "80", "%", ")", "showed", "increased", "HERG1", "mRNA", "levels", "compared", "to", "normal", "mucosa", "from", "nononcologic", "patients", ".", "Aberrant", "HERG1", "expression", "increases", "as", "oral", "tumorigenesis", "progresses", "from", "oral", "hyperplasia", "to", "OSCC", ".", "Increased", "HERG1", "mRNA", "levels", "were", "also", "frequently", "detected", "in", "OSCC", "and", "other", "HNSCC", "subsites", ".", "HERG1", "expression", "emerges", "as", "a", "clinically", "relevant", "feature", "during", "tumor", "progression", "and", "a", "potential", "poor", "prognostic", "biomarker", "for", "OSCC", ".", "©", "2016", "Wiley", "Periodicals", ",", "Inc.", "Head", "Neck", "38", ":", "1708-1716", ",", "2016", "." ]	[ "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Intellectual Product", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "B-Conceptual Entity", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Research Activity", "O", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Activity", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Neoplastic Process", "B-Cell Function", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "B-Activity", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "O", "B-Idea or Concept", "O", "B-Neoplastic Process", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "B-Activity", "O", "B-Tissue", "B-Tissue", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Genetic Function", "B-Functional Concept", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Neoplastic Process", "O", "B-Quantitative Concept", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "O", "O", "B-Finding", "O", "B-Neoplastic Process", "O", "O", "B-Neoplastic Process", "B-Spatial Concept", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Intellectual Product", "B-Clinical Attribute", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Malignancy", "is", "associated", "with", "microcalcification", "and", "higher", "AP/T", "ratio", "in", "ultrasonography", ",", "but", "not", "with", "Hashimoto", "'s", "thyroiditis", "in", "histopathology", "in", "patients", "with", "thyroid", "nodules", "evaluated", "as", "Bethesda", "Category", "III", "(", "AUS", "/", "FLUS", ")", "in", "cytology", "The", "predictors", "of", "malignancy", "are", "important", "for", "the", "decision", "of", "appropriate", "management", "in", "nodules", "with", "atypia", "of", "undetermined", "significance", "/", "follicular", "lesion", "of", "undetermined", "significance", "(", "AUS", "/", "FLUS", ")", ".", "Our", "aim", "was", "to", "determine", "the", "ultrasonographical", ",", "clinical", ",", "and", "biochemical", "predictors", "of", "malignancy", "in", "these", "patients", ".", "A", "total", "of", "427", "patients", "with", "cytologically", "Bethesda", "Category", "III", "(", "AUS", "/", "FLUS", ")", "thyroid", "nodules", "were", "included", "in", "this", "retrospective", "study", ".", "We", "divided", "the", "nodules", "into", "two", "subgroups", "according", "to", "the", "histopathology", "as", "benign", "and", "malignant", ",", "and", "compared", "the", "preoperative", "ultrasonographical", ",", "clinical", ",", "and", "biochemical", "findings", ".", "In", "overall", ",", "427", "patients", "with", "449", "AUS", "/", "FLUS", "nodules", "who", "had", "undergone", "surgery", ",", "the", "rate", "of", "malignancy", "was", "23.4", "%", "(", "105/449", ")", ".", "When", "evaluated", "separately", ",", "the", "rate", "of", "malignancy", "was", "25.8", "%", "in", "nodules", "with", "AUS", "(", "82/318", ")", "and", "17.6", "%", "in", "nodules", "with", "FLUS", "(", "23/131", ")", "(", "p", "=", "0.061", ")", ".", "The", "vast", "majority", "of", "malignant", "specimens", "in", "histopathology", "consisted", "of", "papillary", "thyroid", "carcinoma", "(", "PTC", ")", "(", "n", "=", "91", ",", "86.7", "%", ")", ".", "Preoperative", "ultrasonographic", "features", "of", "105", "malignant", "nodules", "in", "histopathology", "were", "compared", "with", "the", "344", "benign", "nodules", "in", "histopathology", ".", "Anteroposterior/Transverse", "(", "AP/T", ")", "ratio", "was", "significantly", "higher", "in", "malignant", "group", "compared", "to", "benign", "group", "(", "p", "=", "0.013", ")", ".", "In", "multiple", "logistic", "analysis", ",", "we", "found", "that", "higher", "AP/T", "ratio", "and", "microcalcification", "were", "independently", "associated", "with", "malignancy", "(", "p", "<", "0.05", ")", ".", "The", "malignancy", "-associated", "cut-off", "value", "of", "AP/T", "ratio", "at", "maximum", "sensitivity", "and", "specificity", "was", "≥0.81", ".", "We", "did", "not", "find", "any", "correlation", "between", "malignancy", "and", "Hashimoto", "'s", "thyroiditis", "in", "histopathology", "in", "multivariate", "analysis", "(", "p", ">", "0.05", ")", ".", "In", "Bethesda", "Category", "III", "nodules", "with", "higher", "AP/T", "ratio", "and", "microcalcification", ",", "surgery", "might", "be", "considered", "as", "a", "first", "therapeutic", "option", "instead", "of", "repeat", "fine-needle", "aspiration", "biopsy", "or", "observation", "." ]	[ "B-Neoplastic Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Pathologic Function", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "O", "B-Laboratory Procedure", "O", "B-Intellectual Product", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Neoplastic Process", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "B-Population Group", "O", "O", "O", "B-Laboratory Procedure", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Temporal Concept", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "B-Neoplastic Process", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "B-Laboratory Procedure", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Pathologic Function", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Pathologic Function", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Research Activity", "O" ]
[ "Low", "serum", "vitamin", "D", "is", "associated", "with", "higher", "cortical", "porosity", "in", "elderly", "men", "Bone", "loss", "at", "peripheral", "sites", "in", "the", "elderly", "is", "mainly", "cortical", "and", "involves", "increased", "cortical", "porosity", ".", "However", ",", "an", "association", "between", "bone", "loss", "at", "these", "sites", "and", "25-hydroxyvitamin", "D", "has", "not", "been", "reported", ".", "To", "investigate", "the", "association", "between", "serum", "levels", "of", "25-hydroxyvitamin", "D", ",", "bone", "microstructure", "and", "areal", "bone", "mineral", "density", "(", "BMD", ")", "in", "elderly", "men", ".", "A", "population", "-based", "cohort", "of", "444", "elderly", "men", "(", "mean", "±", "SD", "age", "80.2", "±", "3.5", "years", ")", "was", "investigated", ".", "Bone", "microstructure", "was", "measured", "by", "high-resolution", "peripheral", "quantitative", "computed", "tomography", ",", "areal", "BMD", "by", "dual-energy", "X-ray", "absorptiometry", "and", "serum", "25-hydroxyvitamin", "D", "and", "parathyroid", "hormone", "levels", "by", "immunoassay", ".", "Mean", "cortical", "porosity", "at", "the", "distal", "tibia", "was", "14.7", "%", "higher", "(", "12.5", "±", "4.3", "%", "vs.", "10.9", "±", "4.1", "%", ",", "P", "<", "0.05", ")", "whilst", "cortical", "volumetric", "BMD", ",", "area", ",", "trabecular", "bone", "volume", "fraction", "and", "femoral", "neck", "areal", "BMD", "were", "lower", "in", "men", "in", "the", "lowest", "quartile", "of", "vitamin", "D", "levels", "compared", "to", "the", "highest", ".", "In", "men", "with", "vitamin", "D", "deficiency", "(", "<", "25", "nmol", "L", "(", "-1", ")", ")", "or", "insufficiency", "[", "25-49", "nmol", "L", "(", "-1", ")", ",", "in", "combination", "with", "an", "elevated", "serum", "level", "of", "parathyroid", "hormone", "(", ">", "6.8", "pmol", "L", "(", "-1", ")", ")", "]", ",", "cortical", "porosity", "was", "17.2", "%", "higher", "than", "in", "vitamin", "D", "-", "sufficient", "men", "(", "P", "<", "0.01", ")", ".", "A", "linear", "regression", "model", "including", "age", ",", "weight", ",", "height", ",", "daily", "calcium", "intake", ",", "physical", "activity", ",", "smoking", "vitamin", "D", "supplementation", "and", "parathyroid", "hormone", "showed", "that", "25-hydroxyvitamin", "D", "independently", "predicted", "cortical", "porosity", "(", "standardized", "β", "=", "-0.110", ",", "R", "(", "2", ")", "=", "1.1", "%", ",", "P", "=", "0.024", ")", ",", "area", "(", "β", "=", "0.123", ",", "R", "(", "2", ")", "=", "1.4", "%", ",", "P", "=", "0.007", ")", "and", "cortical", "volumetric", "BMD", "(", "β", "=", "0.125", ",", "R", "(", "2", ")", "=", "1.4", "%", ",", "P", "=", "0.007", ")", "of", "the", "tibia", "as", "well", "as", "areal", "BMD", "of", "the", "femoral", "neck", "(", "β", "=", "0.102", ",", "R", "(", "2", ")", "=", "0.9", "%", ",", "P", "=", "0.04", ")", ".", "Serum", "vitamin", "D", "is", "associated", "with", "cortical", "porosity", ",", "area", "and", "density", ",", "indicating", "that", "bone", "fragility", "as", "a", "result", "of", "low", "vitamin", "D", "could", "be", "due", "to", "changes", "in", "cortical", "bone", "microstructure", "and", "geometry", "." ]	[ "B-Qualitative Concept", "B-Body Substance", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "B-Population Group", "B-Population Group", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Spatial Concept", "B-Body Location or Region", "O", "O", "B-Population Group", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Quantitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Body Location or Region", "O", "B-Vitamin", "B-Vitamin", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "O", "B-Population Group", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Qualitative Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Intellectual Product", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Individual Behavior", "B-Vitamin", "B-Vitamin", "B-Pharmacologic Substance", "O", "B-Hormone", "B-Hormone", "O", "O", "B-Vitamin", "B-Vitamin", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Substance", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "B-Clinical Attribute", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "B-Qualitative Concept", "B-Vitamin", "B-Vitamin", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Spatial Concept", "O" ]
[ "Nationwide", "reduction", "in", "the", "number", "of", "corneal", "transplantations", "for", "keratoconus", "following", "the", "implementation", "of", "cross-linking", "Keratoconus", "is", "characterized", "by", "corneal", "ectasia", "and", "irregular", "astigmatism", ",", "which", "can", "lead", "to", "diminished", "vision", "and", "corneal", "scarring", ".", "Approximately", "10-20", "%", "of", "patients", "with", "keratoconus", "eventually", "require", "a", "corneal", "transplant", ".", "Corneal", "cross-linking", "(", "CXL", ")", "is", "a", "relatively", "new", "treatment", "that", "may", "help", "prevent", "the", "need", "for", "corneal", "transplantation", ".", "Here", ",", "we", "investigated", "whether", "the", "introduction", "of", "CXL", "has", "reduced", "the", "number", "of", "corneal", "transplants", "performed", "annually", ".", "Data", "regarding", "the", "transplantation", "procedures", "performed", "in", "patients", "under", "the", "age", "of", "50", "years", "were", "extracted", "from", "the", "Dutch", "National", "Organ", "Transplant", "Registry", ".", "The", "number", "of", "corneal", "transplants", "performed", "prior", "to", "(", "i.e", ".", "in", "2005", "through", "2007", ")", "and", "following", "the", "introduction", "of", "CXL", "(", "i.e", ".", "in", "2012", "through", "2014", ")", "were", "compared", ".", "Furthermore", ",", "a", "trend", "analysis", "on", "annual", "keratoplasties", "over", "time", "was", "performed", ".", "Approximately", "25", "%", "fewer", "corneal", "transplants", "were", "performed", "in", "the", "3-", "year", "period", "following", "the", "introduction", "of", "CXL", "compared", "to", "the", "3-", "year", "period", "prior", "to", "the", "introduction", "of", "CXL", "(", "201", "versus", "269", "transplants", ",", "respectively", ";", "p", "=", "0.005", ")", ".", "Age", ",", "gender", "and", "visual", "acuity", "were", "similar", "between", "the", "patient", "groups", "in", "the", "two", "time", "periods", ".", "Trend", "analysis", "also", "demonstrated", "a", "significant", "decrease", "in", "the", "amount", "of", "corneal", "transplants", "(", "p", "=", "0.001", ")", ".", "Significantly", "fewer", "corneal", "transplants", "were", "performed", "for", "treating", "keratoconus", "following", "the", "nationwide", "introduction", "of", "CXL", ".", "This", "reduction", "suggests", "that", "corneal", "cross-linking", "can", "significantly", "reduce", "the", "need", "for", "corneal", "transplantation", "." ]	[ "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "O", "O", "B-Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "B-Temporal Concept", "O", "B-Idea or Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "O", "B-Patient or Disabled Group", "O", "O", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Functional Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Activity", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "B-Spatial Concept", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Quantitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O" ]
[ "Rapid", "Fabrication", "of", "a", "Cell", "-", "Seeded", "Collagen", "Gel", "-Based", "Tubular", "Construct", "that", "Withstands", "Arterial", "Pressure", ":", "Rapid", "Fabrication", "of", "a", "Gel", "-Based", "Media", "Equivalent", "Based", "on", "plastically", "compressed", "cell", "-", "seeded", "collagen", "gels", ",", "we", "fabricated", "a", "small-diameter", "tubular", "construct", "that", "withstands", "arterial", "pressure", "without", "prolonged", "culture", "in", "vitro", ".", "Specifically", ",", "to", "mimic", "the", "microstructure", "of", "vascular", "media", ",", "the", "cell", "-", "seeded", "collagen", "gel", "was", "uniaxially", "stretched", "prior", "to", "plastic", "compression", "to", "align", "collagen", "fibers", "and", "hence", "cells", "in", "the", "gel", ".", "The", "resulting", "gel", "sheet", "was", "then", "wrapped", "around", "a", "custom-made", "multi-layered", "braided", "tube", "to", "form", "aligned", "tubular", "constructs", "whereas", "the", "gel", "sheet", "prepared", "similarly", "but", "without", "uniaxial", "stretching", "formed", "control", "constructs", ".", "With", "the", "braided", "tube", ",", "fluid", "in", "the", "gel", "construct", "was", "further", "removed", "by", "vacuum", "suction", "aiming", "to", "consolidate", "the", "concentric", "layers", "of", "the", "construct", ".", "The", "construct", "was", "finally", "treated", "with", "transglutaminase", ".", "Both", "SEM", "and", "histology", "confirmed", "the", "absence", "of", "gaps", "in", "the", "wall", "of", "the", "construct", ".", "Particularly", ",", "cells", "in", "the", "wall", "of", "the", "aligned", "tubular", "construct", "were", "circumferentially", "aligned", ".", "The", "enzyme", "-mediated", "crosslinking", "increased", "burst", "pressure", "of", "both", "the", "constructs", "significantly", ";", "the", "extent", "of", "the", "increase", "of", "burst", "pressure", "for", "the", "aligned", "tubular", "construct", "was", "greater", "than", "that", "for", "the", "control", "counterpart", ".", "Increasing", "crosslinking", "left", "the", "compliance", "of", "the", "aligned", "tubular", "construct", "unchanged", "but", "reduced", "that", "of", "the", "control", "construct", ".", "Cells", "remained", "viable", "in", "transglutaminase", "-treated", "plastically", "compressed", "gels", "after", "6", "days", "in", "culture", ".", "This", "study", "demonstrated", "that", "by", "combining", "stretch-induced", "fiber", "alignment", ",", "plastic", "compression", ",", "and", "enzyme", "-mediated", "crosslinking", ",", "a", "cell", "-", "seeded", "collagen", "gel", "-based", "tubular", "construct", "with", "potential", "to", "be", "used", "as", "vascular", "media", "can", "be", "made", "within", "3", "days", "." ]	[ "O", "B-Activity", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Activity", "O", "O", "B-Biomedical or Dental Material", "O", "B-Substance", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "O", "B-Activity", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Laboratory Procedure", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "B-Substance", "B-Natural Phenomenon or Process", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Cell", "O", "O", "B-Biomedical or Dental Material", "O", "O", "O", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "B-Substance", "O", "O", "B-Biomedical or Dental Material", "B-Medical Device", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "B-Medical Device", "O", "O", "O", "O", "B-Enzyme", "O", "O", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "B-Cell", "O", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Biomedical or Dental Material", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Tissue", "B-Quantitative Concept", "O", "B-Substance", "B-Natural Phenomenon or Process", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "O", "O", "B-Temporal Concept", "O" ]
[ "Impact", "of", "cofactor", "-", "binding", "loop", "mutations", "on", "thermotolerance", "and", "activity", "of", "E.", "coli", "transketolase", "Improvement", "of", "thermostability", "in", "engineered", "enzymes", "can", "allow", "biocatalysis", "on", "substrates", "with", "poor", "aqueous", "solubility", ".", "Denaturation", "of", "the", "cofactor", "-", "binding", "loops", "of", "Escherichia", "coli", "transketolase", "(", "TK", ")", "was", "previously", "linked", "to", "the", "loss", "of", "enzyme", "activity", "under", "conditions", "of", "high", "pH", "or", "urea", ".", "Incubation", "at", "temperatures", "just", "below", "the", "thermal", "melting", "transition", ",", "above", "which", "the", "protein", "aggregates", ",", "was", "also", "found", "to", "anneal", "the", "enzyme", "to", "give", "an", "increased", "specific", "activity", ".", "The", "potential", "role", "of", "cofactor", "-", "binding", "loop", "instability", "in", "this", "process", "remained", "unclear", ".", "In", "this", "work", ",", "the", "two", "cofactor", "-", "binding", "loops", "(", "residues", "185-192", "and", "382-392", ")", "were", "progressively", "mutated", "towards", "the", "equivalent", "sequence", "from", "the", "thermostable", "Thermus", "thermophilus", "TK", "and", "variants", "assessed", "for", "their", "impact", "on", "both", "thermostability", "and", "activity", ".", "Cofactor-binding", "loop", "2", "variants", "had", "detrimental", "effects", "on", "specific", "activity", "at", "elevated", "temperatures", ",", "whereas", "the", "H192P", "mutation", "in", "cofactor-binding", "loop", "1", "resulted", "in", "a", "two-fold", "improved", "stability", "to", "inactivation", "at", "elevated", "temperatures", ",", "and", "increased", "the", "critical", "onset", "temperature", "for", "aggregation", ".", "The", "specific", "activity", "of", "H192P", "was", "3-fold", "and", "19-fold", "higher", "than", "that", "for", "wild-type", "at", "60°C", "and", "65°C", "respectively", ",", "and", "also", "remained", "2.7-4", "fold", "higher", "after", "re-cooling", "from", "pre-incubations", "at", "either", "55°C", "or", "60°C", "for", "1h", ".", "Interestingly", ",", "H192P", "was", "also", "2-times", "more", "active", "than", "wild-type", "TK", "at", "25°C", ".", "Optimal", "activity", "was", "achieved", "at", "60°C", "for", "H192P", "compared", "to", "55°C", "for", "wild", "type", ".", "These", "results", "show", "that", "cofactor-binding", "loop", "1", ",", "plays", "a", "pivotal", "role", "in", "partial", "denaturation", "and", "aggregation", "at", "elevated", "temperatures", ".", "Furthermore", ",", "a", "single", "rigidifying", "mutation", "within", "this", "loop", "can", "significantly", "improve", "the", "enzyme", "specific", "activity", ",", "as", "well", "as", "the", "stability", "to", "thermal", "denaturation", "and", "aggregation", ",", "to", "give", "an", "increased", "temperature", "optimum", "for", "activity", "." ]	[ "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "B-Genetic Function", "O", "B-Physiologic Function", "O", "B-Molecular Function", "O", "B-Bacterium", "B-Bacterium", "B-Enzyme", "B-Conceptual Entity", "O", "B-Natural Phenomenon or Process", "O", "B-Enzyme", "B-Enzyme", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Molecular Function", "O", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Bacterium", "B-Bacterium", "B-Enzyme", "O", "B-Enzyme", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Molecular Function", "B-Molecular Function", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Enzyme", "O", "O", "O", "B-Quantitative Concept", "O", "B-Molecular Function", "O", "O", "O", "B-Conceptual Entity", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Amino Acid Sequence", "O", "O", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "O", "O", "B-Qualitative Concept", "B-Bacterium", "B-Bacterium", "B-Enzyme", "O", "B-Gene or Genome", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Activity", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Gene or Genome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Activity", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Natural Phenomenon or Process", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Gene or Genome", "B-Enzyme", "O", "O", "O", "B-Qualitative Concept", "B-Activity", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Quantitative Concept", "B-Molecular Function", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Nucleotide Sequence", "O", "O", "O", "O", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "B-Molecular Function", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Molecular Function", "O" ]
[ "Expression", "and", "Purification", "of", "E2", "Glycoprotein", "from", "Insect", "Cells", "(", "Sf9", ")", "for", "Use", "in", "Serology", "Chikungunya", "virus", "(", "CHIKV", ")", "is", "a", "mosquito", "-", "borne", "arbovirus", "which", "poses", "a", "major", "threat", "to", "global", "public", "health", ".", "Definitive", "CHIKV", "diagnosis", "is", "crucial", ",", "especially", "in", "distinguishing", "the", "disease", "from", "dengue", "virus", ",", "which", "co-circulates", "in", "endemic", "areas", "and", "shares", "the", "same", "mosquito", "vectors", ".", "Laboratory", "diagnosis", "is", "mainly", "based", "on", "serological", "or", "molecular", "approaches", ".", "The", "E2", "glycoprotein", "is", "a", "good", "candidate", "for", "serological", "diagnosis", "since", "it", "is", "the", "immunodominant", "antigen", "during", "the", "course", "of", "infection", ",", "and", "reacts", "with", "seropositive", "CHIKV", "sera", ".", "In", "this", "chapter", ",", "we", "describe", "the", "generation", "of", "stable", "clone", "Sf9", "(", "Spodoptera", "frugiperda", ")", "cells", "expressing", "secreted", ",", "soluble", ",", "and", "native", "recombinant", "CHIKV", "E2", "glycoprotein", ".", "We", "use", "direct", "plasmid", "expression", "in", "insect", "cells", ",", "rather", "than", "the", "traditional", "technique", "of", "generating", "recombinant", "baculovirus", ".", "This", "recombinant", "protein", "is", "useful", "for", "serological", "diagnosis", "of", "CHIKV", "infection", "." ]	[ "B-Genetic Function", "O", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Eukaryote", "B-Cell", "O", "B-Cell", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Virus", "B-Virus", "O", "B-Virus", "O", "O", "O", "B-Eukaryote", "O", "B-Finding", "B-Virus", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Temporal Concept", "B-Virus", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Virus", "B-Virus", "O", "O", "B-Functional Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Immunologic Factor", "B-Immunologic Factor", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "B-Pathologic Function", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Virus", "B-Body Substance", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Idea or Concept", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Cell", "B-Cell", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Cell", "B-Genetic Function", "B-Cell Function", "O", "B-Cell Component", "O", "O", "B-Functional Concept", "B-Organism", "B-Virus", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Therapeutic or Preventive Procedure", "O", "B-Eukaryote", "B-Cell", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Activity", "B-Virus", "B-Virus", "O", "O", "B-Amino Acid, Peptide, or Protein", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Virus", "B-Pathologic Function", "O" ]
[ "Acute", "risk", "factors", "for", "suicide", "attempts", "and", "death", ":", "prospective", "findings", "from", "the", "STEP", "-", "BD", "study", "Suicide", "is", "unfortunately", "common", "in", "psychiatric", "practice", ",", "but", "difficult", "to", "predict", ".", "The", "present", "study", "sought", "to", "assess", "which", "clinical", "symptoms", "increase", "in", "the", "months", "before", "suicidal", "behavior", "in", "a", "sample", "of", "psychiatric", "outpatients", "with", "bipolar", "disorder", ".", "Data", "from", "the", "Systematic", "Treatment", "Enhancement", "Program", "for", "Bipolar", "Disorder", "(", "STEP", "-", "BD", ")", "trial", "were", "used", ".", "A", "total", "of", "103", "participants", "who", "attempted", "suicide", "or", "died", "by", "suicide", "during", "the", "trial", "were", "included", ";", "a", "15", "%", "random", "sample", "of", "the", "remaining", "participants", "(", "n", "=", "427", ")", "was", "used", "as", "a", "comparison", "sample", ".", "Linear", "mixed", "models", "in", "the", "six", "months", "before", "suicidal", "behavior", "were", "conducted", "for", "each", "of", "five", "proposed", "acute", "risk", "factors", "for", "suicidal", "behavior", ".", "Participants", "were", "assessed", "using", "the", "Clinical", "Monitoring", "Form", "(", "CMF", ")", "at", "each", "visit", "for", "the", "following", "potential", "acute", "risk", "factors", "for", "suicidal", "behavior", ":", "suicidal", "ideation", ",", "loss", "of", "interest", ",", "anxiety", ",", "psychomotor", "agitation", ",", "and", "high-risk", "behavior", ".", "Each", "of", "the", "five", "symptoms", "was", "elevated", "overall", "in", "individuals", "who", "engaged", "in", "suicidal", "behavior", "(", "p", "<", "0.05", ")", ".", "The", "severity", "of", "both", "suicidal", "ideation", "and", "loss", "of", "interest", "significantly", "increased", "in", "the", "months", "before", "suicidal", "behavior", "(", "p", "<", "0.001", ")", ".", "Anxiety", "demonstrated", "comparable", "effect", "sizes", "across", "multiple", "models", ".", "Psychomotor", "agitation", "and", "high-risk", "behavior", "were", "not", "significantly", "elevated", "before", "suicidal", "behavior", ".", "Suicidal", "ideation", ",", "loss", "of", "interest", "and", ",", "to", "a", "lesser", "extent", ",", "anxiety", "may", "represent", "acute", "suicide", "risk", "factors", "up", "to", "four", "months", "before", "suicidal", "behavior", "in", "outpatients", "with", "bipolar", "disorder", ".", "Further", "investigation", "of", "these", "potential", "acute", "risk", "factors", "in", "prospective", "analyses", "is", "warranted", "." ]	[ "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "B-Research Activity", "B-Finding", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Mental Process", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Research Activity", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Sign or Symptom", "B-Functional Concept", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "B-Substance", "O", "B-Biomedical Occupation or Discipline", "B-Patient or Disabled Group", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Idea or Concept", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Substance", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "B-Substance", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Population Group", "O", "B-Activity", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "B-Finding", "O", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "O", "O", "B-Sign or Symptom", "O", "B-Qualitative Concept", "O", "O", "B-Population Group", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Finding", "B-Finding", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Finding", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "B-Patient or Disabled Group", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O" ]
[ "Measurement", "of", "Outcomes", "of", "Upper", "Limb", "Reconstructive", "Surgery", "for", "Tetraplegia", "Reconstructive", "arm/hand", "surgery", "for", "tetraplegia", "is", "performed", "to", "improve", "arm/hand", "function", "and", "therefore", "personal", "well-being", "for", "individuals", "who", "accept", "such", "elective", "surgeries", ".", "However", ",", "changes", "at", "an", "impairment", "level", "do", "not", "always", "translate", "into", "functional", "or", "quality", "of", "life", "changes", ".", "Therefore", ",", "multiple", "outcome", "tools", "should", "be", "used", "that", "incorporate", "sufficient", "responsiveness", "to", "detect", "changes", "in", "arm/hand", "function", ",", "activity", "and", "participation", ",", "and", "quality", "of", "life", "of", "the", "individuals", "involved", ".", "This", "narrative", "review", "aims", "to", "assist", "clinicians", "to", "choose", "the", "most", "appropriate", "tools", "to", "assess", "the", "need", "for", "reconstructive", "surgery", "and", "to", "evaluate", "its", "outcomes", ".", "Our", "specific", "objectives", "are", "(", "1", ")", "to", "describe", "aspects", "to", "consider", "when", "choosing", "a", "measure", "and", "(", "2", ")", "to", "describe", "the", "measures", "advised", "by", "an", "international", "therapist", "consensus", "group", "established", "in", "2007", ".", "All", "advised", "measures", "are", "appraised", "in", "terms", "of", "the", "underlying", "construct", ",", "administration", ",", "and", "clinical", "relevance", "to", "arm/hand", "reconstructions", ".", "Essentially", "there", "are", "currently", "no", "criterion", "standard", "measures", "to", "evaluate", "the", "consequences", "of", "reconstructive", "arm/hand", "surgery", ".", "However", ",", "with", "judicious", "use", "of", "available", "measures", "it", "is", "possible", "to", "ensure", "the", "questions", "asked", "or", "tasks", "completed", "are", "relevant", "to", "the", "surgical", "reconstruction", "(", "s", ")", "undertaken", ".", "Further", "work", "in", "this", "field", "is", "required", ".", "This", "would", "be", "best", "met", "by", "immediate", "collaboration", "between", "2", "outcome", "'s", "tool", "developers", "and", "by", "analysis", "of", "pre", "-", "and", "postoperative", "data", "already", "held", "in", "various", "international", "sites", ",", "which", "would", "allow", "further", "evaluation", "of", "the", "measures", "already", "in", "use", ",", "or", "components", "thereof", "." ]	[ "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "B-Finding", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Functional Concept", "O", "B-Finding", "B-Organism Function", "B-Organism Function", "O", "O", "B-Finding", "B-Finding", "O", "B-Population Group", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "B-Functional Concept", "O", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "B-Functional Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Functional Concept", "O", "B-Organism Function", "B-Organism Function", "O", "B-Activity", "O", "B-Functional Concept", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Health Care Activity", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Qualitative Concept", "B-Manufactured Object", "O", "B-Activity", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Idea or Concept", "B-Professional or Occupational Group", "O", "B-Idea or Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Idea or Concept", "B-Quantitative Concept", "B-Functional Concept", "O", "B-Health Care Activity", "O", "B-Functional Concept", "B-Functional Concept", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Occupational Activity", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "B-Conceptual Entity", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Social Behavior", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Occupational Activity", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Manufactured Object", "O", "O" ]
[ "Basal", "and", "maximal", "metabolic", "rates", "differ", "in", "their", "response", "to", "rapid", "temperature", "change", "among", "avian", "species", "In", "birds", ",", "acclimation", "and", "acclimatization", "to", "temperature", "are", "associated", "with", "changes", "in", "basal", "(", "BMR", ")", ",", "summit", "(", "Msum", ")", "and", "maximal", "(", "MMR", ")", "metabolic", "rates", "but", "little", "is", "known", "about", "the", "rate", "at", "which", "species", "adjust", "their", "phenotype", "to", "short-term", "temperature", "variations", ".", "Our", "aims", "were", "(", "1", ")", "to", "determine", "the", "pattern", "of", "metabolic", "adjustments", "following", "a", "rapid", "temperature", "change", ",", "(", "2", ")", "to", "determine", "whether", "performance", "varies", "at", "similar", "rates", "during", "exposure", "to", "warm", "or", "cold", "environments", ",", "and", "(", "3", ")", "to", "determine", "if", "BMR", ",", "Msum", "and", "MMR", "change", "at", "comparable", "rates", "during", "thermal", "acclimation", ".", "We", "measured", "these", "parameters", "in", "white-throated", "sparrows", "(", "Zonotrichia", "albicollis", ")", ",", "black-capped", "chickadees", "(", "Poecile", "atricapillus", ")", ",", "and", "snow", "buntings", "(", "Plectrophenax", "nivalis", ")", "after", "acclimation", "to", "10", "°C", "(", "day", "0", ")", "and", "on", "the", "4th", "and", "8th", "days", "of", "acclimation", "to", "either", "-5", "or", "28", "°C", ".", "Birds", "changed", "their", "metabolic", "phenotype", "within", "8", "days", "with", "patterns", "differing", "among", "species", ".", "Sparrows", "expressed", "the", "expected", "metabolic", "increases", "in", "the", "cold", "and", "decreases", "at", "thermoneutrality", "while", "performance", "in", "chickadees", "and", "buntings", "was", "not", "influenced", "by", "temperature", "but", "changed", "over", "time", "with", "inverse", "patterns", ".", "Our", "results", "suggest", "that", "BMR", "varies", "at", "comparable", "rates", "in", "warm", "and", "cold", "environments", "but", "changes", "faster", "than", "Msum", "and", "MMR", ",", "likely", "due", "to", "limitations", "in", "the", "rate", "of", "change", "in", "organ", "size", "and", "function", ".", "They", "also", "suggest", "that", "maximal", "metabolic", "capacity", "is", "lost", "faster", "in", "a", "warm", "environment", "than", "it", "is", "gained", "in", "a", "cold", "environment", ".", "With", "the", "expected", "increase", "in", "temperature", "stochasticity", "at", "northern", "latitudes", ",", "a", "loss", "of", "thermogenic", "capacity", "during", "warm", "winter", "days", "could", ",", "therefore", ",", "be", "detrimental", "if", "birds", "are", "slow", "to", "readjust", "their", "phenotype", "with", "the", "return", "of", "cold", "days", "." ]	[ "B-Organism Function", "O", "B-Qualitative Concept", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Bird", "B-Classification", "O", "B-Bird", "O", "B-Organism Function", "O", "B-Organism Function", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Organism Function", "O", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "B-Qualitative Concept", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "O", "O", "O", "O", "B-Physiologic Function", "O", "O", "B-Classification", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Physiologic Function", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "O", "B-Physiologic Function", "O", "B-Natural Phenomenon or Process", "B-Organism Function", "O", "O", "O", "O", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "B-Organism Function", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "B-Bird", "O", "O", "B-Functional Concept", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O", "B-Spatial Concept", "O", "O", "B-Classification", "O", "B-Bird", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Bird", "O", "B-Bird", "O", "O", "B-Conceptual Entity", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "B-Finding", "O", "O", "B-Organism Function", "O", "O", "O", "B-Physiologic Function", "O", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Physiologic Function", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Quantitative Concept", "O", "B-Natural Phenomenon or Process", "B-Quantitative Concept", "O", "B-Phenomenon or Process", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Bird", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Temporal Concept", "O" ]
[ "Factors", "preventing", "kneeling", "in", "a", "group", "of", "pre-educated", "patients", "post", "total", "knee", "arthroplasty", "Difficulties", "in", "kneeling", ",", "one", "of", "the", "poorest", "scoring", "functional", "outcomes", "post", "total", "knee", "arthroplasty", "(", "TKA", ")", ",", "have", "been", "attributed", "to", "a", "lack", "of", "patient", "education", ".", "This", "is", "the", "first", "study", "to", "investigate", "specific", "factors", "affecting", "a", "patient", "'s", "perceived", "ability", "to", "kneel", "post", "TKA", ",", "following", "exposure", "to", "a", "preoperative", "kneeling", "education", "session", ".", "A", "cross-sectional", "study", "was", "conducted", "following", "TKA", "with", "patients", "who", "had", "been", "educated", "about", "kneeling", "prior", "to", "the", "operation", ".", "Patients", "completed", "kneeling", "questionnaires", "at", "6", "(", "n", "=", "115", ")", "and", "12", "(", "n", "=", "82", ")", "months", "post", "TKA", ".", "In", "addition", "to", "the", "12-month", "kneeling", "questionnaire", ",", "patients", "also", "completed", "the", "Oxford", "knee", "score", "(", "OKS", ")", "survey", ".", "Seventy-two", "percent", "of", "patients", "perceived", "they", "could", "kneel", "at", "12", "months", "post", "TKA", ".", "Overall", ",", "pain", "and", "discomfort", "were", "the", "most", "common", "factors", "deterring", "patients", "from", "kneeling", ".", "Perceived", "kneeling", "ability", "was", "the", "poorest", "scored", "outcome", "on", "the", "OKS", "with", "patients", "reporting", "mild", "to", "moderate", "difficulty", "with", "this", "task", ".", "Kneeling", "scores", "were", "strongly", "correlated", "with", "overall", "knee", "function", "scores", "(", "R", "=", "0.70", ")", ",", "strongly", "correlated", "with", "pain", "scores", "(", "R", "=", "0.45", ")", "and", "weakly", "correlated", "with", "knee", "stability", "scores", "(", "R", "=", "0.29", ")", ".", "When", "asked", "about", "other", "factors", "preventing", "kneeling", "other", "than", "pain", "or", "discomfor", "t", ",", "75", "%", "had", "reasons", "unrelated", "to", "the", "knee", "or", "TKA", ".", "The", "most", "common", "reason", "was", "'problems", "with", "the", "other", "knee", "'", "(", "n", "=", "19", ")", ".", "Patients", "in", "this", "study", "were", "provided", "with", "education", "regarding", "their", "kneeling", "ability", "post", "TKA", ",", "yet", "still", "experienced", "limitations", "in", "perceived", "kneeling", "ability", "post", "operatively", ".", "Contrary", "to", "previous", "research", ",", "our", "study", "suggests", "that", "factors", "other", "than", "patient", "education", "affect", "a", "patient", "'s", "perceived", "kneeling", "ability", "post", "TKA", "." ]	[ "B-Functional Concept", "B-Functional Concept", "B-Physiologic Function", "O", "O", "B-Idea or Concept", "O", "B-Educational Activity", "B-Patient or Disabled Group", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "O", "B-Patient or Disabled Group", "B-Educational Activity", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "B-Mental Process", "B-Organism Attribute", "B-Organism Attribute", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Temporal Concept", "B-Physiologic Function", "B-Educational Activity", "B-Educational Activity", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Educational Activity", "O", "B-Physiologic Function", "B-Temporal Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "B-Physiologic Function", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Physiologic Function", "B-Intellectual Product", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "B-Mental Process", "O", "O", "B-Physiologic Function", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Patient or Disabled Group", "O", "B-Physiologic Function", "O", "B-Mental Process", "B-Physiologic Function", "B-Organism Attribute", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Clinical Attribute", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "O", "O", "O", "O", "B-Physiologic Function", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Physiologic Function", "O", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Educational Activity", "O", "O", "B-Physiologic Function", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Physiologic Function", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Patient or Disabled Group", "B-Educational Activity", "B-Health Care Activity", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "B-Mental Process", "B-Physiologic Function", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O" ]
[ "Improved", "diagnostic", "yield", "of", "neuromuscular", "disorders", "applying", "clinical", "exome", "sequencing", "in", "patients", "arising", "from", "a", "consanguineous", "population", "Neuromuscular", "diseases", "(", "NMDs", ")", "include", "a", "broad", "range", "of", "disorders", "affecting", "muscles", ",", "nerves", "and", "neuromuscular", "junctions", ".", "Their", "overlapping", "phenotypes", "and", "heterogeneous", "genetic", "nature", "have", "created", "challenges", "in", "diagnosis", "which", "calls", "for", "the", "implementation", "of", "massive", "parallel", "sequencing", "as", "a", "candidate", "strategy", "to", "increase", "the", "diagnostic", "yield", ".", "In", "this", "study", ",", "total", "of", "45", "patients", ",", "mostly", "offspring", "of", "consanguineous", "marriages", "were", "examined", "using", "whole", "exome", "sequencing", ".", "Data", "analysis", "was", "performed", "to", "identify", "the", "most", "probable", "pathogenic", "rare", "variants", "in", "known", "NMD", "genes", "which", "led", "to", "identification", "of", "causal", "variants", "for", "33", "out", "of", "45", "patients", "(", "73.3", "%", ")", "in", "the", "following", "known", "genes", ":", "CAPN3", ",", "Col6A1", ",", "Col6A3", ",", "DMD", ",", "DYSF", ",", "FHL1", ",", "GJB1", ",", "ISPD", ",", "LAMA2", ",", "LMNA", ",", "PLEC1", ",", "RYR1", ",", "SGCA", ",", "SGCB", ",", "SYNE1", ",", "TNNT1", "and", "22", "novel", "pathogenic", "variants", "were", "detected", ".", "Today", ",", "the", "advantage", "of", "whole", "exome", "sequencing", "in", "clinical", "diagnostic", "strategies", "of", "heterogeneous", "disorders", "is", "clear", ".", "In", "this", "cohort", ",", "a", "diagnostic", "yield", "of", "73.3", "%", "was", "achieved", "which", "is", "quite", "high", "compared", "to", "the", "overall", "reported", "diagnostic", "yield", "of", "25", "%", "to", "50", "%", ".", "This", "could", "be", "explained", "by", "the", "consanguineous", "background", "of", "these", "patients", "and", "is", "another", "strong", "advantage", "of", "offering", "clinical", "exome", "sequencing", "in", "diagnostic", "laboratories", ",", "especially", "in", "populations", "with", "high", "rate", "of", "consanguinity", "." ]	[ "B-Finding", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Population Group", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Tissue", "O", "B-Tissue", "O", "B-Cell Component", "B-Cell Component", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Organism Attribute", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Activity", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Family Group", "O", "B-Social Behavior", "B-Social Behavior", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Disease or Syndrome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "B-Finding", "B-Gene or Genome", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Finding", "O" ]
[ "Safety", "of", "transradial", "diagnostic", "cardiac", "catheterization", "in", "patients", "under", "oral", "anticoagulant", "therapy", "Cardiac", "catheterization", "in", "anticoagulated", "patients", "is", "usually", "performed", "after", "the", "anticoagulation", "has", "been", "withdrawn", ",", "at", "least", "in", "the", "previous", "48h", ",", "and", "sometimes", "bridging", "therapy", "with", "heparin", "is", "used", ".", "A", "prospective", "observational", "study", "including", "489", "patients", "undergoing", "transradial", "catheterization", "was", "conducted", ".", "A", "total", "of", "140", "patients", "were", "under", "acenocoumarol", "(", "group", "A", ")", "and", "they", "were", "compared", "with", "the", "remainder", "(", "group", "B", ")", "for", "complications", "after", "the", "procedure", "(", "bleeding", "and", "vascular", "access", "complications", ")", ".", "Patients", "in", "group", "A", "were", "older", "(", "74±12", "years", "vs.", "68±17", "years", ",", "p", "<", "0.01", ")", "and", "the", "main", "indication", "for", "anticoagulation", "was", "atrial", "fibrillation", "(", "58.6", "%", ")", ".", "No", "complications", "occurred", "during", "the", "procedures", ".", "There", "were", "no", "acute", "bleedings", "just", "after", "the", "bandage", "removal", ".", "During", "the", "first", "24h", ",", "only", "3", "(", "2.1", "%", ")", "radial", "occlusions", "in", "group", "A", "and", "2", "(", "0.6", "%", ")", "in", "group", "B", "(", "p=0.14", ")", "were", "recorded", ".", "Hematomas", "between", "5", "and", "10cm", "appeared", "in", "5", "%", "of", "the", "group", "A", "vs.", "4.6", "%", "in", "group", "B", ".", "During", "the", "1-month", "follow-up", "period", ",", "one", "more", "radial", "occlusion", "in", "each", "group", "was", "recorded", "and", "there", "were", "4", "(", "1.1", "%", ")", "additional", "mild", "hematomas", "in", "group", "B", "and", "none", "in", "group", "A", "(", "p=0.48", ")", ".", "Performing", "a", "transradial", "diagnostic", "cardiac", "catheterization", "without", "removal", "of", "the", "oral", "chronic", "anticoagulation", "appears", "safe", "in", "patients", "under", "acenocumarol", "therapy", "." ]	[ "B-Research Activity", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Patient or Disabled Group", "O", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Functional Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Patient or Disabled Group", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Pharmacologic Substance", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "B-Classification", "B-Classification", "O", "O", "B-Pathologic Function", "O", "O", "B-Health Care Activity", "O", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Patient or Disabled Group", "O", "B-Classification", "B-Classification", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Finding", "B-Pathologic Function", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Finding", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Temporal Concept", "O", "B-Medical Device", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Temporal Concept", "B-Health Care Activity", "B-Temporal Concept", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Pathologic Function", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Qualitative Concept", "B-Activity", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Finding", "O", "B-Patient or Disabled Group", "O", "B-Pharmacologic Substance", "B-Therapeutic or Preventive Procedure", "O" ]

[ "DCTN4", "as", "a", "modifier", "of", "chronic", "Pseudomonas", "aeruginosa", "infection", "in", "cystic", "fibrosis", "Pseudomonas", "aeruginosa", "(", "Pa", ")", "infection", "in", "cystic", "fibrosis", "(", "CF", ")", "patients", "is", "associated", "with", "worse", "long-term", "pulmonary", "disease", "and", "shorter", "survival", ",", "and", "chronic", "Pa", "infection", "(", "CPA", ")", "is", "associated", "with", "reduced", "lung", "function", ",", "faster", "rate", "of", "lung", "decline", ",", "increased", "rates", "of", "exacerbations", "and", "shorter", "survival", ".", "By", "using", "exome", "sequencing", "and", "extreme", "phenotype", "design", ",", "it", "was", "recently", "shown", "that", "isoforms", "of", "dynactin", "4", "(", "DCTN4", ")", "may", "influence", "Pa", "infection", "in", "CF", ",", "leading", "to", "worse", "respiratory", "disease", ".", "The", "purpose", "of", "this", "study", "was", "to", "investigate", "the", "role", "of", "DCTN4", "missense", "variants", "on", "Pa", "infection", "incidence", ",", "age", "at", "first", "Pa", "infection", "and", "chronic", "Pa", "infection", "incidence", "in", "a", "cohort", "of", "adult", "CF", "patients", "from", "a", "single", "centre", ".", "Polymerase", "chain", "reaction", "and", "direct", "sequencing", "were", "used", "to", "screen", "DNA", "samples", "for", "DCTN4", "variants", ".", "A", "total", "of", "121", "adult", "CF", "patients", "from", "the", "Cochin", "Hospital", "CF", "centre", "have", "been", "included", ",", "all", "of", "them", "carrying", "two", "CFTR", "defects", ":", "103", "developed", "at", "least", "1", "pulmonary", "infection", "with", "Pa", ",", "and", "68", "patients", "of", "them", "had", "CPA", ".", "DCTN4", "variants", "were", "identified", "in", "24", "%", "(", "29/121", ")", "CF", "patients", "with", "Pa", "infection", "and", "in", "only", "17", "%", "(", "3/18", ")", "CF", "patients", "with", "no", "Pa", "infection", ".", "Of", "the", "patients", "with", "CPA", ",", "29", "%", "(", "20/68", ")", "had", "DCTN4", "missense", "variants", "vs", "23", "%", "(", "8/35", ")", "in", "patients", "without", "CPA", ".", "Interestingly", ",", "p.Tyr263Cys", "tend", "to", "be", "more", "frequently", "observed", "in", "CF", "patients", "with", "CPA", "than", "in", "patients", "without", "CPA", "(", "4/68", "vs", "0/35", ")", ",", "and", "DCTN4", "missense", "variants", "tend", "to", "be", "more", "frequent", "in", "male", "CF", "patients", "with", "CPA", "bearing", "two", "class", "II", "mutations", "than", "in", "male", "CF", "patients", "without", "CPA", "bearing", "two", "class", "II", "mutations", "(", "P", "=", "0.06", ")", ".", "Our", "observations", "reinforce", "that", "DCTN4", "missense", "variants", ",", "especially", "p.Tyr263Cys", ",", "may", "be", "involved", "in", "the", "pathogenesis", "of", "CPA", "in", "male", "CF", "." ]

[ "B-Biologically Active Substance", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Temporal Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Activity", "B-Activity", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "B-Organism Attribute", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "B-Population Group", "O", "B-Age Group", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "B-Health Care Related Organization", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Biologically Active Substance", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "B-Age Group", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Bacterium", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Biologically Active Substance", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Organism Attribute", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "B-Disease or Syndrome", "O", "B-Organism Attribute", "B-Disease or Syndrome", "O" ]

[ "Nonylphenol", "diethoxylate", "inhibits", "apoptosis", "induced", "in", "PC12", "cells", "Nonylphenol", "and", "short-chain", "nonylphenol", "ethoxylates", "such", "as", "NP2", "EO", "are", "present", "in", "aquatic", "environment", "as", "wastewater", "contaminants", ",", "and", "their", "toxic", "effects", "on", "aquatic", "species", "have", "been", "reported", ".", "Apoptosis", "has", "been", "shown", "to", "be", "induced", "by", "serum", "deprivation", "or", "copper", "treatment", ".", "To", "understand", "the", "toxicity", "of", "nonylphenol", "diethoxylate", ",", "we", "investigated", "the", "effects", "of", "NP2", "EO", "on", "apoptosis", "induced", "by", "serum", "deprivation", "and", "copper", "by", "using", "PC12", "cell", "system", ".", "Nonylphenol", "diethoxylate", "itself", "showed", "no", "toxicity", "and", "recovered", "cell", "viability", "from", "apoptosis", ".", "In", "addition", ",", "nonylphenol", "diethoxylate", "decreased", "DNA", "fragmentation", "caused", "by", "apoptosis", "in", "PC12", "cells", ".", "This", "phenomenon", "was", "confirmed", "after", "treating", "apoptotic", "PC12", "cells", "with", "nonylphenol", "diethoxylate", ",", "whereas", "the", "cytochrome", "c", "release", "into", "the", "cytosol", "decreased", "as", "compared", "to", "that", "in", "apoptotic", "cells", "not", "treated", "with", "nonylphenol", "diethoxylate", "s.", "Furthermore", ",", "Bax", "contents", "in", "apoptotic", "cells", "were", "reduced", "after", "exposure", "to", "nonylphenol", "diethoxylate", ".", "Thus", ",", "nonylphenol", "diethoxylate", "has", "the", "opposite", "effect", "on", "apoptosis", "in", "PC12", "cells", "compared", "to", "nonylphenol", ",", "which", "enhances", "apoptosis", "induced", "by", "serum", "deprivation", ".", "The", "difference", "in", "structure", "of", "the", "two", "compounds", "is", "hypothesized", "to", "be", "responsible", "for", "this", "phenomenon", ".", "These", "results", "indicated", "that", "nonylphenol", "diethoxylate", "has", "capability", "to", "affect", "cell", "differentiation", "and", "development", "and", "has", "potentially", "harmful", "effect", "on", "organisms", "because", "of", "its", "unexpected", "impact", "on", "apoptosis", ".", "©", "2015", "Wiley", "Periodicals", ",", "Inc.", "Environ", "Toxicol", "31", ":", "1389-1398", ",", "2016", "." ]

[ "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Activity", "B-Cell Function", "B-Functional Concept", "O", "B-Cell", "B-Cell", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Finding", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Environmental Effect of Humans", "B-Substance", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Organism", "B-Organism", "O", "O", "O", "O", "B-Cell Function", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "B-Element, Ion, or Isotope", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Cell Function", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "B-Element, Ion, or Isotope", "O", "O", "B-Cell", "B-Cell", "B-Cell", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Cell Function", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Quantitative Concept", "B-Molecular Function", "B-Molecular Function", "O", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "O", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Cell", "B-Cell", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Enzyme", "B-Enzyme", "O", "O", "O", "B-Cell Component", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "B-Functional Concept", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Conceptual Entity", "O", "B-Cell", "B-Cell", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Activity", "B-Cell Function", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "O", "O", "B-Chemical", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Finding", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Qualitative Concept", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Physiologic Function", "O", "O", "B-Qualitative Concept", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Organism", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Cell Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Prevascularized", "silicon", "membranes", "for", "the", "enhancement", "of", "transport", "to", "implanted", "medical", "devices", "Recent", "advances", "in", "drug", "delivery", "and", "sensing", "devices", "for", "in", "situ", "applications", "are", "limited", "by", "the", "diffusion", "-limiting", "foreign", "body", "response", "of", "fibrous", "encapsulation", ".", "In", "this", "study", ",", "we", "fabricated", "prevascularized", "synthetic", "device", "ports", "to", "help", "mitigate", "this", "limitation", ".", "Membranes", "with", "rectilinear", "arrays", "of", "square", "pores", "with", "widths", "ranging", "from", "40", "to", "200", "μm", "were", "created", "using", "materials", "(", "50", "μm", "thick", "double-sided", "polished", "silicon", ")", "and", "processes", "(", "photolithography", "and", "directed", "reactive", "ion", "etching", ")", "common", "in", "the", "manufacturing", "of", "microfabricated", "sensors", ".", "Vascular", "endothelial", "cells", "responded", "to", "membrane", "geometry", "by", "either", "forming", "vascular", "tubes", "that", "extended", "through", "the", "pore", "or", "completely", "filling", "membrane", "pores", "after", "4", "days", "in", "culture", ".", "Although", "tube", "formation", "began", "to", "predominate", "overgrowth", "around", "75", "μm", "and", "continued", "to", "increase", "at", "even", "larger", "pore", "sizes", ",", "tubes", "formed", "at", "these", "large", "pore", "sizes", "were", "not", "completely", "round", "and", "had", "relatively", "thin", "walls", ".", "Thus", ",", "the", "optimum", "range", "of", "pore", "size", "for", "prevascularization", "of", "these", "membranes", "was", "estimated", "to", "be", "75-100", "μm", ".", "This", "study", "lays", "the", "foundation", "for", "creating", "a", "prevascularized", "port", "that", "can", "be", "used", "to", "reduce", "fibrous", "encapsulation", "and", "thus", "enhance", "diffusion", "to", "implanted", "medical", "devices", "and", "sensors", ".", "©", "2015", "Wiley", "Periodicals", ",", "Inc.", "J", "Biomed", "Mater", "Res", "Part", "B", ":", "Appl", "Biomater", ",", "104B", ":", "1602-1609", ",", "2016", "." ]

[ "B-Functional Concept", "B-Biomedical or Dental Material", "B-Manufactured Object", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Health Care Activity", "O", "B-Functional Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Manufactured Object", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "B-Phenomenon or Process", "O", "B-Functional Concept", "O", "B-Manufactured Object", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "B-Phenomenon or Process", "O", "B-Occupational Activity", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Occupational Activity", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Spatial Concept", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "I-Activity", "B-Manufactured Object", "B-Spatial Concept", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "B-Manufactured Object", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "O", "B-Activity", "B-Natural Phenomenon or Process", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Seated", "maximum", "flexion", ":", "An", "alternative", "to", "standing", "maximum", "flexion", "for", "determining", "presence", "of", "flexion", "-", "relaxation", "?", "The", "flexion", "-", "relaxation", "phenomenon", "(", "FRP", ")", "in", "standing", "is", "a", "specific", "and", "sensitive", "diagnostic", "tool", "for", "low", "back", "pain", ".", "Seated", "flexion", "as", "an", "alternative", "could", "be", "beneficial", "for", "certain", "populations", ",", "yet", "the", "behavior", "of", "the", "trunk", "extensors", "during", "seated", "maximum", "flexion", "compared", "to", "standing", "flexion", "remains", "unclear", ".", "Compare", "FRP", "occurrences", "and", "spine", "angles", "between", "seated", "and", "standing", "flexion", "postures", "in", "three", "levels", "of", "the", "erector", "spinae", "muscles", ".", "Thirty-one", "participants", "free", "of", "back", "pain", "performed", "seated", "and", "standing", "maximum", "trunk", "flexion", ".", "Electromyographical", "signals", "were", "recorded", "from", "the", "bilateral", "lumbar", "(", "L3", ")", ",", "lower-thoracic", "(", "T9", ")", ",", "and", "upper-thoracic", "(", "T4", ")", "erector", "spinae", "and", "assessed", "for", "the", "occurrence", "of", "FRP", ".", "Spine", "angles", "corresponding", "to", "FRP", "onset", "and", "cessation", "were", "determined", ",", "and", "FRP", "occurrences", "and", "angles", "were", "compared", "between", "posture", "and", "muscle", ".", "FRP", "occurrence", "was", "similar", "in", "standing", "and", "seated", "maximum", "flexion", "across", "all", "muscles", ",", "with", "the", "lumbar", "muscles", "showing", "the", "greatest", "consistency", ".", "Standing", "FRP", "onset", "and", "cessation", "angles", "were", "consistently", "greater", "than", "the", "corresponding", "seated", "FRP", "angles", ".", "Considering", "the", "similar", "number", "of", "FRP", "occurrences", ",", "seated", "maximum", "flexion", "may", "constitute", "an", "objective", "criterion", "for", "low", "back", "pain", "diagnosis", ".", "Future", "work", "should", "seek", "to", "confirm", "the", "utility", "of", "this", "test", "in", "individuals", "with", "low", "back", "pain", "." ]

[ "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Conceptual Entity", "O", "B-Spatial Concept", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Organ or Tissue Function", "O", "B-Activity", "O", "O", "B-Organ or Tissue Function", "O", "B-Activity", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Spatial Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Spatial Concept", "O", "B-Finding", "O", "B-Spatial Concept", "B-Organ or Tissue Function", "B-Organism Attribute", "O", "O", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Population Group", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Finding", "O", "B-Spatial Concept", "B-Quantitative Concept", "B-Body Location or Region", "B-Organ or Tissue Function", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Activity", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Activity", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "B-Activity", "O", "B-Organism Attribute", "O", "B-Tissue", "O", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Tissue", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Phenomenon or Process", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Population Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O" ]

[ "The", "Relationship", "Between", "Distance", "and", "Post-operative", "Visit", "Attendance", "Following", "Medical", "Male", "Circumcision", "in", "Nyanza", "Province", ",", "Kenya", "To", "date", ",", "there", "is", "no", "research", "on", "voluntary", "medical", "male", "circumcision", "(", "VMMC", ")", "catchment", "areas", "or", "the", "relationship", "between", "distance", "to", "a", "VMMC", "facility", "and", "attendance", "at", "a", "post-operative", "follow-up", "visit", ".", "We", "analyzed", "data", "from", "a", "randomly", "selected", "subset", "of", "males", "self-seeking", "circumcision", "at", "one", "of", "16", "participating", "facilities", "in", "Nyanza", "Province", ",", "Kenya", "between", "2008", "and", "2010", ".", "Among", "1437", "participants", ",", "46.7", "%", "attended", "follow-up", ".", "The", "median", "distance", "from", "residence", "to", "utilized", "facility", "was", "2.98", "km", "(", "IQR", "1.31-5.38", ")", ".", "Nearly", "all", "participants", "(", "98.8", "%", ")", "lived", "within", "5", "km", "from", "a", "facility", ",", "however", ",", "26.3", "%", "visited", "a", "facility", "more", "than", "5", "km", "away", ".", "Stratified", "results", "demonstrated", "that", "among", "those", "utilizing", "fixed", "facilities", ",", "greater", "distance", "was", "associated", "with", "higher", "odds", "of", "follow-up", "non-attendance", "(", "OR", "5.01-10km", "vs.", "0-1km", "=", "1.71", ",", "95", "%", "CI", "1.08", ",", "2.70", ",", "p", "=", "0.02", ";", "OR", ">", "10km", "vs.", "0-1", "km", "=", "2.80", ",", "95", "%", "CI", "1.26", ",", "6.21", ",", "p", "=", "0.01", ")", ",", "adjusting", "for", "age", "and", "district", "of", "residence", ".", "We", "found", "5", "km", "marked", "the", "threshold", "distance", "beyond", "which", "follow-up", "attendance", "significantly", "dropped", ".", "These", "results", "demonstrate", "distance", "is", "an", "important", "predictor", "of", "attending", "follow-up", ",", "and", "this", "relationship", "appears", "to", "be", "modified", "by", "facility", "type", "." ]

[ "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Behavior", "B-Activity", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Individual Behavior", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Health Care Related Organization", "O", "B-Activity", "O", "O", "B-Finding", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Research Activity", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "B-Activity", "B-Classification", "O", "B-Population Group", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Functional Concept", "B-Health Care Activity", "O", "O", "B-Spatial Concept", "B-Quantitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "B-Behavior", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Health Care Activity", "B-Activity", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Health Care Activity", "B-Activity", "B-Idea or Concept", "B-Quantitative Concept", "O", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "O", "O", "B-Idea or Concept", "O", "B-Functional Concept", "B-Health Care Activity", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Health Care Related Organization", "B-Qualitative Concept", "O" ]

[ "Promoting", "lifestyle", "behaviour", "change", "and", "well-being", "in", "hospital", "patients", ":", "a", "pilot", "study", "of", "an", "evidence-based", "psychological", "intervention", "Lifestyle", "risk", "behaviours", "show", "an", "inverse", "social", "gradient", ",", "clustering", "in", "vulnerable", "groups", ".", "We", "designed", "and", "piloted", "an", "intervention", "to", "address", "barriers", "to", "lifestyle", "behaviour", "change", "among", "hospital", "patients", ".", "We", "designed", "our", "intervention", "using", "effective", "components", "of", "behaviour", "change", "interventions", "informed", "by", "psychological", "theory", ".", "Delivered", "by", "a", "health", "psychologist", "based", "at", "the", "Royal", "Free", "London", "NHS", "Foundation", "Trust", ",", "the", "4-week", "intervention", "included", "detailed", "baseline", "assessment", ",", "personalized", "goal", "setting", ",", "psychological", "skills", "development", ",", "motivation", "support", "and", "referral", "to", "community", "services", ".", "Primary", "outcomes", "were", "feasibility", "and", "patient", "acceptability", ".", "We", "also", "evaluated", "changes", "to", "health", "and", "well-being", ".", "From", "1", "July", "2013", "to", "31", "September", "2014", ",", "686", "patients", "were", "referred", ",", "338", "(", "49.3", "%", ")", "attended", "a", "first", "appointment", "and", "172", "(", "25.1", "%", ")", "completed", "follow-up", ".", "Furthermore", ",", "72.1", "%", "of", "attenders", "were", "female", "with", "the", "median", "age", "55", "years", "and", "poor", "self-reported", "baseline", "health", ".", "After", "4", "weeks", ",", "self-efficacy", ",", "health", "and", "well-being", "scores", "significantly", "improved", ":", "63", "%", "of", "lifestyle", "goals", "and", "89", "%", "of", "health", "management", "goals", "were", "fully", "achieved", ";", "58", "%", "of", "referrals", "to", "community", "lifestyle", "behaviour", "change", "services", "and", "79", "%", "of", "referrals", "to", "other", "services", "(", "e.g", ".", "Citizen", "'s", "Advice", "Bureau", ")", "were", "accepted", ";", "99", "%", "were", "satisfied", "/", "very", "satisfied", "with", "the", "service", ".", "Our", "hospital-based", "intervention", "was", "feasible", ",", "acceptable", "and", "showed", "preliminary", "health", "and", "well-being", "gains", "." ]

[ "B-Activity", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "B-Finding", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Individual Behavior", "B-Individual Behavior", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Self-help or Relief Organization", "B-Self-help or Relief Organization", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Patient or Disabled Group", "B-Qualitative Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "O", "B-Finding", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "B-Organism Attribute", "O", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Mental Process", "O", "B-Idea or Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Intellectual Product", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Self-help or Relief Organization", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Finding", "B-Finding", "O", "O", "B-Health Care Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O" ]

[ "The", "Impact", "of", "Deployment", "on", "Parental", ",", "Family", "and", "Child", "Adjustment", "in", "Military", "Families", "Since", "9/11", ",", "military", "service", "in", "the", "United", "States", "has", "been", "characterized", "by", "wartime", "deployments", "and", "reintegration", "challenges", "that", "contribute", "to", "a", "context", "of", "stress", "for", "military", "families", ".", "Research", "indicates", "the", "negative", "impact", "of", "wartime", "deployment", "on", "the", "well", "being", "of", "service", "members", ",", "military", "spouses", ",", "and", "children", ".", "Yet", ",", "few", "studies", "have", "considered", "how", "parental", "deployments", "may", "affect", "adjustment", "in", "young", "children", "and", "their", "families", ".", "Using", "deployment", "records", "and", "parent", "-", "reported", "measures", "from", "primary", "caregiving", "(", "N", "=", "680", ")", "and", "military", "(", "n", "=", "310", ")", "parents", ",", "we", "examined", "the", "influence", "of", "deployment", "on", "adjustment", "in", "military", "families", "with", "children", "ages", "0-10", "years", ".", "Greater", "deployment", "exposure", "was", "related", "to", "impaired", "family", "functioning", "and", "marital", "instability", ".", "Parental", "depressive", "and", "posttraumatic", "stress", "symptoms", "were", "associated", "with", "impairments", "in", "social", "emotional", "adjustment", "in", "young", "children", ",", "increased", "anxiety", "in", "early", "childhood", ",", "and", "adjustment", "problems", "in", "school-age", "children", ".", "Conversely", ",", "parental", "sensitivity", "was", "associated", "with", "improved", "social", "and", "emotional", "outcomes", "across", "childhood", ".", "These", "findings", "provide", "guidance", "to", "developing", "preventive", "approaches", "for", "military", "families", "with", "young", "children", "." ]

[ "O", "O", "O", "B-Activity", "O", "B-Family Group", "O", "B-Family Group", "O", "B-Age Group", "B-Individual Behavior", "O", "B-Family Group", "B-Family Group", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "B-Temporal Concept", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Family Group", "B-Family Group", "O", "B-Research Activity", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Activity", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Professional or Occupational Group", "B-Population Group", "O", "B-Professional or Occupational Group", "B-Family Group", "O", "O", "B-Age Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Family Group", "B-Activity", "O", "O", "B-Individual Behavior", "O", "B-Age Group", "B-Age Group", "O", "O", "B-Family Group", "O", "O", "I-Intellectual Product", "B-Intellectual Product", "O", "B-Family Group", "O", "B-Intellectual Product", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "B-Family Group", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Individual Behavior", "O", "B-Family Group", "B-Family Group", "O", "B-Age Group", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "B-Functional Concept", "B-Social Behavior", "B-Social Behavior", "O", "B-Finding", "B-Finding", "O", "B-Family Group", "B-Mental or Behavioral Dysfunction", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Functional Concept", "O", "B-Social Behavior", "B-Finding", "B-Individual Behavior", "O", "B-Age Group", "B-Age Group", "O", "O", "B-Finding", "O", "O", "B-Temporal Concept", "O", "O", "B-Individual Behavior", "O", "O", "B-Age Group", "B-Age Group", "O", "O", "O", "B-Family Group", "B-Mental Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Social Behavior", "O", "B-Finding", "B-Finding", "O", "B-Temporal Concept", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Family Group", "B-Family Group", "O", "O", "B-Age Group", "O" ]

[ "Combining", "electrostatic", "powder", "with", "an", "insecticide", ":", "effect", "on", "stored", "-", "product", "beetles", "and", "on", "the", "commodity", "The", "opportunity", "to", "reduce", "the", "amount", "of", "pirimiphos-methyl", "applied", "to", "grain", "by", "formulating", "it", "in", "an", "electrostatic", "powder", "was", "investigated", ".", "The", "insecticidal", "efficacy", "of", "pirimiphos-methyl", "in", "EC", "formulation", "or", "formulated", "using", "electrostatic", "powder", "(", "EP", ")", "as", "an", "inert", "carrier", "was", "investigated", "against", "Sitophilus", "oryzae", "(", "L.", ")", ",", "Oryzaephilus", "surinamensis", "(", "L.", ")", ",", "Rhyzopertha", "dominica", "(", "F.", ")", "and", "Tribolium", "confusum", "Jacquelin", "du", "Val", ".", "Furthermore", ",", "the", "adhesive", "properties", "of", "EP", "to", "rice", ",", "corn", "and", "wheat", ",", "together", "with", "the", "effect", "on", "bulk", "density", "and", "bread", "-", "and", "pasta", "-", "making", "properties", ",", "were", "investigated", ".", "The", "results", "showed", "that", "pirimiphos-methyl", "formulated", "with", "EP", "provided", "better", "efficacy", "against", "adults", "when", "compared", "with", "EC", "formulation", "for", "O.", "surinamensis", "and", "T.", "confusum", ",", "but", "there", "was", "no", "difference", "for", "R.", "dominica", ".", "Progeny", "production", "was", "consistently", "lower", "in", "grain", "treated", "with", "the", "EP", "formulation", "than", "in", "grain", "treated", "with", "the", "EC", ".", "Tests", "showed", "that", "EP", "adhered", "to", "the", "kernels", "for", "longer", "on", "hard", "wheat", "than", "on", "maize", "or", "rice", ".", "In", "most", "commodities", ",", "EP", "did", "not", "alter", "the", "bulk", "density", ".", "Finally", ",", "the", "addition", "of", "EP", "did", "not", "affect", "flour", "-", "and", "bread", "-", "making", "properties", ",", "nor", "the", "pasta", "-making", "properties", ".", "The", "results", "of", "the", "present", "study", "suggest", "that", "an", "EP", "could", "be", "used", "to", "reduce", "the", "amount", "of", "pirimiphos-methyl", "applied", "to", "grain", "for", "effective", "pest", "control", ",", "with", "no", "detrimental", "effects", "on", "grain", "quality", ".", "©", "2016", "Society", "of", "Chemical", "Industry", "." ]

[ "O", "B-Substance", "B-Substance", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Functional Concept", "O", "B-Entity", "B-Eukaryote", "O", "O", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Food", "O", "O", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Qualitative Concept", "O", "B-Pharmacologic Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Substance", "B-Substance", "O", "B-Substance", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Substance", "O", "B-Food", "O", "B-Food", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Food", "O", "O", "B-Food", "O", "B-Activity", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Substance", "O", "O", "B-Qualitative Concept", "O", "B-Eukaryote", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Family Group", "O", "O", "O", "O", "O", "B-Food", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Substance", "O", "O", "O", "B-Food", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "B-Substance", "B-Phenomenon or Process", "O", "O", "B-Food", "O", "O", "O", "O", "B-Food", "O", "O", "B-Food", "O", "B-Food", "O", "O", "O", "B-Food", "O", "B-Substance", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "B-Food", "O", "O", "B-Food", "O", "B-Activity", "B-Qualitative Concept", "O", "O", "O", "B-Food", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Food", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Food", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Radiofrequency", "ablation", "of", "posteroseptal", "accessory", "pathways", "associated", "with", "coronary", "sinus", "diverticula", "Posteroseptal", "accessory", "pathways", "may", "be", "associated", "with", "a", "coronary", "sinus", "(", "CS", ")", "diverticulum", ".", "Our", "purpose", "was", "to", "describe", "the", "clinical", "characteristics", ",", "mapping", "and", "ablation", "of", "these", "pathways", ".", "This", "was", "a", "retrospective", "study", "of", "all", "patients", "who", "underwent", "ablation", "of", "posteroseptal", "accessory", "pathways", "in", "a", "single", "centre", ".", "Patients", "with", "a", "diverticulum", "of", "the", "CS", "or", "one", "of", "its", "tributaries", "were", "included", "in", "group", "I", ",", "while", "the", "other", "patients", "formed", "group", "II", ".", "Clinical", "presentation", ",", "ablation", "procedure", "and", "outcome", "were", "compared", "between", "the", "two", "groups", ".", "A", "total", "of", "51", "patients", "were", "included", ",", "16", "in", "group", "I", "and", "35", "in", "group", "II", ".", "There", "were", "no", "significant", "differences", "in", "age", "or", "sex", "distribution", ".", "Atrial", "fibrillation", "(", "AF", ")", "and", "previous", "unsuccessful", "ablation", "were", "more", "common", "in", "group", "I", ".", "A", "negative", "delta", "wave", "in", "lead", "II", "was", "the", "ECG", "finding", "with", "best", "sensitivity", "and", "specificity", "for", "the", "presence", "of", "a", "diverticulum", ".", "A", "pathway", "potential", "was", "common", "at", "the", "successful", "site", "in", "group", "I", ",", "and", "the", "interval", "between", "local", "ventricular", "electrogram", "and", "delta", "wave", "onset", "was", "shorter", "(", "19.5", "±", "8", "vs", "33.1", "±", "7.6", "ms", ",", "p", "<", "0.001", ")", ".", "There", "was", "a", "trend", "toward", "lower", "procedural", "success", "rate", "and", "higher", "recurrence", "rate", "in", "group", "I", ",", "although", "this", "was", "not", "significant", ".", "CS", "diverticula", "should", "be", "suspected", "in", "patients", "with", "manifest", "posteroseptal", "accessory", "pathways", "who", "have", "a", "previous", "failed", "ablation", ",", "documented", "AF", "or", "typical", "electrocardiographic", "signs", ".", "A", "discrete", "potential", "is", "frequently", "seen", "at", "the", "successful", "site", ",", "but", "the", "local", "ventricular", "electrogram", "is", "not", "as", "early", "as", "in", "other", "accessory", "pathways", "." ]

[ "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Diagnostic Procedure", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Finding", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "B-Quantitative Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Disease or Syndrome", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O" ]

[ "Association", "of", "RBP4", "levels", "with", "increased", "arterial", "stiffness", "in", "adolescents", "with", "family", "history", "of", "type", "2", "diabetes", "The", "aim", "of", "this", "study", "was", "to", "explore", "the", "impact", "of", "family", "history", "of", "type", "2", "diabetes", "(", "FH2D", ")", "on", "arterial", "stiffness", "in", "young", "people", "and", "its", "relationship", "to", "adipocytokines", ".", "This", "case-control", "study", "included", "52", "adolescents", "(", "male", "/", "female", "28/24", ")", "with", "FH2D", "(", "FH2D+", ")", "and", "40", "adolescents", "(", "male", "/", "female", "21/19", ")", "without", "FH2D", "(", "FH2D-", ")", ".", "Anthropometric", "measurements", ",", "including", "height", ",", "weight", ",", "waist", "circumference", "(", "WC", ")", ",", "and", "blood", "pressure", ",", "were", "obtained", ".", "Blood", "samples", "were", "collected", ",", "fasting", "plasma", "glucose", "(", "FPG", ")", ",", "serum", "lipids", ",", "Retinol", "Binding", "Protein", "4", "(", "RBP4", ")", ",", "C", "reactive", "protein", "(", "CRP", ")", ",", "adiponectin", "and", "visfatin", "were", "examined", ".", "Brachial-ankle", "pulse", "wave", "velocity", "(", "baPWV", ")", "was", "used", "to", "evaluate", "arterial", "stiffness", ".", "Visceral", "fat", "area", "(", "VFA", ")", "was", "measured", "by", "computerized", "tomography", ".", "Compared", "with", "FH2D-", "group", ",", "FH2D+", "group", "had", "a", "significantly", "higher", "oral", "glucose", "tolerance", "test", "(", "OGTT", ")", "2-hour", "insulin", ",", "RBP4", "and", "baPWV", "levels", ",", "a", "lower", "adiponectin", "and", "glucose", "infusing", "rate", "(", "GIR", ")", "(", "P", "<", "0.05", ")", ".", "BaPWV", "was", "positively", "correlated", "with", "age", ",", "systolic", "blood", "pressure", "(", "SBP", ")", ",", "diastolic", "blood", "pressure", "(", "DBP", ")", ",", "2-hour", "(", "OGTT", ")", "insulin", ",", "RBP4", ",", "and", "VFA", ",", "and", "negatively", "correlated", "with", "GIR", "in", "FH2D+", "group", ".", "After", "multivariate", "analysis", ",", "age", ",", "SBP", ",", "RBP4", "and", "VFA", "maintained", "an", "independent", "association", "with", "baPWV", "in", "FH2D+", "group", "(", "P", "<", "0.05", ")", ",", "while", "only", "age", ",", "SBP", ",", "and", "VFA", "were", "independent", "predictors", "of", "baPWV", "in", "FH2D-", "group", "(", "P", "<", "0.05", ")", ".", "These", "findings", "led", "to", "the", "conclusion", "that", "RBP4", "level", "was", "associated", "with", "increased", "arterial", "stiffness", "in", "young", "subjects", "with", "family", "history", "of", "type", "2", "diabetes", "." ]

[ "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Age Group", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Temporal Concept", "B-Population Group", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Age Group", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "B-Finding", "O", "B-Finding", "O", "O", "O", "B-Age Group", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "B-Finding", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "B-Organism Function", "B-Organism Function", "O", "O", "O", "O", "B-Body Substance", "B-Body Substance", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Laboratory Procedure", "O", "B-Enzyme", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Finding", "B-Population Group", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Population Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "O", "B-Biologically Active Substance", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Clinical Attribute", "O", "O", "B-Idea or Concept", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Temporal Concept", "B-Population Group", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O" ]

[ "EZH2", "and", "ZFX", "oncogenes", "in", "malignant", "behaviour", "of", "parathyroid", "neoplasms", "Several", "studies", "reported", "somatic", "mutations", "of", "many", "genes", "(", "MEN1", ",", "CTNNB1", ",", "CDKIs", "and", "others", ")", "in", "parathyroid", "adenoma", ",", "although", "with", "different", "prevalence", ".", "Recently", ",", "activating", "mutations", "of", "the", "EZH2", "and", "ZFX", "oncogenes", "were", "identified", "in", "benign", "parathyroid", "adenoma", "by", "whole", "exome", "sequencing", ".", "The", "same", "mutations", "had", "been", "found", "in", "blood", "and", "ovary", "malignant", "tumours", ".", "On", "one", "hand", ",", "this", "result", "raised", "the", "hypothesis", "that", "these", "oncogenes", "may", "play", "a", "role", "in", "the", "onset", "of", "parathyroid", "tumour", ",", "but", "it", "would", "also", "suggest", "they", "may", "be", "involved", "in", "malignant", ",", "rather", "benign", ",", "parathyroid", "neoplasm", ".", "Our", "aim", "was", "to", "verify", "the", "occurrence", "of", "selected", "mutations", "of", "the", "EZH2", "and", "ZFX", "genes", "in", "an", "Italian", "cohort", "of", "23", "sporadic", "parathyroid", "carcinomas", ",", "12", "atypical", "and", "45", "typical", "adenomas", ".", "DNA", "was", "extracted", "from", "paraffin-embedded", "tissues", ",", "PCR", "amplified", "and", "directly", "sequenced", ".", "No", "mutations", "were", "detected", "in", "the", "coding", "sequence", "and", "boundaries", "of", "both", "genes", "in", "any", "of", "the", "samples", ".", "Two", "polymorphisms", "of", "the", "EZH2", "gene", "were", "identified", "with", "different", "prevalence", ":", "the", "rs2072407", "variant", "was", "present", "in", "the", "30", "%", "of", "the", "samples", ",", "in", "keeping", "with", "the", "overall", "frequency", "in", "larger", "populations", ",", "while", "the", "rs78589034", "variant", ",", "located", "close", "to", "the", "5", "'", "end", "of", "the", "exon", "16", ",", "was", "detected", "in", "only", "one", "proband", "with", "familial", "isolated", "hyperparathyroidism", ";", "we", "investigated", "the", "possible", "outcome", "on", "the", "splicing", "process", ".", "EZH2", "and", "ZFX", "genes", "do", "not", "seem", "to", "have", "an", "impact", "on", "the", "onset", "of", "most", "parathyroid", "tumours", ",", "both", "benign", "and", "malignant", ",", "though", "further", "studies", "on", "larger", "cohorts", "of", "different", "ethnicity", "are", "needed", "." ]

[ "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Research Activity", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Activity", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Body Substance", "O", "B-Body Part, Organ, or Organ Component", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Neoplastic Process", "O", "B-Biologically Active Substance", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Tissue", "B-Tissue", "O", "B-Molecular Biology Research Technique", "B-Phenomenon or Process", "O", "O", "B-Functional Concept", "O", "B-Finding", "B-Genetic Function", "O", "B-Finding", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Substance", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Temporal Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Finding", "O", "O", "O", "B-Family Group", "O", "B-Functional Concept", "B-Functional Concept", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Population Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O" ]

[ "The", "effect", "of", "total", "hip", "arthroplasty", "on", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "and", "low", "back", "pain", "in", "patients", "with", "severe", "hip", "osteoarthritis", "Sagittal", "spinopelvic", "malalignment", "has", "been", "reported", "in", "spinal", "disorders", "such", "as", "low", "back", "pain", "(", "LBP", ")", ",", "and", "restoration", "of", "normal", "alignment", "is", "targeted", "when", "treating", "these", "disorders", ".", "Abnormal", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "has", "been", "reported", "in", "patients", "with", "severe", "hip", "osteoarthritis", "(", "OA", ")", ",", "who", "have", "a", "high", "prevalence", "of", "associated", "LBP", ".", "This", "prospective", "longitudinal", "study", "aimed", "to", "investigate", "changes", "in", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "after", "total", "hip", "arthroplasty", "(", "THA", ")", "in", "patients", "with", "severe", "hip", "OA", ",", "and", "whether", "these", "changes", "contribute", "to", "LBP", "relief", ".", "Patients", "undergoing", "primary", "THA", "due", "to", "severe", "unilateral", "hip", "OA", "were", "recruited", ".", "Physical", "examination", "and", "X-ray", "films", "were", "taken", "to", "rule", "out", "any", "spinal", "disorder", ".", "Sagittal", "alignment", "of", "pelvis", ",", "hip", ",", "and", "spine", "was", "analyzed", "on", "lateral", "radiographs", "taken", "before", "(", "baseline", ")", "and", "1", "year", "after", "(", "follow-up", ")", "THA", ".", "Functional", "instruments", "were", "completed", "by", "patients", "including", ":", "visual", "analog", "scale", "(", "VAS", ")", "for", "LBP", ",", "Roland-Morris", "Disability", "Questionnaire", "(", "RMDQ", ")", ",", "and", "Harris", "Hip", "Score", "(", "HHS", ")", ".", "Comparisons", "were", "carried", "out", "at", "baseline", "and", "follow-up", ",", "and", "between", "patients", "with", "and", "without", "LBP", ".", "The", "recruited", "69", "patients", "showed", "significantly", "reduced", "hip", "flexion", "and", "improved", "global", "spinal", "balance", "at", "follow-up", "compared", "with", "baseline", ".", "LBP", "was", "reported", "by", "39", "patients", "(", "56.5", "%", ")", "before", "surgery", ";", "at", "follow-up", ",", "17", "reported", "complete", "resolution", ",", "while", "22", "reported", "significant", "relief", ".", "Significant", "decreases", "in", "VAS", "and", "RMDQ", "scores", "in", "lumbar", "spine", "and", "increase", "in", "hip", "HHS", "were", "observed", ".", "THA", "in", "patients", "with", "severe", "hip", "OA", "could", "help", "correct", "abnormal", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "and", "relieve", "comorbid", "LBP", ".", "Improvements", "in", "hip", "flexion", "and", "global", "spinal", "balance", "might", "be", "involved", "in", "the", "mechanism", "of", "LBP", "relief", "." ]

[ "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Body Location or Region", "B-Body Part, Organ, or Organ Component", "B-Pathologic Function", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "O", "B-Finding", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Sign or Symptom", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Sign or Symptom", "B-Finding", "O", "B-Patient or Disabled Group", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Body Location or Region", "B-Finding", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Health Care Activity", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "B-Sign or Symptom", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Health Care Activity", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Health Care Activity", "O", "O", "B-Quantitative Concept", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Clinical Attribute", "O", "B-Intellectual Product", "B-Quantitative Concept", "O", "B-Body Location or Region", "B-Body Location or Region", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "B-Finding", "B-Sign or Symptom", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "B-Sign or Symptom", "B-Finding", "O" ]

[ "Beyond", "neutral", "and", "forbidden", "links", ":", "morphological", "matches", "and", "the", "assembly", "of", "mutualistic", "hawkmoth", "-", "plant", "networks", "A", "major", "challenge", "in", "evolutionary", "ecology", "is", "to", "understand", "how", "co-evolutionary", "processes", "shape", "patterns", "of", "interactions", "between", "species", "at", "community", "level", ".", "Pollination", "of", "flowers", "with", "long", "corolla", "tubes", "by", "long-tongued", "hawkmoths", "has", "been", "invoked", "as", "a", "showcase", "model", "of", "co-evolution", ".", "Recently", ",", "optimal", "foraging", "models", "have", "predicted", "that", "there", "might", "be", "a", "close", "association", "between", "mouthparts", "'", "length", "and", "the", "corolla", "depth", "of", "the", "visited", "flowers", ",", "thus", "favouring", "trait", "convergence", "and", "specialization", "at", "community", "level", ".", "Here", ",", "we", "assessed", "whether", "hawkmoths", "more", "frequently", "pollinate", "plants", "with", "floral", "tube", "lengths", "similar", "to", "their", "proboscis", "lengths", "(", "morphological", "match", "hypothesis", ")", "against", "abundance", "-based", "processes", "(", "neutral", "hypothesis", ")", "and", "ecological", "trait", "mismatches", "constraints", "(", "forbidden", "links", "hypothesis", ")", ",", "and", "how", "these", "processes", "structure", "hawkmoth", "-", "plant", "mutualistic", "networks", "from", "five", "communities", "in", "four", "biogeographical", "regions", "of", "South", "America", ".", "We", "found", "convergence", "in", "morphological", "traits", "across", "the", "five", "communities", "and", "that", "the", "distribution", "of", "morphological", "differences", "between", "hawkmoths", "and", "plants", "is", "consistent", "with", "expectations", "under", "the", "morphological", "match", "hypothesis", "in", "three", "of", "the", "five", "communities", ".", "In", "the", "two", "remaining", "communities", ",", "which", "are", "ecotones", "between", "two", "distinct", "biogeographical", "areas", ",", "interactions", "are", "better", "predicted", "by", "the", "neutral", "hypothesis", ".", "Our", "findings", "are", "consistent", "with", "the", "idea", "that", "diffuse", "co-evolution", "drives", "the", "evolution", "of", "extremely", "long", "proboscises", "and", "flower", "tubes", ",", "and", "highlight", "the", "importance", "of", "morphological", "traits", ",", "beyond", "the", "forbidden", "links", "hypothesis", ",", "in", "structuring", "interactions", "between", "mutualistic", "partners", ",", "revealing", "that", "the", "role", "of", "niche-based", "processes", "can", "be", "much", "more", "complex", "than", "previously", "known", "." ]

[ "O", "B-Conceptual Entity", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "B-Phenomenon or Process", "B-Eukaryote", "O", "B-Plant", "B-Functional Concept", "O", "O", "O", "O", "B-Occupation or Discipline", "B-Occupation or Discipline", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Spatial Concept", "O", "B-Functional Concept", "O", "B-Classification", "O", "B-Group", "B-Qualitative Concept", "O", "B-Organism Function", "O", "B-Plant", "O", "B-Plant", "B-Plant", "B-Plant", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "O", "O", "B-Research Device", "O", "B-Genetic Function", "O", "O", "O", "O", "O", "B-Research Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Plant", "B-Spatial Concept", "O", "O", "O", "B-Plant", "O", "O", "O", "B-Organism Attribute", "B-Activity", "O", "B-Occupation or Discipline", "O", "B-Group", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Eukaryote", "O", "O", "B-Plant", "B-Plant", "O", "B-Classification", "B-Classification", "B-Quantitative Concept", "O", "O", "O", "B-Eukaryote", "B-Quantitative Concept", "O", "B-Spatial Concept", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "O", "B-Phenomenon or Process", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Qualitative Concept", "B-Occupational Activity", "O", "B-Conceptual Entity", "B-Conceptual Entity", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Spatial Concept", "B-Eukaryote", "O", "B-Plant", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Group", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "B-Activity", "O", "B-Spatial Concept", "B-Organism Attribute", "O", "O", "O", "B-Group", "O", "O", "O", "B-Functional Concept", "O", "B-Spatial Concept", "O", "O", "B-Eukaryote", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "B-Genetic Function", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Organism Attribute", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "B-Idea or Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Impact", "of", "totally", "laparoscopic", "combined", "management", "of", "colorectal", "cancer", "with", "synchronous", "hepatic", "metastases", "on", "severity", "of", "complications", ":", "a", "propensity-score", "-based", "analysis", "Thanks", "to", "widespread", "diffusion", "of", "minimally", "invasive", "approach", "in", "the", "setting", "of", "both", "colorectal", "and", "hepatic", "surgeries", ",", "the", "interest", "in", "combined", "resections", "for", "colorectal", "cancer", "and", "synchronous", "liver", "metastases", "(", "SCLM", ")", "by", "totally", "laparoscopic", "approach", "(", "TLA", ")", "has", "increased", ".", "Aim", "of", "this", "study", "was", "to", "compare", "outcome", "of", "combined", "resections", "for", "SCLM", "performed", "by", "TLA", "or", "by", "open", "approach", ",", "in", "a", "propensity-score-based", "study", ".", "All", "25", "patients", "undergoing", "combined", "TLA", "for", "SCLM", "at", "San", "Raffaele", "Hospital", "in", "Milano", "were", "compared", "in", "a", "case-matched", "analysis", "with", "25", "out", "of", "91", "patients", "undergoing", "totally", "open", "approach", "(", "TOA", "group", ")", ".", "Groups", "were", "matched", "with", "1:2", "ratio", "using", "propensity", "scores", "based", "on", "covariates", "representing", "disease", "severity", ".", "Main", "endpoints", "were", "postoperative", "morbidity", "and", "long-term", "outcome", ".", "The", "Modified", "Accordion", "Severity", "Grading", "System", "was", "used", "to", "quantify", "complications", ".", "The", "groups", "resulted", "comparable", "in", "terms", "of", "patients", "and", "disease", "characteristics", ".", "The", "TLA", "group", ",", "as", "compared", "to", "the", "TOA", "group", ",", "had", "lower", "blood", "loss", "(", "350", "vs", "600", "mL", ")", ",", "shorter", "postoperative", "stay", "(", "9", "vs", "12", "days", ")", ",", "lower", "postoperative", "morbidity", "index", "(", "0.14", "vs", "0.20", ")", "and", "severity", "score", "for", "complicated", "patients", "(", "0.60", "vs", "0.85", ")", ".", "Colonic", "anastomosis", "leakage", "had", "the", "highest", "fractional", "complication", "burden", "in", "both", "groups", ".", "In", "spite", "of", "comparable", "long-term", "overall", "survival", ",", "the", "TLA", "group", "had", "better", "recurrence-free", "survival", ".", "TLA", "for", "combined", "resections", "is", "feasible", ",", "and", "its", "indications", "can", "be", "widened", "to", "encompass", "a", "larger", "population", "of", "patients", ",", "provided", "its", "benefits", "in", "terms", "of", "reduced", "overall", "risk", "and", "severity", "of", "complications", ",", "rapid", "functional", "recovery", "and", "favorable", "long-term", "outcomes", "." ]

[ "O", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Diagnostic Procedure", "O", "B-Neoplastic Process", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Quantitative Concept", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "I-Population Group", "B-Population Group", "O", "O", "B-Finding", "B-Finding", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Temporal Concept", "B-Functional Concept", "O" ]

[ "Application", "of", "an", "Analytical", "Solution", "as", "a", "Screening", "Tool", "for", "Sea", "Water", "Intrusion", "Sea", "water", "intrusion", "into", "aquifers", "is", "problematic", "in", "many", "coastal", "areas", ".", "The", "physics", "and", "chemistry", "of", "this", "issue", "are", "complex", ",", "and", "sea", "water", "intrusion", "remains", "challenging", "to", "quantify", ".", "Simple", "assessment", "tools", "like", "analytical", "models", "offer", "advantages", "of", "rapid", "application", ",", "but", "their", "applicability", "to", "field", "situations", "is", "unclear", ".", "This", "study", "examines", "the", "reliability", "of", "a", "popular", "sharp-interface", "analytical", "approach", "for", "estimating", "the", "extent", "of", "sea", "water", "in", "a", "homogeneous", "coastal", "aquifer", "subjected", "to", "pumping", "and", "regional", "flow", "effects", "and", "under", "steady-state", "conditions", ".", "The", "analytical", "model", "is", "tested", "against", "observations", "from", "Canada", ",", "the", "United", "States", ",", "and", "Australia", "to", "assess", "its", "utility", "as", "an", "initial", "approximation", "of", "sea", "water", "extent", "for", "the", "purposes", "of", "rapid", "groundwater", "management", "decision", "making", ".", "The", "occurrence", "of", "sea", "water", "intrusion", "resulting", "in", "increased", "salinity", "at", "pumping", "wells", "was", "correctly", "predicted", "in", "approximately", "60", "%", "of", "cases", ".", "Application", "of", "a", "correction", "to", "account", "for", "dispersion", "did", "not", "markedly", "improve", "the", "results", ".", "Failure", "of", "the", "analytical", "model", "to", "provide", "correct", "predictions", "can", "be", "attributed", "to", "mismatches", "between", "its", "simplifying", "assumptions", "and", "more", "complex", "field", "settings", ".", "The", "best", "results", "occurred", "where", "the", "toe", "of", "the", "salt", "water", "wedge", "is", "expected", "to", "be", "the", "closest", "to", "the", "coast", "under", "predevelopment", "conditions", ".", "Predictions", "were", "the", "poorest", "for", "aquifers", "where", "the", "salt", "water", "wedge", "was", "expected", "to", "extend", "further", "inland", "under", "predevelopment", "conditions", "and", "was", "therefore", "more", "dispersive", "prior", "to", "pumping", ".", "Sharp-interface", "solutions", "remain", "useful", "tools", "to", "screen", "for", "the", "vulnerability", "of", "coastal", "aquifers", "to", "sea", "water", "intrusion", ",", "although", "the", "significant", "sources", "of", "uncertainty", "identified", "in", "this", "study", "require", "careful", "consideration", "to", "avoid", "misinterpreting", "sharp-interface", "results", "." ]

[ "B-Functional Concept", "O", "O", "B-Intellectual Product", "B-Conceptual Entity", "O", "O", "B-Health Care Activity", "B-Intellectual Product", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "O", "B-Finding", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Occupation or Discipline", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Quantitative Concept", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Natural Phenomenon or Process", "O", "O", "B-Functional Concept", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Qualitative Concept", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Functional Concept", "O", "B-Idea or Concept", "O", "B-Geographic Area", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Geographic Area", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Substance", "B-Substance", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Occupational Activity", "B-Mental Process", "B-Mental Process", "O", "O", "B-Temporal Concept", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "B-Quantitative Concept", "B-Laboratory or Test Result", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Finding", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "B-Spatial Concept", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "B-Intellectual Product", "O", "B-Health Care Activity", "O", "O", "B-Finding", "O", "B-Spatial Concept", "B-Natural Phenomenon or Process", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O" ]

[ "Patient", "-", "Physician", "Discordance", "in", "Global", "Assessment", "in", "Rheumatoid", "Arthritis", ":", "A", "Systematic", "Literature", "Review", "With", "Meta-Analysis", "The", "integration", "of", "the", "patient", "in", "therapeutic", "decision-making", "is", "important", "in", "the", "management", "of", "rheumatoid", "arthritis", "(", "RA", ")", ",", "but", "the", "patient", "opinion", "regarding", "disease", "status", "may", "differ", "from", "the", "physician", "'s", "opinion", ".", "The", "aim", "of", "this", "study", "was", "to", "assess", "in", "the", "published", "literature", "the", "frequency", "and", "drivers", "of", "patient", "-", "physician", "discordance", "in", "global", "assessment", "in", "RA", ".", "A", "systematic", "literature", "review", "of", "all", "articles", "published", "up", "to", "January", "2015", "in", "Medline", "or", "Embase", ",", "reporting", "discordance", "in", "RA", ",", "was", "conducted", "by", "2", "investigators", ".", "Discordance", "was", "defined", "based", "on", "the", "absolute", "difference", "of", "patient", "global", "(", "PGA", ")", "and", "physician", "global", "assessments", "(", "PhGA", ")", "on", "0-10-cm", "scales", ".", "The", "frequency", "of", "discordance", "and", "its", "predictors", "were", "collected", "in", "each", "study", ".", "Frequencies", "of", "discordance", "were", "pooled", "by", "meta-analysis", "using", "random", "effect", ".", "In", "all", ",", "12", "studies", "were", "selected", "(", "i.e.", ",", "11,879", "patients", ")", ":", "weighted", "mean", "±", "SD", "age", "was", "55.1", "±", "13.9", "years", ",", "weighted", "mean", "±", "SD", "disease", "duration", "was", "10.4", "±", "9.3", "years", ",", "and", "80.7", "%", "were", "women", ".", "The", "value", "of", "the", "difference", "|", "PGA", "-", "PhGA", "|", "defining", "discordance", "varied", "between", "≥0.5", "cm", "(", "n", "=", "2", "studies", ")", "to", "≥3", "cm", "(", "n", "=", "5", "studies", ")", ";", "the", "weighted", "mean", "value", "was", "2.7", "cm", ".", "The", "pooled", "percentage", "of", "patients", "with", "discordance", "was", "43", "%", "(", "95", "%", "confidence", "interval", "36", "%", "-51", "%", ";", "range", "25", "%", "-76", "%", ")", ".", "PGA", "was", "usually", "higher", "than", "PhGA", ".", "The", "drivers", "of", "PGA", "were", "pain", "and", "functional", "incapacity", ",", "whereas", "drivers", "of", "PhGA", "were", "joint", "counts", "and", "acute-phase", "reactants", ".", "Discordance", "in", "global", "assessment", "was", "most", "frequently", "defined", "as", "a", "difference", "of", "3", "points", "or", "more", ";", "even", "with", "such", "a", "stringent", "definition", ",", "up", "to", "half", "the", "patients", "were", "found", "to", "be", "discordant", ".", "The", "long-term", "consequences", "of", "this", "discordance", "remain", "to", "be", "determined", "." ]

[ "B-Patient or Disabled Group", "O", "B-Professional or Occupational Group", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Research Activity", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "B-Mental Process", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Patient or Disabled Group", "B-Mental Process", "O", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Mental Process", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Activity", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Temporal Concept", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Professional or Occupational Group", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Occupational Activity", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Research Activity", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Intellectual Product", "O", "B-Research Activity", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "O", "B-Research Activity", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Sign or Symptom", "O", "B-Functional Concept", "B-Clinical Attribute", "O", "O", "O", "O", "B-Research Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O" ]

[ "Nosocomial", "pneumonia", "caused", "by", "methicillin-resistant", "Staphylococcus", "aureus", "treated", "with", "linezolid", "or", "vancomycin", ":", "A", "secondary", "economic", "analysis", "of", "resource", "use", "from", "a", "Spanish", "perspective", "Adopting", "a", "unique", "Spanish", "perspective", ",", "this", "study", "aims", "to", "assess", "healthcare", "resource", "utilization", "(", "HCRU", ")", "and", "the", "costs", "of", "treating", "nosocomial", "pneumonia", "(", "NP", ")", "produced", "by", "methicillin-resistant", "Staphylococcus", "aureus", "(", "MRSA", ")", "in", "hospitalized", "adults", "using", "linezolid", "or", "vancomycin", ".", "An", "evaluation", "is", "also", "made", "of", "the", "renal", "failure", "rate", "and", "related", "economic", "outcomes", "between", "study", "groups", ".", "An", "economic", "post", "hoc", "evaluation", "of", "a", "randomized", ",", "double-blind", ",", "multicenter", "phase", "4", "study", "was", "carried", "out", ".", "Nosocomial", "pneumonia", "due", "to", "MRSA", "in", "hospitalized", "adults", ".", "The", "modified", "intent", "to", "treat", "(", "mITT", ")", "population", "comprised", "224", "linezolid", "-", "and", "224", "vancomycin", "-", "treated", "patients", ".", "Costs", "and", "HCRU", "were", "evaluated", "between", "patients", "administered", "either", "linezolid", "or", "vancomycin", ",", "and", "between", "patients", "who", "developed", "renal", "failure", "and", "those", "who", "did", "not", ".", "Analysis", "of", "HCRU", "outcomes", "and", "costs", ".", "Total", "costs", "were", "similar", "between", "the", "linezolid", "-", "(", "€17,782±€9,615", ")", "and", "vancomycin", "-", "treated", "patients", "(", "€17,423±€9,460", ")", "(", "P=.69", ")", ".", "The", "renal", "failure", "rate", "was", "significantly", "lower", "in", "the", "linezolid", "-", "treated", "patients", "(", "4", "%", "vs.", "15", "%", ";", "P", "<", ".001", ")", ".", "The", "total", "costs", "tended", "to", "be", "higher", "in", "patients", "who", "developed", "renal", "failure", "(", "€19,626±€10,840", "vs.", "€17,388±€9,369", ";", "P=.14", ")", ".", "Among", "the", "patients", "who", "developed", "renal", "failure", ",", "HCRU", "(", "days", "on", "mechanical", "ventilation", ":", "13.2±10.7", "vs.", "7.6±3.6", "days", ";", "P=.21", ";", "ICU", "stay", ":", "14.4±10.5", "vs.", "9.9±6.6", "days", ";", "P=.30", ";", "hospital", "stay", ":", "19.5±9.5", "vs.", "16.1±11.0", "days", ";", "P=.26", ")", "and", "cost", "(", "€17,219±€8,792", "vs.", "€20,263±€11,350", ";", "P=.51", ")", "tended", "to", "be", "lower", "in", "the", "linezolid", "-", "vs.", "vancomycin", "-", "treated", "patients", ".", "There", "were", "no", "statistically", "significant", "differences", "in", "costs", "per", "patient", "-", "day", "between", "cohorts", "after", "correcting", "for", "mortality", "(", "€1000", "vs.", "€1,010", ";", "P=.98", ")", ".", "From", "a", "Spanish", "perspective", ",", "there", "were", "no", "statistically", "significant", "differences", "in", "total", "costs", "between", "the", "linezolid", "and", "vancomycin", "pneumonia", "cohorts", ".", "The", "drug", "cost", "corresponding", "to", "linezolid", "was", "partially", "offset", "by", "fewer", "renal", "failure", "adverse", "events", "." ]

[ "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Geographic Area", "O", "O", "O", "O", "B-Geographic Area", "O", "O", "O", "B-Research Activity", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Idea or Concept", "O", "O", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "B-Bacterium", "O", "O", "B-Finding", "B-Finding", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Research Activity", "O", "B-Research Activity", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Bacterium", "O", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Population Group", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "B-Quantitative Concept", "O", "B-Idea or Concept", "O", "O", "O", "B-Patient or Disabled Group", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Idea or Concept", "O", "B-Temporal Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "B-Temporal Concept", "O", "B-Population Group", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "B-Disease or Syndrome", "B-Population Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Quantitative Concept", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Pathologic Function", "B-Pathologic Function", "O" ]

[ "The", "Role", "of", "TRAF4", "and", "B3GAT1", "Gene", "Expression", "in", "the", "Food", "Hypersensitivity", "and", "Insect", "Venom", "Allergy", "in", "Mastocytosis", "Mastocytosis", "is", "an", "uncommon", "disease", "classified", "as", "a", "myeloproliferative", "neoplasm", ",", "however", ",", "its", "symptoms", "are", "broad", "and", "place", "patients", "at", "crossroads", "between", "dermatology", ",", "hematology", "and", "allergology", ".", "Patients", "with", "mastocytosis", "often", "suffer", "from", "symptoms", "resulting", "from", "the", "activation", "and", "release", "of", "mediators", "from", "the", "mast", "cells", ",", "such", "as", "generalized", "itching", ",", "redness", ",", "headache", ",", "abdominal", "cramps", ",", "diarrhea", ",", "bone", "pain", "or", "arthritis", ",", "hypotension", "and", "shock", ".", "The", "possible", "severe", ",", "fatal", "or", "near", "fatal", "reactions", "caused", "by", "food", "hypersensitivity", "are", "reasons", "for", "the", "research", "focused", "on", "marker", "identification", ".", "The", "aim", "of", "the", "study", "was", "to", "analyse", "the", "gene", "expression", "differences", "in", "mastocytosis", "patients", "with", "and", "without", "food", "and", "drug", "hypersensitivity", "and", "insect", "venom", "allergy", "(", "IVA", ")", ".", "A", "total", "of", "57", "Caucasian", "patients", "with", "mastocytosis", "were", "studied", "[", "median", "age", "41.8", ";", "range", "18-77", "years", ";", "15", "(", "26.3", "%", ")", "males", "and", "42", "(", "73.7", "%", ")", "females", "]", ".", "Quantitative", "RT-PCRs", "of", "11", "genes", "plus", "ribosomal", "18S", "RNA", "were", "run", ".", "Symptoms", "of", "food", "hypersensitivity", "were", "found", "in", "12", "patients", "(", "21", "%", ")", ",", "including", "3", "patients", "(", "13", "%", ")", "with", "cutaneous", "mastocytosis", "(", "CM", ")", ",", "and", "9", "(", "28", "%", ")", "with", "indolent", "systemic", "mastocytosis", "(", "ISM", ")", ".", "IVA", "was", "confirmed", "in", "13", "patients", "(", "22.8", "%", ")", "including", "6", "patients", "(", "10.5", "%", ")", "with", "CM", ",", "and", "7", "patients", "(", "12.3", "%", ")", "with", "ISM", ".", "Drug", "hypersensitivity", "was", "diagnosed", "in", "10", "patients", "(", "17.5", "%", ")", ".", "Significant", "differences", "in", "the", "gene", "expression", "were", "found", "for", "TRAF4", "(", "p", "=", "0.008", ")", "in", "the", "comparison", "of", "the", "mastocytosis", "patients", "with", "and", "without", "concomitant", "food", "hypersensitivity", ".", "Furthermore", "significant", "differences", "were", "found", "in", "gene", "expression", "for", "B3GAT1", "(", "p", "=", "0.003", ")", "in", "patients", "with", "IVA", "compared", "to", "patients", "without", "insect", "sting", "anaphylaxis", "in", "the", "medical", "history", ".", "The", "expression", "of", "studied", "genes", "did", "not", "differ", "according", "to", "the", "presence", "of", "drug", "hypersensitivity", ".", "The", "TRAF4", "expression", "was", "higher", "in", "mastocytosis", "patients", "with", "food", "hypersensitivity", "in", "their", "medical", "history", ",", "the", "B3GAT1", "expression", "was", "lower", "in", "mastocytosis", "patients", "with", "IVA", "in", "history", "." ]

[ "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Finding", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "B-Gene or Genome", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "B-Sign or Symptom", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "B-Pathologic Function", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Finding", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "O", "O", "B-Patient or Disabled Group", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "O", "O", "O" ]

[ "Generalized", "Weakness", "in", "a", "Transplant", "Patient", ":", "A", "Case", "Presentation", "Generalized", "weakness", "in", "transplant", "patients", "is", "a", "major", "complaint", "in", "tertiary", "rehabilitation", "hospitals", ".", "The", "diagnosis", "and", "management", "of", "generalized", "weakness", "in", "this", "population", "pose", "challenges", "for", "physicians", ".", "We", "present", "the", "case", "of", "a", "transplant", "patient", "with", "generalized", "weakness", "who", "was", "eventually", "diagnosed", "with", "calciphylaxis", "using", "a", "multidisciplinary", "diagnostic", "approach", "of", "electrodiagnostics", ",", "vascular", "study", ",", "and", "skin", "biopsy", ".", "Calciphylaxis", "is", "a", "rare", "cutaneous", "disorder", "that", "mimics", "other", "collagen", "vascular", "diseases", "in", "its", "presentation", "and", "fulminant", "course", ".", "Physiatrists", "should", "be", "cognizant", "of", "calciphylaxis", ",", "as", "it", "signals", "a", "poor", "prognosis", "if", "not", "correctly", "diagnosed", "and", "treated", "in", "a", "timely", "manner", ",", "with", "high", "incidence", "of", "sepsis", ",", "wound", "pain", ",", "and", "disability", ".", "V", "." ]

[ "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Finding", "B-Patient or Disabled Group", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Finding", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Population Group", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Patient or Disabled Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "O", "B-Finding", "O", "B-Disease or Syndrome", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Diagnostic Procedure", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Finding", "O", "O", "O" ]

[ "Use", "of", "ecoacoustics", "to", "determine", "biodiversity", "patterns", "across", "ecological", "gradients", "The", "variety", "of", "local", "animal", "sounds", "characterizes", "a", "landscape", ".", "We", "used", "ecoacoustics", "to", "noninvasively", "assess", "the", "species", "richness", "of", "various", "biotopes", "typical", "of", "an", "ecofriendly", "forest", "plantation", "with", "diverse", "ecological", "gradients", "and", "both", "nonnative", "and", "indigenous", "vegetation", ".", "The", "reference", "area", "was", "an", "adjacent", "large", "World", "Heritage", "Site", "protected", "area", "(", "PA", ")", ".", "All", "sites", "were", "in", "a", "global", "biodiversity", "hotspot", ".", "Our", "results", "showed", "how", "taxa", "segregated", "into", "various", "biotopes", ".", "We", "identified", "65", "singing", "species", ",", "including", "birds", ",", "frogs", ",", "crickets", ",", "and", "katydids", ".", "Large", ",", "natural", ",", "protected", "grassland", "sites", "in", "the", "PA", "had", "the", "highest", "mean", "acoustic", "diversity", "(", "14.1", "species", "/", "site", ")", ".", "Areas", "covered", "in", "nonnative", "timber", "or", "grass", "species", "were", "devoid", "of", "acoustic", "species", ".", "Sites", "grazed", "by", "native", "and", "domestic", "megaherbivores", "were", "fairly", "rich", "(", "5.1", ")", "in", "acoustic", "species", "but", "none", "were", "unique", "to", "this", "habitat", "type", ",", "where", "acoustic", "diversity", "was", "greater", "than", "in", "intensively", "managed", "grassland", "sites", "(", "0.04", ")", ".", "Natural", "vegetation", "patches", "inside", "the", "plantation", "mosaic", "supported", "high", "mean", "acoustic", "diversity", "(", "indigenous", "forests", "7.6", ",", "grasslands", "8.0", ",", "wetlands", "9.1", ")", ",", "which", "increased", "as", "plant", "heterogeneity", "and", "patch", "size", "increased", ".", "Indigenous", "forest", "patches", "within", "the", "plantation", "mosaic", "contained", "a", "highly", "characteristic", "acoustic", "species", "assemblage", ",", "emphasizing", "their", "complementary", "contribution", "to", "local", "biodiversity", ".", "Overall", ",", "acoustic", "signals", "determined", "spatial", "biodiversity", "patterns", "and", "can", "be", "a", "useful", "tool", "for", "guiding", "conservation", "." ]

[ "O", "O", "B-Occupational Activity", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "O", "B-Spatial Concept", "B-Animal", "B-Natural Phenomenon or Process", "B-Idea or Concept", "O", "B-Spatial Concept", "O", "O", "O", "B-Occupational Activity", "O", "O", "B-Functional Concept", "O", "B-Classification", "O", "O", "B-Quantitative Concept", "B-Geographic Area", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "B-Finding", "O", "B-Group Attribute", "B-Plant", "O", "O", "B-Conceptual Entity", "B-Geographic Area", "O", "O", "B-Spatial Concept", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Functional Concept", "O", "O", "B-Conceptual Entity", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "O", "B-Individual Behavior", "B-Classification", "O", "O", "B-Bird", "O", "B-Amphibian", "O", "B-Eukaryote", "O", "O", "B-Eukaryote", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Classification", "O", "B-Spatial Concept", "O", "O", "B-Spatial Concept", "O", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Classification", "O", "O", "O", "B-Classification", "B-Classification", "O", "B-Spatial Concept", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Animal", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Group Attribute", "B-Natural Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Plant", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Quantitative Concept", "O", "B-Group Attribute", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "B-Qualitative Concept", "B-Classification", "B-Classification", "B-Idea or Concept", "O", "O", "O", "O", "B-Activity", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O" ]

[ "A", "Randomized", "Controlled", "Noninferiority", "Trial", "of", "Single", "Dose", "of", "Oral", "Dexamethasone", "Versus", "5", "Days", "of", "Oral", "Prednisone", "in", "Acute", "Adult", "Asthma", "Oral", "dexamethasone", "demonstrates", "bioavailability", "similar", "to", "that", "of", "oral", "prednisone", "but", "has", "a", "longer", "half-life", ".", "We", "evaluate", "whether", "a", "single", "dose", "of", "oral", "dexamethasone", "plus", "4", "days", "of", "placebo", "is", "not", "inferior", "to", "5", "days", "of", "oral", "prednisone", "in", "treatment", "of", "adults", "with", "mild", "to", "moderate", "asthma", "exacerbations", "to", "prevent", "relapse", "defined", "as", "an", "unscheduled", "return", "visit", "for", "additional", "treatment", "for", "persistent", "or", "worsening", "asthma", "within", "14", "days", ".", "Adult", "emergency", "department", "patients", "(", "aged", "18", "to", "55", "years", ")", "were", "randomized", "to", "receive", "either", "a", "single", "dose", "of", "12", "mg", "of", "oral", "dexamethasone", "with", "4", "days", "of", "placebo", "or", "a", "5-", "day", "course", "of", "oral", "prednisone", "60", "mg", "a", "day", ".", "Outcomes", "including", "relapse", "were", "assessed", "by", "a", "follow-up", "telephone", "interview", "at", "2", "weeks", ".", "One", "hundred", "seventy-three", "dexamethasone", "and", "203", "prednisone", "subjects", "completed", "the", "study", "regimen", "and", "telephone", "follow-up", ".", "The", "dexamethasone", "group", "by", "a", "small", "margin", "surpassed", "the", "preset", "8", "%", "difference", "between", "groups", "for", "noninferiority", "in", "relapse", "rates", "within", "14", "days", "(", "12.1", "%", "versus", "9.8", "%", ";", "difference", "2.3", "%", ";", "95", "%", "confidence", "interval", "-4.1", "%", "to", "8.6", "%", ")", ".", "Subjects", "in", "the", "2", "groups", "had", "similar", "rates", "of", "hospitalization", "for", "their", "relapse", "visit", "(", "dexamethasone", "3.4", "%", "versus", "prednisone", "2.9", "%", ";", "difference", "0.5", "%", ";", "95", "%", "confidence", "interval", "-4.1", "%", "to", "3.1", "%", ")", ".", "Adverse", "effect", "rates", "were", "generally", "the", "same", "in", "the", "2", "groups", ".", "A", "single", "dose", "of", "oral", "dexamethasone", "did", "not", "demonstrate", "noninferiority", "to", "prednisone", "for", "5", "days", "by", "a", "very", "small", "margin", "for", "treatment", "of", "adults", "with", "mild", "to", "moderate", "asthma", "exacerbations", ".", "Enhanced", "compliance", "and", "convenience", "may", "support", "the", "use", "of", "dexamethasone", "regardless", "." ]

[ "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Age Group", "B-Disease or Syndrome", "B-Clinical Drug", "B-Clinical Drug", "B-Activity", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "B-Functional Concept", "O", "B-Temporal Concept", "O", "B-Biomedical or Dental Material", "O", "O", "B-Spatial Concept", "O", "O", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "B-Functional Concept", "O", "B-Age Group", "O", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Functional Concept", "B-Phenomenon or Process", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "O", "B-Temporal Concept", "O", "B-Age Group", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Patient or Disabled Group", "O", "B-Organism Attribute", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Research Activity", "O", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Temporal Concept", "O", "B-Biomedical or Dental Material", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "B-Functional Concept", "B-Phenomenon or Process", "O", "B-Activity", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Temporal Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Pharmacologic Substance", "O", "O", "B-Hormone", "B-Group", "B-Qualitative Concept", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Phenomenon or Process", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Health Care Activity", "O", "O", "B-Phenomenon or Process", "B-Health Care Activity", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Hormone", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Activity", "B-Qualitative Concept", "O", "B-Hormone", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Age Group", "O", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Activity", "B-Finding", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O", "O" ]

[ "Relationship", "between", "XspI", "Site", "Polymorphisms", "of", "LDL-R", "Gene", "and", "Serum", "IL-2", "and", "IL-10", "in", "Patients", "with", "Hypercholesterolemia", "Relationship", "has", "been", "identified", "in", "sporadic", "reports", "between", "polymorphisms", "and", "hypercholesterolemia", ".", "However", ",", "the", "relationship", "between", "inflammatory", "cytokines", "and", "polymorphism", "of", "low-density", "lipoprotein", "receptor", "(", "LDL-R", ")", "gene", "in", "hypercholesterolemia", "is", "unclear", ".", "This", "study", "aimed", "to", "explore", "the", "relationship", "and", "significance", "between", "polymorphisms", "of", "LDL-R", "gene", "and", "serum", "Interleukin-2", "(", "IL-2", ")", ",", "IL-10", "in", "patients", "with", "hypercholesterolemia", ".", "PCR-RFLP", "and", "direct", "DNA", "sequencing", "assay", "were", "employed", "to", "determine", "polymorphism", "of", "LDL-R", "gene", "in", "900", "patients", "with", "hypercholesterolemia", "and", "400", "healthy", "cases", ".", "ELISA", "was", "applied", "to", "assay", "serum", "concentration", "of", "IL-2", "and", "IL-10", ".", "Blood", "lipid", "indexes", "were", "tested", "in", "all", "cases", ".", "Compared", "with", "the", "healthy", "controls", ",", "level", "of", "IL-2", "increased", "significantly", ",", "while", "IL-10", "decreased", "significantly", "(", "P", "<", "0.05", ")", ".", "Correlation", "analysis", "showed", "that", "IL-2", "was", "positively", "correlated", "with", "total", "cholesterol", "(", "TC", ")", ",", "LDL-c", ",", "and", "genotype", "(", "r", "=", "0.542", ",", "0.410", ",", "0.598", ",", "P", "<", "0.05", ")", "and", "negatively", "correlated", "with", "HDL-c", "(", "r", "=", "-0.352", ",", "P", "<", "0.05", ")", ".", "Negative", "relationship", "also", "was", "found", "between", "TC", ",", "LDL-c", ",", "genotype", ",", "and", "IL-10", "(", "r", "=", "-0.452", ",", "-0.390", ",", "-0.613", ",", "P", "<", "0.05", ")", ",", "and", "positive", "correlation", "between", "HDL-c", "and", "IL-10", "(", "r", "=", "0.398", ",", "P", "<", "0.05", ")", ".", "Multiple", "linear", "regression", "showed", "that", "genotypes", "and", "TC", "were", "independent", "factors", "affecting", "the", "levels", "of", "IL-2", "and", "IL-10", "(", "P", "<", "0.05", ")", ".", "IL-2", "and", "IL-10", "were", "related", "to", "gene", "polymorphisms", "of", "LDL-R", ",", "which", "might", "be", "involved", "in", "the", "development", "and", "progress", "of", "hypercholesterolemia", "." ]

[ "B-Qualitative Concept", "O", "B-Enzyme", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Genetic Function", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Immunologic Factor", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Disease or Syndrome", "O", "B-Finding", "O", "O", "B-Research Activity", "B-Idea or Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "O", "B-Immunologic Factor", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Finding", "O", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "B-Laboratory Procedure", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Intellectual Product", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "B-Immunologic Factor", "B-Quantitative Concept", "B-Idea or Concept", "O", "O", "B-Immunologic Factor", "B-Quantitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Immunologic Factor", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "O", "O", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "O", "B-Organism Attribute", "O", "O", "B-Immunologic Factor", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Immunologic Factor", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "B-Organic Chemical", "O", "B-Idea or Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "I-Immunologic Factor", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Qualitative Concept", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O" ]

[ "HERG1", "potassium", "channel", "expression", "in", "potentially", "malignant", "disorders", "of", "the", "oral", "mucosa", "and", "prognostic", "relevance", "in", "oral", "squamous", "cell", "carcinoma", "HERG1", "potassium", "channel", "plays", "a", "critical", "role", "in", "the", "cell", "proliferation", ".", "HERG1", "protein", "expression", "was", "analyzed", "by", "immunohistochemistry", "(", "IHC", ")", "in", "62", "patients", "with", "oral", "leukoplakias", "and", "100", "patients", "with", "oral", "squamous", "cell", "carcinomas", "(", "OSCC", ")", ".", "HERG1", "mRNA", "levels", "were", "assessed", "by", "real-time", "reverse", "transcriptase-polymerase", "chain", "reaction", "(", "RT-PCR", ")", "in", "22", "patients", "with", "primary", "head", "and", "neck", "squamous", "cell", "carcinoma", "(", "HNSCC", ")", ".", "Statistically", "significant", "associations", "were", "found", "between", "HERG1", "expression", "and", "tobacco", "consumption", ",", "disease", "stage", ",", "tumor", "differentiation", ",", "tumor", "recurrence", ",", "and", "reduced", "survival", ".", "There", "was", "no", "association", "between", "HERG1", "expression", "and", "the", "risk", "of", "progression", "from", "oral", "leukoplakia", "to", "OSCC", ".", "In", "addition", ",", "a", "high", "proportion", "of", "tumors", "(", "80", "%", ")", "showed", "increased", "HERG1", "mRNA", "levels", "compared", "to", "normal", "mucosa", "from", "nononcologic", "patients", ".", "Aberrant", "HERG1", "expression", "increases", "as", "oral", "tumorigenesis", "progresses", "from", "oral", "hyperplasia", "to", "OSCC", ".", "Increased", "HERG1", "mRNA", "levels", "were", "also", "frequently", "detected", "in", "OSCC", "and", "other", "HNSCC", "subsites", ".", "HERG1", "expression", "emerges", "as", "a", "clinically", "relevant", "feature", "during", "tumor", "progression", "and", "a", "potential", "poor", "prognostic", "biomarker", "for", "OSCC", ".", "©", "2016", "Wiley", "Periodicals", ",", "Inc.", "Head", "Neck", "38", ":", "1708-1716", ",", "2016", "." ]

[ "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Intellectual Product", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "B-Conceptual Entity", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Research Activity", "O", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Activity", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Neoplastic Process", "B-Cell Function", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "B-Activity", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "O", "B-Idea or Concept", "O", "B-Neoplastic Process", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "B-Activity", "O", "B-Tissue", "B-Tissue", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Genetic Function", "B-Functional Concept", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Neoplastic Process", "O", "B-Quantitative Concept", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "O", "O", "B-Finding", "O", "B-Neoplastic Process", "O", "O", "B-Neoplastic Process", "B-Spatial Concept", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Intellectual Product", "B-Clinical Attribute", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Malignancy", "is", "associated", "with", "microcalcification", "and", "higher", "AP/T", "ratio", "in", "ultrasonography", ",", "but", "not", "with", "Hashimoto", "'s", "thyroiditis", "in", "histopathology", "in", "patients", "with", "thyroid", "nodules", "evaluated", "as", "Bethesda", "Category", "III", "(", "AUS", "/", "FLUS", ")", "in", "cytology", "The", "predictors", "of", "malignancy", "are", "important", "for", "the", "decision", "of", "appropriate", "management", "in", "nodules", "with", "atypia", "of", "undetermined", "significance", "/", "follicular", "lesion", "of", "undetermined", "significance", "(", "AUS", "/", "FLUS", ")", ".", "Our", "aim", "was", "to", "determine", "the", "ultrasonographical", ",", "clinical", ",", "and", "biochemical", "predictors", "of", "malignancy", "in", "these", "patients", ".", "A", "total", "of", "427", "patients", "with", "cytologically", "Bethesda", "Category", "III", "(", "AUS", "/", "FLUS", ")", "thyroid", "nodules", "were", "included", "in", "this", "retrospective", "study", ".", "We", "divided", "the", "nodules", "into", "two", "subgroups", "according", "to", "the", "histopathology", "as", "benign", "and", "malignant", ",", "and", "compared", "the", "preoperative", "ultrasonographical", ",", "clinical", ",", "and", "biochemical", "findings", ".", "In", "overall", ",", "427", "patients", "with", "449", "AUS", "/", "FLUS", "nodules", "who", "had", "undergone", "surgery", ",", "the", "rate", "of", "malignancy", "was", "23.4", "%", "(", "105/449", ")", ".", "When", "evaluated", "separately", ",", "the", "rate", "of", "malignancy", "was", "25.8", "%", "in", "nodules", "with", "AUS", "(", "82/318", ")", "and", "17.6", "%", "in", "nodules", "with", "FLUS", "(", "23/131", ")", "(", "p", "=", "0.061", ")", ".", "The", "vast", "majority", "of", "malignant", "specimens", "in", "histopathology", "consisted", "of", "papillary", "thyroid", "carcinoma", "(", "PTC", ")", "(", "n", "=", "91", ",", "86.7", "%", ")", ".", "Preoperative", "ultrasonographic", "features", "of", "105", "malignant", "nodules", "in", "histopathology", "were", "compared", "with", "the", "344", "benign", "nodules", "in", "histopathology", ".", "Anteroposterior/Transverse", "(", "AP/T", ")", "ratio", "was", "significantly", "higher", "in", "malignant", "group", "compared", "to", "benign", "group", "(", "p", "=", "0.013", ")", ".", "In", "multiple", "logistic", "analysis", ",", "we", "found", "that", "higher", "AP/T", "ratio", "and", "microcalcification", "were", "independently", "associated", "with", "malignancy", "(", "p", "<", "0.05", ")", ".", "The", "malignancy", "-associated", "cut-off", "value", "of", "AP/T", "ratio", "at", "maximum", "sensitivity", "and", "specificity", "was", "≥0.81", ".", "We", "did", "not", "find", "any", "correlation", "between", "malignancy", "and", "Hashimoto", "'s", "thyroiditis", "in", "histopathology", "in", "multivariate", "analysis", "(", "p", ">", "0.05", ")", ".", "In", "Bethesda", "Category", "III", "nodules", "with", "higher", "AP/T", "ratio", "and", "microcalcification", ",", "surgery", "might", "be", "considered", "as", "a", "first", "therapeutic", "option", "instead", "of", "repeat", "fine-needle", "aspiration", "biopsy", "or", "observation", "." ]

[ "B-Neoplastic Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Pathologic Function", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "O", "B-Laboratory Procedure", "O", "B-Intellectual Product", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Neoplastic Process", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "B-Population Group", "O", "O", "O", "B-Laboratory Procedure", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Temporal Concept", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "B-Neoplastic Process", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "B-Laboratory Procedure", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Pathologic Function", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Pathologic Function", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Research Activity", "O" ]

[ "Low", "serum", "vitamin", "D", "is", "associated", "with", "higher", "cortical", "porosity", "in", "elderly", "men", "Bone", "loss", "at", "peripheral", "sites", "in", "the", "elderly", "is", "mainly", "cortical", "and", "involves", "increased", "cortical", "porosity", ".", "However", ",", "an", "association", "between", "bone", "loss", "at", "these", "sites", "and", "25-hydroxyvitamin", "D", "has", "not", "been", "reported", ".", "To", "investigate", "the", "association", "between", "serum", "levels", "of", "25-hydroxyvitamin", "D", ",", "bone", "microstructure", "and", "areal", "bone", "mineral", "density", "(", "BMD", ")", "in", "elderly", "men", ".", "A", "population", "-based", "cohort", "of", "444", "elderly", "men", "(", "mean", "±", "SD", "age", "80.2", "±", "3.5", "years", ")", "was", "investigated", ".", "Bone", "microstructure", "was", "measured", "by", "high-resolution", "peripheral", "quantitative", "computed", "tomography", ",", "areal", "BMD", "by", "dual-energy", "X-ray", "absorptiometry", "and", "serum", "25-hydroxyvitamin", "D", "and", "parathyroid", "hormone", "levels", "by", "immunoassay", ".", "Mean", "cortical", "porosity", "at", "the", "distal", "tibia", "was", "14.7", "%", "higher", "(", "12.5", "±", "4.3", "%", "vs.", "10.9", "±", "4.1", "%", ",", "P", "<", "0.05", ")", "whilst", "cortical", "volumetric", "BMD", ",", "area", ",", "trabecular", "bone", "volume", "fraction", "and", "femoral", "neck", "areal", "BMD", "were", "lower", "in", "men", "in", "the", "lowest", "quartile", "of", "vitamin", "D", "levels", "compared", "to", "the", "highest", ".", "In", "men", "with", "vitamin", "D", "deficiency", "(", "<", "25", "nmol", "L", "(", "-1", ")", ")", "or", "insufficiency", "[", "25-49", "nmol", "L", "(", "-1", ")", ",", "in", "combination", "with", "an", "elevated", "serum", "level", "of", "parathyroid", "hormone", "(", ">", "6.8", "pmol", "L", "(", "-1", ")", ")", "]", ",", "cortical", "porosity", "was", "17.2", "%", "higher", "than", "in", "vitamin", "D", "-", "sufficient", "men", "(", "P", "<", "0.01", ")", ".", "A", "linear", "regression", "model", "including", "age", ",", "weight", ",", "height", ",", "daily", "calcium", "intake", ",", "physical", "activity", ",", "smoking", "vitamin", "D", "supplementation", "and", "parathyroid", "hormone", "showed", "that", "25-hydroxyvitamin", "D", "independently", "predicted", "cortical", "porosity", "(", "standardized", "β", "=", "-0.110", ",", "R", "(", "2", ")", "=", "1.1", "%", ",", "P", "=", "0.024", ")", ",", "area", "(", "β", "=", "0.123", ",", "R", "(", "2", ")", "=", "1.4", "%", ",", "P", "=", "0.007", ")", "and", "cortical", "volumetric", "BMD", "(", "β", "=", "0.125", ",", "R", "(", "2", ")", "=", "1.4", "%", ",", "P", "=", "0.007", ")", "of", "the", "tibia", "as", "well", "as", "areal", "BMD", "of", "the", "femoral", "neck", "(", "β", "=", "0.102", ",", "R", "(", "2", ")", "=", "0.9", "%", ",", "P", "=", "0.04", ")", ".", "Serum", "vitamin", "D", "is", "associated", "with", "cortical", "porosity", ",", "area", "and", "density", ",", "indicating", "that", "bone", "fragility", "as", "a", "result", "of", "low", "vitamin", "D", "could", "be", "due", "to", "changes", "in", "cortical", "bone", "microstructure", "and", "geometry", "." ]

[ "B-Qualitative Concept", "B-Body Substance", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "B-Population Group", "B-Population Group", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Spatial Concept", "B-Body Location or Region", "O", "O", "B-Population Group", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Quantitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Body Location or Region", "O", "B-Vitamin", "B-Vitamin", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "O", "B-Population Group", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Qualitative Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Intellectual Product", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Individual Behavior", "B-Vitamin", "B-Vitamin", "B-Pharmacologic Substance", "O", "B-Hormone", "B-Hormone", "O", "O", "B-Vitamin", "B-Vitamin", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Substance", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "B-Clinical Attribute", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "B-Qualitative Concept", "B-Vitamin", "B-Vitamin", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Spatial Concept", "O" ]

[ "Nationwide", "reduction", "in", "the", "number", "of", "corneal", "transplantations", "for", "keratoconus", "following", "the", "implementation", "of", "cross-linking", "Keratoconus", "is", "characterized", "by", "corneal", "ectasia", "and", "irregular", "astigmatism", ",", "which", "can", "lead", "to", "diminished", "vision", "and", "corneal", "scarring", ".", "Approximately", "10-20", "%", "of", "patients", "with", "keratoconus", "eventually", "require", "a", "corneal", "transplant", ".", "Corneal", "cross-linking", "(", "CXL", ")", "is", "a", "relatively", "new", "treatment", "that", "may", "help", "prevent", "the", "need", "for", "corneal", "transplantation", ".", "Here", ",", "we", "investigated", "whether", "the", "introduction", "of", "CXL", "has", "reduced", "the", "number", "of", "corneal", "transplants", "performed", "annually", ".", "Data", "regarding", "the", "transplantation", "procedures", "performed", "in", "patients", "under", "the", "age", "of", "50", "years", "were", "extracted", "from", "the", "Dutch", "National", "Organ", "Transplant", "Registry", ".", "The", "number", "of", "corneal", "transplants", "performed", "prior", "to", "(", "i.e", ".", "in", "2005", "through", "2007", ")", "and", "following", "the", "introduction", "of", "CXL", "(", "i.e", ".", "in", "2012", "through", "2014", ")", "were", "compared", ".", "Furthermore", ",", "a", "trend", "analysis", "on", "annual", "keratoplasties", "over", "time", "was", "performed", ".", "Approximately", "25", "%", "fewer", "corneal", "transplants", "were", "performed", "in", "the", "3-", "year", "period", "following", "the", "introduction", "of", "CXL", "compared", "to", "the", "3-", "year", "period", "prior", "to", "the", "introduction", "of", "CXL", "(", "201", "versus", "269", "transplants", ",", "respectively", ";", "p", "=", "0.005", ")", ".", "Age", ",", "gender", "and", "visual", "acuity", "were", "similar", "between", "the", "patient", "groups", "in", "the", "two", "time", "periods", ".", "Trend", "analysis", "also", "demonstrated", "a", "significant", "decrease", "in", "the", "amount", "of", "corneal", "transplants", "(", "p", "=", "0.001", ")", ".", "Significantly", "fewer", "corneal", "transplants", "were", "performed", "for", "treating", "keratoconus", "following", "the", "nationwide", "introduction", "of", "CXL", ".", "This", "reduction", "suggests", "that", "corneal", "cross-linking", "can", "significantly", "reduce", "the", "need", "for", "corneal", "transplantation", "." ]

[ "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "O", "O", "B-Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "B-Temporal Concept", "O", "B-Idea or Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "O", "B-Patient or Disabled Group", "O", "O", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Functional Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Activity", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "B-Spatial Concept", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Quantitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O" ]

[ "Rapid", "Fabrication", "of", "a", "Cell", "-", "Seeded", "Collagen", "Gel", "-Based", "Tubular", "Construct", "that", "Withstands", "Arterial", "Pressure", ":", "Rapid", "Fabrication", "of", "a", "Gel", "-Based", "Media", "Equivalent", "Based", "on", "plastically", "compressed", "cell", "-", "seeded", "collagen", "gels", ",", "we", "fabricated", "a", "small-diameter", "tubular", "construct", "that", "withstands", "arterial", "pressure", "without", "prolonged", "culture", "in", "vitro", ".", "Specifically", ",", "to", "mimic", "the", "microstructure", "of", "vascular", "media", ",", "the", "cell", "-", "seeded", "collagen", "gel", "was", "uniaxially", "stretched", "prior", "to", "plastic", "compression", "to", "align", "collagen", "fibers", "and", "hence", "cells", "in", "the", "gel", ".", "The", "resulting", "gel", "sheet", "was", "then", "wrapped", "around", "a", "custom-made", "multi-layered", "braided", "tube", "to", "form", "aligned", "tubular", "constructs", "whereas", "the", "gel", "sheet", "prepared", "similarly", "but", "without", "uniaxial", "stretching", "formed", "control", "constructs", ".", "With", "the", "braided", "tube", ",", "fluid", "in", "the", "gel", "construct", "was", "further", "removed", "by", "vacuum", "suction", "aiming", "to", "consolidate", "the", "concentric", "layers", "of", "the", "construct", ".", "The", "construct", "was", "finally", "treated", "with", "transglutaminase", ".", "Both", "SEM", "and", "histology", "confirmed", "the", "absence", "of", "gaps", "in", "the", "wall", "of", "the", "construct", ".", "Particularly", ",", "cells", "in", "the", "wall", "of", "the", "aligned", "tubular", "construct", "were", "circumferentially", "aligned", ".", "The", "enzyme", "-mediated", "crosslinking", "increased", "burst", "pressure", "of", "both", "the", "constructs", "significantly", ";", "the", "extent", "of", "the", "increase", "of", "burst", "pressure", "for", "the", "aligned", "tubular", "construct", "was", "greater", "than", "that", "for", "the", "control", "counterpart", ".", "Increasing", "crosslinking", "left", "the", "compliance", "of", "the", "aligned", "tubular", "construct", "unchanged", "but", "reduced", "that", "of", "the", "control", "construct", ".", "Cells", "remained", "viable", "in", "transglutaminase", "-treated", "plastically", "compressed", "gels", "after", "6", "days", "in", "culture", ".", "This", "study", "demonstrated", "that", "by", "combining", "stretch-induced", "fiber", "alignment", ",", "plastic", "compression", ",", "and", "enzyme", "-mediated", "crosslinking", ",", "a", "cell", "-", "seeded", "collagen", "gel", "-based", "tubular", "construct", "with", "potential", "to", "be", "used", "as", "vascular", "media", "can", "be", "made", "within", "3", "days", "." ]

[ "O", "B-Activity", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Activity", "O", "O", "B-Biomedical or Dental Material", "O", "B-Substance", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "O", "B-Activity", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Laboratory Procedure", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "B-Substance", "B-Natural Phenomenon or Process", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Cell", "O", "O", "B-Biomedical or Dental Material", "O", "O", "O", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "B-Substance", "O", "O", "B-Biomedical or Dental Material", "B-Medical Device", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "B-Medical Device", "O", "O", "O", "O", "B-Enzyme", "O", "O", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "B-Cell", "O", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Biomedical or Dental Material", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Tissue", "B-Quantitative Concept", "O", "B-Substance", "B-Natural Phenomenon or Process", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "O", "O", "B-Temporal Concept", "O" ]

[ "Impact", "of", "cofactor", "-", "binding", "loop", "mutations", "on", "thermotolerance", "and", "activity", "of", "E.", "coli", "transketolase", "Improvement", "of", "thermostability", "in", "engineered", "enzymes", "can", "allow", "biocatalysis", "on", "substrates", "with", "poor", "aqueous", "solubility", ".", "Denaturation", "of", "the", "cofactor", "-", "binding", "loops", "of", "Escherichia", "coli", "transketolase", "(", "TK", ")", "was", "previously", "linked", "to", "the", "loss", "of", "enzyme", "activity", "under", "conditions", "of", "high", "pH", "or", "urea", ".", "Incubation", "at", "temperatures", "just", "below", "the", "thermal", "melting", "transition", ",", "above", "which", "the", "protein", "aggregates", ",", "was", "also", "found", "to", "anneal", "the", "enzyme", "to", "give", "an", "increased", "specific", "activity", ".", "The", "potential", "role", "of", "cofactor", "-", "binding", "loop", "instability", "in", "this", "process", "remained", "unclear", ".", "In", "this", "work", ",", "the", "two", "cofactor", "-", "binding", "loops", "(", "residues", "185-192", "and", "382-392", ")", "were", "progressively", "mutated", "towards", "the", "equivalent", "sequence", "from", "the", "thermostable", "Thermus", "thermophilus", "TK", "and", "variants", "assessed", "for", "their", "impact", "on", "both", "thermostability", "and", "activity", ".", "Cofactor-binding", "loop", "2", "variants", "had", "detrimental", "effects", "on", "specific", "activity", "at", "elevated", "temperatures", ",", "whereas", "the", "H192P", "mutation", "in", "cofactor-binding", "loop", "1", "resulted", "in", "a", "two-fold", "improved", "stability", "to", "inactivation", "at", "elevated", "temperatures", ",", "and", "increased", "the", "critical", "onset", "temperature", "for", "aggregation", ".", "The", "specific", "activity", "of", "H192P", "was", "3-fold", "and", "19-fold", "higher", "than", "that", "for", "wild-type", "at", "60°C", "and", "65°C", "respectively", ",", "and", "also", "remained", "2.7-4", "fold", "higher", "after", "re-cooling", "from", "pre-incubations", "at", "either", "55°C", "or", "60°C", "for", "1h", ".", "Interestingly", ",", "H192P", "was", "also", "2-times", "more", "active", "than", "wild-type", "TK", "at", "25°C", ".", "Optimal", "activity", "was", "achieved", "at", "60°C", "for", "H192P", "compared", "to", "55°C", "for", "wild", "type", ".", "These", "results", "show", "that", "cofactor-binding", "loop", "1", ",", "plays", "a", "pivotal", "role", "in", "partial", "denaturation", "and", "aggregation", "at", "elevated", "temperatures", ".", "Furthermore", ",", "a", "single", "rigidifying", "mutation", "within", "this", "loop", "can", "significantly", "improve", "the", "enzyme", "specific", "activity", ",", "as", "well", "as", "the", "stability", "to", "thermal", "denaturation", "and", "aggregation", ",", "to", "give", "an", "increased", "temperature", "optimum", "for", "activity", "." ]

[ "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "B-Genetic Function", "O", "B-Physiologic Function", "O", "B-Molecular Function", "O", "B-Bacterium", "B-Bacterium", "B-Enzyme", "B-Conceptual Entity", "O", "B-Natural Phenomenon or Process", "O", "B-Enzyme", "B-Enzyme", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Molecular Function", "O", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Bacterium", "B-Bacterium", "B-Enzyme", "O", "B-Enzyme", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Molecular Function", "B-Molecular Function", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Enzyme", "O", "O", "O", "B-Quantitative Concept", "O", "B-Molecular Function", "O", "O", "O", "B-Conceptual Entity", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Amino Acid Sequence", "O", "O", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "O", "O", "B-Qualitative Concept", "B-Bacterium", "B-Bacterium", "B-Enzyme", "O", "B-Gene or Genome", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Activity", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Gene or Genome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Activity", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Natural Phenomenon or Process", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Gene or Genome", "B-Enzyme", "O", "O", "O", "B-Qualitative Concept", "B-Activity", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Quantitative Concept", "B-Molecular Function", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Nucleotide Sequence", "O", "O", "O", "O", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "B-Molecular Function", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Molecular Function", "O" ]

[ "Expression", "and", "Purification", "of", "E2", "Glycoprotein", "from", "Insect", "Cells", "(", "Sf9", ")", "for", "Use", "in", "Serology", "Chikungunya", "virus", "(", "CHIKV", ")", "is", "a", "mosquito", "-", "borne", "arbovirus", "which", "poses", "a", "major", "threat", "to", "global", "public", "health", ".", "Definitive", "CHIKV", "diagnosis", "is", "crucial", ",", "especially", "in", "distinguishing", "the", "disease", "from", "dengue", "virus", ",", "which", "co-circulates", "in", "endemic", "areas", "and", "shares", "the", "same", "mosquito", "vectors", ".", "Laboratory", "diagnosis", "is", "mainly", "based", "on", "serological", "or", "molecular", "approaches", ".", "The", "E2", "glycoprotein", "is", "a", "good", "candidate", "for", "serological", "diagnosis", "since", "it", "is", "the", "immunodominant", "antigen", "during", "the", "course", "of", "infection", ",", "and", "reacts", "with", "seropositive", "CHIKV", "sera", ".", "In", "this", "chapter", ",", "we", "describe", "the", "generation", "of", "stable", "clone", "Sf9", "(", "Spodoptera", "frugiperda", ")", "cells", "expressing", "secreted", ",", "soluble", ",", "and", "native", "recombinant", "CHIKV", "E2", "glycoprotein", ".", "We", "use", "direct", "plasmid", "expression", "in", "insect", "cells", ",", "rather", "than", "the", "traditional", "technique", "of", "generating", "recombinant", "baculovirus", ".", "This", "recombinant", "protein", "is", "useful", "for", "serological", "diagnosis", "of", "CHIKV", "infection", "." ]

[ "B-Genetic Function", "O", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Eukaryote", "B-Cell", "O", "B-Cell", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Virus", "B-Virus", "O", "B-Virus", "O", "O", "O", "B-Eukaryote", "O", "B-Finding", "B-Virus", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Temporal Concept", "B-Virus", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Virus", "B-Virus", "O", "O", "B-Functional Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Immunologic Factor", "B-Immunologic Factor", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "B-Pathologic Function", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Virus", "B-Body Substance", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Idea or Concept", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Cell", "B-Cell", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Cell", "B-Genetic Function", "B-Cell Function", "O", "B-Cell Component", "O", "O", "B-Functional Concept", "B-Organism", "B-Virus", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Therapeutic or Preventive Procedure", "O", "B-Eukaryote", "B-Cell", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Activity", "B-Virus", "B-Virus", "O", "O", "B-Amino Acid, Peptide, or Protein", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Virus", "B-Pathologic Function", "O" ]

[ "Acute", "risk", "factors", "for", "suicide", "attempts", "and", "death", ":", "prospective", "findings", "from", "the", "STEP", "-", "BD", "study", "Suicide", "is", "unfortunately", "common", "in", "psychiatric", "practice", ",", "but", "difficult", "to", "predict", ".", "The", "present", "study", "sought", "to", "assess", "which", "clinical", "symptoms", "increase", "in", "the", "months", "before", "suicidal", "behavior", "in", "a", "sample", "of", "psychiatric", "outpatients", "with", "bipolar", "disorder", ".", "Data", "from", "the", "Systematic", "Treatment", "Enhancement", "Program", "for", "Bipolar", "Disorder", "(", "STEP", "-", "BD", ")", "trial", "were", "used", ".", "A", "total", "of", "103", "participants", "who", "attempted", "suicide", "or", "died", "by", "suicide", "during", "the", "trial", "were", "included", ";", "a", "15", "%", "random", "sample", "of", "the", "remaining", "participants", "(", "n", "=", "427", ")", "was", "used", "as", "a", "comparison", "sample", ".", "Linear", "mixed", "models", "in", "the", "six", "months", "before", "suicidal", "behavior", "were", "conducted", "for", "each", "of", "five", "proposed", "acute", "risk", "factors", "for", "suicidal", "behavior", ".", "Participants", "were", "assessed", "using", "the", "Clinical", "Monitoring", "Form", "(", "CMF", ")", "at", "each", "visit", "for", "the", "following", "potential", "acute", "risk", "factors", "for", "suicidal", "behavior", ":", "suicidal", "ideation", ",", "loss", "of", "interest", ",", "anxiety", ",", "psychomotor", "agitation", ",", "and", "high-risk", "behavior", ".", "Each", "of", "the", "five", "symptoms", "was", "elevated", "overall", "in", "individuals", "who", "engaged", "in", "suicidal", "behavior", "(", "p", "<", "0.05", ")", ".", "The", "severity", "of", "both", "suicidal", "ideation", "and", "loss", "of", "interest", "significantly", "increased", "in", "the", "months", "before", "suicidal", "behavior", "(", "p", "<", "0.001", ")", ".", "Anxiety", "demonstrated", "comparable", "effect", "sizes", "across", "multiple", "models", ".", "Psychomotor", "agitation", "and", "high-risk", "behavior", "were", "not", "significantly", "elevated", "before", "suicidal", "behavior", ".", "Suicidal", "ideation", ",", "loss", "of", "interest", "and", ",", "to", "a", "lesser", "extent", ",", "anxiety", "may", "represent", "acute", "suicide", "risk", "factors", "up", "to", "four", "months", "before", "suicidal", "behavior", "in", "outpatients", "with", "bipolar", "disorder", ".", "Further", "investigation", "of", "these", "potential", "acute", "risk", "factors", "in", "prospective", "analyses", "is", "warranted", "." ]

[ "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "B-Research Activity", "B-Finding", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Mental Process", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Research Activity", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Sign or Symptom", "B-Functional Concept", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "B-Substance", "O", "B-Biomedical Occupation or Discipline", "B-Patient or Disabled Group", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Idea or Concept", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Substance", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "B-Substance", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Population Group", "O", "B-Activity", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "B-Finding", "O", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "O", "O", "B-Sign or Symptom", "O", "B-Qualitative Concept", "O", "O", "B-Population Group", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Finding", "B-Finding", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Finding", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "B-Patient or Disabled Group", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O" ]

[ "Measurement", "of", "Outcomes", "of", "Upper", "Limb", "Reconstructive", "Surgery", "for", "Tetraplegia", "Reconstructive", "arm/hand", "surgery", "for", "tetraplegia", "is", "performed", "to", "improve", "arm/hand", "function", "and", "therefore", "personal", "well-being", "for", "individuals", "who", "accept", "such", "elective", "surgeries", ".", "However", ",", "changes", "at", "an", "impairment", "level", "do", "not", "always", "translate", "into", "functional", "or", "quality", "of", "life", "changes", ".", "Therefore", ",", "multiple", "outcome", "tools", "should", "be", "used", "that", "incorporate", "sufficient", "responsiveness", "to", "detect", "changes", "in", "arm/hand", "function", ",", "activity", "and", "participation", ",", "and", "quality", "of", "life", "of", "the", "individuals", "involved", ".", "This", "narrative", "review", "aims", "to", "assist", "clinicians", "to", "choose", "the", "most", "appropriate", "tools", "to", "assess", "the", "need", "for", "reconstructive", "surgery", "and", "to", "evaluate", "its", "outcomes", ".", "Our", "specific", "objectives", "are", "(", "1", ")", "to", "describe", "aspects", "to", "consider", "when", "choosing", "a", "measure", "and", "(", "2", ")", "to", "describe", "the", "measures", "advised", "by", "an", "international", "therapist", "consensus", "group", "established", "in", "2007", ".", "All", "advised", "measures", "are", "appraised", "in", "terms", "of", "the", "underlying", "construct", ",", "administration", ",", "and", "clinical", "relevance", "to", "arm/hand", "reconstructions", ".", "Essentially", "there", "are", "currently", "no", "criterion", "standard", "measures", "to", "evaluate", "the", "consequences", "of", "reconstructive", "arm/hand", "surgery", ".", "However", ",", "with", "judicious", "use", "of", "available", "measures", "it", "is", "possible", "to", "ensure", "the", "questions", "asked", "or", "tasks", "completed", "are", "relevant", "to", "the", "surgical", "reconstruction", "(", "s", ")", "undertaken", ".", "Further", "work", "in", "this", "field", "is", "required", ".", "This", "would", "be", "best", "met", "by", "immediate", "collaboration", "between", "2", "outcome", "'s", "tool", "developers", "and", "by", "analysis", "of", "pre", "-", "and", "postoperative", "data", "already", "held", "in", "various", "international", "sites", ",", "which", "would", "allow", "further", "evaluation", "of", "the", "measures", "already", "in", "use", ",", "or", "components", "thereof", "." ]

[ "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "B-Finding", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Functional Concept", "O", "B-Finding", "B-Organism Function", "B-Organism Function", "O", "O", "B-Finding", "B-Finding", "O", "B-Population Group", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "B-Functional Concept", "O", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "B-Functional Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Functional Concept", "O", "B-Organism Function", "B-Organism Function", "O", "B-Activity", "O", "B-Functional Concept", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Health Care Activity", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Qualitative Concept", "B-Manufactured Object", "O", "B-Activity", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Idea or Concept", "B-Professional or Occupational Group", "O", "B-Idea or Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Idea or Concept", "B-Quantitative Concept", "B-Functional Concept", "O", "B-Health Care Activity", "O", "B-Functional Concept", "B-Functional Concept", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Occupational Activity", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "B-Conceptual Entity", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Social Behavior", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Occupational Activity", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Manufactured Object", "O", "O" ]

[ "Basal", "and", "maximal", "metabolic", "rates", "differ", "in", "their", "response", "to", "rapid", "temperature", "change", "among", "avian", "species", "In", "birds", ",", "acclimation", "and", "acclimatization", "to", "temperature", "are", "associated", "with", "changes", "in", "basal", "(", "BMR", ")", ",", "summit", "(", "Msum", ")", "and", "maximal", "(", "MMR", ")", "metabolic", "rates", "but", "little", "is", "known", "about", "the", "rate", "at", "which", "species", "adjust", "their", "phenotype", "to", "short-term", "temperature", "variations", ".", "Our", "aims", "were", "(", "1", ")", "to", "determine", "the", "pattern", "of", "metabolic", "adjustments", "following", "a", "rapid", "temperature", "change", ",", "(", "2", ")", "to", "determine", "whether", "performance", "varies", "at", "similar", "rates", "during", "exposure", "to", "warm", "or", "cold", "environments", ",", "and", "(", "3", ")", "to", "determine", "if", "BMR", ",", "Msum", "and", "MMR", "change", "at", "comparable", "rates", "during", "thermal", "acclimation", ".", "We", "measured", "these", "parameters", "in", "white-throated", "sparrows", "(", "Zonotrichia", "albicollis", ")", ",", "black-capped", "chickadees", "(", "Poecile", "atricapillus", ")", ",", "and", "snow", "buntings", "(", "Plectrophenax", "nivalis", ")", "after", "acclimation", "to", "10", "°C", "(", "day", "0", ")", "and", "on", "the", "4th", "and", "8th", "days", "of", "acclimation", "to", "either", "-5", "or", "28", "°C", ".", "Birds", "changed", "their", "metabolic", "phenotype", "within", "8", "days", "with", "patterns", "differing", "among", "species", ".", "Sparrows", "expressed", "the", "expected", "metabolic", "increases", "in", "the", "cold", "and", "decreases", "at", "thermoneutrality", "while", "performance", "in", "chickadees", "and", "buntings", "was", "not", "influenced", "by", "temperature", "but", "changed", "over", "time", "with", "inverse", "patterns", ".", "Our", "results", "suggest", "that", "BMR", "varies", "at", "comparable", "rates", "in", "warm", "and", "cold", "environments", "but", "changes", "faster", "than", "Msum", "and", "MMR", ",", "likely", "due", "to", "limitations", "in", "the", "rate", "of", "change", "in", "organ", "size", "and", "function", ".", "They", "also", "suggest", "that", "maximal", "metabolic", "capacity", "is", "lost", "faster", "in", "a", "warm", "environment", "than", "it", "is", "gained", "in", "a", "cold", "environment", ".", "With", "the", "expected", "increase", "in", "temperature", "stochasticity", "at", "northern", "latitudes", ",", "a", "loss", "of", "thermogenic", "capacity", "during", "warm", "winter", "days", "could", ",", "therefore", ",", "be", "detrimental", "if", "birds", "are", "slow", "to", "readjust", "their", "phenotype", "with", "the", "return", "of", "cold", "days", "." ]

[ "B-Organism Function", "O", "B-Qualitative Concept", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Bird", "B-Classification", "O", "B-Bird", "O", "B-Organism Function", "O", "B-Organism Function", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Organism Function", "O", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "B-Qualitative Concept", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "O", "O", "O", "O", "B-Physiologic Function", "O", "O", "B-Classification", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Physiologic Function", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "O", "B-Physiologic Function", "O", "B-Natural Phenomenon or Process", "B-Organism Function", "O", "O", "O", "O", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "B-Organism Function", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "B-Bird", "O", "O", "B-Functional Concept", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O", "B-Spatial Concept", "O", "O", "B-Classification", "O", "B-Bird", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Bird", "O", "B-Bird", "O", "O", "B-Conceptual Entity", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "B-Finding", "O", "O", "B-Organism Function", "O", "O", "O", "B-Physiologic Function", "O", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Physiologic Function", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Quantitative Concept", "O", "B-Natural Phenomenon or Process", "B-Quantitative Concept", "O", "B-Phenomenon or Process", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Bird", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Temporal Concept", "O" ]

[ "Factors", "preventing", "kneeling", "in", "a", "group", "of", "pre-educated", "patients", "post", "total", "knee", "arthroplasty", "Difficulties", "in", "kneeling", ",", "one", "of", "the", "poorest", "scoring", "functional", "outcomes", "post", "total", "knee", "arthroplasty", "(", "TKA", ")", ",", "have", "been", "attributed", "to", "a", "lack", "of", "patient", "education", ".", "This", "is", "the", "first", "study", "to", "investigate", "specific", "factors", "affecting", "a", "patient", "'s", "perceived", "ability", "to", "kneel", "post", "TKA", ",", "following", "exposure", "to", "a", "preoperative", "kneeling", "education", "session", ".", "A", "cross-sectional", "study", "was", "conducted", "following", "TKA", "with", "patients", "who", "had", "been", "educated", "about", "kneeling", "prior", "to", "the", "operation", ".", "Patients", "completed", "kneeling", "questionnaires", "at", "6", "(", "n", "=", "115", ")", "and", "12", "(", "n", "=", "82", ")", "months", "post", "TKA", ".", "In", "addition", "to", "the", "12-month", "kneeling", "questionnaire", ",", "patients", "also", "completed", "the", "Oxford", "knee", "score", "(", "OKS", ")", "survey", ".", "Seventy-two", "percent", "of", "patients", "perceived", "they", "could", "kneel", "at", "12", "months", "post", "TKA", ".", "Overall", ",", "pain", "and", "discomfort", "were", "the", "most", "common", "factors", "deterring", "patients", "from", "kneeling", ".", "Perceived", "kneeling", "ability", "was", "the", "poorest", "scored", "outcome", "on", "the", "OKS", "with", "patients", "reporting", "mild", "to", "moderate", "difficulty", "with", "this", "task", ".", "Kneeling", "scores", "were", "strongly", "correlated", "with", "overall", "knee", "function", "scores", "(", "R", "=", "0.70", ")", ",", "strongly", "correlated", "with", "pain", "scores", "(", "R", "=", "0.45", ")", "and", "weakly", "correlated", "with", "knee", "stability", "scores", "(", "R", "=", "0.29", ")", ".", "When", "asked", "about", "other", "factors", "preventing", "kneeling", "other", "than", "pain", "or", "discomfor", "t", ",", "75", "%", "had", "reasons", "unrelated", "to", "the", "knee", "or", "TKA", ".", "The", "most", "common", "reason", "was", "'problems", "with", "the", "other", "knee", "'", "(", "n", "=", "19", ")", ".", "Patients", "in", "this", "study", "were", "provided", "with", "education", "regarding", "their", "kneeling", "ability", "post", "TKA", ",", "yet", "still", "experienced", "limitations", "in", "perceived", "kneeling", "ability", "post", "operatively", ".", "Contrary", "to", "previous", "research", ",", "our", "study", "suggests", "that", "factors", "other", "than", "patient", "education", "affect", "a", "patient", "'s", "perceived", "kneeling", "ability", "post", "TKA", "." ]

[ "B-Functional Concept", "B-Functional Concept", "B-Physiologic Function", "O", "O", "B-Idea or Concept", "O", "B-Educational Activity", "B-Patient or Disabled Group", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "O", "B-Patient or Disabled Group", "B-Educational Activity", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "B-Mental Process", "B-Organism Attribute", "B-Organism Attribute", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Temporal Concept", "B-Physiologic Function", "B-Educational Activity", "B-Educational Activity", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Educational Activity", "O", "B-Physiologic Function", "B-Temporal Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "B-Physiologic Function", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Physiologic Function", "B-Intellectual Product", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "B-Mental Process", "O", "O", "B-Physiologic Function", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Patient or Disabled Group", "O", "B-Physiologic Function", "O", "B-Mental Process", "B-Physiologic Function", "B-Organism Attribute", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Clinical Attribute", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "O", "O", "O", "O", "B-Physiologic Function", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Physiologic Function", "O", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Educational Activity", "O", "O", "B-Physiologic Function", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Physiologic Function", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Patient or Disabled Group", "B-Educational Activity", "B-Health Care Activity", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "B-Mental Process", "B-Physiologic Function", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O" ]

[ "Improved", "diagnostic", "yield", "of", "neuromuscular", "disorders", "applying", "clinical", "exome", "sequencing", "in", "patients", "arising", "from", "a", "consanguineous", "population", "Neuromuscular", "diseases", "(", "NMDs", ")", "include", "a", "broad", "range", "of", "disorders", "affecting", "muscles", ",", "nerves", "and", "neuromuscular", "junctions", ".", "Their", "overlapping", "phenotypes", "and", "heterogeneous", "genetic", "nature", "have", "created", "challenges", "in", "diagnosis", "which", "calls", "for", "the", "implementation", "of", "massive", "parallel", "sequencing", "as", "a", "candidate", "strategy", "to", "increase", "the", "diagnostic", "yield", ".", "In", "this", "study", ",", "total", "of", "45", "patients", ",", "mostly", "offspring", "of", "consanguineous", "marriages", "were", "examined", "using", "whole", "exome", "sequencing", ".", "Data", "analysis", "was", "performed", "to", "identify", "the", "most", "probable", "pathogenic", "rare", "variants", "in", "known", "NMD", "genes", "which", "led", "to", "identification", "of", "causal", "variants", "for", "33", "out", "of", "45", "patients", "(", "73.3", "%", ")", "in", "the", "following", "known", "genes", ":", "CAPN3", ",", "Col6A1", ",", "Col6A3", ",", "DMD", ",", "DYSF", ",", "FHL1", ",", "GJB1", ",", "ISPD", ",", "LAMA2", ",", "LMNA", ",", "PLEC1", ",", "RYR1", ",", "SGCA", ",", "SGCB", ",", "SYNE1", ",", "TNNT1", "and", "22", "novel", "pathogenic", "variants", "were", "detected", ".", "Today", ",", "the", "advantage", "of", "whole", "exome", "sequencing", "in", "clinical", "diagnostic", "strategies", "of", "heterogeneous", "disorders", "is", "clear", ".", "In", "this", "cohort", ",", "a", "diagnostic", "yield", "of", "73.3", "%", "was", "achieved", "which", "is", "quite", "high", "compared", "to", "the", "overall", "reported", "diagnostic", "yield", "of", "25", "%", "to", "50", "%", ".", "This", "could", "be", "explained", "by", "the", "consanguineous", "background", "of", "these", "patients", "and", "is", "another", "strong", "advantage", "of", "offering", "clinical", "exome", "sequencing", "in", "diagnostic", "laboratories", ",", "especially", "in", "populations", "with", "high", "rate", "of", "consanguinity", "." ]

[ "B-Finding", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Population Group", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Tissue", "O", "B-Tissue", "O", "B-Cell Component", "B-Cell Component", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Organism Attribute", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Activity", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Family Group", "O", "B-Social Behavior", "B-Social Behavior", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Disease or Syndrome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "B-Finding", "B-Gene or Genome", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Finding", "O" ]

[ "Safety", "of", "transradial", "diagnostic", "cardiac", "catheterization", "in", "patients", "under", "oral", "anticoagulant", "therapy", "Cardiac", "catheterization", "in", "anticoagulated", "patients", "is", "usually", "performed", "after", "the", "anticoagulation", "has", "been", "withdrawn", ",", "at", "least", "in", "the", "previous", "48h", ",", "and", "sometimes", "bridging", "therapy", "with", "heparin", "is", "used", ".", "A", "prospective", "observational", "study", "including", "489", "patients", "undergoing", "transradial", "catheterization", "was", "conducted", ".", "A", "total", "of", "140", "patients", "were", "under", "acenocoumarol", "(", "group", "A", ")", "and", "they", "were", "compared", "with", "the", "remainder", "(", "group", "B", ")", "for", "complications", "after", "the", "procedure", "(", "bleeding", "and", "vascular", "access", "complications", ")", ".", "Patients", "in", "group", "A", "were", "older", "(", "74±12", "years", "vs.", "68±17", "years", ",", "p", "<", "0.01", ")", "and", "the", "main", "indication", "for", "anticoagulation", "was", "atrial", "fibrillation", "(", "58.6", "%", ")", ".", "No", "complications", "occurred", "during", "the", "procedures", ".", "There", "were", "no", "acute", "bleedings", "just", "after", "the", "bandage", "removal", ".", "During", "the", "first", "24h", ",", "only", "3", "(", "2.1", "%", ")", "radial", "occlusions", "in", "group", "A", "and", "2", "(", "0.6", "%", ")", "in", "group", "B", "(", "p=0.14", ")", "were", "recorded", ".", "Hematomas", "between", "5", "and", "10cm", "appeared", "in", "5", "%", "of", "the", "group", "A", "vs.", "4.6", "%", "in", "group", "B", ".", "During", "the", "1-month", "follow-up", "period", ",", "one", "more", "radial", "occlusion", "in", "each", "group", "was", "recorded", "and", "there", "were", "4", "(", "1.1", "%", ")", "additional", "mild", "hematomas", "in", "group", "B", "and", "none", "in", "group", "A", "(", "p=0.48", ")", ".", "Performing", "a", "transradial", "diagnostic", "cardiac", "catheterization", "without", "removal", "of", "the", "oral", "chronic", "anticoagulation", "appears", "safe", "in", "patients", "under", "acenocumarol", "therapy", "." ]

[ "B-Research Activity", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Patient or Disabled Group", "O", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Functional Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Patient or Disabled Group", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Pharmacologic Substance", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "B-Classification", "B-Classification", "O", "O", "B-Pathologic Function", "O", "O", "B-Health Care Activity", "O", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Patient or Disabled Group", "O", "B-Classification", "B-Classification", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Finding", "B-Pathologic Function", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Finding", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Temporal Concept", "O", "B-Medical Device", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Temporal Concept", "B-Health Care Activity", "B-Temporal Concept", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Pathologic Function", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Qualitative Concept", "B-Activity", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Finding", "O", "B-Patient or Disabled Group", "O", "B-Pharmacologic Substance", "B-Therapeutic or Preventive Procedure", "O" ]

Datasets:

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medmentions-ner

MedMentions BioNER (Custom Processed)

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Dataset Structure