geraldamasi/medmentions-ner · Datasets at Hugging Face

tokens listlengths 11 826	ner_tags listlengths 11 826
[ "DCTN4", "as", "a", "modifier", "of", "chronic", "Pseudomonas", "aeruginosa", "infection", "in", "cystic", "fibrosis", "Pseudomonas", "aeruginosa", "(", "Pa", ")", "infection", "in", "cystic", "fibrosis", "(", "CF", ")", "patients", "is", "associated", "with", "worse", "long-term", "pulmonary", "disease", "and", "shorter", "survival", ",", "and", "chronic", "Pa", "infection", "(", "CPA", ")", "is", "associated", "with", "reduced", "lung", "function", ",", "faster", "rate", "of", "lung", "decline", ",", "increased", "rates", "of", "exacerbations", "and", "shorter", "survival", ".", "By", "using", "exome", "sequencing", "and", "extreme", "phenotype", "design", ",", "it", "was", "recently", "shown", "that", "isoforms", "of", "dynactin", "4", "(", "DCTN4", ")", "may", "influence", "Pa", "infection", "in", "CF", ",", "leading", "to", "worse", "respiratory", "disease", ".", "The", "purpose", "of", "this", "study", "was", "to", "investigate", "the", "role", "of", "DCTN4", "missense", "variants", "on", "Pa", "infection", "incidence", ",", "age", "at", "first", "Pa", "infection", "and", "chronic", "Pa", "infection", "incidence", "in", "a", "cohort", "of", "adult", "CF", "patients", "from", "a", "single", "centre", ".", "Polymerase", "chain", "reaction", "and", "direct", "sequencing", "were", "used", "to", "screen", "DNA", "samples", "for", "DCTN4", "variants", ".", "A", "total", "of", "121", "adult", "CF", "patients", "from", "the", "Cochin", "Hospital", "CF", "centre", "have", "been", "included", ",", "all", "of", "them", "carrying", "two", "CFTR", "defects", ":", "103", "developed", "at", "least", "1", "pulmonary", "infection", "with", "Pa", ",", "and", "68", "patients", "of", "them", "had", "CPA", ".", "DCTN4", "variants", "were", "identified", "in", "24", "%", "(", "29/121", ")", "CF", "patients", "with", "Pa", "infection", "and", "in", "only", "17", "%", "(", "3/18", ")", "CF", "patients", "with", "no", "Pa", "infection", ".", "Of", "the", "patients", "with", "CPA", ",", "29", "%", "(", "20/68", ")", "had", "DCTN4", "missense", "variants", "vs", "23", "%", "(", "8/35", ")", "in", "patients", "without", "CPA", ".", "Interestingly", ",", "p.Tyr263Cys", "tend", "to", "be", "more", "frequently", "observed", "in", "CF", "patients", "with", "CPA", "than", "in", "patients", "without", "CPA", "(", "4/68", "vs", "0/35", ")", ",", "and", "DCTN4", "missense", "variants", "tend", "to", "be", "more", "frequent", "in", "male", "CF", "patients", "with", "CPA", "bearing", "two", "class", "II", "mutations", "than", "in", "male", "CF", "patients", "without", "CPA", "bearing", "two", "class", "II", "mutations", "(", "P", "=", "0.06", ")", ".", "Our", "observations", "reinforce", "that", "DCTN4", "missense", "variants", ",", "especially", "p.Tyr263Cys", ",", "may", "be", "involved", "in", "the", "pathogenesis", "of", "CPA", "in", "male", "CF", "." ]	[ "B-Biologically Active Substance", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Temporal Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Activity", "B-Activity", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "B-Organism Attribute", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "B-Population Group", "O", "B-Age Group", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "B-Health Care Related Organization", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Biologically Active Substance", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "B-Age Group", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Bacterium", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Biologically Active Substance", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Organism Attribute", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "B-Disease or Syndrome", "O", "B-Organism Attribute", "B-Disease or Syndrome", "O" ]
[ "Nonylphenol", "diethoxylate", "inhibits", "apoptosis", "induced", "in", "PC12", "cells", "Nonylphenol", "and", "short-chain", "nonylphenol", "ethoxylates", "such", "as", "NP2", "EO", "are", "present", "in", "aquatic", "environment", "as", "wastewater", "contaminants", ",", "and", "their", "toxic", "effects", "on", "aquatic", "species", "have", "been", "reported", ".", "Apoptosis", "has", "been", "shown", "to", "be", "induced", "by", "serum", "deprivation", "or", "copper", "treatment", ".", "To", "understand", "the", "toxicity", "of", "nonylphenol", "diethoxylate", ",", "we", "investigated", "the", "effects", "of", "NP2", "EO", "on", "apoptosis", "induced", "by", "serum", "deprivation", "and", "copper", "by", "using", "PC12", "cell", "system", ".", "Nonylphenol", "diethoxylate", "itself", "showed", "no", "toxicity", "and", "recovered", "cell", "viability", "from", "apoptosis", ".", "In", "addition", ",", "nonylphenol", "diethoxylate", "decreased", "DNA", "fragmentation", "caused", "by", "apoptosis", "in", "PC12", "cells", ".", "This", "phenomenon", "was", "confirmed", "after", "treating", "apoptotic", "PC12", "cells", "with", "nonylphenol", "diethoxylate", ",", "whereas", "the", "cytochrome", "c", "release", "into", "the", "cytosol", "decreased", "as", "compared", "to", "that", "in", "apoptotic", "cells", "not", "treated", "with", "nonylphenol", "diethoxylate", "s.", "Furthermore", ",", "Bax", "contents", "in", "apoptotic", "cells", "were", "reduced", "after", "exposure", "to", "nonylphenol", "diethoxylate", ".", "Thus", ",", "nonylphenol", "diethoxylate", "has", "the", "opposite", "effect", "on", "apoptosis", "in", "PC12", "cells", "compared", "to", "nonylphenol", ",", "which", "enhances", "apoptosis", "induced", "by", "serum", "deprivation", ".", "The", "difference", "in", "structure", "of", "the", "two", "compounds", "is", "hypothesized", "to", "be", "responsible", "for", "this", "phenomenon", ".", "These", "results", "indicated", "that", "nonylphenol", "diethoxylate", "has", "capability", "to", "affect", "cell", "differentiation", "and", "development", "and", "has", "potentially", "harmful", "effect", "on", "organisms", "because", "of", "its", "unexpected", "impact", "on", "apoptosis", ".", "©", "2015", "Wiley", "Periodicals", ",", "Inc.", "Environ", "Toxicol", "31", ":", "1389-1398", ",", "2016", "." ]	[ "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Activity", "B-Cell Function", "B-Functional Concept", "O", "B-Cell", "B-Cell", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Finding", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Environmental Effect of Humans", "B-Substance", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Organism", "B-Organism", "O", "O", "O", "O", "B-Cell Function", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "B-Element, Ion, or Isotope", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Cell Function", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "B-Element, Ion, or Isotope", "O", "O", "B-Cell", "B-Cell", "B-Cell", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Cell Function", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Quantitative Concept", "B-Molecular Function", "B-Molecular Function", "O", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "O", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Cell", "B-Cell", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Enzyme", "B-Enzyme", "O", "O", "O", "B-Cell Component", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "B-Functional Concept", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Conceptual Entity", "O", "B-Cell", "B-Cell", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Activity", "B-Cell Function", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "O", "O", "B-Chemical", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Finding", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Qualitative Concept", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Physiologic Function", "O", "O", "B-Qualitative Concept", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Organism", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Cell Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Prevascularized", "silicon", "membranes", "for", "the", "enhancement", "of", "transport", "to", "implanted", "medical", "devices", "Recent", "advances", "in", "drug", "delivery", "and", "sensing", "devices", "for", "in", "situ", "applications", "are", "limited", "by", "the", "diffusion", "-limiting", "foreign", "body", "response", "of", "fibrous", "encapsulation", ".", "In", "this", "study", ",", "we", "fabricated", "prevascularized", "synthetic", "device", "ports", "to", "help", "mitigate", "this", "limitation", ".", "Membranes", "with", "rectilinear", "arrays", "of", "square", "pores", "with", "widths", "ranging", "from", "40", "to", "200", "μm", "were", "created", "using", "materials", "(", "50", "μm", "thick", "double-sided", "polished", "silicon", ")", "and", "processes", "(", "photolithography", "and", "directed", "reactive", "ion", "etching", ")", "common", "in", "the", "manufacturing", "of", "microfabricated", "sensors", ".", "Vascular", "endothelial", "cells", "responded", "to", "membrane", "geometry", "by", "either", "forming", "vascular", "tubes", "that", "extended", "through", "the", "pore", "or", "completely", "filling", "membrane", "pores", "after", "4", "days", "in", "culture", ".", "Although", "tube", "formation", "began", "to", "predominate", "overgrowth", "around", "75", "μm", "and", "continued", "to", "increase", "at", "even", "larger", "pore", "sizes", ",", "tubes", "formed", "at", "these", "large", "pore", "sizes", "were", "not", "completely", "round", "and", "had", "relatively", "thin", "walls", ".", "Thus", ",", "the", "optimum", "range", "of", "pore", "size", "for", "prevascularization", "of", "these", "membranes", "was", "estimated", "to", "be", "75-100", "μm", ".", "This", "study", "lays", "the", "foundation", "for", "creating", "a", "prevascularized", "port", "that", "can", "be", "used", "to", "reduce", "fibrous", "encapsulation", "and", "thus", "enhance", "diffusion", "to", "implanted", "medical", "devices", "and", "sensors", ".", "©", "2015", "Wiley", "Periodicals", ",", "Inc.", "J", "Biomed", "Mater", "Res", "Part", "B", ":", "Appl", "Biomater", ",", "104B", ":", "1602-1609", ",", "2016", "." ]	[ "B-Functional Concept", "B-Biomedical or Dental Material", "B-Manufactured Object", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Health Care Activity", "O", "B-Functional Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Manufactured Object", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "B-Phenomenon or Process", "O", "B-Functional Concept", "O", "B-Manufactured Object", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "B-Phenomenon or Process", "O", "B-Occupational Activity", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Occupational Activity", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Spatial Concept", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "I-Activity", "B-Manufactured Object", "B-Spatial Concept", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "B-Manufactured Object", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "O", "B-Activity", "B-Natural Phenomenon or Process", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Seated", "maximum", "flexion", ":", "An", "alternative", "to", "standing", "maximum", "flexion", "for", "determining", "presence", "of", "flexion", "-", "relaxation", "?", "The", "flexion", "-", "relaxation", "phenomenon", "(", "FRP", ")", "in", "standing", "is", "a", "specific", "and", "sensitive", "diagnostic", "tool", "for", "low", "back", "pain", ".", "Seated", "flexion", "as", "an", "alternative", "could", "be", "beneficial", "for", "certain", "populations", ",", "yet", "the", "behavior", "of", "the", "trunk", "extensors", "during", "seated", "maximum", "flexion", "compared", "to", "standing", "flexion", "remains", "unclear", ".", "Compare", "FRP", "occurrences", "and", "spine", "angles", "between", "seated", "and", "standing", "flexion", "postures", "in", "three", "levels", "of", "the", "erector", "spinae", "muscles", ".", "Thirty-one", "participants", "free", "of", "back", "pain", "performed", "seated", "and", "standing", "maximum", "trunk", "flexion", ".", "Electromyographical", "signals", "were", "recorded", "from", "the", "bilateral", "lumbar", "(", "L3", ")", ",", "lower-thoracic", "(", "T9", ")", ",", "and", "upper-thoracic", "(", "T4", ")", "erector", "spinae", "and", "assessed", "for", "the", "occurrence", "of", "FRP", ".", "Spine", "angles", "corresponding", "to", "FRP", "onset", "and", "cessation", "were", "determined", ",", "and", "FRP", "occurrences", "and", "angles", "were", "compared", "between", "posture", "and", "muscle", ".", "FRP", "occurrence", "was", "similar", "in", "standing", "and", "seated", "maximum", "flexion", "across", "all", "muscles", ",", "with", "the", "lumbar", "muscles", "showing", "the", "greatest", "consistency", ".", "Standing", "FRP", "onset", "and", "cessation", "angles", "were", "consistently", "greater", "than", "the", "corresponding", "seated", "FRP", "angles", ".", "Considering", "the", "similar", "number", "of", "FRP", "occurrences", ",", "seated", "maximum", "flexion", "may", "constitute", "an", "objective", "criterion", "for", "low", "back", "pain", "diagnosis", ".", "Future", "work", "should", "seek", "to", "confirm", "the", "utility", "of", "this", "test", "in", "individuals", "with", "low", "back", "pain", "." ]	[ "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Conceptual Entity", "O", "B-Spatial Concept", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Organ or Tissue Function", "O", "B-Activity", "O", "O", "B-Organ or Tissue Function", "O", "B-Activity", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Spatial Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Spatial Concept", "O", "B-Finding", "O", "B-Spatial Concept", "B-Organ or Tissue Function", "B-Organism Attribute", "O", "O", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Population Group", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Finding", "O", "B-Spatial Concept", "B-Quantitative Concept", "B-Body Location or Region", "B-Organ or Tissue Function", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Activity", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Activity", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "B-Activity", "O", "B-Organism Attribute", "O", "B-Tissue", "O", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Tissue", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Phenomenon or Process", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Population Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O" ]
[ "The", "Relationship", "Between", "Distance", "and", "Post-operative", "Visit", "Attendance", "Following", "Medical", "Male", "Circumcision", "in", "Nyanza", "Province", ",", "Kenya", "To", "date", ",", "there", "is", "no", "research", "on", "voluntary", "medical", "male", "circumcision", "(", "VMMC", ")", "catchment", "areas", "or", "the", "relationship", "between", "distance", "to", "a", "VMMC", "facility", "and", "attendance", "at", "a", "post-operative", "follow-up", "visit", ".", "We", "analyzed", "data", "from", "a", "randomly", "selected", "subset", "of", "males", "self-seeking", "circumcision", "at", "one", "of", "16", "participating", "facilities", "in", "Nyanza", "Province", ",", "Kenya", "between", "2008", "and", "2010", ".", "Among", "1437", "participants", ",", "46.7", "%", "attended", "follow-up", ".", "The", "median", "distance", "from", "residence", "to", "utilized", "facility", "was", "2.98", "km", "(", "IQR", "1.31-5.38", ")", ".", "Nearly", "all", "participants", "(", "98.8", "%", ")", "lived", "within", "5", "km", "from", "a", "facility", ",", "however", ",", "26.3", "%", "visited", "a", "facility", "more", "than", "5", "km", "away", ".", "Stratified", "results", "demonstrated", "that", "among", "those", "utilizing", "fixed", "facilities", ",", "greater", "distance", "was", "associated", "with", "higher", "odds", "of", "follow-up", "non-attendance", "(", "OR", "5.01-10km", "vs.", "0-1km", "=", "1.71", ",", "95", "%", "CI", "1.08", ",", "2.70", ",", "p", "=", "0.02", ";", "OR", ">", "10km", "vs.", "0-1", "km", "=", "2.80", ",", "95", "%", "CI", "1.26", ",", "6.21", ",", "p", "=", "0.01", ")", ",", "adjusting", "for", "age", "and", "district", "of", "residence", ".", "We", "found", "5", "km", "marked", "the", "threshold", "distance", "beyond", "which", "follow-up", "attendance", "significantly", "dropped", ".", "These", "results", "demonstrate", "distance", "is", "an", "important", "predictor", "of", "attending", "follow-up", ",", "and", "this", "relationship", "appears", "to", "be", "modified", "by", "facility", "type", "." ]	[ "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Behavior", "B-Activity", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Individual Behavior", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Health Care Related Organization", "O", "B-Activity", "O", "O", "B-Finding", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Research Activity", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "B-Activity", "B-Classification", "O", "B-Population Group", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Functional Concept", "B-Health Care Activity", "O", "O", "B-Spatial Concept", "B-Quantitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "B-Behavior", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Health Care Activity", "B-Activity", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Health Care Activity", "B-Activity", "B-Idea or Concept", "B-Quantitative Concept", "O", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "O", "O", "B-Idea or Concept", "O", "B-Functional Concept", "B-Health Care Activity", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Health Care Related Organization", "B-Qualitative Concept", "O" ]
[ "Promoting", "lifestyle", "behaviour", "change", "and", "well-being", "in", "hospital", "patients", ":", "a", "pilot", "study", "of", "an", "evidence-based", "psychological", "intervention", "Lifestyle", "risk", "behaviours", "show", "an", "inverse", "social", "gradient", ",", "clustering", "in", "vulnerable", "groups", ".", "We", "designed", "and", "piloted", "an", "intervention", "to", "address", "barriers", "to", "lifestyle", "behaviour", "change", "among", "hospital", "patients", ".", "We", "designed", "our", "intervention", "using", "effective", "components", "of", "behaviour", "change", "interventions", "informed", "by", "psychological", "theory", ".", "Delivered", "by", "a", "health", "psychologist", "based", "at", "the", "Royal", "Free", "London", "NHS", "Foundation", "Trust", ",", "the", "4-week", "intervention", "included", "detailed", "baseline", "assessment", ",", "personalized", "goal", "setting", ",", "psychological", "skills", "development", ",", "motivation", "support", "and", "referral", "to", "community", "services", ".", "Primary", "outcomes", "were", "feasibility", "and", "patient", "acceptability", ".", "We", "also", "evaluated", "changes", "to", "health", "and", "well-being", ".", "From", "1", "July", "2013", "to", "31", "September", "2014", ",", "686", "patients", "were", "referred", ",", "338", "(", "49.3", "%", ")", "attended", "a", "first", "appointment", "and", "172", "(", "25.1", "%", ")", "completed", "follow-up", ".", "Furthermore", ",", "72.1", "%", "of", "attenders", "were", "female", "with", "the", "median", "age", "55", "years", "and", "poor", "self-reported", "baseline", "health", ".", "After", "4", "weeks", ",", "self-efficacy", ",", "health", "and", "well-being", "scores", "significantly", "improved", ":", "63", "%", "of", "lifestyle", "goals", "and", "89", "%", "of", "health", "management", "goals", "were", "fully", "achieved", ";", "58", "%", "of", "referrals", "to", "community", "lifestyle", "behaviour", "change", "services", "and", "79", "%", "of", "referrals", "to", "other", "services", "(", "e.g", ".", "Citizen", "'s", "Advice", "Bureau", ")", "were", "accepted", ";", "99", "%", "were", "satisfied", "/", "very", "satisfied", "with", "the", "service", ".", "Our", "hospital-based", "intervention", "was", "feasible", ",", "acceptable", "and", "showed", "preliminary", "health", "and", "well-being", "gains", "." ]	[ "B-Activity", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "B-Finding", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Individual Behavior", "B-Individual Behavior", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Self-help or Relief Organization", "B-Self-help or Relief Organization", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Patient or Disabled Group", "B-Qualitative Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "O", "B-Finding", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "B-Organism Attribute", "O", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Mental Process", "O", "B-Idea or Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Intellectual Product", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Self-help or Relief Organization", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Finding", "B-Finding", "O", "O", "B-Health Care Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O" ]
[ "The", "Impact", "of", "Deployment", "on", "Parental", ",", "Family", "and", "Child", "Adjustment", "in", "Military", "Families", "Since", "9/11", ",", "military", "service", "in", "the", "United", "States", "has", "been", "characterized", "by", "wartime", "deployments", "and", "reintegration", "challenges", "that", "contribute", "to", "a", "context", "of", "stress", "for", "military", "families", ".", "Research", "indicates", "the", "negative", "impact", "of", "wartime", "deployment", "on", "the", "well", "being", "of", "service", "members", ",", "military", "spouses", ",", "and", "children", ".", "Yet", ",", "few", "studies", "have", "considered", "how", "parental", "deployments", "may", "affect", "adjustment", "in", "young", "children", "and", "their", "families", ".", "Using", "deployment", "records", "and", "parent", "-", "reported", "measures", "from", "primary", "caregiving", "(", "N", "=", "680", ")", "and", "military", "(", "n", "=", "310", ")", "parents", ",", "we", "examined", "the", "influence", "of", "deployment", "on", "adjustment", "in", "military", "families", "with", "children", "ages", "0-10", "years", ".", "Greater", "deployment", "exposure", "was", "related", "to", "impaired", "family", "functioning", "and", "marital", "instability", ".", "Parental", "depressive", "and", "posttraumatic", "stress", "symptoms", "were", "associated", "with", "impairments", "in", "social", "emotional", "adjustment", "in", "young", "children", ",", "increased", "anxiety", "in", "early", "childhood", ",", "and", "adjustment", "problems", "in", "school-age", "children", ".", "Conversely", ",", "parental", "sensitivity", "was", "associated", "with", "improved", "social", "and", "emotional", "outcomes", "across", "childhood", ".", "These", "findings", "provide", "guidance", "to", "developing", "preventive", "approaches", "for", "military", "families", "with", "young", "children", "." ]	[ "O", "O", "O", "B-Activity", "O", "B-Family Group", "O", "B-Family Group", "O", "B-Age Group", "B-Individual Behavior", "O", "B-Family Group", "B-Family Group", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "B-Temporal Concept", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Family Group", "B-Family Group", "O", "B-Research Activity", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Activity", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Professional or Occupational Group", "B-Population Group", "O", "B-Professional or Occupational Group", "B-Family Group", "O", "O", "B-Age Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Family Group", "B-Activity", "O", "O", "B-Individual Behavior", "O", "B-Age Group", "B-Age Group", "O", "O", "B-Family Group", "O", "O", "I-Intellectual Product", "B-Intellectual Product", "O", "B-Family Group", "O", "B-Intellectual Product", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "B-Family Group", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Individual Behavior", "O", "B-Family Group", "B-Family Group", "O", "B-Age Group", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "B-Functional Concept", "B-Social Behavior", "B-Social Behavior", "O", "B-Finding", "B-Finding", "O", "B-Family Group", "B-Mental or Behavioral Dysfunction", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Functional Concept", "O", "B-Social Behavior", "B-Finding", "B-Individual Behavior", "O", "B-Age Group", "B-Age Group", "O", "O", "B-Finding", "O", "O", "B-Temporal Concept", "O", "O", "B-Individual Behavior", "O", "O", "B-Age Group", "B-Age Group", "O", "O", "O", "B-Family Group", "B-Mental Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Social Behavior", "O", "B-Finding", "B-Finding", "O", "B-Temporal Concept", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Family Group", "B-Family Group", "O", "O", "B-Age Group", "O" ]
[ "Combining", "electrostatic", "powder", "with", "an", "insecticide", ":", "effect", "on", "stored", "-", "product", "beetles", "and", "on", "the", "commodity", "The", "opportunity", "to", "reduce", "the", "amount", "of", "pirimiphos-methyl", "applied", "to", "grain", "by", "formulating", "it", "in", "an", "electrostatic", "powder", "was", "investigated", ".", "The", "insecticidal", "efficacy", "of", "pirimiphos-methyl", "in", "EC", "formulation", "or", "formulated", "using", "electrostatic", "powder", "(", "EP", ")", "as", "an", "inert", "carrier", "was", "investigated", "against", "Sitophilus", "oryzae", "(", "L.", ")", ",", "Oryzaephilus", "surinamensis", "(", "L.", ")", ",", "Rhyzopertha", "dominica", "(", "F.", ")", "and", "Tribolium", "confusum", "Jacquelin", "du", "Val", ".", "Furthermore", ",", "the", "adhesive", "properties", "of", "EP", "to", "rice", ",", "corn", "and", "wheat", ",", "together", "with", "the", "effect", "on", "bulk", "density", "and", "bread", "-", "and", "pasta", "-", "making", "properties", ",", "were", "investigated", ".", "The", "results", "showed", "that", "pirimiphos-methyl", "formulated", "with", "EP", "provided", "better", "efficacy", "against", "adults", "when", "compared", "with", "EC", "formulation", "for", "O.", "surinamensis", "and", "T.", "confusum", ",", "but", "there", "was", "no", "difference", "for", "R.", "dominica", ".", "Progeny", "production", "was", "consistently", "lower", "in", "grain", "treated", "with", "the", "EP", "formulation", "than", "in", "grain", "treated", "with", "the", "EC", ".", "Tests", "showed", "that", "EP", "adhered", "to", "the", "kernels", "for", "longer", "on", "hard", "wheat", "than", "on", "maize", "or", "rice", ".", "In", "most", "commodities", ",", "EP", "did", "not", "alter", "the", "bulk", "density", ".", "Finally", ",", "the", "addition", "of", "EP", "did", "not", "affect", "flour", "-", "and", "bread", "-", "making", "properties", ",", "nor", "the", "pasta", "-making", "properties", ".", "The", "results", "of", "the", "present", "study", "suggest", "that", "an", "EP", "could", "be", "used", "to", "reduce", "the", "amount", "of", "pirimiphos-methyl", "applied", "to", "grain", "for", "effective", "pest", "control", ",", "with", "no", "detrimental", "effects", "on", "grain", "quality", ".", "©", "2016", "Society", "of", "Chemical", "Industry", "." ]	[ "O", "B-Substance", "B-Substance", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Functional Concept", "O", "B-Entity", "B-Eukaryote", "O", "O", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Food", "O", "O", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Qualitative Concept", "O", "B-Pharmacologic Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Substance", "B-Substance", "O", "B-Substance", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Substance", "O", "B-Food", "O", "B-Food", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Food", "O", "O", "B-Food", "O", "B-Activity", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Substance", "O", "O", "B-Qualitative Concept", "O", "B-Eukaryote", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Family Group", "O", "O", "O", "O", "O", "B-Food", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Substance", "O", "O", "O", "B-Food", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "B-Substance", "B-Phenomenon or Process", "O", "O", "B-Food", "O", "O", "O", "O", "B-Food", "O", "O", "B-Food", "O", "B-Food", "O", "O", "O", "B-Food", "O", "B-Substance", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "B-Food", "O", "O", "B-Food", "O", "B-Activity", "B-Qualitative Concept", "O", "O", "O", "B-Food", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Food", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Food", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Radiofrequency", "ablation", "of", "posteroseptal", "accessory", "pathways", "associated", "with", "coronary", "sinus", "diverticula", "Posteroseptal", "accessory", "pathways", "may", "be", "associated", "with", "a", "coronary", "sinus", "(", "CS", ")", "diverticulum", ".", "Our", "purpose", "was", "to", "describe", "the", "clinical", "characteristics", ",", "mapping", "and", "ablation", "of", "these", "pathways", ".", "This", "was", "a", "retrospective", "study", "of", "all", "patients", "who", "underwent", "ablation", "of", "posteroseptal", "accessory", "pathways", "in", "a", "single", "centre", ".", "Patients", "with", "a", "diverticulum", "of", "the", "CS", "or", "one", "of", "its", "tributaries", "were", "included", "in", "group", "I", ",", "while", "the", "other", "patients", "formed", "group", "II", ".", "Clinical", "presentation", ",", "ablation", "procedure", "and", "outcome", "were", "compared", "between", "the", "two", "groups", ".", "A", "total", "of", "51", "patients", "were", "included", ",", "16", "in", "group", "I", "and", "35", "in", "group", "II", ".", "There", "were", "no", "significant", "differences", "in", "age", "or", "sex", "distribution", ".", "Atrial", "fibrillation", "(", "AF", ")", "and", "previous", "unsuccessful", "ablation", "were", "more", "common", "in", "group", "I", ".", "A", "negative", "delta", "wave", "in", "lead", "II", "was", "the", "ECG", "finding", "with", "best", "sensitivity", "and", "specificity", "for", "the", "presence", "of", "a", "diverticulum", ".", "A", "pathway", "potential", "was", "common", "at", "the", "successful", "site", "in", "group", "I", ",", "and", "the", "interval", "between", "local", "ventricular", "electrogram", "and", "delta", "wave", "onset", "was", "shorter", "(", "19.5", "±", "8", "vs", "33.1", "±", "7.6", "ms", ",", "p", "<", "0.001", ")", ".", "There", "was", "a", "trend", "toward", "lower", "procedural", "success", "rate", "and", "higher", "recurrence", "rate", "in", "group", "I", ",", "although", "this", "was", "not", "significant", ".", "CS", "diverticula", "should", "be", "suspected", "in", "patients", "with", "manifest", "posteroseptal", "accessory", "pathways", "who", "have", "a", "previous", "failed", "ablation", ",", "documented", "AF", "or", "typical", "electrocardiographic", "signs", ".", "A", "discrete", "potential", "is", "frequently", "seen", "at", "the", "successful", "site", ",", "but", "the", "local", "ventricular", "electrogram", "is", "not", "as", "early", "as", "in", "other", "accessory", "pathways", "." ]	[ "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Diagnostic Procedure", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Finding", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "B-Quantitative Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Disease or Syndrome", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O" ]
[ "Association", "of", "RBP4", "levels", "with", "increased", "arterial", "stiffness", "in", "adolescents", "with", "family", "history", "of", "type", "2", "diabetes", "The", "aim", "of", "this", "study", "was", "to", "explore", "the", "impact", "of", "family", "history", "of", "type", "2", "diabetes", "(", "FH2D", ")", "on", "arterial", "stiffness", "in", "young", "people", "and", "its", "relationship", "to", "adipocytokines", ".", "This", "case-control", "study", "included", "52", "adolescents", "(", "male", "/", "female", "28/24", ")", "with", "FH2D", "(", "FH2D+", ")", "and", "40", "adolescents", "(", "male", "/", "female", "21/19", ")", "without", "FH2D", "(", "FH2D-", ")", ".", "Anthropometric", "measurements", ",", "including", "height", ",", "weight", ",", "waist", "circumference", "(", "WC", ")", ",", "and", "blood", "pressure", ",", "were", "obtained", ".", "Blood", "samples", "were", "collected", ",", "fasting", "plasma", "glucose", "(", "FPG", ")", ",", "serum", "lipids", ",", "Retinol", "Binding", "Protein", "4", "(", "RBP4", ")", ",", "C", "reactive", "protein", "(", "CRP", ")", ",", "adiponectin", "and", "visfatin", "were", "examined", ".", "Brachial-ankle", "pulse", "wave", "velocity", "(", "baPWV", ")", "was", "used", "to", "evaluate", "arterial", "stiffness", ".", "Visceral", "fat", "area", "(", "VFA", ")", "was", "measured", "by", "computerized", "tomography", ".", "Compared", "with", "FH2D-", "group", ",", "FH2D+", "group", "had", "a", "significantly", "higher", "oral", "glucose", "tolerance", "test", "(", "OGTT", ")", "2-hour", "insulin", ",", "RBP4", "and", "baPWV", "levels", ",", "a", "lower", "adiponectin", "and", "glucose", "infusing", "rate", "(", "GIR", ")", "(", "P", "<", "0.05", ")", ".", "BaPWV", "was", "positively", "correlated", "with", "age", ",", "systolic", "blood", "pressure", "(", "SBP", ")", ",", "diastolic", "blood", "pressure", "(", "DBP", ")", ",", "2-hour", "(", "OGTT", ")", "insulin", ",", "RBP4", ",", "and", "VFA", ",", "and", "negatively", "correlated", "with", "GIR", "in", "FH2D+", "group", ".", "After", "multivariate", "analysis", ",", "age", ",", "SBP", ",", "RBP4", "and", "VFA", "maintained", "an", "independent", "association", "with", "baPWV", "in", "FH2D+", "group", "(", "P", "<", "0.05", ")", ",", "while", "only", "age", ",", "SBP", ",", "and", "VFA", "were", "independent", "predictors", "of", "baPWV", "in", "FH2D-", "group", "(", "P", "<", "0.05", ")", ".", "These", "findings", "led", "to", "the", "conclusion", "that", "RBP4", "level", "was", "associated", "with", "increased", "arterial", "stiffness", "in", "young", "subjects", "with", "family", "history", "of", "type", "2", "diabetes", "." ]	[ "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Age Group", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Temporal Concept", "B-Population Group", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Age Group", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "B-Finding", "O", "B-Finding", "O", "O", "O", "B-Age Group", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "B-Finding", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "B-Organism Function", "B-Organism Function", "O", "O", "O", "O", "B-Body Substance", "B-Body Substance", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Laboratory Procedure", "O", "B-Enzyme", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Finding", "B-Population Group", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Population Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "O", "B-Biologically Active Substance", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Clinical Attribute", "O", "O", "B-Idea or Concept", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Temporal Concept", "B-Population Group", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O" ]
[ "EZH2", "and", "ZFX", "oncogenes", "in", "malignant", "behaviour", "of", "parathyroid", "neoplasms", "Several", "studies", "reported", "somatic", "mutations", "of", "many", "genes", "(", "MEN1", ",", "CTNNB1", ",", "CDKIs", "and", "others", ")", "in", "parathyroid", "adenoma", ",", "although", "with", "different", "prevalence", ".", "Recently", ",", "activating", "mutations", "of", "the", "EZH2", "and", "ZFX", "oncogenes", "were", "identified", "in", "benign", "parathyroid", "adenoma", "by", "whole", "exome", "sequencing", ".", "The", "same", "mutations", "had", "been", "found", "in", "blood", "and", "ovary", "malignant", "tumours", ".", "On", "one", "hand", ",", "this", "result", "raised", "the", "hypothesis", "that", "these", "oncogenes", "may", "play", "a", "role", "in", "the", "onset", "of", "parathyroid", "tumour", ",", "but", "it", "would", "also", "suggest", "they", "may", "be", "involved", "in", "malignant", ",", "rather", "benign", ",", "parathyroid", "neoplasm", ".", "Our", "aim", "was", "to", "verify", "the", "occurrence", "of", "selected", "mutations", "of", "the", "EZH2", "and", "ZFX", "genes", "in", "an", "Italian", "cohort", "of", "23", "sporadic", "parathyroid", "carcinomas", ",", "12", "atypical", "and", "45", "typical", "adenomas", ".", "DNA", "was", "extracted", "from", "paraffin-embedded", "tissues", ",", "PCR", "amplified", "and", "directly", "sequenced", ".", "No", "mutations", "were", "detected", "in", "the", "coding", "sequence", "and", "boundaries", "of", "both", "genes", "in", "any", "of", "the", "samples", ".", "Two", "polymorphisms", "of", "the", "EZH2", "gene", "were", "identified", "with", "different", "prevalence", ":", "the", "rs2072407", "variant", "was", "present", "in", "the", "30", "%", "of", "the", "samples", ",", "in", "keeping", "with", "the", "overall", "frequency", "in", "larger", "populations", ",", "while", "the", "rs78589034", "variant", ",", "located", "close", "to", "the", "5", "'", "end", "of", "the", "exon", "16", ",", "was", "detected", "in", "only", "one", "proband", "with", "familial", "isolated", "hyperparathyroidism", ";", "we", "investigated", "the", "possible", "outcome", "on", "the", "splicing", "process", ".", "EZH2", "and", "ZFX", "genes", "do", "not", "seem", "to", "have", "an", "impact", "on", "the", "onset", "of", "most", "parathyroid", "tumours", ",", "both", "benign", "and", "malignant", ",", "though", "further", "studies", "on", "larger", "cohorts", "of", "different", "ethnicity", "are", "needed", "." ]	[ "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Research Activity", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Activity", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Body Substance", "O", "B-Body Part, Organ, or Organ Component", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Neoplastic Process", "O", "B-Biologically Active Substance", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Tissue", "B-Tissue", "O", "B-Molecular Biology Research Technique", "B-Phenomenon or Process", "O", "O", "B-Functional Concept", "O", "B-Finding", "B-Genetic Function", "O", "B-Finding", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Substance", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Temporal Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Finding", "O", "O", "O", "B-Family Group", "O", "B-Functional Concept", "B-Functional Concept", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Population Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O" ]
[ "The", "effect", "of", "total", "hip", "arthroplasty", "on", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "and", "low", "back", "pain", "in", "patients", "with", "severe", "hip", "osteoarthritis", "Sagittal", "spinopelvic", "malalignment", "has", "been", "reported", "in", "spinal", "disorders", "such", "as", "low", "back", "pain", "(", "LBP", ")", ",", "and", "restoration", "of", "normal", "alignment", "is", "targeted", "when", "treating", "these", "disorders", ".", "Abnormal", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "has", "been", "reported", "in", "patients", "with", "severe", "hip", "osteoarthritis", "(", "OA", ")", ",", "who", "have", "a", "high", "prevalence", "of", "associated", "LBP", ".", "This", "prospective", "longitudinal", "study", "aimed", "to", "investigate", "changes", "in", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "after", "total", "hip", "arthroplasty", "(", "THA", ")", "in", "patients", "with", "severe", "hip", "OA", ",", "and", "whether", "these", "changes", "contribute", "to", "LBP", "relief", ".", "Patients", "undergoing", "primary", "THA", "due", "to", "severe", "unilateral", "hip", "OA", "were", "recruited", ".", "Physical", "examination", "and", "X-ray", "films", "were", "taken", "to", "rule", "out", "any", "spinal", "disorder", ".", "Sagittal", "alignment", "of", "pelvis", ",", "hip", ",", "and", "spine", "was", "analyzed", "on", "lateral", "radiographs", "taken", "before", "(", "baseline", ")", "and", "1", "year", "after", "(", "follow-up", ")", "THA", ".", "Functional", "instruments", "were", "completed", "by", "patients", "including", ":", "visual", "analog", "scale", "(", "VAS", ")", "for", "LBP", ",", "Roland-Morris", "Disability", "Questionnaire", "(", "RMDQ", ")", ",", "and", "Harris", "Hip", "Score", "(", "HHS", ")", ".", "Comparisons", "were", "carried", "out", "at", "baseline", "and", "follow-up", ",", "and", "between", "patients", "with", "and", "without", "LBP", ".", "The", "recruited", "69", "patients", "showed", "significantly", "reduced", "hip", "flexion", "and", "improved", "global", "spinal", "balance", "at", "follow-up", "compared", "with", "baseline", ".", "LBP", "was", "reported", "by", "39", "patients", "(", "56.5", "%", ")", "before", "surgery", ";", "at", "follow-up", ",", "17", "reported", "complete", "resolution", ",", "while", "22", "reported", "significant", "relief", ".", "Significant", "decreases", "in", "VAS", "and", "RMDQ", "scores", "in", "lumbar", "spine", "and", "increase", "in", "hip", "HHS", "were", "observed", ".", "THA", "in", "patients", "with", "severe", "hip", "OA", "could", "help", "correct", "abnormal", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "and", "relieve", "comorbid", "LBP", ".", "Improvements", "in", "hip", "flexion", "and", "global", "spinal", "balance", "might", "be", "involved", "in", "the", "mechanism", "of", "LBP", "relief", "." ]	[ "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Body Location or Region", "B-Body Part, Organ, or Organ Component", "B-Pathologic Function", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "O", "B-Finding", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Sign or Symptom", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Sign or Symptom", "B-Finding", "O", "B-Patient or Disabled Group", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Body Location or Region", "B-Finding", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Health Care Activity", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "B-Sign or Symptom", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Health Care Activity", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Health Care Activity", "O", "O", "B-Quantitative Concept", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Clinical Attribute", "O", "B-Intellectual Product", "B-Quantitative Concept", "O", "B-Body Location or Region", "B-Body Location or Region", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "B-Finding", "B-Sign or Symptom", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "B-Sign or Symptom", "B-Finding", "O" ]
[ "Beyond", "neutral", "and", "forbidden", "links", ":", "morphological", "matches", "and", "the", "assembly", "of", "mutualistic", "hawkmoth", "-", "plant", "networks", "A", "major", "challenge", "in", "evolutionary", "ecology", "is", "to", "understand", "how", "co-evolutionary", "processes", "shape", "patterns", "of", "interactions", "between", "species", "at", "community", "level", ".", "Pollination", "of", "flowers", "with", "long", "corolla", "tubes", "by", "long-tongued", "hawkmoths", "has", "been", "invoked", "as", "a", "showcase", "model", "of", "co-evolution", ".", "Recently", ",", "optimal", "foraging", "models", "have", "predicted", "that", "there", "might", "be", "a", "close", "association", "between", "mouthparts", "'", "length", "and", "the", "corolla", "depth", "of", "the", "visited", "flowers", ",", "thus", "favouring", "trait", "convergence", "and", "specialization", "at", "community", "level", ".", "Here", ",", "we", "assessed", "whether", "hawkmoths", "more", "frequently", "pollinate", "plants", "with", "floral", "tube", "lengths", "similar", "to", "their", "proboscis", "lengths", "(", "morphological", "match", "hypothesis", ")", "against", "abundance", "-based", "processes", "(", "neutral", "hypothesis", ")", "and", "ecological", "trait", "mismatches", "constraints", "(", "forbidden", "links", "hypothesis", ")", ",", "and", "how", "these", "processes", "structure", "hawkmoth", "-", "plant", "mutualistic", "networks", "from", "five", "communities", "in", "four", "biogeographical", "regions", "of", "South", "America", ".", "We", "found", "convergence", "in", "morphological", "traits", "across", "the", "five", "communities", "and", "that", "the", "distribution", "of", "morphological", "differences", "between", "hawkmoths", "and", "plants", "is", "consistent", "with", "expectations", "under", "the", "morphological", "match", "hypothesis", "in", "three", "of", "the", "five", "communities", ".", "In", "the", "two", "remaining", "communities", ",", "which", "are", "ecotones", "between", "two", "distinct", "biogeographical", "areas", ",", "interactions", "are", "better", "predicted", "by", "the", "neutral", "hypothesis", ".", "Our", "findings", "are", "consistent", "with", "the", "idea", "that", "diffuse", "co-evolution", "drives", "the", "evolution", "of", "extremely", "long", "proboscises", "and", "flower", "tubes", ",", "and", "highlight", "the", "importance", "of", "morphological", "traits", ",", "beyond", "the", "forbidden", "links", "hypothesis", ",", "in", "structuring", "interactions", "between", "mutualistic", "partners", ",", "revealing", "that", "the", "role", "of", "niche-based", "processes", "can", "be", "much", "more", "complex", "than", "previously", "known", "." ]	[ "O", "B-Conceptual Entity", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "B-Phenomenon or Process", "B-Eukaryote", "O", "B-Plant", "B-Functional Concept", "O", "O", "O", "O", "B-Occupation or Discipline", "B-Occupation or Discipline", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Spatial Concept", "O", "B-Functional Concept", "O", "B-Classification", "O", "B-Group", "B-Qualitative Concept", "O", "B-Organism Function", "O", "B-Plant", "O", "B-Plant", "B-Plant", "B-Plant", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "O", "O", "B-Research Device", "O", "B-Genetic Function", "O", "O", "O", "O", "O", "B-Research Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Plant", "B-Spatial Concept", "O", "O", "O", "B-Plant", "O", "O", "O", "B-Organism Attribute", "B-Activity", "O", "B-Occupation or Discipline", "O", "B-Group", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Eukaryote", "O", "O", "B-Plant", "B-Plant", "O", "B-Classification", "B-Classification", "B-Quantitative Concept", "O", "O", "O", "B-Eukaryote", "B-Quantitative Concept", "O", "B-Spatial Concept", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "O", "B-Phenomenon or Process", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Qualitative Concept", "B-Occupational Activity", "O", "B-Conceptual Entity", "B-Conceptual Entity", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Spatial Concept", "B-Eukaryote", "O", "B-Plant", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Group", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "B-Activity", "O", "B-Spatial Concept", "B-Organism Attribute", "O", "O", "O", "B-Group", "O", "O", "O", "B-Functional Concept", "O", "B-Spatial Concept", "O", "O", "B-Eukaryote", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "B-Genetic Function", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Organism Attribute", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "B-Idea or Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Impact", "of", "totally", "laparoscopic", "combined", "management", "of", "colorectal", "cancer", "with", "synchronous", "hepatic", "metastases", "on", "severity", "of", "complications", ":", "a", "propensity-score", "-based", "analysis", "Thanks", "to", "widespread", "diffusion", "of", "minimally", "invasive", "approach", "in", "the", "setting", "of", "both", "colorectal", "and", "hepatic", "surgeries", ",", "the", "interest", "in", "combined", "resections", "for", "colorectal", "cancer", "and", "synchronous", "liver", "metastases", "(", "SCLM", ")", "by", "totally", "laparoscopic", "approach", "(", "TLA", ")", "has", "increased", ".", "Aim", "of", "this", "study", "was", "to", "compare", "outcome", "of", "combined", "resections", "for", "SCLM", "performed", "by", "TLA", "or", "by", "open", "approach", ",", "in", "a", "propensity-score-based", "study", ".", "All", "25", "patients", "undergoing", "combined", "TLA", "for", "SCLM", "at", "San", "Raffaele", "Hospital", "in", "Milano", "were", "compared", "in", "a", "case-matched", "analysis", "with", "25", "out", "of", "91", "patients", "undergoing", "totally", "open", "approach", "(", "TOA", "group", ")", ".", "Groups", "were", "matched", "with", "1:2", "ratio", "using", "propensity", "scores", "based", "on", "covariates", "representing", "disease", "severity", ".", "Main", "endpoints", "were", "postoperative", "morbidity", "and", "long-term", "outcome", ".", "The", "Modified", "Accordion", "Severity", "Grading", "System", "was", "used", "to", "quantify", "complications", ".", "The", "groups", "resulted", "comparable", "in", "terms", "of", "patients", "and", "disease", "characteristics", ".", "The", "TLA", "group", ",", "as", "compared", "to", "the", "TOA", "group", ",", "had", "lower", "blood", "loss", "(", "350", "vs", "600", "mL", ")", ",", "shorter", "postoperative", "stay", "(", "9", "vs", "12", "days", ")", ",", "lower", "postoperative", "morbidity", "index", "(", "0.14", "vs", "0.20", ")", "and", "severity", "score", "for", "complicated", "patients", "(", "0.60", "vs", "0.85", ")", ".", "Colonic", "anastomosis", "leakage", "had", "the", "highest", "fractional", "complication", "burden", "in", "both", "groups", ".", "In", "spite", "of", "comparable", "long-term", "overall", "survival", ",", "the", "TLA", "group", "had", "better", "recurrence-free", "survival", ".", "TLA", "for", "combined", "resections", "is", "feasible", ",", "and", "its", "indications", "can", "be", "widened", "to", "encompass", "a", "larger", "population", "of", "patients", ",", "provided", "its", "benefits", "in", "terms", "of", "reduced", "overall", "risk", "and", "severity", "of", "complications", ",", "rapid", "functional", "recovery", "and", "favorable", "long-term", "outcomes", "." ]	[ "O", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Diagnostic Procedure", "O", "B-Neoplastic Process", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Quantitative Concept", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "I-Population Group", "B-Population Group", "O", "O", "B-Finding", "B-Finding", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Temporal Concept", "B-Functional Concept", "O" ]
[ "Application", "of", "an", "Analytical", "Solution", "as", "a", "Screening", "Tool", "for", "Sea", "Water", "Intrusion", "Sea", "water", "intrusion", "into", "aquifers", "is", "problematic", "in", "many", "coastal", "areas", ".", "The", "physics", "and", "chemistry", "of", "this", "issue", "are", "complex", ",", "and", "sea", "water", "intrusion", "remains", "challenging", "to", "quantify", ".", "Simple", "assessment", "tools", "like", "analytical", "models", "offer", "advantages", "of", "rapid", "application", ",", "but", "their", "applicability", "to", "field", "situations", "is", "unclear", ".", "This", "study", "examines", "the", "reliability", "of", "a", "popular", "sharp-interface", "analytical", "approach", "for", "estimating", "the", "extent", "of", "sea", "water", "in", "a", "homogeneous", "coastal", "aquifer", "subjected", "to", "pumping", "and", "regional", "flow", "effects", "and", "under", "steady-state", "conditions", ".", "The", "analytical", "model", "is", "tested", "against", "observations", "from", "Canada", ",", "the", "United", "States", ",", "and", "Australia", "to", "assess", "its", "utility", "as", "an", "initial", "approximation", "of", "sea", "water", "extent", "for", "the", "purposes", "of", "rapid", "groundwater", "management", "decision", "making", ".", "The", "occurrence", "of", "sea", "water", "intrusion", "resulting", "in", "increased", "salinity", "at", "pumping", "wells", "was", "correctly", "predicted", "in", "approximately", "60", "%", "of", "cases", ".", "Application", "of", "a", "correction", "to", "account", "for", "dispersion", "did", "not", "markedly", "improve", "the", "results", ".", "Failure", "of", "the", "analytical", "model", "to", "provide", "correct", "predictions", "can", "be", "attributed", "to", "mismatches", "between", "its", "simplifying", "assumptions", "and", "more", "complex", "field", "settings", ".", "The", "best", "results", "occurred", "where", "the", "toe", "of", "the", "salt", "water", "wedge", "is", "expected", "to", "be", "the", "closest", "to", "the", "coast", "under", "predevelopment", "conditions", ".", "Predictions", "were", "the", "poorest", "for", "aquifers", "where", "the", "salt", "water", "wedge", "was", "expected", "to", "extend", "further", "inland", "under", "predevelopment", "conditions", "and", "was", "therefore", "more", "dispersive", "prior", "to", "pumping", ".", "Sharp-interface", "solutions", "remain", "useful", "tools", "to", "screen", "for", "the", "vulnerability", "of", "coastal", "aquifers", "to", "sea", "water", "intrusion", ",", "although", "the", "significant", "sources", "of", "uncertainty", "identified", "in", "this", "study", "require", "careful", "consideration", "to", "avoid", "misinterpreting", "sharp-interface", "results", "." ]	[ "B-Functional Concept", "O", "O", "B-Intellectual Product", "B-Conceptual Entity", "O", "O", "B-Health Care Activity", "B-Intellectual Product", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "O", "B-Finding", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Occupation or Discipline", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Quantitative Concept", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Natural Phenomenon or Process", "O", "O", "B-Functional Concept", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Qualitative Concept", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Functional Concept", "O", "B-Idea or Concept", "O", "B-Geographic Area", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Geographic Area", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Substance", "B-Substance", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Occupational Activity", "B-Mental Process", "B-Mental Process", "O", "O", "B-Temporal Concept", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "B-Quantitative Concept", "B-Laboratory or Test Result", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Finding", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "B-Spatial Concept", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "B-Intellectual Product", "O", "B-Health Care Activity", "O", "O", "B-Finding", "O", "B-Spatial Concept", "B-Natural Phenomenon or Process", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O" ]
[ "Patient", "-", "Physician", "Discordance", "in", "Global", "Assessment", "in", "Rheumatoid", "Arthritis", ":", "A", "Systematic", "Literature", "Review", "With", "Meta-Analysis", "The", "integration", "of", "the", "patient", "in", "therapeutic", "decision-making", "is", "important", "in", "the", "management", "of", "rheumatoid", "arthritis", "(", "RA", ")", ",", "but", "the", "patient", "opinion", "regarding", "disease", "status", "may", "differ", "from", "the", "physician", "'s", "opinion", ".", "The", "aim", "of", "this", "study", "was", "to", "assess", "in", "the", "published", "literature", "the", "frequency", "and", "drivers", "of", "patient", "-", "physician", "discordance", "in", "global", "assessment", "in", "RA", ".", "A", "systematic", "literature", "review", "of", "all", "articles", "published", "up", "to", "January", "2015", "in", "Medline", "or", "Embase", ",", "reporting", "discordance", "in", "RA", ",", "was", "conducted", "by", "2", "investigators", ".", "Discordance", "was", "defined", "based", "on", "the", "absolute", "difference", "of", "patient", "global", "(", "PGA", ")", "and", "physician", "global", "assessments", "(", "PhGA", ")", "on", "0-10-cm", "scales", ".", "The", "frequency", "of", "discordance", "and", "its", "predictors", "were", "collected", "in", "each", "study", ".", "Frequencies", "of", "discordance", "were", "pooled", "by", "meta-analysis", "using", "random", "effect", ".", "In", "all", ",", "12", "studies", "were", "selected", "(", "i.e.", ",", "11,879", "patients", ")", ":", "weighted", "mean", "±", "SD", "age", "was", "55.1", "±", "13.9", "years", ",", "weighted", "mean", "±", "SD", "disease", "duration", "was", "10.4", "±", "9.3", "years", ",", "and", "80.7", "%", "were", "women", ".", "The", "value", "of", "the", "difference", "\|", "PGA", "-", "PhGA", "\|", "defining", "discordance", "varied", "between", "≥0.5", "cm", "(", "n", "=", "2", "studies", ")", "to", "≥3", "cm", "(", "n", "=", "5", "studies", ")", ";", "the", "weighted", "mean", "value", "was", "2.7", "cm", ".", "The", "pooled", "percentage", "of", "patients", "with", "discordance", "was", "43", "%", "(", "95", "%", "confidence", "interval", "36", "%", "-51", "%", ";", "range", "25", "%", "-76", "%", ")", ".", "PGA", "was", "usually", "higher", "than", "PhGA", ".", "The", "drivers", "of", "PGA", "were", "pain", "and", "functional", "incapacity", ",", "whereas", "drivers", "of", "PhGA", "were", "joint", "counts", "and", "acute-phase", "reactants", ".", "Discordance", "in", "global", "assessment", "was", "most", "frequently", "defined", "as", "a", "difference", "of", "3", "points", "or", "more", ";", "even", "with", "such", "a", "stringent", "definition", ",", "up", "to", "half", "the", "patients", "were", "found", "to", "be", "discordant", ".", "The", "long-term", "consequences", "of", "this", "discordance", "remain", "to", "be", "determined", "." ]	[ "B-Patient or Disabled Group", "O", "B-Professional or Occupational Group", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Research Activity", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "B-Mental Process", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Patient or Disabled Group", "B-Mental Process", "O", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Mental Process", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Activity", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Temporal Concept", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Professional or Occupational Group", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Occupational Activity", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Research Activity", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Intellectual Product", "O", "B-Research Activity", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "O", "B-Research Activity", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Sign or Symptom", "O", "B-Functional Concept", "B-Clinical Attribute", "O", "O", "O", "O", "B-Research Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O" ]
[ "Nosocomial", "pneumonia", "caused", "by", "methicillin-resistant", "Staphylococcus", "aureus", "treated", "with", "linezolid", "or", "vancomycin", ":", "A", "secondary", "economic", "analysis", "of", "resource", "use", "from", "a", "Spanish", "perspective", "Adopting", "a", "unique", "Spanish", "perspective", ",", "this", "study", "aims", "to", "assess", "healthcare", "resource", "utilization", "(", "HCRU", ")", "and", "the", "costs", "of", "treating", "nosocomial", "pneumonia", "(", "NP", ")", "produced", "by", "methicillin-resistant", "Staphylococcus", "aureus", "(", "MRSA", ")", "in", "hospitalized", "adults", "using", "linezolid", "or", "vancomycin", ".", "An", "evaluation", "is", "also", "made", "of", "the", "renal", "failure", "rate", "and", "related", "economic", "outcomes", "between", "study", "groups", ".", "An", "economic", "post", "hoc", "evaluation", "of", "a", "randomized", ",", "double-blind", ",", "multicenter", "phase", "4", "study", "was", "carried", "out", ".", "Nosocomial", "pneumonia", "due", "to", "MRSA", "in", "hospitalized", "adults", ".", "The", "modified", "intent", "to", "treat", "(", "mITT", ")", "population", "comprised", "224", "linezolid", "-", "and", "224", "vancomycin", "-", "treated", "patients", ".", "Costs", "and", "HCRU", "were", "evaluated", "between", "patients", "administered", "either", "linezolid", "or", "vancomycin", ",", "and", "between", "patients", "who", "developed", "renal", "failure", "and", "those", "who", "did", "not", ".", "Analysis", "of", "HCRU", "outcomes", "and", "costs", ".", "Total", "costs", "were", "similar", "between", "the", "linezolid", "-", "(", "€17,782±€9,615", ")", "and", "vancomycin", "-", "treated", "patients", "(", "€17,423±€9,460", ")", "(", "P=.69", ")", ".", "The", "renal", "failure", "rate", "was", "significantly", "lower", "in", "the", "linezolid", "-", "treated", "patients", "(", "4", "%", "vs.", "15", "%", ";", "P", "<", ".001", ")", ".", "The", "total", "costs", "tended", "to", "be", "higher", "in", "patients", "who", "developed", "renal", "failure", "(", "€19,626±€10,840", "vs.", "€17,388±€9,369", ";", "P=.14", ")", ".", "Among", "the", "patients", "who", "developed", "renal", "failure", ",", "HCRU", "(", "days", "on", "mechanical", "ventilation", ":", "13.2±10.7", "vs.", "7.6±3.6", "days", ";", "P=.21", ";", "ICU", "stay", ":", "14.4±10.5", "vs.", "9.9±6.6", "days", ";", "P=.30", ";", "hospital", "stay", ":", "19.5±9.5", "vs.", "16.1±11.0", "days", ";", "P=.26", ")", "and", "cost", "(", "€17,219±€8,792", "vs.", "€20,263±€11,350", ";", "P=.51", ")", "tended", "to", "be", "lower", "in", "the", "linezolid", "-", "vs.", "vancomycin", "-", "treated", "patients", ".", "There", "were", "no", "statistically", "significant", "differences", "in", "costs", "per", "patient", "-", "day", "between", "cohorts", "after", "correcting", "for", "mortality", "(", "€1000", "vs.", "€1,010", ";", "P=.98", ")", ".", "From", "a", "Spanish", "perspective", ",", "there", "were", "no", "statistically", "significant", "differences", "in", "total", "costs", "between", "the", "linezolid", "and", "vancomycin", "pneumonia", "cohorts", ".", "The", "drug", "cost", "corresponding", "to", "linezolid", "was", "partially", "offset", "by", "fewer", "renal", "failure", "adverse", "events", "." ]	[ "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Geographic Area", "O", "O", "O", "O", "B-Geographic Area", "O", "O", "O", "B-Research Activity", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Idea or Concept", "O", "O", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "B-Bacterium", "O", "O", "B-Finding", "B-Finding", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Research Activity", "O", "B-Research Activity", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Bacterium", "O", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Population Group", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "B-Quantitative Concept", "O", "B-Idea or Concept", "O", "O", "O", "B-Patient or Disabled Group", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Idea or Concept", "O", "B-Temporal Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "B-Temporal Concept", "O", "B-Population Group", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "B-Disease or Syndrome", "B-Population Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Quantitative Concept", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Pathologic Function", "B-Pathologic Function", "O" ]
[ "The", "Role", "of", "TRAF4", "and", "B3GAT1", "Gene", "Expression", "in", "the", "Food", "Hypersensitivity", "and", "Insect", "Venom", "Allergy", "in", "Mastocytosis", "Mastocytosis", "is", "an", "uncommon", "disease", "classified", "as", "a", "myeloproliferative", "neoplasm", ",", "however", ",", "its", "symptoms", "are", "broad", "and", "place", "patients", "at", "crossroads", "between", "dermatology", ",", "hematology", "and", "allergology", ".", "Patients", "with", "mastocytosis", "often", "suffer", "from", "symptoms", "resulting", "from", "the", "activation", "and", "release", "of", "mediators", "from", "the", "mast", "cells", ",", "such", "as", "generalized", "itching", ",", "redness", ",", "headache", ",", "abdominal", "cramps", ",", "diarrhea", ",", "bone", "pain", "or", "arthritis", ",", "hypotension", "and", "shock", ".", "The", "possible", "severe", ",", "fatal", "or", "near", "fatal", "reactions", "caused", "by", "food", "hypersensitivity", "are", "reasons", "for", "the", "research", "focused", "on", "marker", "identification", ".", "The", "aim", "of", "the", "study", "was", "to", "analyse", "the", "gene", "expression", "differences", "in", "mastocytosis", "patients", "with", "and", "without", "food", "and", "drug", "hypersensitivity", "and", "insect", "venom", "allergy", "(", "IVA", ")", ".", "A", "total", "of", "57", "Caucasian", "patients", "with", "mastocytosis", "were", "studied", "[", "median", "age", "41.8", ";", "range", "18-77", "years", ";", "15", "(", "26.3", "%", ")", "males", "and", "42", "(", "73.7", "%", ")", "females", "]", ".", "Quantitative", "RT-PCRs", "of", "11", "genes", "plus", "ribosomal", "18S", "RNA", "were", "run", ".", "Symptoms", "of", "food", "hypersensitivity", "were", "found", "in", "12", "patients", "(", "21", "%", ")", ",", "including", "3", "patients", "(", "13", "%", ")", "with", "cutaneous", "mastocytosis", "(", "CM", ")", ",", "and", "9", "(", "28", "%", ")", "with", "indolent", "systemic", "mastocytosis", "(", "ISM", ")", ".", "IVA", "was", "confirmed", "in", "13", "patients", "(", "22.8", "%", ")", "including", "6", "patients", "(", "10.5", "%", ")", "with", "CM", ",", "and", "7", "patients", "(", "12.3", "%", ")", "with", "ISM", ".", "Drug", "hypersensitivity", "was", "diagnosed", "in", "10", "patients", "(", "17.5", "%", ")", ".", "Significant", "differences", "in", "the", "gene", "expression", "were", "found", "for", "TRAF4", "(", "p", "=", "0.008", ")", "in", "the", "comparison", "of", "the", "mastocytosis", "patients", "with", "and", "without", "concomitant", "food", "hypersensitivity", ".", "Furthermore", "significant", "differences", "were", "found", "in", "gene", "expression", "for", "B3GAT1", "(", "p", "=", "0.003", ")", "in", "patients", "with", "IVA", "compared", "to", "patients", "without", "insect", "sting", "anaphylaxis", "in", "the", "medical", "history", ".", "The", "expression", "of", "studied", "genes", "did", "not", "differ", "according", "to", "the", "presence", "of", "drug", "hypersensitivity", ".", "The", "TRAF4", "expression", "was", "higher", "in", "mastocytosis", "patients", "with", "food", "hypersensitivity", "in", "their", "medical", "history", ",", "the", "B3GAT1", "expression", "was", "lower", "in", "mastocytosis", "patients", "with", "IVA", "in", "history", "." ]	[ "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Finding", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "B-Gene or Genome", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "B-Sign or Symptom", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "B-Pathologic Function", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Finding", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "O", "O", "B-Patient or Disabled Group", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "O", "O", "O" ]
[ "Generalized", "Weakness", "in", "a", "Transplant", "Patient", ":", "A", "Case", "Presentation", "Generalized", "weakness", "in", "transplant", "patients", "is", "a", "major", "complaint", "in", "tertiary", "rehabilitation", "hospitals", ".", "The", "diagnosis", "and", "management", "of", "generalized", "weakness", "in", "this", "population", "pose", "challenges", "for", "physicians", ".", "We", "present", "the", "case", "of", "a", "transplant", "patient", "with", "generalized", "weakness", "who", "was", "eventually", "diagnosed", "with", "calciphylaxis", "using", "a", "multidisciplinary", "diagnostic", "approach", "of", "electrodiagnostics", ",", "vascular", "study", ",", "and", "skin", "biopsy", ".", "Calciphylaxis", "is", "a", "rare", "cutaneous", "disorder", "that", "mimics", "other", "collagen", "vascular", "diseases", "in", "its", "presentation", "and", "fulminant", "course", ".", "Physiatrists", "should", "be", "cognizant", "of", "calciphylaxis", ",", "as", "it", "signals", "a", "poor", "prognosis", "if", "not", "correctly", "diagnosed", "and", "treated", "in", "a", "timely", "manner", ",", "with", "high", "incidence", "of", "sepsis", ",", "wound", "pain", ",", "and", "disability", ".", "V", "." ]	[ "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Finding", "B-Patient or Disabled Group", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Finding", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Population Group", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Patient or Disabled Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "O", "B-Finding", "O", "B-Disease or Syndrome", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Diagnostic Procedure", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Finding", "O", "O", "O" ]
[ "Use", "of", "ecoacoustics", "to", "determine", "biodiversity", "patterns", "across", "ecological", "gradients", "The", "variety", "of", "local", "animal", "sounds", "characterizes", "a", "landscape", ".", "We", "used", "ecoacoustics", "to", "noninvasively", "assess", "the", "species", "richness", "of", "various", "biotopes", "typical", "of", "an", "ecofriendly", "forest", "plantation", "with", "diverse", "ecological", "gradients", "and", "both", "nonnative", "and", "indigenous", "vegetation", ".", "The", "reference", "area", "was", "an", "adjacent", "large", "World", "Heritage", "Site", "protected", "area", "(", "PA", ")", ".", "All", "sites", "were", "in", "a", "global", "biodiversity", "hotspot", ".", "Our", "results", "showed", "how", "taxa", "segregated", "into", "various", "biotopes", ".", "We", "identified", "65", "singing", "species", ",", "including", "birds", ",", "frogs", ",", "crickets", ",", "and", "katydids", ".", "Large", ",", "natural", ",", "protected", "grassland", "sites", "in", "the", "PA", "had", "the", "highest", "mean", "acoustic", "diversity", "(", "14.1", "species", "/", "site", ")", ".", "Areas", "covered", "in", "nonnative", "timber", "or", "grass", "species", "were", "devoid", "of", "acoustic", "species", ".", "Sites", "grazed", "by", "native", "and", "domestic", "megaherbivores", "were", "fairly", "rich", "(", "5.1", ")", "in", "acoustic", "species", "but", "none", "were", "unique", "to", "this", "habitat", "type", ",", "where", "acoustic", "diversity", "was", "greater", "than", "in", "intensively", "managed", "grassland", "sites", "(", "0.04", ")", ".", "Natural", "vegetation", "patches", "inside", "the", "plantation", "mosaic", "supported", "high", "mean", "acoustic", "diversity", "(", "indigenous", "forests", "7.6", ",", "grasslands", "8.0", ",", "wetlands", "9.1", ")", ",", "which", "increased", "as", "plant", "heterogeneity", "and", "patch", "size", "increased", ".", "Indigenous", "forest", "patches", "within", "the", "plantation", "mosaic", "contained", "a", "highly", "characteristic", "acoustic", "species", "assemblage", ",", "emphasizing", "their", "complementary", "contribution", "to", "local", "biodiversity", ".", "Overall", ",", "acoustic", "signals", "determined", "spatial", "biodiversity", "patterns", "and", "can", "be", "a", "useful", "tool", "for", "guiding", "conservation", "." ]	[ "O", "O", "B-Occupational Activity", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "O", "B-Spatial Concept", "B-Animal", "B-Natural Phenomenon or Process", "B-Idea or Concept", "O", "B-Spatial Concept", "O", "O", "O", "B-Occupational Activity", "O", "O", "B-Functional Concept", "O", "B-Classification", "O", "O", "B-Quantitative Concept", "B-Geographic Area", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "B-Finding", "O", "B-Group Attribute", "B-Plant", "O", "O", "B-Conceptual Entity", "B-Geographic Area", "O", "O", "B-Spatial Concept", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Functional Concept", "O", "O", "B-Conceptual Entity", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "O", "B-Individual Behavior", "B-Classification", "O", "O", "B-Bird", "O", "B-Amphibian", "O", "B-Eukaryote", "O", "O", "B-Eukaryote", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Classification", "O", "B-Spatial Concept", "O", "O", "B-Spatial Concept", "O", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Classification", "O", "O", "O", "B-Classification", "B-Classification", "O", "B-Spatial Concept", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Animal", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Group Attribute", "B-Natural Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Plant", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Quantitative Concept", "O", "B-Group Attribute", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "B-Qualitative Concept", "B-Classification", "B-Classification", "B-Idea or Concept", "O", "O", "O", "O", "B-Activity", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O" ]
[ "A", "Randomized", "Controlled", "Noninferiority", "Trial", "of", "Single", "Dose", "of", "Oral", "Dexamethasone", "Versus", "5", "Days", "of", "Oral", "Prednisone", "in", "Acute", "Adult", "Asthma", "Oral", "dexamethasone", "demonstrates", "bioavailability", "similar", "to", "that", "of", "oral", "prednisone", "but", "has", "a", "longer", "half-life", ".", "We", "evaluate", "whether", "a", "single", "dose", "of", "oral", "dexamethasone", "plus", "4", "days", "of", "placebo", "is", "not", "inferior", "to", "5", "days", "of", "oral", "prednisone", "in", "treatment", "of", "adults", "with", "mild", "to", "moderate", "asthma", "exacerbations", "to", "prevent", "relapse", "defined", "as", "an", "unscheduled", "return", "visit", "for", "additional", "treatment", "for", "persistent", "or", "worsening", "asthma", "within", "14", "days", ".", "Adult", "emergency", "department", "patients", "(", "aged", "18", "to", "55", "years", ")", "were", "randomized", "to", "receive", "either", "a", "single", "dose", "of", "12", "mg", "of", "oral", "dexamethasone", "with", "4", "days", "of", "placebo", "or", "a", "5-", "day", "course", "of", "oral", "prednisone", "60", "mg", "a", "day", ".", "Outcomes", "including", "relapse", "were", "assessed", "by", "a", "follow-up", "telephone", "interview", "at", "2", "weeks", ".", "One", "hundred", "seventy-three", "dexamethasone", "and", "203", "prednisone", "subjects", "completed", "the", "study", "regimen", "and", "telephone", "follow-up", ".", "The", "dexamethasone", "group", "by", "a", "small", "margin", "surpassed", "the", "preset", "8", "%", "difference", "between", "groups", "for", "noninferiority", "in", "relapse", "rates", "within", "14", "days", "(", "12.1", "%", "versus", "9.8", "%", ";", "difference", "2.3", "%", ";", "95", "%", "confidence", "interval", "-4.1", "%", "to", "8.6", "%", ")", ".", "Subjects", "in", "the", "2", "groups", "had", "similar", "rates", "of", "hospitalization", "for", "their", "relapse", "visit", "(", "dexamethasone", "3.4", "%", "versus", "prednisone", "2.9", "%", ";", "difference", "0.5", "%", ";", "95", "%", "confidence", "interval", "-4.1", "%", "to", "3.1", "%", ")", ".", "Adverse", "effect", "rates", "were", "generally", "the", "same", "in", "the", "2", "groups", ".", "A", "single", "dose", "of", "oral", "dexamethasone", "did", "not", "demonstrate", "noninferiority", "to", "prednisone", "for", "5", "days", "by", "a", "very", "small", "margin", "for", "treatment", "of", "adults", "with", "mild", "to", "moderate", "asthma", "exacerbations", ".", "Enhanced", "compliance", "and", "convenience", "may", "support", "the", "use", "of", "dexamethasone", "regardless", "." ]	[ "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Age Group", "B-Disease or Syndrome", "B-Clinical Drug", "B-Clinical Drug", "B-Activity", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "B-Functional Concept", "O", "B-Temporal Concept", "O", "B-Biomedical or Dental Material", "O", "O", "B-Spatial Concept", "O", "O", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "B-Functional Concept", "O", "B-Age Group", "O", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Functional Concept", "B-Phenomenon or Process", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "O", "B-Temporal Concept", "O", "B-Age Group", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Patient or Disabled Group", "O", "B-Organism Attribute", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Research Activity", "O", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Temporal Concept", "O", "B-Biomedical or Dental Material", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "B-Functional Concept", "B-Phenomenon or Process", "O", "B-Activity", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Temporal Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Pharmacologic Substance", "O", "O", "B-Hormone", "B-Group", "B-Qualitative Concept", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Phenomenon or Process", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Health Care Activity", "O", "O", "B-Phenomenon or Process", "B-Health Care Activity", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Hormone", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Activity", "B-Qualitative Concept", "O", "B-Hormone", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Age Group", "O", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Activity", "B-Finding", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O", "O" ]
[ "Relationship", "between", "XspI", "Site", "Polymorphisms", "of", "LDL-R", "Gene", "and", "Serum", "IL-2", "and", "IL-10", "in", "Patients", "with", "Hypercholesterolemia", "Relationship", "has", "been", "identified", "in", "sporadic", "reports", "between", "polymorphisms", "and", "hypercholesterolemia", ".", "However", ",", "the", "relationship", "between", "inflammatory", "cytokines", "and", "polymorphism", "of", "low-density", "lipoprotein", "receptor", "(", "LDL-R", ")", "gene", "in", "hypercholesterolemia", "is", "unclear", ".", "This", "study", "aimed", "to", "explore", "the", "relationship", "and", "significance", "between", "polymorphisms", "of", "LDL-R", "gene", "and", "serum", "Interleukin-2", "(", "IL-2", ")", ",", "IL-10", "in", "patients", "with", "hypercholesterolemia", ".", "PCR-RFLP", "and", "direct", "DNA", "sequencing", "assay", "were", "employed", "to", "determine", "polymorphism", "of", "LDL-R", "gene", "in", "900", "patients", "with", "hypercholesterolemia", "and", "400", "healthy", "cases", ".", "ELISA", "was", "applied", "to", "assay", "serum", "concentration", "of", "IL-2", "and", "IL-10", ".", "Blood", "lipid", "indexes", "were", "tested", "in", "all", "cases", ".", "Compared", "with", "the", "healthy", "controls", ",", "level", "of", "IL-2", "increased", "significantly", ",", "while", "IL-10", "decreased", "significantly", "(", "P", "<", "0.05", ")", ".", "Correlation", "analysis", "showed", "that", "IL-2", "was", "positively", "correlated", "with", "total", "cholesterol", "(", "TC", ")", ",", "LDL-c", ",", "and", "genotype", "(", "r", "=", "0.542", ",", "0.410", ",", "0.598", ",", "P", "<", "0.05", ")", "and", "negatively", "correlated", "with", "HDL-c", "(", "r", "=", "-0.352", ",", "P", "<", "0.05", ")", ".", "Negative", "relationship", "also", "was", "found", "between", "TC", ",", "LDL-c", ",", "genotype", ",", "and", "IL-10", "(", "r", "=", "-0.452", ",", "-0.390", ",", "-0.613", ",", "P", "<", "0.05", ")", ",", "and", "positive", "correlation", "between", "HDL-c", "and", "IL-10", "(", "r", "=", "0.398", ",", "P", "<", "0.05", ")", ".", "Multiple", "linear", "regression", "showed", "that", "genotypes", "and", "TC", "were", "independent", "factors", "affecting", "the", "levels", "of", "IL-2", "and", "IL-10", "(", "P", "<", "0.05", ")", ".", "IL-2", "and", "IL-10", "were", "related", "to", "gene", "polymorphisms", "of", "LDL-R", ",", "which", "might", "be", "involved", "in", "the", "development", "and", "progress", "of", "hypercholesterolemia", "." ]	[ "B-Qualitative Concept", "O", "B-Enzyme", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Genetic Function", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Immunologic Factor", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Disease or Syndrome", "O", "B-Finding", "O", "O", "B-Research Activity", "B-Idea or Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "O", "B-Immunologic Factor", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Finding", "O", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "B-Laboratory Procedure", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Intellectual Product", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "B-Immunologic Factor", "B-Quantitative Concept", "B-Idea or Concept", "O", "O", "B-Immunologic Factor", "B-Quantitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Immunologic Factor", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "O", "O", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "O", "B-Organism Attribute", "O", "O", "B-Immunologic Factor", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Immunologic Factor", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "B-Organic Chemical", "O", "B-Idea or Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "I-Immunologic Factor", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Qualitative Concept", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O" ]
[ "HERG1", "potassium", "channel", "expression", "in", "potentially", "malignant", "disorders", "of", "the", "oral", "mucosa", "and", "prognostic", "relevance", "in", "oral", "squamous", "cell", "carcinoma", "HERG1", "potassium", "channel", "plays", "a", "critical", "role", "in", "the", "cell", "proliferation", ".", "HERG1", "protein", "expression", "was", "analyzed", "by", "immunohistochemistry", "(", "IHC", ")", "in", "62", "patients", "with", "oral", "leukoplakias", "and", "100", "patients", "with", "oral", "squamous", "cell", "carcinomas", "(", "OSCC", ")", ".", "HERG1", "mRNA", "levels", "were", "assessed", "by", "real-time", "reverse", "transcriptase-polymerase", "chain", "reaction", "(", "RT-PCR", ")", "in", "22", "patients", "with", "primary", "head", "and", "neck", "squamous", "cell", "carcinoma", "(", "HNSCC", ")", ".", "Statistically", "significant", "associations", "were", "found", "between", "HERG1", "expression", "and", "tobacco", "consumption", ",", "disease", "stage", ",", "tumor", "differentiation", ",", "tumor", "recurrence", ",", "and", "reduced", "survival", ".", "There", "was", "no", "association", "between", "HERG1", "expression", "and", "the", "risk", "of", "progression", "from", "oral", "leukoplakia", "to", "OSCC", ".", "In", "addition", ",", "a", "high", "proportion", "of", "tumors", "(", "80", "%", ")", "showed", "increased", "HERG1", "mRNA", "levels", "compared", "to", "normal", "mucosa", "from", "nononcologic", "patients", ".", "Aberrant", "HERG1", "expression", "increases", "as", "oral", "tumorigenesis", "progresses", "from", "oral", "hyperplasia", "to", "OSCC", ".", "Increased", "HERG1", "mRNA", "levels", "were", "also", "frequently", "detected", "in", "OSCC", "and", "other", "HNSCC", "subsites", ".", "HERG1", "expression", "emerges", "as", "a", "clinically", "relevant", "feature", "during", "tumor", "progression", "and", "a", "potential", "poor", "prognostic", "biomarker", "for", "OSCC", ".", "©", "2016", "Wiley", "Periodicals", ",", "Inc.", "Head", "Neck", "38", ":", "1708-1716", ",", "2016", "." ]	[ "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Intellectual Product", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "B-Conceptual Entity", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Research Activity", "O", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Activity", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Neoplastic Process", "B-Cell Function", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "B-Activity", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "O", "B-Idea or Concept", "O", "B-Neoplastic Process", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "B-Activity", "O", "B-Tissue", "B-Tissue", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Genetic Function", "B-Functional Concept", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Neoplastic Process", "O", "B-Quantitative Concept", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "O", "O", "B-Finding", "O", "B-Neoplastic Process", "O", "O", "B-Neoplastic Process", "B-Spatial Concept", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Intellectual Product", "B-Clinical Attribute", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Malignancy", "is", "associated", "with", "microcalcification", "and", "higher", "AP/T", "ratio", "in", "ultrasonography", ",", "but", "not", "with", "Hashimoto", "'s", "thyroiditis", "in", "histopathology", "in", "patients", "with", "thyroid", "nodules", "evaluated", "as", "Bethesda", "Category", "III", "(", "AUS", "/", "FLUS", ")", "in", "cytology", "The", "predictors", "of", "malignancy", "are", "important", "for", "the", "decision", "of", "appropriate", "management", "in", "nodules", "with", "atypia", "of", "undetermined", "significance", "/", "follicular", "lesion", "of", "undetermined", "significance", "(", "AUS", "/", "FLUS", ")", ".", "Our", "aim", "was", "to", "determine", "the", "ultrasonographical", ",", "clinical", ",", "and", "biochemical", "predictors", "of", "malignancy", "in", "these", "patients", ".", "A", "total", "of", "427", "patients", "with", "cytologically", "Bethesda", "Category", "III", "(", "AUS", "/", "FLUS", ")", "thyroid", "nodules", "were", "included", "in", "this", "retrospective", "study", ".", "We", "divided", "the", "nodules", "into", "two", "subgroups", "according", "to", "the", "histopathology", "as", "benign", "and", "malignant", ",", "and", "compared", "the", "preoperative", "ultrasonographical", ",", "clinical", ",", "and", "biochemical", "findings", ".", "In", "overall", ",", "427", "patients", "with", "449", "AUS", "/", "FLUS", "nodules", "who", "had", "undergone", "surgery", ",", "the", "rate", "of", "malignancy", "was", "23.4", "%", "(", "105/449", ")", ".", "When", "evaluated", "separately", ",", "the", "rate", "of", "malignancy", "was", "25.8", "%", "in", "nodules", "with", "AUS", "(", "82/318", ")", "and", "17.6", "%", "in", "nodules", "with", "FLUS", "(", "23/131", ")", "(", "p", "=", "0.061", ")", ".", "The", "vast", "majority", "of", "malignant", "specimens", "in", "histopathology", "consisted", "of", "papillary", "thyroid", "carcinoma", "(", "PTC", ")", "(", "n", "=", "91", ",", "86.7", "%", ")", ".", "Preoperative", "ultrasonographic", "features", "of", "105", "malignant", "nodules", "in", "histopathology", "were", "compared", "with", "the", "344", "benign", "nodules", "in", "histopathology", ".", "Anteroposterior/Transverse", "(", "AP/T", ")", "ratio", "was", "significantly", "higher", "in", "malignant", "group", "compared", "to", "benign", "group", "(", "p", "=", "0.013", ")", ".", "In", "multiple", "logistic", "analysis", ",", "we", "found", "that", "higher", "AP/T", "ratio", "and", "microcalcification", "were", "independently", "associated", "with", "malignancy", "(", "p", "<", "0.05", ")", ".", "The", "malignancy", "-associated", "cut-off", "value", "of", "AP/T", "ratio", "at", "maximum", "sensitivity", "and", "specificity", "was", "≥0.81", ".", "We", "did", "not", "find", "any", "correlation", "between", "malignancy", "and", "Hashimoto", "'s", "thyroiditis", "in", "histopathology", "in", "multivariate", "analysis", "(", "p", ">", "0.05", ")", ".", "In", "Bethesda", "Category", "III", "nodules", "with", "higher", "AP/T", "ratio", "and", "microcalcification", ",", "surgery", "might", "be", "considered", "as", "a", "first", "therapeutic", "option", "instead", "of", "repeat", "fine-needle", "aspiration", "biopsy", "or", "observation", "." ]	[ "B-Neoplastic Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Pathologic Function", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "O", "B-Laboratory Procedure", "O", "B-Intellectual Product", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Neoplastic Process", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "B-Population Group", "O", "O", "O", "B-Laboratory Procedure", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Temporal Concept", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "B-Neoplastic Process", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "B-Laboratory Procedure", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Pathologic Function", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Pathologic Function", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Research Activity", "O" ]
[ "Low", "serum", "vitamin", "D", "is", "associated", "with", "higher", "cortical", "porosity", "in", "elderly", "men", "Bone", "loss", "at", "peripheral", "sites", "in", "the", "elderly", "is", "mainly", "cortical", "and", "involves", "increased", "cortical", "porosity", ".", "However", ",", "an", "association", "between", "bone", "loss", "at", "these", "sites", "and", "25-hydroxyvitamin", "D", "has", "not", "been", "reported", ".", "To", "investigate", "the", "association", "between", "serum", "levels", "of", "25-hydroxyvitamin", "D", ",", "bone", "microstructure", "and", "areal", "bone", "mineral", "density", "(", "BMD", ")", "in", "elderly", "men", ".", "A", "population", "-based", "cohort", "of", "444", "elderly", "men", "(", "mean", "±", "SD", "age", "80.2", "±", "3.5", "years", ")", "was", "investigated", ".", "Bone", "microstructure", "was", "measured", "by", "high-resolution", "peripheral", "quantitative", "computed", "tomography", ",", "areal", "BMD", "by", "dual-energy", "X-ray", "absorptiometry", "and", "serum", "25-hydroxyvitamin", "D", "and", "parathyroid", "hormone", "levels", "by", "immunoassay", ".", "Mean", "cortical", "porosity", "at", "the", "distal", "tibia", "was", "14.7", "%", "higher", "(", "12.5", "±", "4.3", "%", "vs.", "10.9", "±", "4.1", "%", ",", "P", "<", "0.05", ")", "whilst", "cortical", "volumetric", "BMD", ",", "area", ",", "trabecular", "bone", "volume", "fraction", "and", "femoral", "neck", "areal", "BMD", "were", "lower", "in", "men", "in", "the", "lowest", "quartile", "of", "vitamin", "D", "levels", "compared", "to", "the", "highest", ".", "In", "men", "with", "vitamin", "D", "deficiency", "(", "<", "25", "nmol", "L", "(", "-1", ")", ")", "or", "insufficiency", "[", "25-49", "nmol", "L", "(", "-1", ")", ",", "in", "combination", "with", "an", "elevated", "serum", "level", "of", "parathyroid", "hormone", "(", ">", "6.8", "pmol", "L", "(", "-1", ")", ")", "]", ",", "cortical", "porosity", "was", "17.2", "%", "higher", "than", "in", "vitamin", "D", "-", "sufficient", "men", "(", "P", "<", "0.01", ")", ".", "A", "linear", "regression", "model", "including", "age", ",", "weight", ",", "height", ",", "daily", "calcium", "intake", ",", "physical", "activity", ",", "smoking", "vitamin", "D", "supplementation", "and", "parathyroid", "hormone", "showed", "that", "25-hydroxyvitamin", "D", "independently", "predicted", "cortical", "porosity", "(", "standardized", "β", "=", "-0.110", ",", "R", "(", "2", ")", "=", "1.1", "%", ",", "P", "=", "0.024", ")", ",", "area", "(", "β", "=", "0.123", ",", "R", "(", "2", ")", "=", "1.4", "%", ",", "P", "=", "0.007", ")", "and", "cortical", "volumetric", "BMD", "(", "β", "=", "0.125", ",", "R", "(", "2", ")", "=", "1.4", "%", ",", "P", "=", "0.007", ")", "of", "the", "tibia", "as", "well", "as", "areal", "BMD", "of", "the", "femoral", "neck", "(", "β", "=", "0.102", ",", "R", "(", "2", ")", "=", "0.9", "%", ",", "P", "=", "0.04", ")", ".", "Serum", "vitamin", "D", "is", "associated", "with", "cortical", "porosity", ",", "area", "and", "density", ",", "indicating", "that", "bone", "fragility", "as", "a", "result", "of", "low", "vitamin", "D", "could", "be", "due", "to", "changes", "in", "cortical", "bone", "microstructure", "and", "geometry", "." ]	[ "B-Qualitative Concept", "B-Body Substance", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "B-Population Group", "B-Population Group", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Spatial Concept", "B-Body Location or Region", "O", "O", "B-Population Group", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Quantitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Body Location or Region", "O", "B-Vitamin", "B-Vitamin", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "O", "B-Population Group", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Qualitative Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Intellectual Product", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Individual Behavior", "B-Vitamin", "B-Vitamin", "B-Pharmacologic Substance", "O", "B-Hormone", "B-Hormone", "O", "O", "B-Vitamin", "B-Vitamin", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Substance", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "B-Clinical Attribute", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "B-Qualitative Concept", "B-Vitamin", "B-Vitamin", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Spatial Concept", "O" ]
[ "Nationwide", "reduction", "in", "the", "number", "of", "corneal", "transplantations", "for", "keratoconus", "following", "the", "implementation", "of", "cross-linking", "Keratoconus", "is", "characterized", "by", "corneal", "ectasia", "and", "irregular", "astigmatism", ",", "which", "can", "lead", "to", "diminished", "vision", "and", "corneal", "scarring", ".", "Approximately", "10-20", "%", "of", "patients", "with", "keratoconus", "eventually", "require", "a", "corneal", "transplant", ".", "Corneal", "cross-linking", "(", "CXL", ")", "is", "a", "relatively", "new", "treatment", "that", "may", "help", "prevent", "the", "need", "for", "corneal", "transplantation", ".", "Here", ",", "we", "investigated", "whether", "the", "introduction", "of", "CXL", "has", "reduced", "the", "number", "of", "corneal", "transplants", "performed", "annually", ".", "Data", "regarding", "the", "transplantation", "procedures", "performed", "in", "patients", "under", "the", "age", "of", "50", "years", "were", "extracted", "from", "the", "Dutch", "National", "Organ", "Transplant", "Registry", ".", "The", "number", "of", "corneal", "transplants", "performed", "prior", "to", "(", "i.e", ".", "in", "2005", "through", "2007", ")", "and", "following", "the", "introduction", "of", "CXL", "(", "i.e", ".", "in", "2012", "through", "2014", ")", "were", "compared", ".", "Furthermore", ",", "a", "trend", "analysis", "on", "annual", "keratoplasties", "over", "time", "was", "performed", ".", "Approximately", "25", "%", "fewer", "corneal", "transplants", "were", "performed", "in", "the", "3-", "year", "period", "following", "the", "introduction", "of", "CXL", "compared", "to", "the", "3-", "year", "period", "prior", "to", "the", "introduction", "of", "CXL", "(", "201", "versus", "269", "transplants", ",", "respectively", ";", "p", "=", "0.005", ")", ".", "Age", ",", "gender", "and", "visual", "acuity", "were", "similar", "between", "the", "patient", "groups", "in", "the", "two", "time", "periods", ".", "Trend", "analysis", "also", "demonstrated", "a", "significant", "decrease", "in", "the", "amount", "of", "corneal", "transplants", "(", "p", "=", "0.001", ")", ".", "Significantly", "fewer", "corneal", "transplants", "were", "performed", "for", "treating", "keratoconus", "following", "the", "nationwide", "introduction", "of", "CXL", ".", "This", "reduction", "suggests", "that", "corneal", "cross-linking", "can", "significantly", "reduce", "the", "need", "for", "corneal", "transplantation", "." ]	[ "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "O", "O", "B-Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "B-Temporal Concept", "O", "B-Idea or Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "O", "B-Patient or Disabled Group", "O", "O", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Functional Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Activity", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "B-Spatial Concept", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Quantitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O" ]
[ "Rapid", "Fabrication", "of", "a", "Cell", "-", "Seeded", "Collagen", "Gel", "-Based", "Tubular", "Construct", "that", "Withstands", "Arterial", "Pressure", ":", "Rapid", "Fabrication", "of", "a", "Gel", "-Based", "Media", "Equivalent", "Based", "on", "plastically", "compressed", "cell", "-", "seeded", "collagen", "gels", ",", "we", "fabricated", "a", "small-diameter", "tubular", "construct", "that", "withstands", "arterial", "pressure", "without", "prolonged", "culture", "in", "vitro", ".", "Specifically", ",", "to", "mimic", "the", "microstructure", "of", "vascular", "media", ",", "the", "cell", "-", "seeded", "collagen", "gel", "was", "uniaxially", "stretched", "prior", "to", "plastic", "compression", "to", "align", "collagen", "fibers", "and", "hence", "cells", "in", "the", "gel", ".", "The", "resulting", "gel", "sheet", "was", "then", "wrapped", "around", "a", "custom-made", "multi-layered", "braided", "tube", "to", "form", "aligned", "tubular", "constructs", "whereas", "the", "gel", "sheet", "prepared", "similarly", "but", "without", "uniaxial", "stretching", "formed", "control", "constructs", ".", "With", "the", "braided", "tube", ",", "fluid", "in", "the", "gel", "construct", "was", "further", "removed", "by", "vacuum", "suction", "aiming", "to", "consolidate", "the", "concentric", "layers", "of", "the", "construct", ".", "The", "construct", "was", "finally", "treated", "with", "transglutaminase", ".", "Both", "SEM", "and", "histology", "confirmed", "the", "absence", "of", "gaps", "in", "the", "wall", "of", "the", "construct", ".", "Particularly", ",", "cells", "in", "the", "wall", "of", "the", "aligned", "tubular", "construct", "were", "circumferentially", "aligned", ".", "The", "enzyme", "-mediated", "crosslinking", "increased", "burst", "pressure", "of", "both", "the", "constructs", "significantly", ";", "the", "extent", "of", "the", "increase", "of", "burst", "pressure", "for", "the", "aligned", "tubular", "construct", "was", "greater", "than", "that", "for", "the", "control", "counterpart", ".", "Increasing", "crosslinking", "left", "the", "compliance", "of", "the", "aligned", "tubular", "construct", "unchanged", "but", "reduced", "that", "of", "the", "control", "construct", ".", "Cells", "remained", "viable", "in", "transglutaminase", "-treated", "plastically", "compressed", "gels", "after", "6", "days", "in", "culture", ".", "This", "study", "demonstrated", "that", "by", "combining", "stretch-induced", "fiber", "alignment", ",", "plastic", "compression", ",", "and", "enzyme", "-mediated", "crosslinking", ",", "a", "cell", "-", "seeded", "collagen", "gel", "-based", "tubular", "construct", "with", "potential", "to", "be", "used", "as", "vascular", "media", "can", "be", "made", "within", "3", "days", "." ]	[ "O", "B-Activity", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Activity", "O", "O", "B-Biomedical or Dental Material", "O", "B-Substance", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "O", "B-Activity", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Laboratory Procedure", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "B-Substance", "B-Natural Phenomenon or Process", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Cell", "O", "O", "B-Biomedical or Dental Material", "O", "O", "O", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "B-Substance", "O", "O", "B-Biomedical or Dental Material", "B-Medical Device", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "B-Medical Device", "O", "O", "O", "O", "B-Enzyme", "O", "O", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "B-Cell", "O", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Biomedical or Dental Material", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Tissue", "B-Quantitative Concept", "O", "B-Substance", "B-Natural Phenomenon or Process", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "O", "O", "B-Temporal Concept", "O" ]
[ "Impact", "of", "cofactor", "-", "binding", "loop", "mutations", "on", "thermotolerance", "and", "activity", "of", "E.", "coli", "transketolase", "Improvement", "of", "thermostability", "in", "engineered", "enzymes", "can", "allow", "biocatalysis", "on", "substrates", "with", "poor", "aqueous", "solubility", ".", "Denaturation", "of", "the", "cofactor", "-", "binding", "loops", "of", "Escherichia", "coli", "transketolase", "(", "TK", ")", "was", "previously", "linked", "to", "the", "loss", "of", "enzyme", "activity", "under", "conditions", "of", "high", "pH", "or", "urea", ".", "Incubation", "at", "temperatures", "just", "below", "the", "thermal", "melting", "transition", ",", "above", "which", "the", "protein", "aggregates", ",", "was", "also", "found", "to", "anneal", "the", "enzyme", "to", "give", "an", "increased", "specific", "activity", ".", "The", "potential", "role", "of", "cofactor", "-", "binding", "loop", "instability", "in", "this", "process", "remained", "unclear", ".", "In", "this", "work", ",", "the", "two", "cofactor", "-", "binding", "loops", "(", "residues", "185-192", "and", "382-392", ")", "were", "progressively", "mutated", "towards", "the", "equivalent", "sequence", "from", "the", "thermostable", "Thermus", "thermophilus", "TK", "and", "variants", "assessed", "for", "their", "impact", "on", "both", "thermostability", "and", "activity", ".", "Cofactor-binding", "loop", "2", "variants", "had", "detrimental", "effects", "on", "specific", "activity", "at", "elevated", "temperatures", ",", "whereas", "the", "H192P", "mutation", "in", "cofactor-binding", "loop", "1", "resulted", "in", "a", "two-fold", "improved", "stability", "to", "inactivation", "at", "elevated", "temperatures", ",", "and", "increased", "the", "critical", "onset", "temperature", "for", "aggregation", ".", "The", "specific", "activity", "of", "H192P", "was", "3-fold", "and", "19-fold", "higher", "than", "that", "for", "wild-type", "at", "60°C", "and", "65°C", "respectively", ",", "and", "also", "remained", "2.7-4", "fold", "higher", "after", "re-cooling", "from", "pre-incubations", "at", "either", "55°C", "or", "60°C", "for", "1h", ".", "Interestingly", ",", "H192P", "was", "also", "2-times", "more", "active", "than", "wild-type", "TK", "at", "25°C", ".", "Optimal", "activity", "was", "achieved", "at", "60°C", "for", "H192P", "compared", "to", "55°C", "for", "wild", "type", ".", "These", "results", "show", "that", "cofactor-binding", "loop", "1", ",", "plays", "a", "pivotal", "role", "in", "partial", "denaturation", "and", "aggregation", "at", "elevated", "temperatures", ".", "Furthermore", ",", "a", "single", "rigidifying", "mutation", "within", "this", "loop", "can", "significantly", "improve", "the", "enzyme", "specific", "activity", ",", "as", "well", "as", "the", "stability", "to", "thermal", "denaturation", "and", "aggregation", ",", "to", "give", "an", "increased", "temperature", "optimum", "for", "activity", "." ]	[ "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "B-Genetic Function", "O", "B-Physiologic Function", "O", "B-Molecular Function", "O", "B-Bacterium", "B-Bacterium", "B-Enzyme", "B-Conceptual Entity", "O", "B-Natural Phenomenon or Process", "O", "B-Enzyme", "B-Enzyme", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Molecular Function", "O", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Bacterium", "B-Bacterium", "B-Enzyme", "O", "B-Enzyme", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Molecular Function", "B-Molecular Function", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Enzyme", "O", "O", "O", "B-Quantitative Concept", "O", "B-Molecular Function", "O", "O", "O", "B-Conceptual Entity", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Amino Acid Sequence", "O", "O", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "O", "O", "B-Qualitative Concept", "B-Bacterium", "B-Bacterium", "B-Enzyme", "O", "B-Gene or Genome", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Activity", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Gene or Genome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Activity", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Natural Phenomenon or Process", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Gene or Genome", "B-Enzyme", "O", "O", "O", "B-Qualitative Concept", "B-Activity", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Quantitative Concept", "B-Molecular Function", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Nucleotide Sequence", "O", "O", "O", "O", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "B-Molecular Function", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Molecular Function", "O" ]
[ "Expression", "and", "Purification", "of", "E2", "Glycoprotein", "from", "Insect", "Cells", "(", "Sf9", ")", "for", "Use", "in", "Serology", "Chikungunya", "virus", "(", "CHIKV", ")", "is", "a", "mosquito", "-", "borne", "arbovirus", "which", "poses", "a", "major", "threat", "to", "global", "public", "health", ".", "Definitive", "CHIKV", "diagnosis", "is", "crucial", ",", "especially", "in", "distinguishing", "the", "disease", "from", "dengue", "virus", ",", "which", "co-circulates", "in", "endemic", "areas", "and", "shares", "the", "same", "mosquito", "vectors", ".", "Laboratory", "diagnosis", "is", "mainly", "based", "on", "serological", "or", "molecular", "approaches", ".", "The", "E2", "glycoprotein", "is", "a", "good", "candidate", "for", "serological", "diagnosis", "since", "it", "is", "the", "immunodominant", "antigen", "during", "the", "course", "of", "infection", ",", "and", "reacts", "with", "seropositive", "CHIKV", "sera", ".", "In", "this", "chapter", ",", "we", "describe", "the", "generation", "of", "stable", "clone", "Sf9", "(", "Spodoptera", "frugiperda", ")", "cells", "expressing", "secreted", ",", "soluble", ",", "and", "native", "recombinant", "CHIKV", "E2", "glycoprotein", ".", "We", "use", "direct", "plasmid", "expression", "in", "insect", "cells", ",", "rather", "than", "the", "traditional", "technique", "of", "generating", "recombinant", "baculovirus", ".", "This", "recombinant", "protein", "is", "useful", "for", "serological", "diagnosis", "of", "CHIKV", "infection", "." ]	[ "B-Genetic Function", "O", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Eukaryote", "B-Cell", "O", "B-Cell", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Virus", "B-Virus", "O", "B-Virus", "O", "O", "O", "B-Eukaryote", "O", "B-Finding", "B-Virus", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Temporal Concept", "B-Virus", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Virus", "B-Virus", "O", "O", "B-Functional Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Immunologic Factor", "B-Immunologic Factor", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "B-Pathologic Function", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Virus", "B-Body Substance", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Idea or Concept", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Cell", "B-Cell", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Cell", "B-Genetic Function", "B-Cell Function", "O", "B-Cell Component", "O", "O", "B-Functional Concept", "B-Organism", "B-Virus", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Therapeutic or Preventive Procedure", "O", "B-Eukaryote", "B-Cell", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Activity", "B-Virus", "B-Virus", "O", "O", "B-Amino Acid, Peptide, or Protein", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Virus", "B-Pathologic Function", "O" ]
[ "Acute", "risk", "factors", "for", "suicide", "attempts", "and", "death", ":", "prospective", "findings", "from", "the", "STEP", "-", "BD", "study", "Suicide", "is", "unfortunately", "common", "in", "psychiatric", "practice", ",", "but", "difficult", "to", "predict", ".", "The", "present", "study", "sought", "to", "assess", "which", "clinical", "symptoms", "increase", "in", "the", "months", "before", "suicidal", "behavior", "in", "a", "sample", "of", "psychiatric", "outpatients", "with", "bipolar", "disorder", ".", "Data", "from", "the", "Systematic", "Treatment", "Enhancement", "Program", "for", "Bipolar", "Disorder", "(", "STEP", "-", "BD", ")", "trial", "were", "used", ".", "A", "total", "of", "103", "participants", "who", "attempted", "suicide", "or", "died", "by", "suicide", "during", "the", "trial", "were", "included", ";", "a", "15", "%", "random", "sample", "of", "the", "remaining", "participants", "(", "n", "=", "427", ")", "was", "used", "as", "a", "comparison", "sample", ".", "Linear", "mixed", "models", "in", "the", "six", "months", "before", "suicidal", "behavior", "were", "conducted", "for", "each", "of", "five", "proposed", "acute", "risk", "factors", "for", "suicidal", "behavior", ".", "Participants", "were", "assessed", "using", "the", "Clinical", "Monitoring", "Form", "(", "CMF", ")", "at", "each", "visit", "for", "the", "following", "potential", "acute", "risk", "factors", "for", "suicidal", "behavior", ":", "suicidal", "ideation", ",", "loss", "of", "interest", ",", "anxiety", ",", "psychomotor", "agitation", ",", "and", "high-risk", "behavior", ".", "Each", "of", "the", "five", "symptoms", "was", "elevated", "overall", "in", "individuals", "who", "engaged", "in", "suicidal", "behavior", "(", "p", "<", "0.05", ")", ".", "The", "severity", "of", "both", "suicidal", "ideation", "and", "loss", "of", "interest", "significantly", "increased", "in", "the", "months", "before", "suicidal", "behavior", "(", "p", "<", "0.001", ")", ".", "Anxiety", "demonstrated", "comparable", "effect", "sizes", "across", "multiple", "models", ".", "Psychomotor", "agitation", "and", "high-risk", "behavior", "were", "not", "significantly", "elevated", "before", "suicidal", "behavior", ".", "Suicidal", "ideation", ",", "loss", "of", "interest", "and", ",", "to", "a", "lesser", "extent", ",", "anxiety", "may", "represent", "acute", "suicide", "risk", "factors", "up", "to", "four", "months", "before", "suicidal", "behavior", "in", "outpatients", "with", "bipolar", "disorder", ".", "Further", "investigation", "of", "these", "potential", "acute", "risk", "factors", "in", "prospective", "analyses", "is", "warranted", "." ]	[ "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "B-Research Activity", "B-Finding", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Mental Process", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Research Activity", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Sign or Symptom", "B-Functional Concept", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "B-Substance", "O", "B-Biomedical Occupation or Discipline", "B-Patient or Disabled Group", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Idea or Concept", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Substance", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "B-Substance", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Population Group", "O", "B-Activity", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "B-Finding", "O", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "O", "O", "B-Sign or Symptom", "O", "B-Qualitative Concept", "O", "O", "B-Population Group", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Finding", "B-Finding", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Finding", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "B-Patient or Disabled Group", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O" ]
[ "Measurement", "of", "Outcomes", "of", "Upper", "Limb", "Reconstructive", "Surgery", "for", "Tetraplegia", "Reconstructive", "arm/hand", "surgery", "for", "tetraplegia", "is", "performed", "to", "improve", "arm/hand", "function", "and", "therefore", "personal", "well-being", "for", "individuals", "who", "accept", "such", "elective", "surgeries", ".", "However", ",", "changes", "at", "an", "impairment", "level", "do", "not", "always", "translate", "into", "functional", "or", "quality", "of", "life", "changes", ".", "Therefore", ",", "multiple", "outcome", "tools", "should", "be", "used", "that", "incorporate", "sufficient", "responsiveness", "to", "detect", "changes", "in", "arm/hand", "function", ",", "activity", "and", "participation", ",", "and", "quality", "of", "life", "of", "the", "individuals", "involved", ".", "This", "narrative", "review", "aims", "to", "assist", "clinicians", "to", "choose", "the", "most", "appropriate", "tools", "to", "assess", "the", "need", "for", "reconstructive", "surgery", "and", "to", "evaluate", "its", "outcomes", ".", "Our", "specific", "objectives", "are", "(", "1", ")", "to", "describe", "aspects", "to", "consider", "when", "choosing", "a", "measure", "and", "(", "2", ")", "to", "describe", "the", "measures", "advised", "by", "an", "international", "therapist", "consensus", "group", "established", "in", "2007", ".", "All", "advised", "measures", "are", "appraised", "in", "terms", "of", "the", "underlying", "construct", ",", "administration", ",", "and", "clinical", "relevance", "to", "arm/hand", "reconstructions", ".", "Essentially", "there", "are", "currently", "no", "criterion", "standard", "measures", "to", "evaluate", "the", "consequences", "of", "reconstructive", "arm/hand", "surgery", ".", "However", ",", "with", "judicious", "use", "of", "available", "measures", "it", "is", "possible", "to", "ensure", "the", "questions", "asked", "or", "tasks", "completed", "are", "relevant", "to", "the", "surgical", "reconstruction", "(", "s", ")", "undertaken", ".", "Further", "work", "in", "this", "field", "is", "required", ".", "This", "would", "be", "best", "met", "by", "immediate", "collaboration", "between", "2", "outcome", "'s", "tool", "developers", "and", "by", "analysis", "of", "pre", "-", "and", "postoperative", "data", "already", "held", "in", "various", "international", "sites", ",", "which", "would", "allow", "further", "evaluation", "of", "the", "measures", "already", "in", "use", ",", "or", "components", "thereof", "." ]	[ "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "B-Finding", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Functional Concept", "O", "B-Finding", "B-Organism Function", "B-Organism Function", "O", "O", "B-Finding", "B-Finding", "O", "B-Population Group", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "B-Functional Concept", "O", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "B-Functional Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Functional Concept", "O", "B-Organism Function", "B-Organism Function", "O", "B-Activity", "O", "B-Functional Concept", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Health Care Activity", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Qualitative Concept", "B-Manufactured Object", "O", "B-Activity", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Idea or Concept", "B-Professional or Occupational Group", "O", "B-Idea or Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Idea or Concept", "B-Quantitative Concept", "B-Functional Concept", "O", "B-Health Care Activity", "O", "B-Functional Concept", "B-Functional Concept", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Occupational Activity", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "B-Conceptual Entity", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Social Behavior", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Occupational Activity", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Manufactured Object", "O", "O" ]
[ "Basal", "and", "maximal", "metabolic", "rates", "differ", "in", "their", "response", "to", "rapid", "temperature", "change", "among", "avian", "species", "In", "birds", ",", "acclimation", "and", "acclimatization", "to", "temperature", "are", "associated", "with", "changes", "in", "basal", "(", "BMR", ")", ",", "summit", "(", "Msum", ")", "and", "maximal", "(", "MMR", ")", "metabolic", "rates", "but", "little", "is", "known", "about", "the", "rate", "at", "which", "species", "adjust", "their", "phenotype", "to", "short-term", "temperature", "variations", ".", "Our", "aims", "were", "(", "1", ")", "to", "determine", "the", "pattern", "of", "metabolic", "adjustments", "following", "a", "rapid", "temperature", "change", ",", "(", "2", ")", "to", "determine", "whether", "performance", "varies", "at", "similar", "rates", "during", "exposure", "to", "warm", "or", "cold", "environments", ",", "and", "(", "3", ")", "to", "determine", "if", "BMR", ",", "Msum", "and", "MMR", "change", "at", "comparable", "rates", "during", "thermal", "acclimation", ".", "We", "measured", "these", "parameters", "in", "white-throated", "sparrows", "(", "Zonotrichia", "albicollis", ")", ",", "black-capped", "chickadees", "(", "Poecile", "atricapillus", ")", ",", "and", "snow", "buntings", "(", "Plectrophenax", "nivalis", ")", "after", "acclimation", "to", "10", "°C", "(", "day", "0", ")", "and", "on", "the", "4th", "and", "8th", "days", "of", "acclimation", "to", "either", "-5", "or", "28", "°C", ".", "Birds", "changed", "their", "metabolic", "phenotype", "within", "8", "days", "with", "patterns", "differing", "among", "species", ".", "Sparrows", "expressed", "the", "expected", "metabolic", "increases", "in", "the", "cold", "and", "decreases", "at", "thermoneutrality", "while", "performance", "in", "chickadees", "and", "buntings", "was", "not", "influenced", "by", "temperature", "but", "changed", "over", "time", "with", "inverse", "patterns", ".", "Our", "results", "suggest", "that", "BMR", "varies", "at", "comparable", "rates", "in", "warm", "and", "cold", "environments", "but", "changes", "faster", "than", "Msum", "and", "MMR", ",", "likely", "due", "to", "limitations", "in", "the", "rate", "of", "change", "in", "organ", "size", "and", "function", ".", "They", "also", "suggest", "that", "maximal", "metabolic", "capacity", "is", "lost", "faster", "in", "a", "warm", "environment", "than", "it", "is", "gained", "in", "a", "cold", "environment", ".", "With", "the", "expected", "increase", "in", "temperature", "stochasticity", "at", "northern", "latitudes", ",", "a", "loss", "of", "thermogenic", "capacity", "during", "warm", "winter", "days", "could", ",", "therefore", ",", "be", "detrimental", "if", "birds", "are", "slow", "to", "readjust", "their", "phenotype", "with", "the", "return", "of", "cold", "days", "." ]	[ "B-Organism Function", "O", "B-Qualitative Concept", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Bird", "B-Classification", "O", "B-Bird", "O", "B-Organism Function", "O", "B-Organism Function", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Organism Function", "O", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "B-Qualitative Concept", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "O", "O", "O", "O", "B-Physiologic Function", "O", "O", "B-Classification", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Physiologic Function", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "O", "B-Physiologic Function", "O", "B-Natural Phenomenon or Process", "B-Organism Function", "O", "O", "O", "O", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "B-Organism Function", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "B-Bird", "O", "O", "B-Functional Concept", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O", "B-Spatial Concept", "O", "O", "B-Classification", "O", "B-Bird", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Bird", "O", "B-Bird", "O", "O", "B-Conceptual Entity", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "B-Finding", "O", "O", "B-Organism Function", "O", "O", "O", "B-Physiologic Function", "O", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Physiologic Function", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Quantitative Concept", "O", "B-Natural Phenomenon or Process", "B-Quantitative Concept", "O", "B-Phenomenon or Process", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Bird", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Temporal Concept", "O" ]
[ "Factors", "preventing", "kneeling", "in", "a", "group", "of", "pre-educated", "patients", "post", "total", "knee", "arthroplasty", "Difficulties", "in", "kneeling", ",", "one", "of", "the", "poorest", "scoring", "functional", "outcomes", "post", "total", "knee", "arthroplasty", "(", "TKA", ")", ",", "have", "been", "attributed", "to", "a", "lack", "of", "patient", "education", ".", "This", "is", "the", "first", "study", "to", "investigate", "specific", "factors", "affecting", "a", "patient", "'s", "perceived", "ability", "to", "kneel", "post", "TKA", ",", "following", "exposure", "to", "a", "preoperative", "kneeling", "education", "session", ".", "A", "cross-sectional", "study", "was", "conducted", "following", "TKA", "with", "patients", "who", "had", "been", "educated", "about", "kneeling", "prior", "to", "the", "operation", ".", "Patients", "completed", "kneeling", "questionnaires", "at", "6", "(", "n", "=", "115", ")", "and", "12", "(", "n", "=", "82", ")", "months", "post", "TKA", ".", "In", "addition", "to", "the", "12-month", "kneeling", "questionnaire", ",", "patients", "also", "completed", "the", "Oxford", "knee", "score", "(", "OKS", ")", "survey", ".", "Seventy-two", "percent", "of", "patients", "perceived", "they", "could", "kneel", "at", "12", "months", "post", "TKA", ".", "Overall", ",", "pain", "and", "discomfort", "were", "the", "most", "common", "factors", "deterring", "patients", "from", "kneeling", ".", "Perceived", "kneeling", "ability", "was", "the", "poorest", "scored", "outcome", "on", "the", "OKS", "with", "patients", "reporting", "mild", "to", "moderate", "difficulty", "with", "this", "task", ".", "Kneeling", "scores", "were", "strongly", "correlated", "with", "overall", "knee", "function", "scores", "(", "R", "=", "0.70", ")", ",", "strongly", "correlated", "with", "pain", "scores", "(", "R", "=", "0.45", ")", "and", "weakly", "correlated", "with", "knee", "stability", "scores", "(", "R", "=", "0.29", ")", ".", "When", "asked", "about", "other", "factors", "preventing", "kneeling", "other", "than", "pain", "or", "discomfor", "t", ",", "75", "%", "had", "reasons", "unrelated", "to", "the", "knee", "or", "TKA", ".", "The", "most", "common", "reason", "was", "'problems", "with", "the", "other", "knee", "'", "(", "n", "=", "19", ")", ".", "Patients", "in", "this", "study", "were", "provided", "with", "education", "regarding", "their", "kneeling", "ability", "post", "TKA", ",", "yet", "still", "experienced", "limitations", "in", "perceived", "kneeling", "ability", "post", "operatively", ".", "Contrary", "to", "previous", "research", ",", "our", "study", "suggests", "that", "factors", "other", "than", "patient", "education", "affect", "a", "patient", "'s", "perceived", "kneeling", "ability", "post", "TKA", "." ]	[ "B-Functional Concept", "B-Functional Concept", "B-Physiologic Function", "O", "O", "B-Idea or Concept", "O", "B-Educational Activity", "B-Patient or Disabled Group", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "O", "B-Patient or Disabled Group", "B-Educational Activity", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "B-Mental Process", "B-Organism Attribute", "B-Organism Attribute", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Temporal Concept", "B-Physiologic Function", "B-Educational Activity", "B-Educational Activity", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Educational Activity", "O", "B-Physiologic Function", "B-Temporal Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "B-Physiologic Function", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Physiologic Function", "B-Intellectual Product", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "B-Mental Process", "O", "O", "B-Physiologic Function", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Patient or Disabled Group", "O", "B-Physiologic Function", "O", "B-Mental Process", "B-Physiologic Function", "B-Organism Attribute", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Clinical Attribute", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "O", "O", "O", "O", "B-Physiologic Function", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Physiologic Function", "O", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Educational Activity", "O", "O", "B-Physiologic Function", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Physiologic Function", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Patient or Disabled Group", "B-Educational Activity", "B-Health Care Activity", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "B-Mental Process", "B-Physiologic Function", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O" ]
[ "Improved", "diagnostic", "yield", "of", "neuromuscular", "disorders", "applying", "clinical", "exome", "sequencing", "in", "patients", "arising", "from", "a", "consanguineous", "population", "Neuromuscular", "diseases", "(", "NMDs", ")", "include", "a", "broad", "range", "of", "disorders", "affecting", "muscles", ",", "nerves", "and", "neuromuscular", "junctions", ".", "Their", "overlapping", "phenotypes", "and", "heterogeneous", "genetic", "nature", "have", "created", "challenges", "in", "diagnosis", "which", "calls", "for", "the", "implementation", "of", "massive", "parallel", "sequencing", "as", "a", "candidate", "strategy", "to", "increase", "the", "diagnostic", "yield", ".", "In", "this", "study", ",", "total", "of", "45", "patients", ",", "mostly", "offspring", "of", "consanguineous", "marriages", "were", "examined", "using", "whole", "exome", "sequencing", ".", "Data", "analysis", "was", "performed", "to", "identify", "the", "most", "probable", "pathogenic", "rare", "variants", "in", "known", "NMD", "genes", "which", "led", "to", "identification", "of", "causal", "variants", "for", "33", "out", "of", "45", "patients", "(", "73.3", "%", ")", "in", "the", "following", "known", "genes", ":", "CAPN3", ",", "Col6A1", ",", "Col6A3", ",", "DMD", ",", "DYSF", ",", "FHL1", ",", "GJB1", ",", "ISPD", ",", "LAMA2", ",", "LMNA", ",", "PLEC1", ",", "RYR1", ",", "SGCA", ",", "SGCB", ",", "SYNE1", ",", "TNNT1", "and", "22", "novel", "pathogenic", "variants", "were", "detected", ".", "Today", ",", "the", "advantage", "of", "whole", "exome", "sequencing", "in", "clinical", "diagnostic", "strategies", "of", "heterogeneous", "disorders", "is", "clear", ".", "In", "this", "cohort", ",", "a", "diagnostic", "yield", "of", "73.3", "%", "was", "achieved", "which", "is", "quite", "high", "compared", "to", "the", "overall", "reported", "diagnostic", "yield", "of", "25", "%", "to", "50", "%", ".", "This", "could", "be", "explained", "by", "the", "consanguineous", "background", "of", "these", "patients", "and", "is", "another", "strong", "advantage", "of", "offering", "clinical", "exome", "sequencing", "in", "diagnostic", "laboratories", ",", "especially", "in", "populations", "with", "high", "rate", "of", "consanguinity", "." ]	[ "B-Finding", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Population Group", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Tissue", "O", "B-Tissue", "O", "B-Cell Component", "B-Cell Component", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Organism Attribute", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Activity", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Family Group", "O", "B-Social Behavior", "B-Social Behavior", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Disease or Syndrome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "B-Finding", "B-Gene or Genome", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Finding", "O" ]
[ "Safety", "of", "transradial", "diagnostic", "cardiac", "catheterization", "in", "patients", "under", "oral", "anticoagulant", "therapy", "Cardiac", "catheterization", "in", "anticoagulated", "patients", "is", "usually", "performed", "after", "the", "anticoagulation", "has", "been", "withdrawn", ",", "at", "least", "in", "the", "previous", "48h", ",", "and", "sometimes", "bridging", "therapy", "with", "heparin", "is", "used", ".", "A", "prospective", "observational", "study", "including", "489", "patients", "undergoing", "transradial", "catheterization", "was", "conducted", ".", "A", "total", "of", "140", "patients", "were", "under", "acenocoumarol", "(", "group", "A", ")", "and", "they", "were", "compared", "with", "the", "remainder", "(", "group", "B", ")", "for", "complications", "after", "the", "procedure", "(", "bleeding", "and", "vascular", "access", "complications", ")", ".", "Patients", "in", "group", "A", "were", "older", "(", "74±12", "years", "vs.", "68±17", "years", ",", "p", "<", "0.01", ")", "and", "the", "main", "indication", "for", "anticoagulation", "was", "atrial", "fibrillation", "(", "58.6", "%", ")", ".", "No", "complications", "occurred", "during", "the", "procedures", ".", "There", "were", "no", "acute", "bleedings", "just", "after", "the", "bandage", "removal", ".", "During", "the", "first", "24h", ",", "only", "3", "(", "2.1", "%", ")", "radial", "occlusions", "in", "group", "A", "and", "2", "(", "0.6", "%", ")", "in", "group", "B", "(", "p=0.14", ")", "were", "recorded", ".", "Hematomas", "between", "5", "and", "10cm", "appeared", "in", "5", "%", "of", "the", "group", "A", "vs.", "4.6", "%", "in", "group", "B", ".", "During", "the", "1-month", "follow-up", "period", ",", "one", "more", "radial", "occlusion", "in", "each", "group", "was", "recorded", "and", "there", "were", "4", "(", "1.1", "%", ")", "additional", "mild", "hematomas", "in", "group", "B", "and", "none", "in", "group", "A", "(", "p=0.48", ")", ".", "Performing", "a", "transradial", "diagnostic", "cardiac", "catheterization", "without", "removal", "of", "the", "oral", "chronic", "anticoagulation", "appears", "safe", "in", "patients", "under", "acenocumarol", "therapy", "." ]	[ "B-Research Activity", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Patient or Disabled Group", "O", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Functional Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Patient or Disabled Group", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Pharmacologic Substance", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "B-Classification", "B-Classification", "O", "O", "B-Pathologic Function", "O", "O", "B-Health Care Activity", "O", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Patient or Disabled Group", "O", "B-Classification", "B-Classification", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Finding", "B-Pathologic Function", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Finding", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Temporal Concept", "O", "B-Medical Device", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Temporal Concept", "B-Health Care Activity", "B-Temporal Concept", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Pathologic Function", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Qualitative Concept", "B-Activity", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Finding", "O", "B-Patient or Disabled Group", "O", "B-Pharmacologic Substance", "B-Therapeutic or Preventive Procedure", "O" ]
[ "Does", "infrared", "visualization", "improve", "selection", "of", "venipuncture", "sites", "for", "indwelling", "needle", "at", "the", "forearm", "in", "second-year", "nursing", "students", "?", "To", "evaluate", "the", "effectiveness", "of", "a", "vein", "visualization", "display", "system", "using", "near-infrared", "light", "(", "``", "Vein", "Display", "``", ")", "for", "the", "safe", "and", "proper", "selection", "of", "venipuncture", "sites", "for", "indwelling", "needle", "placement", "in", "the", "forearm", ".", "Ten", "second", "year", "nursing", "students", "were", "recruited", "to", "apply", "an", "indwelling", "needle", "line", "with", "and", "without", "Vein", "Display", ".", "Another", "ten", "participants", "were", "recruited", "from", "various", "faculty", "to", "serve", "as", "patients", ".", "The", "quality", "of", "the", "venipuncture", "procedure", "at", "various", "selected", "sites", "was", "evaluated", "according", "to", "a", "scale", "developed", "by", "the", "authors", ".", "Time", ",", "scores", "and", "patterns", "of", "puncture", "-", "site", "selection", "were", "compared", "with", "respect", "to", "three", "different", "methods", ":", "[", "1", "]", "attempt", "1", "(", "tourniquet", "only", ")", ",", "[", "2", "]", "attempt", "2", "(", "Vein", "Display", "only", ")", "and", "[", "3", "]", "attempt", "3", "(", "both", ")", ".", "To", "validate", "the", "effectiveness", "of", "Vein", "Display", ",", "52", "trials", "were", "conducted", "in", "total", ".", "We", "found", "that", "venipuncture", "site", "selection", "time", "was", "significantly", "improved", "with", "the", "Vein", "Display", ",", "particularly", "in", "the", "case", "of", "difficult", "to", "administer", "venipuncture", "sites", ".", "Overall", ",", "we", "found", "no", "significant", "difference", "with", "respect", "to", "venipuncture", "quality", ",", "as", "determined", "by", "our", "scale", ".", "These", "results", "suggest", "that", "equipment", "such", "as", "the", "Vein", "Display", "can", "contribute", "immensely", "to", "the", "improvement", "of", "practical", "skills", ",", "such", "as", "venipuncture", ",", "especially", "in", "the", "context", "of", "elderly", "patients", "." ]	[ "O", "B-Medical Device", "B-Functional Concept", "O", "B-Activity", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "O", "B-Functional Concept", "B-Medical Device", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Medical Device", "B-Medical Device", "B-Medical Device", "B-Medical Device", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "O", "B-Functional Concept", "B-Medical Device", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Medical Device", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Functional Concept", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "B-Professional or Occupational Group", "O", "B-Temporal Concept", "O", "B-Quantitative Concept", "O", "B-Qualitative Concept", "O", "B-Diagnostic Procedure", "O", "B-Spatial Concept", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Diagnostic Procedure", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Patient or Disabled Group", "O" ]
[ "Elective", "Nephron", "Sparing", "Surgery", "Decreases", "Other", "Cause", "Mortality", "Relative", "to", "Radical", "Nephrectomy", "Only", "in", "Specific", "Subgroups", "of", "Patients", "with", "Renal", "Cell", "Carcinoma", "There", "is", "no", "consensus", "regarding", "a", "protective", "effect", "on", "mortality", "due", "to", "a", "cause", "other", "than", "cancer", "in", "patients", "treated", "with", "elective", "nephron", "sparing", "surgery", "relative", "to", "their", "radical", "nephrectomy", "counterparts", ".", "We", "test", "whether", "the", "protective", "effect", "of", "nephron", "sparing", "surgery", "relative", "to", "radical", "nephrectomy", "is", "universal", "or", "present", "in", "specific", "subgroups", "of", "patients", ".", "A", "collaborative", "database", "of", "5", "institutions", "was", "queried", "to", "evaluate", "1,783", "patients", "without", "chronic", "kidney", "disease", "diagnosed", "with", "a", "clinical", "T1", "renal", "mass", "that", "was", "treated", "with", "nephron", "sparing", "surgery", "or", "radical", "nephrectomy", ".", "Multivariable", "Cox", "regression", "analysis", "was", "done", "to", "assess", "the", "impact", "of", "surgery", "type", "(", "nephron", "sparing", "surgery", "vs", "radical", "nephrectomy", ")", "on", "other", "cause", "mortality", "after", "adjustment", "for", "patient", "and", "cancer", "characteristics", ".", "Interaction", "terms", "were", "used", "to", "test", "the", "hypothesis", "that", "the", "impact", "of", "surgery", "type", "varies", "according", "to", "specific", "subcohorts", "of", "patients", ".", "Ten-year", "other", "cause", "mortality", "-free", "survival", "rates", "were", "90", "%", "and", "88", "%", "after", "nephron", "sparing", "surgery", "and", "radical", "nephrectomy", ",", "respectively", ".", "In", "the", "overall", "population", "radical", "nephrectomy", "was", "not", "associated", "with", "an", "increased", "risk", "of", "other", "cause", "mortality", "on", "multivariable", "analysis", "compared", "to", "nephron", "sparing", "surgery", "(", "HR", "0.91", ",", "95", "%", "CI", "0.6-1.38", ",", "p", "=", "0.6", ")", ".", "However", ",", "radical", "nephrectomy", "increased", "the", "risk", "of", "other", "cause", "mortality", "according", "to", "the", "increasing", "baseline", "Charlson", "comorbidity", "index", "(", "interaction", "test", "p", "=", "0.0008", ")", ".", "For", "example", ",", "in", "a", "patient", "with", "a", "Charlson", "comorbidity", "index", "of", "4", "the", "probability", "of", "10-year", "other", "cause", "mortality", "-free", "survival", "was", "86", "%", "after", "nephron", "sparing", "surgery", "and", "60", "%", "after", "radical", "nephrectomy", ".", "Elective", "nephron", "sparing", "surgery", "does", "not", "improve", "other", "cause", "survival", "relative", "to", "radical", "nephrectomy", "consistently", "in", "all", "patients", "with", "kidney", "cancer", ".", "Patients", "who", "are", "more", "ill", "with", "relevant", "comorbidities", "are", "those", "who", "benefit", "the", "most", "from", "nephron", "sparing", "surgery", "in", "terms", "of", "other", "cause", "mortality", "." ]	[ "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Quantitative Concept", "B-Finding", "B-Finding", "B-Finding", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Classification", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Social Behavior", "O", "O", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Patient or Disabled Group", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Finding", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "B-Classification", "O", "B-Patient or Disabled Group", "O", "O", "B-Quantitative Concept", "B-Intellectual Product", "O", "O", "B-Idea or Concept", "O", "B-Intellectual Product", "O", "B-Health Care Activity", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Qualitative Concept", "B-Population Group", "O", "B-Patient or Disabled Group", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Population Group", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Idea or Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Quantitative Concept", "O", "B-Idea or Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "B-Quantitative Concept", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "B-Finding", "O", "B-Activity", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "O", "O", "B-Activity", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Sign or Symptom", "O", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O" ]
[ "A", "prime", "a", "day", "keeps", "calories", "away", ":", "The", "effects", "of", "supraliminal", "priming", "on", "food", "consumption", "and", "the", "moderating", "role", "of", "gender", "and", "eating", "restraint", "The", "link", "between", "intentions", "and", "action", "in", "weight", "control", "is", "weaker", "than", "previously", "thought", ",", "so", "recent", "research", "has", "called", "for", "further", "investigation", "of", "ways", "to", "improve", "weight", "control", "that", "bypass", "conscious", "intentions", ".", "Priming", "has", "been", "shown", "to", "have", "effects", "on", "individual", "behavior", "in", "a", "variety", "of", "contexts", "by", "influencing", "subconscious", "cognition", ".", "This", "paper", "investigates", "the", "effects", "of", "semantic", "priming", "using", "healthy", "body", "image", ",", "goal-oriented", "words", "on", "food", "consumption", ".", "The", "moderating", "role", "of", "both", "restrained", "eating", "and", "gender", "is", "investigated", ".", "161", "participants", "were", "involved", "in", "an", "experiment", "using", "a", "novel", "version", "of", "a", "scrambled", "sentence", "priming", "game", ".", "The", "outcome", "measure", "was", "the", "number", "of", "kilocalories", "consumed", ",", "examined", "using", "a", "between", "subjects", "ANCOVA", "with", "priming", ",", "gender", ",", "restrained", "eating", "index", ",", "self-reported", "BMI", ",", "and", "two", "interaction", "terms", "(", "priming", "x", "gender", ",", "and", "priming", "x", "restrained", "eating", "index", ")", ".", "There", "was", "no", "main", "effect", "of", "priming", "but", "there", "was", "an", "interaction", "of", "priming", "with", "gender", ".", "Females", "consumed", "significantly", "fewer", "kilocalories", "after", "being", "exposed", "to", "priming", "words", "related", "to", "a", "healthy", "body", "image", "(", "i.e", ".", "``", "slim", "''", ",", "``", "fit", ",", "''", ")", "compared", "to", "females", "receiving", "the", "neutral", "prime", ",", "with", "a", "medium", "effect", "size", "(", "d", "=", "0.58", ")", ".", "The", "body", "image", "prime", "did", "not", "significantly", "affect", "food", "intake", "for", "males", ",", "nor", "did", "it", "have", "a", "differential", "effect", "on", "restrained", "eaters", ".", "This", "study", "shows", "that", "priming", "can", "be", "an", "effective", "method", "for", "influencing", "females", "to", "reduce", "food", "intake", ",", "regardless", "of", "whether", "they", "are", "restrained", "or", "unrestrained", "eaters", ".", "Future", "studies", "could", "investigate", "whether", "different", "priming", "words", "related", "to", "a", "male", "'s", "healthy", "body", "image", "goal", "(", "i.e", ".", "``", "buff", ",", "''", "``", "muscles", ",", "''", "etc", ".", ")", "would", "similarly", "reduce", "food", "intake", "for", "males", "." ]	[ "O", "B-Mental Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Mental Process", "B-Mental Process", "O", "B-Activity", "B-Activity", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Organism Attribute", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "B-Mental Process", "O", "B-Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Mental Process", "B-Mental Process", "O", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Mental Process", "B-Mental Process", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Activity", "B-Activity", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Mental Process", "B-Daily or Recreational Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Mental Process", "O", "B-Organism Attribute", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Research Activity", "B-Clinical Attribute", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Mental Process", "O", "B-Organism Attribute", "O", "O", "B-Mental Process", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Mental Process", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Mental Process", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Mental Process", "B-Intellectual Product", "O", "O", "O", "B-Qualitative Concept", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "B-Organism Function", "B-Organism Function", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Organism Function", "B-Organism Function", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Intellectual Product", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Qualitative Concept", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "B-Organism Function", "O", "B-Organism Attribute", "O" ]
[ "Neurotrophins", "and", "specific", "receptors", "in", "the", "oviduct", "tracts", "of", "Japanese", "quail", "(", "Coturnix", "coturnix", "japonica", ")", "Neurotrophins", "(", "NGF", ",", "BDNF", "and", "NT-3", ")", "and", "their", "specific", "receptors", "(", "TrkA", ",", "TrkB", "and", "TrkC", ")", "were", "studied", "in", "the", "oviduct", "of", "egg", "laying", "quails", ".", "Neurotrophins", "(", "NTs", ")", "are", "mainly", "involved", "in", "the", "development", "and", "maintenance", "of", "neuronal", "populations", "in", "the", "central", "and", "peripheral", "nervous", "system", ",", "but", "also", "in", "reproductive", "system", ".", "In", "this", "survey", ",", "we", "first", "studied", "the", "morphological", "organization", "of", "the", "quail", "oviduct", ",", "distinguished", "in", "infundibulum", ",", "magnum", ",", "isthmus", ",", "uterus", "and", "vagina", ",", "and", "then", "we", "analyzed", "the", "expression", "and", "localization", "of", "NTs", "and", "Trks", "receptors", "in", "the", "whole", "tracts", ".", "By", "western", "blotting", "we", "detected", "that", "the", "investigated", "NTs", "and", "Trks", "receptors", "are", "expressed", "in", "all", "oviductal", "tracts", ".", "By", "immunohistochemistry", "we", "were", "able", "to", "define", "the", "distribution", "of", "NTs", "and", "Trks", ".", "Specifically", ",", "NGF", ",", "BDNF", "and", "NT3", "were", "localized", "in", "lining", "and", "ductal", "epithelial", "cells", ",", "and", "NGF", "was", "also", "detected", "in", "secretory", "cells", "of", "tubular", "glands", "and", "in", "nervous", "fibers", "of", "vessel", "wall", ".", "TrkA", "and", "TrkB", "were", "present", "in", "the", "lining", "and", "ductal", "epithelium", ";", "TrkA", "and", "TrkC", "were", "present", "in", "nervous", "fibers", "of", "vessel", "wall", "in", "all", "oviductal", "tracts", ".", "Furthermore", ",", "we", "also", "observed", "NGF", "and", "BDNF", "co-localized", "with", "TrkA", "and", "TrkB", "in", "cells", "of", "the", "lining", "and", "ductal", "epithelium", ",", "suggesting", "an", "autocrine", "mechanism", "of", "action", "." ]	[ "B-Biologically Active Substance", "O", "B-Receptor", "B-Receptor", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "B-Bird", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Receptor", "B-Receptor", "O", "B-Receptor", "O", "B-Receptor", "O", "B-Receptor", "O", "O", "B-Research Activity", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Organism Function", "B-Organism Function", "B-Bird", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Cell", "B-Cell", "O", "O", "B-Body System", "O", "B-Body System", "B-Body System", "B-Body System", "O", "O", "O", "O", "B-Body System", "B-Body System", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Qualitative Concept", "B-Physiologic Function", "O", "O", "B-Bird", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "B-Research Activity", "O", "B-Genetic Function", "O", "B-Cell Function", "O", "B-Biologically Active Substance", "O", "B-Receptor", "B-Receptor", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "B-Functional Concept", "B-Biologically Active Substance", "O", "B-Receptor", "B-Receptor", "O", "B-Genetic Function", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "B-Cell Function", "O", "B-Biologically Active Substance", "O", "B-Receptor", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Spatial Concept", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Receptor", "O", "B-Receptor", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "O", "B-Receptor", "O", "B-Receptor", "O", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Receptor", "O", "B-Receptor", "O", "B-Cell", "O", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Activity", "O" ]
[ "Laser", "-facilitated", "epicutaneous", "immunotherapy", "to", "IgE-mediated", "allergy", "Allergen", "specific", "immunotherapy", "has", "been", "shown", "to", "be", "the", "only", "effective", "treatment", "for", "long-lasting", "clinical", "benefit", "to", "IgE-mediated", "allergic", "diseases", ",", "but", "a", "fewer", "than", "5", "%", "of", "patients", "choose", "the", "treatment", "because", "of", "inconvenience", "and", "a", "high", "risk", "of", "anaphylaxis", ".", "Recently", ",", "epicutaneous", "allergen-specific", "immunotherapy", "(", "EPIT", ")", "has", "proven", "effective", ",", "yet", "with", "limitations", "owing", "to", "strong", "skin", "reactions", ".", "We", "demonstrate", "here", "safer", "and", "faster", "EPIT", ",", "named", "μEPIT", ",", "by", "delivering", "powdered", "allergen", "and", "adjuvants", "into", "many", "micropores", "in", "the", "epidermis", ".", "We", "fabricated", "a", "microarray", "patch", "fractionally", "coated", "with", "a", "powder", "mixture", "of", "ovalbumin", "(", "OVA", ")", "model", "allergen", ",", "CpG", ",", "and", "1,25-dihydroxyvitamin", "D3", "(", "VD3", ")", ".", "Topical", "application", "of", "the", "patch", "onto", "laser-microperforated", "skin", "resulted", "in", "a", "high", "level", "of", "epidermal", "delivery", "while", "greatly", "minimizing", "allergen", "leakage", "into", "circulation", "system", "as", "compared", "to", "current", "subcutaneous", "immunotherapy", "(", "SCIT", ")", ".", "Moreover", ",", "only", "three", "times", "of", "μEPIT", "over", "two", "weeks", "could", "sufficiently", "inhibit", "allergen-specific", "IgE", "responses", "in", "mice", "suffering", "OVA", "-induced", "airway", "hyperresponsivness", "(", "AHR", ")", ",", "which", "was", "unattainable", "by", "eight", "times", "of", "SCIT", "over", "three", "weeks", ".", "Mechanistically", ",", "μEPIT", "preferably", "enhanced", "IgG2a", "production", "suggesting", "TH1-biased", "immune", "responses", "and", "induced", "a", "high", "level", "of", "T-regulatory", "(", "Treg", ")", "cells", "against", "repeated", "allergen", "sensitization", ".", "The", "immune", "tolerance", "was", "confirmed", "by", "marked", "reduction", "in", "airway", "wall", "thickness", "as", "well", "as", "eosinophil", "and", "neutrophil", "infiltration", "into", "the", "respiratory", "airway", ".", "The", "μEPIT", "represents", "a", "novel", "and", "painless", "technology", "to", "treat", "IgE-mediated", "allergic", "diseases", "with", "little", "local", "skin", "reaction", "and", "a", "minimal", "risk", "of", "anaphylaxis", "." ]	[ "B-Manufactured Object", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Temporal Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Pathologic Function", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Functional Concept", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "O", "B-Cell Component", "O", "O", "B-Tissue", "O", "O", "O", "O", "B-Manufactured Object", "B-Medical Device", "O", "B-Qualitative Concept", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Immunologic Factor", "O", "B-Biologically Active Substance", "O", "O", "B-Vitamin", "B-Vitamin", "O", "B-Vitamin", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Medical Device", "O", "B-Finding", "B-Body System", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "B-Tissue", "B-Functional Concept", "O", "O", "O", "B-Immunologic Factor", "B-Finding", "O", "B-Body System", "B-Body System", "O", "B-Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Activity", "B-Immunologic Factor", "B-Immunologic Factor", "B-Organism Attribute", "O", "B-Mammal", "O", "B-Biologically Active Substance", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Activity", "B-Immunologic Factor", "B-Biologic Function", "O", "B-Cell", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "B-Cell", "O", "B-Cell", "O", "B-Cell", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "O", "B-Cell", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Activity", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Occupation or Discipline", "O", "B-Therapeutic or Preventive Procedure", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "O", "B-Pathologic Function", "O" ]
[ "Predicting", "real", "-", "world", "functional", "milestones", "in", "schizophrenia", "Schizophrenia", "is", "a", "severe", "disorder", "that", "often", "causes", "impairments", "in", "major", "areas", "of", "functioning", ",", "and", "most", "patients", "do", "not", "achieve", "expected", "real", "-", "world", "functional", "milestones", ".", "The", "aim", "of", "this", "study", "was", "to", "identify", "which", "variables", "of", "demography", ",", "illness", "activity", ",", "and", "functional", "capacity", "predict", "patients", "'", "ability", "to", "attain", "real", "-", "world", "functional", "milestones", ".", "Participants", "were", "235", "outpatients", ",", "149", "men", "and", "86", "women", ",", "diagnosed", "with", "schizophrenia", "spectrum", "disorder", ".", "Our", "results", "showed", "that", "younger", "patients", "managed", "to", "achieve", "a", "higher", "level", "of", "functioning", "in", "educational", "level", ",", "marital", "status", ",", "and", "social", "contacts", ".", "Patients", "'", "functional", "capacity", "was", "primarily", "associated", "with", "educational", "level", "and", "housing", "situation", ".", "We", "also", "found", "that", "women", "needed", "less", "support", "regarding", "housing", "and", "obtained", "a", "higher", "level", "of", "marital", "status", "as", "compared", "with", "men", ".", "Our", "findings", "demonstrate", "the", "importance", "of", "considering", "current", "symptoms", ",", "especially", "negative", "symptoms", ",", "and", "remission", "stability", "over", "time", ",", "together", "with", "age", ",", "duration", "of", "illness", ",", "gender", ",", "educational", "level", ",", "and", "current", "functional", "capacity", ",", "when", "predicting", "patients", "'", "future", "real", "-", "world", "functioning", ".", "We", "also", "conclude", "that", "there", "is", "an", "advantage", "in", "exploring", "symptoms", "divided", "into", "positive", ",", "negative", ",", "and", "general", "domains", "considering", "their", "probable", "impact", "on", "functional", "achievements", "." ]	[ "B-Idea or Concept", "B-Qualitative Concept", "O", "B-Population Group", "B-Functional Concept", "B-Conceptual Entity", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Population Group", "B-Functional Concept", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Occupation or Discipline", "O", "B-Sign or Symptom", "B-Activity", "O", "O", "B-Finding", "B-Finding", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Population Group", "B-Functional Concept", "B-Conceptual Entity", "O", "B-Population Group", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Population Group", "O", "O", "B-Population Group", "O", "B-Finding", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Finding", "B-Finding", "O", "B-Group Attribute", "B-Group Attribute", "O", "O", "B-Finding", "B-Finding", "O", "B-Patient or Disabled Group", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Manufactured Object", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Group Attribute", "B-Group Attribute", "O", "O", "O", "B-Population Group", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Sign or Symptom", "O", "O", "B-Finding", "B-Sign or Symptom", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Temporal Concept", "O", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Organism Attribute", "O", "B-Finding", "B-Finding", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Qualitative Concept", "O", "B-Population Group", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Sign or Symptom", "O", "O", "B-Finding", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Behavior", "O" ]
[ "LDLR", ",", "ApoB", "and", "ApoE", "genes", "polymorphisms", "and", "classical", "risk", "factors", "in", "premature", "coronary", "artery", "disease", "Lipoproteins", "play", "a", "central", "role", "in", "the", "development", "of", "atherosclerotic", "disease", ".", "So", ",", "with", "their", "ability", "to", "affect", "lipid", "levels", ",", "the", "LDLR", ",", "ApoB", "and", "ApoE", "polymorphisms", "could", "be", "one", "of", "the", "factors", "influencing", "development", "of", "atherosclerosis", ".", "This", "hypothesis", "has", "been", "tested", "in", "different", "populations", "with", "conflicting", "results", ".", "The", "purpose", "of", "the", "present", "study", "was", "to", "investigate", "the", "association", "between", "the", "LDLR", ",", "ApoB", "and", "ApoE", "genes", "polymorphisms", "with", "premature", "CAD", "(", "PCAD", ")", "in", "Egyptians", ".", "One", "hundred", "thirty-five", "patients", "of", "PCAD", "and", "one", "hundred", "thirty-two", "ages", "and", "sex", "matched", "control", "subjects", "were", "included", "in", "the", "study", ".", "LDLR", "and", "ApoB", "genes", "polymorphisms", "were", "analyzed", "by", "polymerase", "chain", "reaction", "(", "PCR", ")", ".", "The", "ApoE", "genotypes", "were", "identified", "by", "multiplex", "amplification", "refractory", "mutation", "system", "(", "multi-AMRS", ")", ".", "We", "found", "that", "LDLR", "A", "(", "+", ")", "A", "(", "+", ")", "genotype", ",", "ApoB", "X", "(", "+", ")", "allele", "and", "ApoE", "E4", "allele", "increased", "the", "risk", "of", "PCAD", "by", "1.8", ",", "2.1", "and", "12.1", "respectively", ".", "The", "present", "study", "proved", "that", "smoking", ",", "metabolic", "syndrome", ",", "ApoB", "X", "(", "+", ")", "X", "(", "+", ")", "genotype", "and", "ApoE", "E4", "allele", "were", "independent", "risk", "factors", "for", "the", "development", "of", "PCAD", ".", "This", "is", "the", "first", "study", "investigate", "the", "association", "between", "low", "density", "lipoprotein", "receptor", ",", "apolipoprotein", "B", "and", "apolipoprotein", "E", "genes", "polymorphisms", "with", "PCAD", "and", "lipid", "levels", "in", "Egyptians", "and", "we", "concluded", "that", "the", "LDLR", "A", "(", "+", ")", "A", "(", "+", ")", "genotype", ",", "ApoB", "X", "(", "+", ")", "allele", "and", "ApoE", "E4", "allele", "may", "be", "associated", "with", "an", "increased", "risk", "for", "development", "of", "PCAD", "by", "elevated", "levels", "of", "total", "cholesterol", "(", "TC", ")", "and", "low", "density", "lipoprotein", "(", "LDLc", ")", ".", "The", "coexistence", "of", "CAD", "risk", "factors", "with", "LDLR", "A", "(", "+", ")", "A", "(", "+", ")", "genotype", ",", "ApoB", "X", "(", "+", ")", "allele", "and", "ApoE", "E4", "allele", "may", "increase", "the", "risk", "of", "the", "development", "of", "PCAD", "in", "Egyptian", "patients", "." ]	[ "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Genetic Function", "O", "O", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "O", "B-Idea or Concept", "O", "O", "B-Intellectual Product", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Genetic Function", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Genetic Function", "O", "B-Research Activity", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Gene or Genome", "B-Organism Attribute", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual Behavior", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Genetic Function", "O", "B-Disease or Syndrome", "O", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "O", "B-Population Group", "O", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Finding", "B-Finding", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "B-Population Group", "B-Patient or Disabled Group", "O" ]
[ "The", "influence", "of", "liposomal", "formulation", "on", "the", "incorporation", "and", "retention", "of", "PNA", "oligomers", "Liposomal", "formulations", "composed", "of", "phospholipids", "with", "different", "unsaturation", "degrees", ",", "head", "groups", "and", "at", "different", "cholesterol", "content", "have", "been", "tested", "for", "the", "encapsulation", "of", "Peptide", "Nucleic", "Acid", "(", "PNA", ")", "oligomers", ".", "The", "best", "loading", "capability", "(", "177μg", ",", "ER", "%", "=87.2", ")", "was", "obtained", "for", "pure", "liposomes", "of", "phosphatidylglycerol", "(", "DOPG", ")", "with", "negatively", "charged", "head", "group", ".", "The", "insertion", "of", "a", "10-20", "%", "of", "cholesterol", "in", "DOPG", "based", "liposomes", "provides", "a", "slight", "decrease", "(", "∼160μg", ")", "of", "the", "PNA", "loading", ".", "On", "the", "other", "hand", ",", "the", "cholesterol", "addition", "(", "20-30", "%", ")", "slows", "down", "the", "PNA", "'s", "release", "(", "∼27", "%", ")", "in", "fetal", "bovine", "serum", "from", "the", "liposomal", "formulation", ".", "Based", "on", "the", "encapsulation", "and", "the", "release", "properties", ",", "PEGylated", "DOPG", "liposomes", "with", "a", "percentage", "of", "cholesterol", "of", "10-20", "%", "are", "the", "optimal", "formulation", "for", "the", "loading", "of", "PNA-a210", "." ]	[ "O", "O", "O", "B-Organic Chemical", "B-Conceptual Entity", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Organic Chemical", "B-Conceptual Entity", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Phenomenon or Process", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "B-Indicator, Reagent, or Diagnostic Aid", "B-Indicator, Reagent, or Diagnostic Aid", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Organic Chemical", "B-Conceptual Entity", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "B-Biomedical or Dental Material", "B-Organic Chemical", "B-Organic Chemical", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Activity", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "O" ]
[ "Mandibular", "kinesiographic", "pattern", "of", "women", "with", "chronic", "TMD", "after", "management", "with", "educational", "and", "self-care", "therapies", ":", "A", "double-blind", ",", "randomized", "clinical", "trial", "Limited", "mandibular", "movements", "are", "one", "of", "the", "most", "important", "signs", "of", "temporomandibular", "disorders", "(", "TMDs", ")", "and", "may", "cause", "functional", "difficulties", ".", "The", "purpose", "of", "this", "double-blind", ",", "randomized", "clinical", "trial", "was", "to", "evaluate", "the", "effect", "of", "treatment", "with", "only", "educational", "or", "education", "associated", "with", "self-care", "therapies", "on", "the", "pattern", "of", "mandibular", "movements", "of", "women", "with", "chronic", "painful", "TMDs", ".", "Forty-two", "women", "were", "selected", "and", "randomly", "divided", "into", "3", "groups", ",", "control", "group", "(", "CG", ",", "n=13", ")", ",", "education", "group", "(", "EG", ",", "n=16", ")", ",", "and", "education", "and", "self-care", "group", "(", "ESG", ",", "n=13", ")", ",", "according", "to", "the", "sequence", "of", "treatment", "they", "received", ".", "A", "kinesiograph", "device", "recorded", "mandibular", "movements", "during", "maximum", "mouth", "opening", "and", "mastication", "at", "baseline", "(", "T0", ")", "and", "at", "30-day", "(", "T1", ")", "and", "60-day", "(", "T2", ")", "follow-up", ".", "Kinesiographic", "data", "were", "statistically", "analyzed", "using", "1-way", "ANOVA", ",", "followed", "by", "the", "Bonferroni", "test", "for", "multiple", "comparisons", "of", "means", "(", "α=.05", ")", ".", "The", "ESG", "group", "demonstrated", "an", "improvement", "in", "the", "maximum", "vertical", "opening", "(", "MVO", "=", "5.1", "±3.4", "mm", ";", "P=.012", ")", "and", "anteroposterior", "mandibular", "movement", "(", "MAM", ")", "during", "maximum", "opening", "(", "7.4", "±9.5", ";", "P=.019", ")", ",", "significantly", "higher", "than", "that", "of", "the", "EG", "(", "MVO", "=1.8", "±3.5", "mm", ";", "MAM", "=0.8", "±5.0", "mm", ")", "and", "the", "CG", "(", "MVO", "=0.9", "±3.8", "mm", ";", "MAM", "=0.8", "±4.4", "mm", ")", "after", "30", "days", "of", "follow-up", ".", "Moreover", ",", "at", "T1", ",", "vertical", "mandibular", "movement", "during", "mastication", "was", "significantly", "higher", "in", "the", "ESG", "group", "(", "17.4", "±1.7", "mm", ")", "than", "in", "the", "EG", "group", "(", "15.0", "±2.8", ",", "P=.027", ")", ".", "No", "significant", "differences", "were", "found", "between", "the", "women", "who", "received", "treatment", "with", "educational", "and", "self-care", "therapies", "for", "60", "days", "and", "the", "women", "who", "received", "this", "treatment", "for", "30", "days", ".", "In", "the", "short-term", ",", "education", "and", "self-care", "treatment", "positively", "influenced", "the", "mandibular", "movement", "pattern", "of", "women", "with", "chronic", "painful", "TMDs", "." ]	[ "B-Body Part, Organ, or Organ Component", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Population Group", "O", "B-Temporal Concept", "B-Disease or Syndrome", "O", "B-Health Care Activity", "O", "B-Classification", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Research Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Classification", "O", "B-Classification", "B-Qualitative Concept", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Intellectual Product", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "O", "B-Population Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Disease or Syndrome", "O", "B-Quantitative Concept", "B-Population Group", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Group", "B-Group", "O", "B-Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "O", "B-Medical Device", "B-Medical Device", "B-Qualitative Concept", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "B-Temporal Concept", "B-Quantitative Concept", "B-Body Space or Junction", "B-Organism Function", "O", "B-Organ or Tissue Function", "O", "B-Quantitative Concept", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "B-Health Care Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Research Activity", "B-Research Activity", "B-Functional Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Activity", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Conceptual Entity", "O", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "B-Organism Function", "O", "B-Temporal Concept", "B-Quantitative Concept", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "O", "O", "O", "B-Organism Function", "O", "O", "O", "O", "O", "O", "B-Group", "O", "B-Organism Function", "O", "O", "O", "O", "B-Organism Function", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Spatial Concept", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "B-Temporal Concept", "B-Organ or Tissue Function", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Qualitative Concept", "O", "B-Finding", "O", "O", "B-Population Group", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Classification", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "B-Population Group", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Classification", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Finding", "B-Conceptual Entity", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "B-Intellectual Product", "O", "B-Population Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Disease or Syndrome", "O" ]
[ "Histopathology", "of", "the", "filum", "terminale", "in", "children", "with", "and", "without", "tethered", "cord", "syndrome", "with", "attention", "to", "the", "elastic", "tissue", "within", "the", "filum", "To", "compare", "histologically", "transected", "fila", "from", "pediatric", "patients", "with", "tethered", "cord", "syndrome", "(", "TCS", ")", ",", "with", "and", "without", "a", "low", "conus", ",", "with", "controls", ",", "focusing", "on", "collagenous", "and", "elastic", "tissue", ".", "Thirty", "fila", "from", "patients", "with", "TCS", ",", "including", "5", "where", "minimal", "cautery", "was", "used", "prior", "to", "filum", "section", ",", "were", "compared", "with", "fila", "from", "27", "pediatric", "cadavers", "without", "TCS", "(", "controls", ")", ".", "Sections", "of", "fila", "were", "stained", "with", "H", "&", "E", ",", "Masson", "trichrome", "and", "Verhoeff", "von", "Gieson", "elastic", "stains", ",", "and", "7", "with", "Gordon", "and", "Sweet", "'s", "reticulin", "stain", ".", "Fila", "from", "controls", "showed", "loose", "fibrous", "connective", "tissue", "(", "FCT", ")", "with", "thin", "and", "evenly", "dispersed", "elastic", "fibers", "(", "EFs", ")", ".", "Reticulin", "fibers", "(", "RFs", ")", "were", "seen", "in", "blood", "vessel", "walls", "and", "nerve", "twigs", ".", "Fat", "was", "identified", "microscopically", "in", "2", "fila", ".", "All", "fila", "from", "patients", "with", "TCS", "had", "dense", "FCT", ".", "The", "EFs", "were", "in", "normal", "numbers", "in", "17", ",", "and", "focally", "or", "diffusely", "decreased", "in", "13", ".", "All", "25", "patients", "where", "the", "fila", "were", "cauterized", "during", "resection", "had", "thick", "and", "coiled", "EFs", ".", "Coiling", "was", "not", "seen", "when", "minimal", "cautery", "was", "applied", ".", "RFs", "were", "seen", "in", "blood", "vessel", "walls", "and", "nerve", "twigs", ".", "Fat", "was", "identified", "in", "19", "patients", ".", "Findings", "were", "similar", ",", "whether", "the", "conus", "termination", "was", "normal", "or", "low", ".", "The", "fila", "of", "all", "patients", "with", "TCS", ",", "whether", "or", "not", "the", "conus", "was", "low", ",", "showed", "abnormal", "FCT", ".", "EFs", "were", "decreased", "in", "48", "%", "of", "patients", ";", "however", ",", "there", "were", "thick", "and", "coiled", "EFs", "in", "all", "patients", ".", "Coiling", "of", "EFs", ",", "initially", "thought", "to", "be", "an", "abnormality", "in", "patients", ",", "is", "considered", "most", "likely", "to", "be", "a", "result", "of", "cautery", "(", "i.e.", ",", "artifactual", "/", "iatrogenic", "coiling", ")", "." ]	[ "B-Biomedical Occupation or Discipline", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Age Group", "O", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Activity", "B-Functional Concept", "B-Functional Concept", "B-Body Part, Organ, or Organ Component", "O", "B-Qualitative Concept", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Body Location or Region", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Laboratory Procedure", "O", "O", "B-Activity", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "B-Anatomical Structure", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "B-Group", "O", "O", "B-Substance", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Group", "O", "B-Qualitative Concept", "B-Tissue", "B-Tissue", "B-Tissue", "O", "B-Tissue", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "B-Tissue", "B-Tissue", "O", "B-Tissue", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Tissue", "O", "O", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Tissue", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Tissue", "O", "B-Spatial Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "O", "O", "B-Patient or Disabled Group", "O", "B-Finding", "O", "B-Qualitative Concept", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Spatial Concept", "O", "O", "B-Finding", "B-Tissue", "O", "B-Tissue", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Tissue", "O", "O", "B-Patient or Disabled Group", "O", "B-Spatial Concept", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Human-caused Phenomenon or Process", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O" ]
[ "Clinical", "value", "of", "pathologic", "examination", "of", "non-neoplastic", "kidney", "in", "patients", "with", "upper", "urinary", "tract", "malignancies", "While", "surgical", "resection", "remains", "the", "standard", "of", "care", "in", "the", "treatment", "of", "upper", "urinary", "tract", "malignancies", ",", "nephrectomy", "is", "a", "risk", "factor", "for", "the", "development", "of", "chronic", "kidney", "disease", "(", "CKD", ")", ".", "The", "aim", "of", "this", "study", "was", "to", "determine", "whether", "histologic", "evaluation", "of", "non-neoplastic", "kidney", "could", "enable", "early", "identification", "of", "unrecognized", "kidney", "disease", "and", "could", "be", "of", "prognostic", "value", "in", "predicting", "postoperative", "renal", "outcomes", ".", "We", "retrospectively", "analyzed", "51", "patients", "with", "upper", "urinary", "tract", "malignancies", "who", "received", "uninephrectomy", "or", "uninephroureterectomy", ".", "A", "thorough", "pathologic", "evaluation", "of", "non-neoplastic", "kidney", "including", "special", "stains", ",", "immunofluorescence", ",", "and", "electron", "microscopic", "studies", "was", "performed", ".", "The", "degree", "of", "parenchymal", "changes", "was", "graded", "from", "0", "to", "15", ".", "Of", "51", "patients", ",", "only", "13", "showed", "normal", "kidney", "pathology", ".", "Fifteen", "patients", "showed", "glomerular", "abnormalities", ",", "14", "showed", "diabetic", "nephropathy", ",", "and", "11", "showed", "vascular", "nephropathy", ".", "There", "was", "one", "case", "each", "of", "reflux", "nephropathy", "and", "chronic", "pyelonephritis", ".", "The", "median", "histologic", "score", "was", "5", "points", ".", "Only", "25.4", "%", "of", "patients", "had", "≤", "3", "points", ".", "Score", "more", "than", "5", "was", "observed", "in", "47.1", "%", "of", "patients", ".", "Postoperative", "estimated", "glomerular", "filtration", "rate", "(", "eGFR", ")", "at", "3", "to", "36", "months", "were", "obtained", "from", "90.2", "%", "of", "patients", ",", "and", "of", "those", ",", "34.8", "%", "had", "de", "novo", "CKD", ".", "Since", "no", "one", "had", "CKD", "in", "partial", "nephrectomized", "patients", ",", "we", "determined", "risk", "factors", "for", "CKD", "in", "radical", "nephrectomized", "patients", ".", "Cox", "regression", "analysis", "revealed", "that", "postoperative", "AKI", ",", "preoperative", "eGFR", ",", "and", "histologic", "score", "of", "non-neoplastic", "kidney", "were", "the", "independent", "predictors", "for", "CKD", ".", "We", "conclude", "that", "routine", "pathologic", "evaluation", "of", "non-neoplastic", "kidney", "provides", "valuable", "diagnostic", "and", "prognostic", "information", "." ]	[ "B-Finding", "B-Finding", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Patient or Disabled Group", "O", "B-Body System", "B-Body System", "B-Body System", "B-Neoplastic Process", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body System", "B-Body System", "B-Body System", "B-Neoplastic Process", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Activity", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "B-Temporal Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "B-Research Activity", "B-Research Activity", "O", "B-Patient or Disabled Group", "O", "B-Body System", "B-Body System", "B-Body System", "B-Neoplastic Process", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "B-Health Care Activity", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Biomedical Occupation or Discipline", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Temporal Concept", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "O", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Temporal Concept", "B-Injury or Poisoning", "O", "B-Temporal Concept", "B-Laboratory Procedure", "O", "O", "B-Functional Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Idea or Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Activity", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Functional Concept", "O", "B-Intellectual Product", "O", "O" ]
[ "Prospective", "study", "of", "dietary", "Non", "Enzymatic", "Antioxidant", "Capacity", "on", "the", "risk", "of", "hip", "fracture", "in", "the", "elderly", "Dietary", "antioxidants", "may", "play", "an", "important", "role", "in", "the", "prevention", "of", "bone", "loss", "and", "associated", "fractures", "by", "reducing", "levels", "of", "oxidative", "stress", ".", "We", "prospectively", "investigated", "the", "association", "between", "dietary", "Non", "Enzymatic", "Antioxidant", "Capacity", "(", "NEAC", ")", "and", "the", "risk", "of", "hip", "fracture", "and", "whether", "this", "effect", "was", "modified", "by", "smoking", ".", "In", "the", "Swedish", "National", "March", "Cohort", "13,409", "men", "and", "women", "over", "the", "age", "of", "55", "who", "had", "not", "experienced", "cancer", ",", "cardiovascular", "disease", "or", "hip", "fracture", ",", "were", "followed", "through", "record-linkages", "from", "1997", "through", "2010", ".", "NEAC", "was", "assessed", "by", "a", "validated", "food", "frequency", "questionnaire", "collected", "at", "baseline", ".", "We", "categorized", "the", "distribution", "of", "NEAC", "into", "sex", "-", "specific", "quartiles", "and", "used", "multivariable", "adjusted", "Cox", "proportional", "hazards", "regression", "models", "to", "estimate", "hazard", "ratios", "(", "HRs", ")", "with", "95", "%", "confidence", "intervals", "(", "95", "%", "CI", ")", ".", "During", "a", "mean", "follow-up", "time", "of", "12.4years", ",", "we", "identified", "491", "incident", "cases", "of", "first", "hip", "fracture", ".", "Subjects", "in", "the", "highest", "quartile", "of", "dietary", "NEAC", "had", "a", "39", "%", "lower", "risk", "of", "incident", "hip", "fracture", "compared", "to", "those", "in", "the", "lowest", "quartile", "(", "HR", ":", "0.61", ";", "95", "%", "CI", ":", "0.44-0.85", ")", ".", "The", "association", "was", "non-linear", "(", "p", "for", "non-linearity", ":", "0.004", ")", "with", "a", "potential", "threshold", "between", "the", "first", "and", "the", "second", "quartile", "and", "no", "further", "risk", "reduction", "at", "higher", "levels", "of", "dietary", "NEAC", ".", "Due", "to", "a", "low", "smoking", "prevalence", "in", "our", "study", "population", ",", "we", "had", "limited", "power", "to", "detect", "effect", "modification", "between", "dietary", "NEAC", "and", "smoking", "on", "a", "multiplicative", "or", "additive", "scale", ".", "Higher", "dietary", "NEAC", "intake", "is", "associated", "with", "lower", "risk", "of", "hip", "fracture", "in", "the", "elderly", "." ]	[ "O", "O", "O", "B-Food", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Idea or Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "B-Population Group", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Injury or Poisoning", "O", "O", "O", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "B-Idea or Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "O", "B-Individual Behavior", "O", "O", "O", "B-Population Group", "B-Population Group", "B-Population Group", "B-Population Group", "O", "B-Population Group", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "B-Organism Attribute", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Food", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "O", "B-Food", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Laboratory Procedure", "O", "B-Individual Behavior", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O" ]
[ "MiR-211", "is", "epigenetically", "regulated", "by", "DNMT1", "mediated", "methylation", "and", "inhibits", "EMT", "of", "melanoma", "cells", "by", "targeting", "RAB22A", "MiR-211", "has", "strong", "inhibitive", "effects", "on", "melanoma", "cell", "growth", ",", "invasion", "and", "metastasis", ".", "However", ",", "how", "it", "is", "downregulated", "and", "whether", "other", "genes", "are", "involved", "its", "downstream", "regulation", "in", "melanoma", "are", "not", "clear", ".", "In", "this", "study", ",", "we", "firstly", "verified", "the", "expression", "of", "miR-211", "in", "melanoma", "cell", "lines", "and", "observed", "that", "its", "downregulation", "is", "associated", "with", "increased", "DNMT1", "expression", ".", "By", "performing", "qRT-PCR", "and", "MSP", "analysis", ",", "we", "confirmed", "that", "DNMT1", "is", "negatively", "correlated", "with", "miR-211", "expression", "and", "can", "modulate", "DNA", "methylation", "in", "the", "promoter", "region", "of", "miR-211", ".", "By", "performing", "bioinformatics", "analysis", ",", "we", "found", "that", "RAB22A", "is", "a", "possible", "target", "of", "miR-211", ",", "which", "has", "two", "broadly", "conversed", "binding", "sites", "with", "miR-211", "in", "the", "3'UTR", ".", "Following", "dual", "luciferase", "assay", ",", "qRT-PCR", "and", "western", "blot", "analysis", "confirmed", "the", "direct", "binding", "between", "miR-211", "and", "RAB22A", "and", "the", "suppressive", "effect", "of", "miR-211", "on", "RAB22A", "expression", ".", "Knockdown", "of", "RAB22A", "increased", "epithelial", "properties", "and", "impaired", "mesenchymal", "properties", "of", "the", "melanoma", "cells", ",", "suggesting", "that", "miR-211", "modulates", "epithelial", "mesenchymal", "transition", "(", "EMT", ")", "of", "melanoma", "cells", "via", "downregulating", "RAB22A", ".", "In", "summary", ",", "the", "present", "study", "firstly", "demonstrated", "that", "DNMT1", "mediated", "promoter", "methylation", "is", "a", "mechanism", "of", "miRNA", "suppression", "in", "melanoma", "and", "revealed", "a", "new", "tumor", "suppressor", "role", "of", "the", "miR-211", "by", "targeting", "RAB22A", "in", "melanoma", ".", "The", "DNMT1", "/", "miR-211", "/", "RAB22A", "axis", "provides", "a", "novel", "insight", "into", "the", "pathogenesis", "of", "melanoma", ",", "particularly", "in", "the", "EMT", "process", "." ]	[ "B-Gene or Genome", "O", "B-Cell Function", "B-Cell Function", "O", "B-Gene or Genome", "O", "B-Molecular Function", "O", "B-Activity", "B-Cell Function", "O", "B-Cell", "B-Cell", "O", "B-Molecular Biology Research Technique", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Activity", "O", "O", "B-Neoplastic Process", "B-Cell Function", "B-Cell Function", "O", "B-Pathologic Function", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Molecular Function", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "B-Spatial Concept", "B-Molecular Function", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "B-Gene or Genome", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Molecular Function", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "B-Molecular Biology Research Technique", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "B-Spatial Concept", "B-Molecular Function", "B-Molecular Function", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Gene or Genome", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Biomedical Occupation or Discipline", "O", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "B-Functional Concept", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "B-Receptor", "B-Receptor", "O", "B-Gene or Genome", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Indicator, Reagent, or Diagnostic Aid", "B-Laboratory Procedure", "O", "B-Molecular Biology Research Technique", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "B-Molecular Function", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Genetic Function", "O", "B-Molecular Biology Research Technique", "O", "B-Gene or Genome", "O", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "O", "B-Cell", "B-Cell", "O", "O", "O", "B-Gene or Genome", "B-Spatial Concept", "B-Cell Function", "B-Cell Function", "B-Cell Function", "O", "B-Cell Function", "O", "O", "B-Cell", "B-Cell", "O", "B-Molecular Function", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Biologically Active Substance", "B-Molecular Function", "O", "O", "B-Functional Concept", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "B-Gene or Genome", "O", "B-Molecular Biology Research Technique", "B-Gene or Genome", "O", "B-Neoplastic Process", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O" ]
[ "Concordant", "but", "Varied", "Phenotypes", "among", "Duchenne", "Muscular", "Dystrophy", "Patient", "-Specific", "Myoblasts", "Derived", "using", "a", "Human", "iPSC", "-Based", "Model", "Duchenne", "muscular", "dystrophy", "(", "DMD", ")", "remains", "an", "intractable", "genetic", "disease", ".", "Althogh", "there", "are", "several", "animal", "models", "of", "DMD", ",", "there", "is", "no", "human", "cell", "model", "that", "carries", "patient", "-specific", "DYSTROPHIN", "mutations", ".", "Here", ",", "we", "present", "a", "human", "DMD", "model", "using", "human", "induced", "pluripotent", "stem", "cells", "(", "hiPSCs", ")", ".", "Our", "model", "reveals", "concordant", "disease", "-", "related", "phenotypes", "with", "patient", "-", "dependent", "variation", ",", "which", "are", "partially", "reversed", "by", "genetic", "and", "pharmacological", "approaches", ".", "Our", "``", "chemical-compound", "-based", "''", "strategy", "successfully", "directs", "hiPSCs", "into", "expandable", "myoblasts", ",", "which", "exhibit", "a", "myogenic", "transcriptional", "program", ",", "forming", "striated", "contractile", "myofibers", "and", "participating", "in", "muscle", "regeneration", "in", "vivo", ".", "DMD", "-", "hiPSC", "-derived", "myoblasts", "show", "disease", "-", "related", "phenotypes", "with", "patient", "-to-", "patient", "variability", ",", "including", "aberrant", "expression", "of", "inflammation", "or", "immune-response", "genes", "and", "collagens", ",", "increased", "BMP", "/", "TGFβ", "signaling", ",", "and", "reduced", "fusion", "competence", ".", "Furthermore", ",", "by", "genetic", "correction", "and", "pharmacological", "``", "dual-", "SMAD", "``", "inhibition", ",", "the", "DMD", "-", "hiPSC", "-derived", "myoblasts", "and", "genetically", "corrected", "isogenic", "myoblasts", "form", "``", "rescued", "''", "multi", "-", "nucleated", "myotubes", ".", "In", "conclusion", ",", "our", "findings", "demonstrate", "the", "feasibility", "of", "establishing", "a", "human", "``", "DMD", "-in-a-dish", "''", "model", "using", "hiPSC", "-based", "disease", "modeling", "." ]	[ "O", "O", "O", "B-Organism Attribute", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Cell", "O", "O", "O", "B-Human", "B-Cell", "O", "B-Experimental Model of Disease", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Experimental Model of Disease", "B-Experimental Model of Disease", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "O", "O", "O", "B-Human", "B-Disease or Syndrome", "B-Experimental Model of Disease", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Functional Concept", "B-Organism Attribute", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Chemical", "O", "O", "B-Research Activity", "O", "O", "B-Cell", "O", "O", "B-Cell", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Cell Component", "B-Cell Component", "O", "O", "O", "B-Finding", "B-Finding", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Disease or Syndrome", "O", "B-Cell", "O", "B-Cell", "O", "B-Disease or Syndrome", "O", "B-Functional Concept", "B-Organism Attribute", "O", "B-Patient or Disabled Group", "O", "B-Patient or Disabled Group", "B-Conceptual Entity", "O", "O", "B-Qualitative Concept", "O", "O", "B-Pathologic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "B-Molecular Function", "O", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Biologically Active Substance", "O", "B-Cell Function", "O", "O", "B-Disease or Syndrome", "O", "B-Cell", "O", "B-Cell", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Cell", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Human", "O", "B-Disease or Syndrome", "O", "O", "B-Experimental Model of Disease", "O", "B-Cell", "O", "B-Disease or Syndrome", "B-Experimental Model of Disease", "O" ]
[ "SNAI1", "promotes", "the", "development", "of", "HCC", "through", "the", "enhancement", "of", "proliferation", "and", "inhibition", "of", "apoptosis", "SNAI1", ",", "a", "zinc-finger", "transcription", "factor", ",", "plays", "an", "important", "role", "in", "the", "induction", "of", "epithelial-mesenchymal", "transition", "(", "EMT", ")", "in", "various", "cancers", ".", "However", ",", "the", "possible", "functions", "of", "SNAI1", "in", "the", "proliferation", "and", "apoptosis", "of", "hepatocellular", "carcinoma", "have", "not", "been", "clearly", "identified", ".", "In", "this", "study", ",", "we", "investigated", "the", "effects", "and", "mechanisms", "of", "SNAI1", "in", "the", "proliferation", "and", "apoptosis", "of", "hepatocellular", "carcinoma", "using", "clinical", "samples", "and", "cell", "lines", ".", "We", "found", "that", "SNAI1", "is", "highly", "expressed", "in", "the", "tissues", "of", "liver", "cancer", "compared", "with", "adjacent", "nontumor", "tissues", ".", "SNAI1", "is", "also", "highly", "expressed", "in", "the", "hepatoma", "cell", "lines", "HepG2", ",", "SMMC-7721", ",", "and", "BEL-7402", "compared", "with", "the", "human", "normal", "liver", "cell", "line", "L02", ".", "We", "also", "observed", "that", "SNAI1", "expression", "was", "correlated", "with", "distal", "metastasis", ",", "incomplete", "tumor", "capsule", "formation", ",", "and", "histological", "differentiation", "in", "hepatocellular", "carcinoma", "(", "HCC", ")", ".", "Moreover", ",", "we", "demonstrated", "that", "knockdown", "of", "SNAI1", "via", "lentiviral", "vectors", "of", "RNAi", "against", "SNAI", "inhibited", "cell", "proliferation", "by", "inducing", "G1", "arrest", ",", "which", "was", "accompanied", "by", "the", "downregulation", "of", "cyclin", "D1", "but", "not", "that", "of", "cyclin", "A", ".", "In", "addition", ",", "knockdown", "of", "SNAI1", "promoted", "apoptosis", "by", "decreasing", "the", "expression", "of", "Bcl-2", ".", "In", "conclusion", ",", "our", "findings", "revealed", "that", "SNAI1", "is", "involved", "in", "the", "development", "of", "hepatocellular", "carcinoma", "via", "regulating", "the", "growth", "and", "apoptosis", "of", "tumor", "cells", "." ]	[ "B-Biologically Active Substance", "B-Activity", "O", "B-Functional Concept", "O", "B-Neoplastic Process", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Cell Function", "B-Cell Function", "B-Cell Function", "B-Biologically Active Substance", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Cell Function", "B-Cell Function", "O", "B-Cell Function", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Functional Concept", "O", "B-Cell Function", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Biologically Active Substance", "O", "O", "B-Functional Concept", "O", "B-Cell Function", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Qualitative Concept", "B-Substance", "O", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Genetic Function", "O", "O", "B-Tissue", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Genetic Function", "O", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "O", "O", "B-Cell", "O", "O", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "O", "B-Gene or Genome", "O", "B-Virus", "B-Pharmacologic Substance", "O", "B-Genetic Function", "O", "B-Biologically Active Substance", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Cell Function", "B-Cell Function", "O", "O", "O", "O", "O", "O", "B-Molecular Function", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "O", "B-Gene or Genome", "B-Activity", "B-Cell Function", "O", "O", "O", "B-Genetic Function", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "O" ]
[ "Function", "and", "clinical", "meaningfulness", "of", "treatments", "for", "mild", "Alzheimer", "'s", "disease", "Effectiveness", "of", "Alzheimer", "'s", "disease", "(", "AD", ")", "treatments", "is", "commonly", "evaluated", "with", "coprimary", "outcomes", ";", "cognition", "with", "function", "to", "ensure", "clinical", "meaningfulness", "of", "a", "cognitive", "effect", ".", "We", "reviewed", "the", "literature", "for", "functional", "outcomes", "in", "mild", "AD", "or", "mild", "cognitive", "impairment", "(", "MCI", ")", "patients", "(", "distinct", "from", "combined", "mild-moderate", "/", "severe", "AD", ")", "treated", "with", "approved", "AD", "drugs", ".", "Cognitive", "and", "functional", "treatment", "differences", "in", "mild", "AD", "patients", "in", "solanezumab", "EXPEDITION", "/", "EXPEDITION2", "studies", "were", "compared", "across", "time", ".", "Seven", "publications", "provided", "MCI", "/", "mild", "AD", "functional", "outcomes", ",", "one", "of", "which", "reported", "a", "significant", "functional", "treatment", "effect", ".", "Secondary", "analyses", "of", "EXPEDITION", "studies", "suggested", "a", "smaller", "functional", "effect", "of", "solanezumab", "relative", "to", "cognition", ".", "An", "increasing", "effect", "of", "solanezumab", "over", "18", "months", "was", "shown", "for", "cognition", "and", "function", ".", "Function", "as", "the", "sole", "measure", "to", "demonstrate", "clinical", "meaningfulness", "of", "cognitive", "effects", "in", "mild", "AD", "may", "have", "limitations", ".", "For", "disease", "-", "modifying", "treatments", ",", "point", "differences", "on", "cognitive", "and", "functional", "scales", "should", "be", "qualified", "with", "duration", "of", "treatment", "." ]	[ "B-Mental Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Mental Process", "O", "B-Mental Process", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Mental Process", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Intellectual Product", "O", "B-Mental Process", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Pharmacologic Substance", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Mental Process", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Immunologic Factor", "B-Activity", "O", "B-Activity", "B-Research Activity", "O", "B-Activity", "O", "B-Temporal Concept", "O", "O", "B-Intellectual Product", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Mental Process", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Activity", "B-Research Activity", "O", "O", "O", "B-Mental Process", "B-Qualitative Concept", "O", "B-Immunologic Factor", "O", "O", "B-Mental Process", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Immunologic Factor", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Mental Process", "O", "B-Mental Process", "O", "B-Mental Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Mental Process", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "O", "O", "B-Disease or Syndrome", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Mental Process", "O", "B-Mental Process", "B-Intellectual Product", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O" ]
[ "Body", "mass", "index", "and", "suicide", "methods", "Overweight", "and", "obesity", "is", "associated", "with", "lower", "rates", "of", "suicide", ".", "However", ",", "little", "is", "known", "about", "the", "association", "with", "different", "suicide", "methods", ".", "We", "studied", "the", "association", "between", "groups", "of", "body", "mass", "index", "and", "suicide", "methods", ".", "We", "identified", "all", "medicolegal", "autopsy", "cases", "with", "a", "cause", "of", "death", "due", "to", "external", "causes", "in", "Sweden", "during", "1999-2013", "(", "N", "=", "39,368", ")", "and", "included", "11,715", "suicides", "and", "13,316", "accidents", "or", "homicides", "as", "controls", ".", "We", "applied", "multinomial", "regression", "models", "adjusted", "for", "age", ",", "sex", ",", "year", "and", "season", "of", "death", ".", "Obesity", "was", "associated", "with", "suicidal", "intoxication", ",", "OR", "1.15", "[", "95", "%", "confidence", "interval", "(", "CI", ")", "1.02", ",", "1.30", "]", "and", "negatively", "associated", "with", "all", "other", "suicide", "methods", "studied", ".", "Underweight", "showed", "a", "negative", "association", "with", "suicidal", "drowning", "and", "there", "was", "an", "indication", "towards", "a", "negative", "association", "with", "hanging", "in", "men", "OR", "0.81", "(", "95", "%", "CI", "0.65", ",", "1.01", ")", ".", "We", "conclude", "that", "body", "mass", "index", "(", "BMI", ")", "is", "associated", "with", "the", "choice", "of", "suicide", "method", ".", "This", "may", "be", "of", "importance", "in", "a", "public", "health", "perspective", ",", "e.g", ".", "potential", "for", "prevention", "of", "intoxications", ".", "In", "the", "practice", "of", "forensic", "medicine", ",", "the", "physician", "'s", "level", "of", "suspicion", "may", "rise", "if", "the", "apparent", "suicidal", "method", "is", "less", "common", "for", "the", "individual", "characteristics", "of", "the", "deceased", ",", "such", "as", "BMI", "." ]	[ "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Finding", "B-Functional Concept", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Finding", "B-Functional Concept", "O", "O", "O", "O", "B-Regulation or Law", "B-Diagnostic Procedure", "B-Functional Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Finding", "B-Finding", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Finding", "O", "O", "B-Phenomenon or Process", "O", "B-Individual Behavior", "O", "B-Group", "O", "O", "O", "B-Quantitative Concept", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Functional Concept", "O", "O", "B-Finding", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Finding", "B-Injury or Poisoning", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Injury or Poisoning", "O", "B-Population Group", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Finding", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Finding", "O", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Biomedical Occupation or Discipline", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "B-Mental Process", "O", "O", "O", "O", "B-Idea or Concept", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Organism Function", "O", "O", "O", "B-Clinical Attribute", "O" ]
[ "Quantitative", "assessment", "of", "fluorescent", "proteins", "The", "advent", "of", "fluorescent", "proteins", "(", "FPs", ")", "for", "genetic", "labeling", "of", "molecules", "and", "cells", "has", "revolutionized", "fluorescence", "microscopy", ".", "Genetic", "manipulations", "have", "created", "a", "vast", "array", "of", "bright", "and", "stable", "FPs", "spanning", "blue", "to", "red", "spectral", "regions", ".", "Common", "to", "autofluorescent", "FPs", "is", "their", "tight", "β-barrel", "structure", ",", "which", "provides", "the", "rigidity", "and", "chemical", "environment", "needed", "for", "effectual", "fluorescence", ".", "Despite", "the", "common", "structure", ",", "each", "FP", "has", "unique", "properties", ".", "Thus", ",", "there", "is", "no", "single", "'best", "'", "FP", "for", "every", "circumstance", ",", "and", "each", "FP", "has", "advantages", "and", "disadvantages", ".", "To", "guide", "decisions", "about", "which", "FP", "is", "right", "for", "a", "given", "application", ",", "we", "have", "quantitatively", "characterized", "the", "brightness", ",", "photostability", ",", "pH", "stability", "and", "monomeric", "properties", "of", "more", "than", "40", "FPs", "to", "enable", "straightforward", "and", "direct", "comparison", "between", "them", ".", "We", "focus", "on", "popular", "and/or", "top-performing", "FPs", "in", "each", "spectral", "region", "." ]	[ "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Substance", "O", "B-Cell", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Spatial Concept", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "B-Laboratory Procedure", "B-Biologically Active Substance", "O", "O", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Chemical", "B-Spatial Concept", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "B-Molecular Sequence", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Finding", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Chemical Viewed Structurally", "B-Qualitative Concept", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O" ]
[ "Cognitive", "impairment", "in", "HIV", "and", "HCV", "co-infected", "patients", ":", "a", "systematic", "review", "and", "meta-analysis", "Cognitive", "impairment", "has", "been", "well", "documented", "in", "human", "immunodeficiency", "virus", "(", "HIV", ")", "and", "hepatitis", "C", "virus", "(", "HCV", ")", "mono-infections", ".", "However", ",", "in", "the", "context", "of", "HIV", "/", "HCV", "co-infection", "the", "research", "is", "more", "limited", ".", "The", "aim", "of", "this", "systematic", "review", "was", "to", "describe", "the", "characteristics", "of", "cognitive", "impairment", "in", "HIV", "/", "HCV", "co-infection", "and", "to", "examine", "the", "differences", "in", "cognitive", "performance", "between", "HIV", "/", "HCV", "and", "HIV", "and", "HCV", "mono-infected", "patients", ".", "Of", "the", "437", "records", "initially", "screened", ",", "24", "papers", "met", "the", "inclusion", "criteria", "and", "were", "included", "in", "the", "systematic", "review", ".", "Four", "studies", "were", "included", "in", "the", "meta-analysis", ".", "Most", "studies", "indicated", "that", "HIV", "/", "HCV", "co-infected", "patients", "had", "a", "higher", "level", "of", "cognitive", "impairment", "than", "HIV", "mono-infected", "patients", ".", "Meta-analysis", "also", "indicated", "that", "HIV", "mono-infected", "patients", "had", "a", "significantly", "lower", "global", "deficit", "score", "than", "co-infected", "patients", ".", "The", "results", "also", "indicated", "that", "co-infected", "patients", "were", "more", "likely", "to", "be", "impaired", "in", "information", "processing", "speed", "than", "HIV", "mono-infected", "patients", ".", "These", "findings", "can", "be", "challenged", "by", "biasing", "factors", "such", "as", "the", "small", "number", "of", "included", "studies", ",", "heterogeneity", "of", "the", "samples", "and", "a", "large", "diversity", "of", "methodological", "procedures", ".", "Future", "research", "with", "consistent", "and", "comprehensive", "neuropsychological", "batteries", "and", "covering", "a", "greater", "diversity", "of", "risk", "factors", "is", "needed", ",", "in", "order", "to", "clarify", "the", "effects", "of", "both", "viruses", "on", "cognitive", "function", "and", "the", "mechanisms", "that", "underlie", "these", "effects", ".", "Because", "cognitive", "impairments", "may", "pose", "significant", "challenges", "to", "medication", "adherence", ",", "quality", "of", "life", "and", "overall", "functioning", ",", "such", "knowledge", "may", "have", "important", "implications", "to", "the", "planning", "and", "implementation", "of", "effective", "interventions", "aimed", "at", "optimising", "the", "clinical", "management", "of", "these", "infections", "." ]	[ "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Virus", "O", "B-Virus", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "B-Intellectual Product", "O", "B-Research Activity", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "O", "O", "O", "B-Virus", "B-Virus", "B-Virus", "O", "B-Virus", "O", "O", "B-Virus", "B-Virus", "B-Virus", "O", "B-Virus", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Virus", "O", "B-Virus", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Virus", "O", "B-Virus", "B-Disease or Syndrome", "O", "O", "B-Finding", "O", "O", "O", "B-Mental Process", "B-Mental Process", "O", "B-Virus", "O", "B-Virus", "O", "B-Virus", "O", "B-Virus", "B-Pathologic Function", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Research Activity", "O", "O", "B-Virus", "O", "B-Virus", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Virus", "B-Pathologic Function", "B-Patient or Disabled Group", "O", "B-Research Activity", "O", "O", "O", "B-Virus", "B-Pathologic Function", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "B-Virus", "B-Pathologic Function", "B-Patient or Disabled Group", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Group Attribute", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Virus", "O", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "O", "B-Health Care Activity", "O", "B-Finding", "B-Finding", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Pathologic Function", "O" ]
[ "Consumption", "of", "fruits", "and", "vegetables", "associated", "with", "other", "risk", "behaviors", "among", "adolescents", "in", "Northeast", "Brazil", "To", "determine", "the", "prevalence", "of", "consumption", "of", "fruits", "and", "vegetables", "and", "identify", "the", "association", "with", "low", "level", "of", "physical", "activity", ",", "exposure", "to", "sedentary", "behavior", ",", "consumption", "of", "soft", "drinks", "and", "overweight", "/", "obesity", "in", "adolescents", ".", "This", "is", "a", "cross-sectional", "school-based", "study", "with", "a", "representative", "sample", "of", "3992", "students", "aged", "14-19", "years", "from", "the", "state", "of", "Sergipe", ",", "Brazil", ".", "The", "outcome", "was", "low", "consumption", "of", "fruits", "and", "vegetables", "(", "<", "5", "servings/day", ")", ".", "Independent", "variables", "were", ":", "level", "of", "physical", "activity", ",", "sedentary", "behavior", ",", "consumption", "of", "soft", "drinks", ",", "and", "overweight", "/", "obesity", ".", "Global", "Student", "Health", "Survey", "questionnaire", "and", "body", "mass", "and", "height", "measurements", "were", "used", ",", "as", "well", "as", "chi-square", "test", "and", "crude", "and", "adjusted", "binary", "logistic", "regression", ".", "The", "significance", "level", "adopted", "was", "5", "%", ".", "The", "prevalence", "of", "inadequate", "consumption", "of", "fruits", "and", "vegetables", "was", "high", "-", "88.6", "%", "(", "95", "%", "CI", "=87.6-89.5", ")", ".", "Higher", "likelihood", "of", "low", "consumption", "of", "fruits", "and", "vegetables", "was", "verified", "among", "boys", "who", "were", "exposed", "to", "sedentary", "behavior", "(", "OR", "=1.63", ";", "95", "%", "CI", "=1.18-2.24", ")", ",", "who", "consumed", "soft", "drinks", "(", "OR", "=3.04", ";", "95", "%", "CI", "=2.10-4.40", ")", ",", "with", "insufficiently", "physical", "activity", "(", "OR", "=1.98", ";", "95", "%", "CI", "=1.43-2.73", ")", "and", "girls", "who", "consumed", "soft", "drinks", "(", "OR", "=1.88", ";", "95", "%", "CI", "=1.43-2.47", ")", "and", "those", "with", "overweight", "/", "obesity", "(", "OR", "=1.63", ";", "95", "%", "CI", "=1.19-2.23", ")", ".", "There", "is", "a", "need", "of", "public", "policies", "aimed", "at", "encouraging", "the", "consumption", "of", "healthy", "foods", "among", "adolescents", "." ]	[ "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "B-Age Group", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "B-Quantitative Concept", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "B-Activity", "O", "B-Food", "B-Food", "O", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Age Group", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Substance", "O", "O", "B-Population Group", "O", "O", "B-Temporal Concept", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Finding", "B-Finding", "O", "B-Activity", "O", "B-Food", "B-Food", "O", "O", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Organism Attribute", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "O", "O", "B-Age Group", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Activity", "B-Food", "B-Food", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Age Group", "O", "B-Activity", "B-Food", "B-Food", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Governmental or Regulatory Activity", "B-Governmental or Regulatory Activity", "O", "O", "O", "O", "B-Activity", "B-Activity", "B-Activity", "B-Activity", "O", "B-Age Group", "O" ]
[ "Usefulness", "of", "Embolization", "for", "Iatrogenic", "Dural", "Arteriovenous", "Fistula", "Associated", "with", "Recurrent", "Chronic", "Subdural", "Hematoma", ":", "A", "Case", "Report", "and", "Literature", "Review", "Refractory", "chronic", "subdural", "hematomas", "due", "to", "iatrogenic", "dural", "arteriovenous", "fistulas", "(", "dAVFs", ")", "are", "difficult", "to", "treat", ".", "We", "report", "our", "experience", "and", "propose", "a", "guideline", "on", "basis", "of", "a", "literature", "review", "for", "the", "usefulness", "of", "embolization", "of", "middle", "meningeal", "artery", "(", "MMA", ")", "for", "the", "treatment", "of", "the", "same", ".", "We", "report", "a", "case", "with", "right", "hemiparesis", "and", "aphasia", "1", "month", "after", "a", "fall", "from", "a", "bicycle", ".", "Computed", "tomography", "scan", "of", "the", "head", "showed", "left", "chronic", "subdural", "hematoma", ",", "which", "was", "evacuated", "by", "burr-hole", "drainage", ".", "The", "postoperative", "course", "was", "complicated", "by", "reaccumulation", "within", "short", "period", "of", "time", ".", "On", "superselective", "digital", "subtraction", "angiography", "of", "MMA", ",", "iatrogenic", "dAVF", "was", "found", "on", "left", "side", ".", "We", "embolized", "successfully", "it", "using", "n-butyl", "cyanoacrylate", "after", "a", "third", "irrigation", ".", "No", "reaccumulation", "found", "in", "the", "postoperative", "period", "or", "at", "last", "follow-up", ".", "We", "propose", "treatment", "protocol", "based", "on", "our", "experience", "and", "literature", "review", ".", "Refractory", "chronic", "subdural", "hematoma", "with", "reaccumulation", "within", "a", "short", "interval", "should", "be", "subjected", "to", "digital", "subtraction", "angiography", "of", "the", "MMA", ".", "Embolization", "of", "ipsilateral", "MMA", "is", "safe", ",", "effective", ",", "and", "a", "useful", "option", "for", "the", "treatment", "of", "iatrogenic", "dAVF", "and", "resolution", "of", "hematoma", "." ]	[ "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "B-Qualitative Concept", "B-Qualitative Concept", "B-Temporal Concept", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Functional Concept", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Disease or Syndrome", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "O", "B-Anatomical Abnormality", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Finding", "B-Finding", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Temporal Concept", "O", "O", "B-Finding", "O", "O", "B-Manufactured Object", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Body Location or Region", "O", "B-Spatial Concept", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Functional Concept", "O", "B-Finding", "O", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Disease or Syndrome", "B-Anatomical Abnormality", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Qualitative Concept", "O", "O", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Qualitative Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Functional Concept", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Finding", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Spatial Concept", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Anatomical Abnormality", "O", "B-Conceptual Entity", "O", "B-Pathologic Function", "O" ]
[ "In", "Search", "of", "the", "E.", "coli", "Compounds", "that", "Change", "the", "Antibiotic", "Production", "Pattern", "of", "Streptomyces", "coelicolor", "During", "Inter-species", "Interaction", "The", "aim", "of", "this", "work", "was", "to", "investigate", "the", "interaction", "between", "E.coli", "and", "Streptomyces", "coelicolor", "A3", "(", "2", ")", "for", "the", "increased", "production", "of", "undecylprodigiosin", "and", "identify", "the", "E.", "coli", "actives", "mediating", "this", "inter-species", "interaction", ".", "The", "antibiotics", "of", "interest", "were", "the", "red-pigmented", "undecylprodigiosin", "and", "blue-pigmented", "actinorhodin", ".", "Pure", "cultures", "of", "S.", "coelicolor", "in", "a", "defined", "medium", "produced", "higher", "concentrations", "of", "actinorhodin", "compared", "to", "those", "of", "undecylprodigiosin", ".", "The", "latter", "however", ",", "is", "more", "important", "due", "to", "its", "immunosuppressive", "and", "antitumor", "properties", ".", "As", "a", "strategy", "to", "increase", "undecylprodigiosin", "production", ",", "we", "added", "separately", ",", "live", "cells", "and", "heat-killed", "cells", "of", "E.", "coli", "C600", ",", "and", "the", "cell-free", "supernatant", "of", "E.", "coli", "culture", "to", "S.", "coelicolor", "cultures", "in", "shake", "flasks", ".", "The", "interaction", "with", "live", "cells", "of", "E.", "coli", "altered", "the", "antibiotic", "production", "pattern", "and", "undecylprodigiosin", "production", "was", "enhanced", "by", "3.5-fold", "compared", "to", "the", "pure", "cultures", "of", "S.", "coelicolor", "and", "actinorhodin", "decreased", "by", "15-fold", ".", "The", "heat-killed", "cells", "of", "E.", "coli", "however", ",", "had", "no", "effect", "on", "antibiotic", "production", ".", "In", "all", "cases", ",", "growth", "and", "glucose", "consumption", "of", "S.", "coelicolor", "remained", "almost", "the", "same", "as", "those", "observed", "in", "the", "pure", "culture", "indicating", "that", "the", "changes", "in", "antibiotic", "production", "were", "not", "due", "to", "nutritional", "stress", ".", "Results", "with", "cell-free", "supernatant", "of", "E.", "coli", "culture", "indicated", "that", "the", "interaction", "between", "S.", "coelicolor", "and", "E.", "coli", "was", "mediated", "via", "diffusible", "molecule", "(", "s", ")", ".", "Using", "a", "set", "of", "extraction", "procedures", "and", "agar-well", "diffusion", "bioassays", ",", "we", "isolated", "and", "preliminarily", "identified", "a", "class", "of", "compounds", ".", "For", "the", "preliminary", "verification", ",", "we", "added", "the", "compound", "which", "was", "the", "common", "chemical", "structural", "moiety", "in", "this", "class", "of", "compounds", "to", "the", "pure", "S.", "coelicolor", "cultures", ".", "We", "observed", "similar", "effects", "on", "antibiotic", "production", "as", "with", "the", "live", "E.", "coli", "cells", "and", "their", "supernatant", "indicating", "that", "this", "class", "of", "compounds", "secreted", "by", "E.", "coli", "indeed", "could", "act", "as", "actives", "during", "interspecies", "interaction", "and", "increase", "the", "production", "of", "undecylprodigiosin", "." ]	[ "O", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Biologically Active Substance", "O", "O", "O", "B-Antibiotic", "B-Functional Concept", "O", "O", "B-Bacterium", "B-Bacterium", "O", "B-Social Behavior", "B-Social Behavior", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Bacterium", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "B-Quantitative Concept", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Functional Concept", "B-Social Behavior", "O", "B-Social Behavior", "B-Social Behavior", "O", "O", "B-Antibiotic", "O", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "B-Antibiotic", "O", "O", "B-Laboratory Procedure", "O", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Quantitative Concept", "O", "B-Antibiotic", "B-Activity", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Pharmacologic Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "B-Phenomenon or Process", "B-Cell", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Body Substance", "B-Body Substance", "O", "B-Bacterium", "B-Bacterium", "B-Laboratory Procedure", "O", "B-Bacterium", "B-Bacterium", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Functional Concept", "O", "B-Cell", "B-Cell", "O", "B-Bacterium", "B-Bacterium", "O", "O", "B-Antibiotic", "B-Functional Concept", "O", "O", "B-Pharmacologic Substance", "B-Functional Concept", "O", "B-Activity", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Bacterium", "B-Bacterium", "O", "B-Antibiotic", "B-Quantitative Concept", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Cell", "O", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Antibiotic", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Finding", "B-Finding", "O", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "B-Functional Concept", "O", "B-Antibiotic", "B-Functional Concept", "O", "O", "O", "O", "B-Organism Function", "B-Finding", "O", "B-Functional Concept", "O", "B-Body Substance", "B-Body Substance", "O", "B-Bacterium", "B-Bacterium", "B-Laboratory Procedure", "O", "O", "O", "B-Functional Concept", "O", "B-Bacterium", "B-Bacterium", "O", "B-Bacterium", "B-Bacterium", "O", "B-Social Behavior", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Antibiotic", "B-Functional Concept", "O", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Cell", "O", "O", "B-Body Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Cell Function", "O", "B-Bacterium", "B-Bacterium", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Social Behavior", "B-Social Behavior", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O" ]
[ "Group", "III/IV", "muscle", "afferents", "limit", "the", "intramuscular", "metabolic", "perturbation", "during", "whole", "body", "exercise", "in", "humans", "The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "role", "of", "group", "III/IV", "muscle", "afferents", "in", "limiting", "the", "endurance", "exercise", "-", "induced", "metabolic", "perturbation", "assayed", "in", "muscle", "biopsy", "samples", "taken", "from", "locomotor", "muscle", ".", "Lumbar", "intrathecal", "fentanyl", "was", "used", "to", "attenuate", "the", "central", "projection", "of", "μ-opioid", "receptor", "-", "sensitive", "locomotor", "muscle", "afferents", "during", "a", "5", "km", "cycling", "time", "trial", ".", "The", "findings", "suggest", "that", "the", "central", "projection", "of", "group", "III/IV", "muscle", "afferent", "feedback", "constrains", "voluntary", "neural", "'", "drive", "'", "to", "working", "locomotor", "muscle", "and", "limits", "the", "exercise", "-", "induced", "intramuscular", "metabolic", "perturbation", ".", "Therefore", ",", "the", "CNS", "might", "regulate", "the", "degree", "of", "metabolic", "perturbation", "within", "locomotor", "muscle", "and", "thereby", "limit", "peripheral", "fatigue", ".", "It", "appears", "that", "the", "group", "III/IV", "muscle", "afferents", "are", "an", "important", "neural", "link", "in", "this", "regulatory", "mechanism", ",", "which", "probably", "serves", "to", "protect", "locomotor", "muscle", "from", "the", "potentially", "severe", "functional", "impairment", "as", "a", "consequence", "of", "severe", "intramuscular", "metabolic", "disturbance", ".", "To", "investigate", "the", "role", "of", "metabo", "-", "and", "mechanosensitive", "group", "III/IV", "muscle", "afferents", "in", "limiting", "the", "intramuscular", "metabolic", "perturbation", "during", "whole", "body", "endurance", "exercise", ",", "eight", "subjects", "performed", "5", "km", "cycling", "time", "trials", "under", "control", "conditions", "(", "CTRL", ")", "and", "with", "lumbar", "intrathecal", "fentanyl", "impairing", "lower", "limb", "muscle", "afferent", "feedback", "(", "FENT", ")", ".", "Vastus", "lateralis", "muscle", "biopsies", "were", "obtained", "before", "and", "immediately", "after", "exercise", ".", "Motoneuronal", "output", "was", "estimated", "through", "vastus", "lateralis", "surface", "electromyography", "(", "EMG", ")", ".", "Exercise", "-", "induced", "changes", "in", "intramuscular", "metabolites", "were", "determine", "d", "using", "liquid", "and", "gas", "chromatography-mass", "spectrometry", ".", "Quadriceps", "fatigue", "was", "quantified", "by", "pre", "-", "to", "post", "-", "exercise", "changes", "in", "potentiated", "quadriceps", "twitch", "torque", "(", "ΔQTsingle", ")", "evoked", "by", "electrical", "femoral", "nerve", "stimulation", ".", "Although", "motoneuronal", "output", "was", "21", "±", "12", "%", "higher", "during", "FENT", "compared", "to", "CTRL", "(", "P", "<", "0.05", ")", ",", "time", "to", "complete", "the", "time", "trial", "was", "similar", "(", "∼8.8", "min", ")", ".", "Compared", "to", "CTRL", ",", "power", "output", "during", "FENT", "was", "10", "±", "4", "%", "higher", "in", "the", "first", "half", "of", "the", "time", "trial", ",", "but", "11", "±", "5", "%", "lower", "in", "the", "second", "half", "(", "both", "P", "<", "0.01", ")", ".", "The", "exercise", "-", "induced", "increase", "in", "intramuscular", "inorganic", "phosphate", ",", "H", "(", "+", ")", ",", "adenosine", "diphosphate", ",", "lactate", "and", "phosphocreatine", "depletion", "was", "55", "±", "30", ",", "62", "±", "18", ",", "129", "±", "63", ",", "47", "±", "14", "(", "P", "<", "0.001", ")", "and", "27", "±", "14", "%", "(", "P", "<", "0.01", ")", "greater", "in", "FENT", "than", "CTRL", ".", "ΔQTsingle", "was", "greater", "following", "FENT", "than", "CTRL", "(", "-52", "±", "2", "vs", "-31", "±", "1", "%", ",", "P", "<", "0.001", ")", "and", "this", "difference", "was", "positively", "correlated", "with", "the", "difference", "in", "inorganic", "phosphate", "(", "r", "(", "2", ")", "=", "0.79", ";", "P", "<", "0.01", ")", "and", "H", "(", "+", ")", "(", "r", "(", "2", ")", "=", "0.92", ";", "P", "<", "0.01", ")", ".", "In", "conclusion", ",", "during", "whole", "body", "exercise", ",", "group", "III/IV", "muscle", "afferents", "provide", "feedback", "to", "the", "CNS", "which", ",", "in", "turn", ",", "constrains", "motoneuronal", "output", "to", "the", "active", "skeletal", "muscle", ".", "This", "regulatory", "mechanism", "limits", "the", "exercise", "-", "induced", "intramuscular", "metabolic", "perturbation", ",", "preventing", "an", "abnormal", "homeostatic", "challenge", "and", "excessive", "peripheral", "fatigue", "." ]	[ "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "B-Functional Concept", "O", "B-Spatial Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Anatomical Structure", "B-Anatomical Structure", "B-Daily or Recreational Activity", "O", "B-Human", "O", "B-Functional Concept", "O", "O", "B-Research Activity", "O", "O", "B-Laboratory Procedure", "O", "B-Conceptual Entity", "O", "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "O", "B-Functional Concept", "O", "B-Finding", "B-Daily or Recreational Activity", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "B-Laboratory Procedure", "O", "B-Tissue", "B-Tissue", "B-Tissue", "O", "O", "B-Organism Function", "B-Tissue", "O", "B-Body Location or Region", "B-Body Space or Junction", "B-Pharmacologic Substance", "O", "O", "O", "B-Activity", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Receptor", "B-Receptor", "O", "B-Functional Concept", "B-Organism Function", "B-Tissue", "B-Cell", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Research Activity", "O", "O", "B-Finding", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "B-Physiologic Function", "B-Conceptual Entity", "B-Individual Behavior", "B-Functional Concept", "O", "B-Mental Process", "O", "O", "B-Functional Concept", "B-Organism Function", "B-Tissue", "O", "B-Functional Concept", "O", "B-Daily or Recreational Activity", "O", "B-Functional Concept", "B-Spatial Concept", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Body System", "O", "B-Biologic Function", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Organism Function", "B-Tissue", "O", "O", "B-Functional Concept", "B-Spatial Concept", "B-Sign or Symptom", "O", "O", "B-Qualitative Concept", "O", "O", "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Body Space or Junction", "O", "O", "B-Biologic Function", "B-Functional Concept", "O", "O", "B-Idea or Concept", "O", "O", "B-Finding", "B-Organism Function", "B-Tissue", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "O", "B-Conceptual Entity", "O", "B-Organism Function", "O", "O", "B-Qualitative Concept", "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "O", "B-Functional Concept", "O", "B-Spatial Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Anatomical Structure", "B-Anatomical Structure", "B-Finding", "B-Daily or Recreational Activity", "O", "O", "B-Group", "B-Functional Concept", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Research Activity", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "B-Body Location or Region", "B-Body Space or Junction", "B-Pharmacologic Substance", "B-Functional Concept", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Tissue", "B-Cell", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Tissue", "B-Tissue", "O", "B-Functional Concept", "B-Temporal Concept", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Daily or Recreational Activity", "O", "B-Cell", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "B-Daily or Recreational Activity", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Spatial Concept", "B-Biologically Active Substance", "O", "B-Laboratory Procedure", "O", "O", "B-Substance", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Sign or Symptom", "O", "B-Quantitative Concept", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "B-Daily or Recreational Activity", "B-Functional Concept", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Cell", "B-Activity", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Physiologic Function", "B-Activity", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "B-Temporal Concept", "B-Research Activity", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Finding", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "B-Physiologic Function", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Temporal Concept", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Daily or Recreational Activity", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Spatial Concept", "B-Inorganic Chemical", "B-Inorganic Chemical", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Physiologic Function", "O", "B-Finding", "O", "B-Phenomenon or Process", "O", "B-Quantitative Concept", "O", "B-Physiologic Function", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Anatomical Structure", "B-Anatomical Structure", "B-Daily or Recreational Activity", "O", "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "B-Activity", "B-Physiologic Function", "O", "O", "B-Body System", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Cell", "B-Activity", "O", "O", "B-Functional Concept", "B-Tissue", "B-Tissue", "O", "O", "B-Biologic Function", "B-Functional Concept", "B-Functional Concept", "O", "B-Daily or Recreational Activity", "O", "B-Functional Concept", "B-Spatial Concept", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Finding", "B-Finding", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Sign or Symptom", "O" ]
[ "Incidence", "of", "crown", "fracture", "and", "risk", "factors", "in", "the", "primary", "dentition", ":", "a", "prospective", "longitudinal", "study", "Few", "studies", "have", "assessed", "the", "incidence", "and", "risk", "factors", "to", "crown", "fractures", "in", "preschool", "children", ".", "The", "aim", "of", "this", "study", "was", "to", "estimate", "the", "incidence", "of", "crown", "fracture", "in", "the", "primary", "dentition", "over", "a", "1-year", "follow-up", "period", ",", "identify", "risk", "factors", ",", "and", "test", "the", "hypothesis", "that", "children", "with", "previous", "crown", "fracture", "are", "more", "prone", "to", "experience", "further", "cases", "of", "crown", "fracture", "independently", "of", "other", "risk", "factors", ".", "This", "study", "was", "developed", "in", "two", "phases", ":", "cross-sectional", "and", "prospective", "longitudinal", "study", ".", "The", "cross-sectional", "study", "was", "carried", "out", "261", "preschool", "children", ".", "The", "prospective", "longitudinal", "study", "was", "carried", "out", "194", "children", "allocated", "to", "two", "groups", ":", "exposed", "group", "(", "children", "with", "prior", "exposure", "to", "crown", "fracture", ")", "and", "non", "-", "exposed", "group", "(", "children", "without", "prior", "exposure", ")", ".", "On", "both", "occasions", ",", "children", "were", "examined", "for", "the", "diagnosis", "of", "crown", "fracture", "and", "evaluation", "of", "lip", "coverage", "and", "overjet", ".", "The", "parents", "were", "interviewed", "with", "regard", "to", "the", "socioeconomic", "indicators", ".", "New", "cases", "of", "crown", "fracture", "were", "identified", "based", "on", "the", "comparison", "of", "the", "two", "examinations", ".", "Data", "analysis", "involved", "Pearson", "'s", "chi-square", "test", ",", "McNemar", "'s", "test", ",", "and", "Poisson", "regression", "with", "robust", "variance", ".", "Among", "the", "261", "children", "who", "participated", "in", "the", "cross-sectional", "study", ",", "194", "were", "re-examined", "(", "65", "in", "the", "exposed", "group", "and", "129", "in", "the", "non", "-", "exposed", "group", ")", ".", "The", "overall", "incidence", "of", "crown", "fracture", "was", "55.7", "%", "(", "n", "=", "108", ")", ".", "The", "difference", "in", "percentage", "of", "increased", "risk", "of", "crown", "fracture", "in", "exposed", "and", "non", "-", "exposed", "groups", "was", "13.4", "%", ".", "A", "greater", "incidence", "of", "crown", "fracture", "was", "found", "in", "the", "exposed", "group", "(", "64.6", "%", ";", "P", "<", "0,001", ")", ".", "The", "children", "exposed", "(", "RR", ":", "1.30", ";", "95", "%", "CI", ":", "1.01-1.67", ")", "had", "a", "greater", "risk", "of", "developing", "new", "cases", "of", "crown", "fracture", "in", "comparison", "with", "the", "non", "-", "exposed", "group", ".", "The", "incidence", "of", "crown", "fracture", "was", "high", "and", "children", "with", "previous", "crown", "fracture", "had", "a", "greater", "risk", "of", "suffering", "new", "cases", "of", "crown", "fracture", "during", "the", "1-year", "follow-up", "period", "." ]	[ "B-Quantitative Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Finding", "B-Finding", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Age Group", "B-Age Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Health Care Activity", "B-Temporal Concept", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Age Group", "O", "B-Temporal Concept", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Age Group", "B-Age Group", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Age Group", "O", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "B-Age Group", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "B-Finding", "O", "B-Population Group", "B-Population Group", "O", "B-Age Group", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Age Group", "O", "O", "O", "O", "B-Finding", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Anatomical Abnormality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Age Group", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "B-Finding", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "B-Finding", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Age Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "B-Finding", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Quantitative Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "B-Age Group", "O", "B-Temporal Concept", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "B-Health Care Activity", "B-Temporal Concept", "O" ]
[ "An", "Efficient", "and", "Reliable", "Statistical", "Method", "for", "Estimating", "Functional", "Connectivity", "in", "Large", "Scale", "Brain", "Networks", "Using", "Partial", "Correlation", "Currently", ",", "network-oriented", "analysis", "of", "fMRI", "data", "has", "become", "an", "important", "tool", "for", "understanding", "brain", "organization", "and", "brain", "networks", ".", "Among", "the", "range", "of", "network", "modeling", "methods", ",", "partial", "correlation", "has", "shown", "great", "promises", "in", "accurately", "detecting", "true", "brain", "network", "connections", ".", "However", ",", "the", "application", "of", "partial", "correlation", "in", "investigating", "brain", "connectivity", ",", "especially", "in", "large-scale", "brain", "networks", ",", "has", "been", "limited", "so", "far", "due", "to", "the", "technical", "challenges", "in", "its", "estimation", ".", "In", "this", "paper", ",", "we", "propose", "an", "efficient", "and", "reliable", "statistical", "method", "for", "estimating", "partial", "correlation", "in", "large-scale", "brain", "network", "modeling", ".", "Our", "method", "derives", "partial", "correlation", "based", "on", "the", "precision", "matrix", "estimated", "via", "Constrained", "L1-minimization", "Approach", "(", "CLIME", ")", ",", "which", "is", "a", "recently", "developed", "statistical", "method", "that", "is", "more", "efficient", "and", "demonstrates", "better", "performance", "than", "the", "existing", "methods", ".", "To", "help", "select", "an", "appropriate", "tuning", "parameter", "for", "sparsity", "control", "in", "the", "network", "estimation", ",", "we", "propose", "a", "new", "Dens-based", "selection", "method", "that", "provides", "a", "more", "informative", "and", "flexible", "tool", "to", "allow", "the", "users", "to", "select", "the", "tuning", "parameter", "based", "on", "the", "desired", "sparsity", "level", ".", "Another", "appealing", "feature", "of", "the", "Dens-based", "method", "is", "that", "it", "is", "much", "faster", "than", "the", "existing", "methods", ",", "which", "provides", "an", "important", "advantage", "in", "neuroimaging", "applications", ".", "Simulation", "studies", "show", "that", "the", "Dens-based", "method", "demonstrates", "comparable", "or", "better", "performance", "with", "respect", "to", "the", "existing", "methods", "in", "network", "estimation", ".", "We", "applied", "the", "proposed", "partial", "correlation", "method", "to", "investigate", "resting", "state", "functional", "connectivity", "using", "rs-fMRI", "data", "from", "the", "Philadelphia", "Neurodevelopmental", "Cohort", "(", "PNC", ")", "study", ".", "Our", "results", "show", "that", "partial", "correlation", "analysis", "removed", "considerable", "between-module", "marginal", "connections", "identified", "by", "full", "correlation", "analysis", ",", "suggesting", "these", "connections", "were", "likely", "caused", "by", "global", "effects", "or", "common", "connection", "to", "other", "nodes", ".", "Based", "on", "partial", "correlation", ",", "we", "find", "that", "the", "most", "significant", "direct", "connections", "are", "between", "homologous", "brain", "locations", "in", "the", "left", "and", "right", "hemisphere", ".", "When", "comparing", "partial", "correlation", "derived", "under", "different", "sparse", "tuning", "parameters", ",", "an", "important", "finding", "is", "that", "the", "sparse", "regularization", "has", "more", "shrinkage", "effects", "on", "negative", "functional", "connections", "than", "on", "positive", "connections", ",", "which", "supports", "previous", "findings", "that", "many", "of", "the", "negative", "brain", "connections", "are", "due", "to", "non-neurophysiological", "effects", ".", "An", "R", "package", "``", "DensParcorr", "''", "can", "be", "downloaded", "from", "CRAN", "for", "implementing", "the", "proposed", "statistical", "methods", "." ]	[ "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Research Activity", "B-Research Activity", "O", "B-Quantitative Concept", "B-Functional Concept", "B-Spatial Concept", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "B-Organism Function", "B-Research Activity", "O", "B-Diagnostic Procedure", "B-Idea or Concept", "O", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Physiologic Function", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "O", "O", "O", "O", "O", "B-Organism Function", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Body Part, Organ, or Organ Component", "B-Spatial Concept", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Research Activity", "B-Research Activity", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "B-Research Activity", "O", "O", "B-Intellectual Product", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Activity", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "B-Qualitative Concept", "O", "O", "B-Organism Function", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "O", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Organism Function", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "B-Intellectual Product", "O", "B-Functional Concept", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "B-Research Activity", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Location or Region", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Spatial Concept", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Finding", "B-Functional Concept", "B-Spatial Concept", "O", "O", "B-Finding", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Body Part, Organ, or Organ Component", "B-Spatial Concept", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O" ]
[ "Mitochondrial", "Ultrastructure", "and", "Glucose", "Signaling", "Pathways", "Attributed", "to", "the", "Kv1.3", "Ion", "Channel", "Gene-targeted", "deletion", "of", "the", "potassium", "channel", "Kv1.3", "(", "Kv1.3", "(", "-∕-", ")", ")", "results", "i", "n", "``", "S", "uper-smeller", "''", "mice", "with", "a", "se", "nsory", "p", "h", "enotype", "t", "hat", "includes", "an", "increased", "olfactory", "ability", "linked", "to", "changes", "in", "olfactory", "circuitry", ",", "increased", "abundance", "of", "olfactory", "cilia", ",", "and", "increased", "expression", "of", "odorant", "receptors", "and", "the", "G-protein", ",", "Golf", ".", "Kv1.3", "(", "-∕-", ")", "mice", "a", "lso", "have", "a", "metabolic", "p", "h", "enotype", "i", "ncluding", "lo", "wer", "b", "o", "dy", "weight", "a", "nd", "de", "creased", "a", "d", "iposity", ",", "in", "creased", "total", "energy", "expenditure", "(", "TEE", ")", ",", "increased", "locomotor", "activity", ",", "and", "resistance", "to", "both", "diet", "-", "and", "genetic-induced", "obesity", ".", "We", "explored", "two", "cellular", "aspects", "to", "elucidate", "the", "mechanism", "by", "which", "loss", "of", "Kv1.3", "channel", "in", "the", "olfactory", "bulb", "(", "OB", ")", "may", "enhance", "glucose", "utilization", "and", "metabolic", "rate", ".", "First", ",", "using", "in", "situ", "hybridization", "we", "find", "that", "Kv1.3", "and", "the", "insulin", "-", "dependent", "glucose", "transporter", "type", "4", "(", "GLUT4", ")", "are", "co-localized", "to", "the", "mitral", "cell", "layer", "of", "the", "OB", ".", "Disruption", "of", "Kv1.3", "conduction", "via", "construction", "of", "a", "pore", "mutation", "(", "W386F", "Kv1.3", ")", "was", "sufficient", "to", "independently", "translocate", "GLUT4", "to", "the", "plasma", "membrane", "in", "HEK", "293", "cells", ".", "Because", "olfactory", "sensory", "perception", "and", "the", "maintenance", "of", "action", "potential", "(", "AP", ")", "firing", "frequency", "by", "mitral", "cells", "of", "the", "OB", "is", "highly", "energy", "demanding", "and", "Kv1.3", "is", "also", "expressed", "in", "mitochondria", ",", "we", "next", "explored", "the", "structure", "of", "this", "organelle", "in", "mitral", "cells", ".", "We", "challenged", "wildtype", "(", "WT", ")", "and", "Kv1.3", "(", "-∕-", ")", "male", "mice", "with", "a", "m", "oderately", "high-fat", "diet", "(", "M", "HF", ",", "31.8", "%", "kcal", "fat", ")", "for", "4", "months", "and", "then", "examined", "OB", "ultrastructure", "using", "transmission", "electron", "microscopy", ".", "In", "WT", "mice", ",", "mitochondria", "were", "significantly", "enlarged", "following", "diet-induced", "obesity", "(", "DIO", ")", "and", "there", "were", "fewer", "mitochondria", ",", "likely", "due", "to", "mitophagy", ".", "Interestingly", ",", "mitochondria", "were", "significantly", "smaller", "in", "Kv1.3", "(", "-∕-", ")", "mice", "c", "ompared", "with", "that", "of", "W", "T", "mice", ".", "Similar", "to", "their", "m", "etabolic", "r", "esistance", "to", "D", "IO", ",", "the", "K", "v1.3", "(", "-∕-", ")", "mice", "ha", "d", "unchanged", "mit", "ochondria", "in", "terms", "of", "cros", "s", "sectional", "area", "and", "abundance", "following", "a", "challenge", "with", "modified", "diet", ".", "We", "are", "very", "interested", "to", "understand", "how", "targeted", "disruption", "of", "the", "Kv1.3", "channel", "in", "the", "OB", "can", "modify", "TEE", ".", "Our", "study", "demonstrates", "that", "Kv1.3", "regulates", "mitochondrial", "structure", "and", "alters", "glucose", "utilization", ";", "two", "important", "metabolic", "changes", "that", "could", "drive", "whole", "system", "changes", "in", "metabolism", "initiated", "at", "the", "OB", "." ]	[ "B-Cell Component", "B-Cell", "O", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Molecular Biology Research Technique", "B-Genetic Function", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "O", "O", "B-Molecular Function", "B-Mammal", "O", "B-Mammal", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "O", "O", "B-Quantitative Concept", "B-Organism Function", "B-Organism Attribute", "O", "O", "O", "O", "B-Organism Function", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Cell Component", "B-Cell Component", "O", "O", "B-Quantitative Concept", "B-Genetic Function", "O", "B-Receptor", "B-Receptor", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Organism Attribute", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Organism Function", "B-Organism Function", "O", "O", "B-Mental Process", "O", "O", "B-Food", "O", "O", "B-Genetic Function", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Molecular Function", "B-Molecular Function", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Hormone", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Cell", "B-Cell", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Functional Concept", "O", "B-Biologically Active Substance", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "O", "O", "B-Cell Function", "B-Biologically Active Substance", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "O", "B-Activity", "O", "B-Cell Function", "B-Cell Function", "B-Cell Function", "B-Cell Function", "B-Cell Function", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Cell", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Cell Component", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell Component", "O", "B-Body Part, Organ, or Organ Component", "B-Cell", "O", "O", "O", "B-Mammal", "O", "B-Mammal", "O", "O", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Cell", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Mammal", "B-Mammal", "O", "B-Cell Component", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Cell Component", "O", "O", "O", "O", "B-Cell Function", "O", "O", "O", "B-Cell Component", "O", "O", "B-Qualitative Concept", "O", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "O", "O", "O", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "O", "B-Cell Component", "B-Cell Component", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Cell Component", "B-Cell Component", "O", "O", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O" ]
[ "Cobalamin", "Protection", "against", "Oxidative", "Stress", "in", "the", "Acidophilic", "Iron-oxidizing", "Bacterium", "Leptospirillum", "Group", "II", "CF-1", "Members", "of", "the", "genus", "Leptospirillum", "are", "aerobic", "iron-oxidizing", "bacteria", "belonging", "to", "the", "phylum", "Nitrospira", ".", "They", "are", "important", "members", "of", "microbial", "communities", "that", "catalyze", "the", "biomining", "of", "sulfidic", "ores", ",", "thereby", "solubilizing", "metal", "ions", ".", "These", "microorganisms", "live", "under", "extremely", "acidic", "and", "metal", "-loaded", "environments", "and", "thus", "must", "tolerate", "high", "concentrations", "of", "reactive", "oxygen", "species", "(", "ROS", ")", ".", "Cobalamin", "(", "vitamin", "B12", ")", "is", "a", "cobalt", "-containing", "tetrapyrrole", "cofactor", "involved", "in", "intramolecular", "rearrangement", "reactions", "and", "has", "recently", "been", "suggested", "to", "be", "an", "intracellular", "antioxidant", ".", "In", "this", "work", ",", "we", "investigated", "the", "effect", "of", "the", "exogenous", "addition", "of", "cobalamin", "on", "oxidative", "stress", "parameters", "in", "Leptospirillum", "group", "II", "strain", "CF-1", ".", "Our", "results", "revealed", "that", "the", "external", "supplementation", "of", "cobalamin", "reduces", "the", "levels", "of", "intracellular", "ROSs", "and", "the", "damage", "to", "biomolecules", ",", "and", "also", "stimulates", "the", "growth", "and", "survival", "of", "cells", "exposed", "to", "oxidative", "stress", "exerted", "by", "ferric", "ion", ",", "hydrogen", "peroxide", ",", "chromate", "and", "diamide", ".", "Furthermore", ",", "exposure", "of", "strain", "CF-1", "to", "oxidative", "stress", "elicitors", "resulted", "in", "the", "transcriptional", "activation", "of", "the", "cbiA", "gene", "encoding", "CbiA", "of", "the", "cobalamin", "biosynthetic", "pathway", ".", "Altogether", ",", "these", "data", "suggest", "that", "cobalamin", "plays", "an", "important", "role", "in", "redox", "protection", "of", "Leptospirillum", "strain", "CF-1", ",", "supporting", "survival", "of", "this", "microorganism", "under", "extremely", "oxidative", "environmental", "conditions", ".", "Understanding", "the", "mechanisms", "underlying", "the", "protective", "effect", "of", "cobalamin", "against", "oxidative", "stress", "may", "help", "to", "develop", "strategies", "to", "make", "biomining", "processes", "more", "effective", "." ]	[ "B-Vitamin", "B-Finding", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Functional Concept", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "O", "O", "B-Bacterium", "O", "B-Qualitative Concept", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Bacterium", "B-Bacterium", "O", "O", "O", "O", "O", "O", "B-Organism", "B-Natural Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "O", "B-Occupational Activity", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "O", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "O", "O", "B-Organism", "O", "O", "O", "O", "O", "B-Inorganic Chemical", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "O", "B-Element, Ion, or Isotope", "O", "O", "B-Vitamin", "O", "B-Vitamin", "B-Vitamin", "O", "O", "O", "B-Element, Ion, or Isotope", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Vitamin", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Conceptual Entity", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Food", "B-Food", "O", "B-Vitamin", "O", "O", "O", "O", "B-Spatial Concept", "B-Element, Ion, or Isotope", "O", "O", "B-Functional Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Organism Function", "O", "B-Cell Function", "B-Cell Function", "B-Cell Function", "O", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "O", "B-Inorganic Chemical", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "O", "O", "O", "B-Bacterium", "B-Bacterium", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Biologically Active Substance", "O", "O", "B-Vitamin", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Vitamin", "O", "O", "O", "O", "O", "B-Molecular Function", "B-Finding", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "O", "O", "O", "B-Organism", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Vitamin", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "B-Phenomenon or Process", "O", "B-Qualitative Concept", "O" ]
[ "Metabolite", "Profiling", "of", "Italian", "Tomato", "Landraces", "with", "Different", "Fruit", "Types", "Increased", "interest", "toward", "traditional", "tomato", "varieties", "is", "fueled", "by", "the", "need", "to", "rescue", "desirable", "organoleptic", "traits", "and", "to", "improve", "the", "quality", "of", "fresh", "and", "processed", "tomatoes", "in", "the", "market", ".", "In", "addition", ",", "the", "phenotypic", "and", "genetic", "variation", "preserved", "in", "tomato", "landraces", "represents", "a", "means", "to", "understand", "the", "genetic", "basis", "of", "traits", "related", "to", "health", "and", "organoleptic", "aspects", "and", "improve", "them", "in", "modern", "varieties", ".", "To", "establish", "a", "framework", "for", "this", "approach", ",", "we", "studied", "the", "content", "of", "several", "metabolites", "in", "a", "panel", "of", "Italian", "tomato", "landraces", "categorized", "into", "three", "broad", "fruit", "type", "classes", "(", "flattened", "/", "ribbed", ",", "pear", "/", "oxheart", ",", "round", "/", "elongate", ")", ".", "Three", "modern", "hybrids", ",", "corresponding", "to", "the", "three", "fruit", "shape", "typologies", ",", "were", "included", "as", "reference", ".", "Red", "ripe", "fruits", "were", "morphologically", "characterized", "and", "biochemically", "analyzed", "for", "their", "content", "in", "glycoalkaloids", ",", "phenols", ",", "amino", "acids", ",", "and", "Amadori", "products", ".", "The", "round", "/", "elongate", "types", "showed", "a", "higher", "content", "in", "glycoalkaloids", ",", "whereas", "flattened", "types", "had", "higher", "levels", "of", "phenolic", "compounds", ".", "Flattened", "tomatoes", "were", "also", "rich", "in", "total", "amino", "acids", "and", "in", "particular", "in", "glutamic", "acid", ".", "Multivariate", "analysis", "of", "amino", "acid", "content", "clearly", "separated", "the", "three", "classes", "of", "fruit", "types", ".", "Making", "allowance", "of", "the", "very", "low", "number", "of", "genotypes", ",", "phenotype-marker", "relationships", "were", "analyzed", "after", "retrieving", "single", "nucleotide", "polymorphisms", "(", "SNPs", ")", "among", "the", "landraces", "available", "in", "the", "literature", ".", "Sixty-six", "markers", "were", "significantly", "associated", "with", "the", "studied", "traits", ".", "The", "positions", "of", "several", "of", "these", "SNPs", "showed", "correspondence", "with", "already", "described", "genomic", "regions", "and", "QTLs", "supporting", "the", "reliability", "of", "the", "association", ".", "Overall", "the", "data", "indicated", "that", "significant", "changes", "in", "quality", "-related", "metabolites", "occur", "depending", "on", "the", "genetic", "background", "in", "traditional", "tomato", "germplasm", ",", "frequently", "according", "to", "specific", "fruit", "shape", "categories", ".", "Such", "a", "variability", "is", "suitable", "to", "harness", "association", "mapping", "for", "metabolic", "quality", "traits", "using", "this", "germplasm", "as", "an", "experimental", "population", ",", "paving", "the", "way", "for", "investigating", "their", "genetic", "/", "molecular", "basis", ",", "and", "facilitating", "breeding", "for", "quality-related", "compounds", "in", "tomato", "fruits", "." ]	[ "B-Biologically Active Substance", "B-Functional Concept", "O", "B-Geographic Area", "B-Food", "B-Conceptual Entity", "O", "O", "B-Food", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "B-Food", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Finding", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "B-Food", "O", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Food", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Organism Attribute", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Geographic Area", "B-Food", "B-Conceptual Entity", "O", "O", "O", "O", "B-Food", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Food", "O", "B-Food", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "O", "O", "O", "B-Organism", "B-Organism", "O", "O", "O", "O", "O", "B-Food", "B-Spatial Concept", "B-Intellectual Product", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Food", "B-Food", "B-Food", "O", "B-Spatial Concept", "B-Activity", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Functional Concept", "B-Food", "O", "O", "B-Qualitative Concept", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "B-Qualitative Concept", "O", "B-Research Activity", "O", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "O", "B-Nucleotide Sequence", "O", "O", "O", "B-Conceptual Entity", "O", "O", "O", "B-Intellectual Product", "O", "O", "B-Nucleotide Sequence", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Research Activity", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Functional Concept", "B-Food", "B-Cell Component", "O", "O", "O", "O", "O", "B-Food", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "B-Activity", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Organism Attribute", "O", "O", "B-Cell Component", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "B-Organism Function", "O", "B-Qualitative Concept", "B-Chemical", "O", "B-Food", "B-Food", "O" ]
[ "Cross-reactivity", "features", "of", "deoxynivalenol", "(", "DON", ")", "-targeted", "immunoaffinity", "columns", "aiming", "to", "achieve", "simultaneous", "analysis", "of", "DON", "and", "major", "conjugates", "in", "cereal", "samples", "Immunoafﬁnity", "columns", "(", "IACs", ")", "are", "a", "well-established", "tool", "in", "the", "determination", "of", "regulated", "mycotoxins", "in", "food", "and", "feed", "commodities", ".", "However", ",", "they", "also", "have", "the", "potential", "to", "become", "attractive", "pre-concentration", "and", "clean-up", "materials", "for", "the", "determination", "of", "masked", "(", "also", "called", "modified", ")", "mycotoxins", ",", "which", "have", "been", "recognised", "as", "important", "contributors", "to", "the", "toxicological", "hazard", "deriving", "from", "fungal", "spoilage", "of", "goods", ".", "However", ",", "the", "information", "available", "in", "the", "literature", "concerning", "the", "cross-reactivity", "of", "DON", "-", "IACs", "against", "the", "major", "conjugates", "(", "DON-3-G", ",", "15-AcDON", "and", "3-AcDON", ")", "is", "incomplete", "and", "often", "contradictory", ".", "We", "have", "carried", "out", "a", "detailed", "characterisation", "of", "the", "cross-reactivity", "of", "the", "four", "main", "IACs", "brands", "against", "DON", "and", "its", "conjugates", "as", "well", "as", "an", "assessment", "of", "the", "competition", "among", "the", "analytes", ".", "Only", "one", "IAC", "enabled", "the", "simultaneous", "analysis", "of", "all", "relevant", "DON", "forms", "while", "two", "missed", "15-AcDON", "and", "the", "fourth", "one", "missed", "DON-3-G", "and", "3-AcDON", ".", "In", "the", "case", "of", "the", "multivalent", "IAC", ",", "the", "analytes", "modified", "at", "the", "C-3", "position", "compete", "for", "the", "antibody", "binding", "with", "preference", "for", "3-AcDON", "(", "less", "spatially", "hindered", ")", "while", "DON-3-G", "has", "the", "more-hindered", "access", "to", "the", "active", "sites", ".", "Taking", "into", "consideration", "the", "levels", "of", "DON", "conjugates", "existing", "in", "real", "samples", ",", "the", "cross-reactivity", "of", "one", "DON", "-", "IAC", "allows", "a", "quantitative", "analysis", "of", "all", "of", "these", "analytes", ".", "Important", "but", "rather", "neglected", "aspects", "such", "as", "the", "continuous", "supply", "of", "IACs", "with", "identical", "characteristics", ",", "and", "of", "columns", "which", "are", "strictly", "blank", ",", "are", "also", "addressed", "in", "this", "paper", "." ]	[ "B-Molecular Function", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Laboratory Procedure", "B-Medical Device", "O", "O", "O", "B-Temporal Concept", "B-Laboratory Procedure", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Chemical Viewed Structurally", "O", "B-Food", "B-Substance", "B-Laboratory Procedure", "B-Medical Device", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Food", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologic Function", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "B-Phenomenon or Process", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Molecular Function", "O", "B-Hazardous or Poisonous Substance", "O", "B-Medical Device", "O", "O", "O", "B-Chemical Viewed Structurally", "O", "B-Organic Chemical", "O", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Molecular Function", "O", "O", "O", "O", "B-Medical Device", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Chemical Viewed Structurally", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Medical Device", "O", "O", "B-Temporal Concept", "B-Laboratory Procedure", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "B-Organic Chemical", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Receptor", "B-Receptor", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "B-Organic Chemical", "O", "O", "O", "O", "O", "O", "B-Receptor", "B-Receptor", "O", "O", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Chemical Viewed Structurally", "O", "O", "B-Substance", "B-Substance", "O", "O", "B-Molecular Function", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Medical Device", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "A", "longitudinal", "study", "assessing", "childcare", "services", "'", "adoption", "of", "obesity", "prevention", "policies", "and", "practices", "Despite", "ongoing", "investments", "to", "improve", "the", "obesogenic", "environments", "of", "childcare", "settings", ",", "little", "is", "known", "regarding", "how", "these", "services", "have", "changed", "their", "physical", "activity", "and", "nutrition-promoting", "practices", ".", "This", "study", "aims", "to", "describe", "changes", "in", "the", "proportion", "of", "Australian", "childcare", "services", "that", "have", "adopted", "best-practice", "healthy", "eating", "and", "physical", "activity", "practices", "between", "2006", "and", "2013", "and", "to", "assess", "whether", "adoption", "varied", "by", "socio-economic", "status", "and", "locality", ".", "A", "randomly", "selected", "sample", "of", "nominated", "supervisors", "(", "n", "=", "358", ")", "from", "childcare", "services", "located", "in", "New", "South", "Wales", ",", "Australia", ",", "participated", "in", "a", "telephone", "survey", "in", "2006", ",", "2009", ",", "2010", "and", "2013", ".", "Supervisors", "reported", "on", "their", "service", "'s", "adoption", "of", "six", "practices", ":", "(", "i", ")", "having", "written", "nutrition", "and", "physical", "activity", "policies", ";", "(", "ii", ")", "staff", "trained", "in", "physical", "activity", "and", "nutrition", "in", "the", "past", "year", ";", "(", "iii", ")", "scheduled", "time", "for", "fundamental", "movement", "skills", "and", "(", "iv", ")", "outdoor", "play", ";", "(", "v", ")", "weekly", "or", "less", "screen", "time", "opportunitie", "s", ";", "and", "(", "vi", ")", "serving", "only", "non-sweetened", "beverages", ".", "A", "significant", "increase", "in", "the", "prevalence", "of", "services", "adopting", "all", "but", "one", "practice", ",", "between", "2006", "and", "2013", "was", "identified", ".", "Ninety", "one", "percent", "of", "services", "adopted", "four", "or", "more", "practices", ",", "a", "significant", "increase", "from", "38", "%", "in", "2006", ".", "There", "were", "no", "differences", "in", "the", "proportion", "of", "services", "adopting", "each", "practice", "by", "locality", "and", "socio-economic", "status", ".", "Government", "investment", "in", "obesity", "prevention", "programmes", "can", "equitably", "improve", "childcare", "service", "'s", "adoption", "of", "healthy", "eating", "and", "physical", "activity", "promoting", "practices", "on", "a", "jurisdiction", "-wide", "basis", ".", "The", "establishment", "of", "a", "routine", "system", "to", "monitor", "adoption", "of", "a", "broader", "range", "of", "practices", "by", "childcare", "services", "is", "warranted", "." ]	[ "O", "B-Research Activity", "B-Research Activity", "O", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Disease or Syndrome", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Spatial Concept", "O", "B-Occupational Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "O", "B-Health Care Activity", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "B-Intellectual Product", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Organism Function", "B-Individual Behavior", "O", "O", "O", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Occupational Activity", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "B-Health Care Activity", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Organization", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "B-Occupational Activity", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Health Care Activity", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "O" ]
[ "Improving", "Early", "Identification", "and", "Ongoing", "Care", "of", "Children", "With", "Autism", "Spectrum", "Disorder", "Poor", "adherence", "to", "recommended", "screening", "for", "autism", "spectrum", "disorder", "(", "ASD", ")", "and", "pediatricians", "'", "lack", "of", "confidence", "in", "providing", "care", "for", "children", "with", "ASD", "reflect", "quality", "gaps", "in", "primary", "care", ".", "This", "study", "aimed", "to", "increase", "the", "proportion", "of", "toddlers", "screened", "for", "ASD", "and", "improve", "physicians", "'", "self-efficacy", "in", "providing", "care", "to", "children", "with", "ASD", ".", "Twenty-six", "Utah", "primary", "care", "practices", "participated", "in", "a", "3", "to", "6", "month", "learning", "collaborative", "(", "LC", ")", "to", "improve", "identification", "and", "ongoing", "care", "of", "children", "with", "ASD", ".", "Monthly", "chart", "audits", "assessed", "whether", "an", "ASD", "screening", "tool", "was", "administered", "at", "18-", "and", "24-", "month", "visits", ".", "Physicians", "completed", "pre-LC", "and", "post-LC", "surveys", "to", "assess", "changes", "in", "self-efficacy", "in", "providing", "care", "and", "changes", "in", "perceived", "barriers", "to", "implementation", "of", "screening", "and", "caring", "for", "children", "with", "ASD", ".", "Before", "the", "LC", ",", "15", "%", "of", "18-", "and", "24-", "month", "visits", "had", "documented", "ASD", "screening", ",", "compared", "with", "91", "%", "during", "the", "last", "month", "of", "the", "LC", "(", "P", "<", ".001", ")", ".", "This", "rate", "of", "ASD", "screening", "was", "sustained", "4", "years", "after", "the", "LC", "by", "most", "practices", ".", "Compared", "with", "survey", "responses", "before", "the", "LC", ",", "physicians", "reported", "significant", "improvement", "in", "their", "ability", "to", "care", "for", "children", "with", "ASD", "and", "decreases", "in", "their", "perceived", "barriers", "to", "screening", "and", "caring", "for", "children", "with", "ASD", ".", "The", "LC", "was", "effective", "in", "increasing", "and", "sustaining", "recommended", "ASD", "screening", "of", "toddlers", "and", "improving", "physicians", "'", "perceived", "self-efficacy", "in", "caring", "for", "children", "with", "ASD", ".", "Improving", "primary", "care", "screening", ",", "skills", ",", "and", "knowledge", "may", "improve", "the", "timing", "of", "diagnosis", ",", "initiation", "of", "treatment", ",", "quality", "of", "care", ",", "and", "outcomes", "for", "children", "with", "ASD", "." ]	[ "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "B-Professional or Occupational Group", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Age Group", "O", "O", "B-Finding", "O", "B-Finding", "B-Professional or Occupational Group", "O", "B-Mental Process", "O", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Organization", "B-Organization", "O", "B-Organization", "O", "O", "B-Finding", "B-Mental Process", "O", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Finding", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Health Care Activity", "O", "B-Professional or Occupational Group", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "B-Intellectual Product", "O", "O", "B-Functional Concept", "O", "B-Mental Process", "O", "O", "B-Activity", "O", "O", "O", "B-Mental Process", "B-Qualitative Concept", "O", "B-Activity", "O", "B-Health Care Activity", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "O", "O", "B-Organization", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Health Care Activity", "O", "B-Health Care Activity", "B-Finding", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Organization", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Health Care Activity", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Organization", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "B-Organization", "O", "B-Professional or Occupational Group", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "O", "O", "O", "B-Mental Process", "B-Qualitative Concept", "O", "B-Health Care Activity", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "O", "B-Organization", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Health Care Activity", "O", "B-Age Group", "O", "O", "B-Professional or Occupational Group", "O", "O", "B-Mental Process", "O", "B-Individual Behavior", "O", "B-Age Group", "O", "B-Finding", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "O", "B-Finding", "O", "B-Temporal Concept", "O", "B-Research Activity", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Functional Concept", "O", "B-Age Group", "O", "B-Finding", "O" ]
[ "Describing", "Self-Care", "Self-Efficacy", ":", "Definition", ",", "Measurement", ",", "Outcomes", ",", "and", "Implications", "The", "pragmatic", "utility", "method", "of", "concept", "analysis", "was", "used", "to", "explore", "the", "usefulness", "of", "the", "concept", "self-care", "self-efficacy", ".", "Empirical", "studies", "across", "disciplines", "published", "between", "1996", "and", "2015", "were", "used", "as", "data", ".", "A", "data", "matrix", "was", "developed", ".", "Analytical", "questions", "and", "responses", "were", "derived", "from", "the", "data", "to", "understand", "patterns", ",", "develop", "new", "knowledge", "and", "achieve", "synthesis", ".", "Usefulness", "of", "the", "concept", "is", "contingent", "on", "how", "it", "is", "defined", "and", "measured", ".", "Self-care", "self-efficacy", "is", "associated", "with", "performance", "of", "self-care", "activities", "and", "positive", "health", "outcomes", "in", "diverse", "populations", ".", "Research", "can", "guide", "development", "of", "targeted", "interventions", "to", "increase", "patients", "'", "self-care", "self-efficacy", ",", "thus", "reducing", "costs", ",", "and", "assisting", "people", "to", "achieve", "optimal", "health", "." ]	[ "O", "B-Daily or Recreational Activity", "B-Mental Process", "O", "B-Intellectual Product", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Idea or Concept", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Idea or Concept", "B-Research Activity", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "B-Daily or Recreational Activity", "B-Mental Process", "O", "B-Research Activity", "B-Research Activity", "O", "B-Occupation or Discipline", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Intellectual Product", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Daily or Recreational Activity", "B-Mental Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Activity", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Finding", "B-Occupational Activity", "B-Occupational Activity", "O", "B-Qualitative Concept", "B-Population Group", "O", "B-Research Activity", "O", "O", "B-Functional Concept", "O", "O", "B-Health Care Activity", "O", "O", "B-Patient or Disabled Group", "O", "B-Daily or Recreational Activity", "B-Mental Process", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Health Care Activity", "B-Population Group", "O", "O", "B-Qualitative Concept", "B-Idea or Concept", "O" ]
[ "Dynamics", "of", "intestinal", "metabolites", "and", "morphology", "in", "response", "to", "necrotic", "enteritis", "challenge", "in", "broiler", "chickens", "Despite", "the", "relatively", "small", "contribution", "to", "metabolizable", "energy", "that", "volatile", "fatty", "acids", "(", "VFAs", ")", "provide", "in", "chickens", ",", "these", "organic", "acids", "have", "been", "reported", "to", "play", "beneficial", "roles", "in", "the", "gastrointestinal", "tract", "(", "GIT", ")", "of", "birds", ",", "for", "example", ",", "inhibition", "of", "the", "growth", "of", "some", "pathogenic", "bacteria", ".", "However", ",", "information", "regarding", "the", "dynamics", "of", "these", "metabolites", "in", "the", "GIT", "of", "chickens", "is", "still", "scarce", ",", "especially", "under", "disease", "conditions", "such", "as", "necrotic", "enteritis", "(", "NE", ")", ".", "Here", ",", "we", "investigated", "the", "dynamics", "of", "VFAs", "and", "lactic", "acid", ",", "and", "intestinal", "morphology", "in", "response", "to", "NE", "predisposing", "factors", ",", "that", "is", ",", "excessive", "dietary", "fishmeal", "and", "Eimeria", "inoculation", ",", "and", "causative", "agent", "Clostridium", "perfringens", "producing", "NetB", "toxin", ".", "The", "experiment", "was", "designed", "in", "a", "2", "×", "2", "×", "2", "factorial", "arrangement", "of", "treatments", "with", "or", "without", ":", "fishmeal", "feeding", ",", "Eimeria", "inoculation", "and", "C.", "perfringens", "challenge", ".", "The", "results", "showed", "that", "these", "factors", "significantly", "influenced", "composition", "and", "concentration", "of", "VFAs", "and", "lactic", "acids", ",", "pH", "and", "histomorphometry", "in", "one", "way", "or", "another", ".", "These", "changes", "may", "be", "important", "for", "the", "onset", "of", "NE", "or", "only", "the", "synergetic", "responses", "to", "micro", "environmental", "stress", ".", "Eimeria", "appeared", "to", "be", "more", "important", "than", "fishmeal", "in", "predisposing", "birds", "to", "NE", ",", "thus", "the", "application", "of", "Eimeria", "in", "NE", "challenge", "provides", "more", "consistent", "success", "in", "inducing", "the", "disease", ".", "The", "metabolic", "responses", "to", "various", "adverse", "factors", "such", "as", "excessive", "dietary", "fishmeal", "and", "Eimeria", "infection", "are", "complex", ".", "Thus", ",", "intensive", "efforts", "are", "required", "to", "better", "understand", "NE", "so", "as", "to", "achieve", "the", "control", "of", "the", "disease", "in", "the", "absence", "of", "antibiotics", "." ]	[ "B-Natural Phenomenon or Process", "O", "B-Body Part, Organ, or Organ Component", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "O", "B-Organism Attribute", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Health Care Activity", "O", "B-Bird", "B-Bird", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "B-Activity", "O", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "B-Activity", "O", "B-Bird", "O", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "O", "B-Health Care Activity", "O", "O", "B-Quantitative Concept", "B-Conceptual Entity", "O", "O", "B-Body System", "B-Body System", "O", "B-Body System", "O", "O", "B-Bird", "O", "O", "O", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "O", "B-Organism", "B-Bacterium", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Body System", "O", "B-Bird", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Natural Phenomenon or Process", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "B-Organism Attribute", "O", "B-Disease or Syndrome", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Food", "B-Substance", "O", "B-Eukaryote", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "B-Finding", "B-Bacterium", "B-Bacterium", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Substance", "B-Activity", "O", "B-Eukaryote", "B-Therapeutic or Preventive Procedure", "O", "B-Bacterium", "B-Bacterium", "B-Health Care Activity", "O", "O", "B-Finding", "O", "O", "O", "B-Functional Concept", "B-Idea or Concept", "B-Conceptual Entity", "B-Clinical Attribute", "O", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Finding", "O", "B-Eukaryote", "O", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Substance", "O", "B-Functional Concept", "B-Bird", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Functional Concept", "O", "B-Eukaryote", "O", "B-Disease or Syndrome", "B-Health Care Activity", "B-Activity", "O", "B-Idea or Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "B-Organism Attribute", "O", "O", "B-Pathologic Function", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Food", "B-Substance", "O", "B-Eukaryote", "B-Pathologic Function", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "B-Organism Function", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Mental Process", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Functional Concept", "O", "B-Antibiotic", "O" ]
[ "The", "effects", "of", "paternal", "high-fat", "diet", "exposure", "on", "offspring", "metabolism", "with", "epigenetic", "changes", "in", "the", "mouse", "adiponectin", "and", "leptin", "gene", "promoters", "Recent", "studies", "have", "demonstrated", "that", "epigenetic", "changes", "resulting", "from", "malnutrition", "might", "play", "important", "roles", "in", "transgenerational", "links", "with", "metabolic", "diseases", ".", "Previously", ",", "we", "observed", "that", "exposure", "to", "a", "high-fat", "diet", "(", "HFD", ")", "in", "utero", "caused", "a", "metabolic", "syndrome", "-like", "phenomenon", "through", "epigenetic", "modifications", "of", "the", "adiponectin", "and", "leptin", "genes", "that", "persisted", "for", "multiple", "generations", ".", "Recent", "etiological", "studies", "indicated", "that", "paternal", "BMI", "had", "effects", "on", "offspring", "BMI", "that", "were", "independent", "of", "but", "additive", "to", "maternal", "BMI", "effects", ".", "Thus", ",", "we", "examined", "whether", "paternal", "HFD", "-", "induced", "obesity", "affected", "the", "metabolic", "status", "of", "offspring", "through", "epigenetic", "changes", "in", "the", "adiponectin", "and", "leptin", "genes", ".", "Additionally", ",", "we", "investigated", "whether", "a", "normal", "diet", "during", "subsequent", "generations", "abolished", "the", "epigenetic", "changes", "associated", "with", "paternal", "HFD", "exposure", "before", "conception", ".", "We", "observed", "the", "effects", "of", "paternal", "HFD", "exposure", "before", "conception", "over", "multiple", "generations", "on", "offspring", "metabolic", "traits", ",", "including", "weight", "and", "fat", "gain", ",", "glucose", "intolerance", ",", "hypertriglyceridemia", ",", "abnormal", "adipocytokine", "levels", ",", "hypertension", ",", "and", "adiponectin", "and", "leptin", "gene", "expression", "and", "epigenetic", "changes", ".", "Normal", "diet", "consumption", "by", "male", "offspring", "during", "the", "subsequent", "generation", "following", "paternal", "HFD", "exposure", "diminished", "whereas", "consumption", "for", "two", "generations", "completely", "abolished", "the", "effect", "of", "paternal", "HFD", "exposure", "on", "metabolic", "traits", "and", "adipocytokine", "promoter", "epigenetic", "changes", "in", "the", "offspring", ".", "The", "effects", "of", "paternal", "HFD", "exposure", "on", "offspring", "were", "relatively", "weaker", "than", "those", "following", "HFD", "exposure", "in", "utero", ".", "However", ",", "paternal", "HFD", "exposure", "had", "an", "additive", "metabolic", "effect", "for", "two", "generations", ",", "suggesting", "that", "both", "paternal", "and", "maternal", "nutrition", "might", "affect", "offspring", "metabolism", "through", "epigenetic", "modifications", "of", "adipocytokine", "genes", "for", "multiple", "generations", "." ]	[ "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Food", "B-Food", "B-Qualitative Concept", "O", "B-Family Group", "B-Organism Function", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Research Activity", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Conceptual Entity", "O", "B-Group Attribute", "B-Group Attribute", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "O", "B-Food", "B-Food", "O", "B-Food", "O", "B-Age Group", "B-Age Group", "B-Functional Concept", "O", "B-Functional Concept", "B-Disease or Syndrome", "O", "B-Phenomenon or Process", "B-Functional Concept", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "B-Quantitative Concept", "B-Temporal Concept", "O", "O", "B-Functional Concept", "B-Research Activity", "B-Finding", "O", "B-Qualitative Concept", "B-Clinical Attribute", "O", "B-Qualitative Concept", "O", "B-Family Group", "B-Clinical Attribute", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Clinical Attribute", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Food", "O", "B-Functional Concept", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Family Group", "B-Functional Concept", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "B-Temporal Concept", "B-Idea or Concept", "B-Idea or Concept", "B-Activity", "O", "B-Genetic Function", "B-Genetic Function", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "B-Temporal Concept", "B-Organism Function", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "B-Temporal Concept", "B-Organism Function", "O", "B-Quantitative Concept", "B-Temporal Concept", "O", "B-Family Group", "B-Functional Concept", "B-Organism Attribute", "O", "B-Functional Concept", "B-Finding", "O", "B-Pharmacologic Substance", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Genetic Function", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "O", "O", "B-Family Group", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Activity", "O", "O", "B-Temporal Concept", "O", "B-Activity", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Organism Attribute", "O", "B-Biologically Active Substance", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Family Group", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "O", "B-Family Group", "O", "O", "B-Qualitative Concept", "O", "O", "B-Temporal Concept", "B-Food", "B-Qualitative Concept", "B-Age Group", "B-Age Group", "O", "O", "O", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Organism Function", "O", "B-Qualitative Concept", "B-Family Group", "B-Organism Function", "B-Functional Concept", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Quantitative Concept", "B-Temporal Concept", "O" ]
[ "Ehlers-Danlos", "syndrome", "The", "Ehlers-Danlos", "syndromes", "(", "EDSs", ")", "were", "originally", "described", "by", "Ehlers", "in", "Denmark", "and", "Danlos", "in", "Paris", "in", "1898", "and", "1908", ",", "respectively", ".", "They", "had", "both", "published", "individual", "case", "studies", "in", "which", "the", "common", "factor", "was", "laxity", "of", "ligaments", "leading", "to", "joint", "hypermobility", "and", "hyperextensibility", "of", "the", "skin", ".", "The", "choice", "of", "the", "name", "of", "this", "eponymous", "disease", "had", "been", "made", "by", "Dr", "Parkes", "Weber", ",", "an", "eminent", "London", "physician", "in", "the", "1930s", ",", "who", "had", "a", "penchant", "for", "eponymous", "diseases", ",", "having", "had", "no", "less", "than", "seven", "attributed", "to", "himself", ",", "at", "least", "in", "part", ".", "Unfortunately", ",", "this", "was", "before", "the", "age", "of", "a", "computerised", "literature", "search", ",", "and", "Parkes", "Weber", "had", "inadvertently", "overlooked", "the", "very", "first", "description", "of", "EDS", "which", "had", "been", "made", "by", "Tchernabogov", ",", "a", "Russian", "dermatologist", ",", "whose", "description", "was", "published", "in", "1891", "and", "remains", "one", "of", "the", "best", "descriptions", "of", "EDS", "in", "the", "literature", "." ]	[ "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Intellectual Product", "O", "B-Human", "O", "B-Geographic Area", "O", "B-Human", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Human", "B-Human", "B-Human", "O", "O", "O", "B-Geographic Area", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "B-Individual Behavior", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Activity", "O", "O", "B-Human", "B-Human", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Human", "O", "O", "B-Population Group", "B-Professional or Occupational Group", "O", "O", "B-Intellectual Product", "O", "B-Occupational Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Disease or Syndrome", "O", "O", "B-Intellectual Product", "O" ]
[ "Assessment", "of", "laparoscopic", "stomach", "preserving", "surgery", "with", "sentinel", "basin", "dissection", "versus", "standard", "gastrectomy", "with", "lymphadenectomy", "in", "early", "gastric", "cancer", "-A", "multicenter", "randomized", "phase", "III", "clinical", "trial", "(", "SENORITA", "trial", ")", "protocol", "Along", "with", "the", "marked", "increase", "in", "early", "gastric", "cancer", "(", "EGC", ")", "in", "the", "Eastern", "countries", ",", "there", "has", "been", "an", "effort", "to", "adopt", "the", "sentinel", "node", "concept", "in", "EGC", "to", "preserve", "gastric", "function", "and", "reduce", "the", "occurrence", "of", "postoperative", "complications", ".", "Based", "on", "promising", "results", "from", "a", "previous", "quality", "control", "study", ",", "this", "prospective", "multicenter", "randomized", "controlled", "phase", "III", "clinical", "trial", "aims", "to", "elucidate", "the", "oncologic", "safety", "of", "laparoscopic", "stomach-preserving", "surgery", "with", "sentinel", "basin", "dissection", "(", "SBD", ")", "compared", "to", "a", "standard", "laparoscopic", "gastrectomy", ".", "This", "trial", "is", "an", "investigator-initiated", ",", "open-label", ",", "multicenter", "randomized", "controlled", "phase", "III", "trial", "with", "a", "non-inferiority", "design", ".", "Patients", "diagnosed", "with", "a", "single", "lesion", "of", "clinical", "stage", "T1N0M0", "gastric", "adenocarcinoma", ",", "with", "a", "diameter", "of", "3", "cm", "or", "less", "are", "eligible", "for", "the", "present", "study", ".", "A", "total", "of", "580", "patients", "(", "290", "per", "group", ")", "will", "be", "randomized", "to", "either", "laparoscopic", "stomach-preserving", "surgery", "with", "SBD", "or", "standard", "surgery", ".", "The", "primary", "end-point", "is", "3-year", "disease-free", "survival", "(", "DFS", ")", "and", "the", "secondary", "endpoints", "include", "postoperative", "morbidity", "and", "mortality", ",", "quality", "of", "life", ",", "5-year", "DFS", ",", "and", "overall", "survival", ".", "Qualified", "investigators", "who", "completed", "the", "prior", "quality", "control", "study", "are", "exclusively", "allowed", "to", "participate", "in", "this", "phase", "III", "clinical", "trial", ".", "The", "proposed", "trial", "is", "expected", "to", "verify", "whether", "laparoscopic", "stomach-preserving", "surgery", "with", "SBD", "achieves", "similar", "oncologic", "outcomes", "and", "improved", "quality", "of", "life", "compared", "to", "a", "standard", "gastrectomy", "in", "EGC", "patients", ".", "This", "study", "was", "registered", "at", "the", "NIH", "ClinicalTrial.gov", "database", "(", "NCT01804998", ")", "on", "March", "4th", ",", "2013", "." ]	[ "B-Health Care Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Neoplastic Process", "O", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Research Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Neoplastic Process", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Isolation", "and", "characterization", "of", "Burkholderia", "sp", ".", "strain", "CCA53", "exhibiting", "ligninolytic", "potential", "Microbial", "degradation", "of", "lignin", "releases", "fermentable", "sugars", ",", "effective", "utilization", "of", "which", "could", "support", "biofuel", "production", "from", "lignocellulosic", "biomass", ".", "In", "the", "present", "study", ",", "a", "lignin-degrading", "bacterium", "was", "isolated", "from", "leaf", "soil", "and", "identified", "as", "Burkholderia", "sp", ".", "based", "on", "16S", "rRNA", "gene", "sequencing", ".", "This", "strain", "was", "named", "CCA53", ",", "and", "its", "lignin-degrading", "capability", "was", "assessed", "by", "observing", "its", "growth", "on", "medium", "containing", "alkali", "lignin", "or", "lignin", "-associated", "aromatic", "monomers", "as", "the", "sole", "carbon", "source", ".", "Alkali", "lignin", "and", "at", "least", "eight", "lignin", "-associated", "aromatic", "monomers", "supported", "growth", "of", "this", "strain", ",", "and", "the", "most", "effective", "utilization", "was", "observed", "for", "p-hydroxybenzene", "monomers", ".", "These", "findings", "indicate", "that", "Burkholderia", "sp", ".", "strain", "CCA53", "has", "fragmentary", "activity", "for", "lignin", "degradation", "." ]	[ "B-Functional Concept", "O", "B-Activity", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "B-Molecular Function", "B-Qualitative Concept", "B-Organism", "B-Organism Function", "O", "B-Biologically Active Substance", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Organic Chemical", "B-Occupational Activity", "O", "B-Organic Chemical", "B-Quantitative Concept", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Molecular Function", "B-Bacterium", "O", "B-Functional Concept", "O", "B-Plant", "B-Substance", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Qualitative Concept", "O", "O", "B-Bacterium", "O", "O", "O", "B-Molecular Function", "B-Qualitative Concept", "O", "B-Activity", "O", "O", "O", "B-Organism Function", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "O", "O", "B-Element, Ion, or Isotope", "B-Finding", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "B-Organism Function", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "O", "B-Finding", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "B-Activity", "B-Activity", "O", "B-Molecular Function", "B-Molecular Function", "O" ]
[ "Association", "of", "Metabolites", "with", "Obesity", "and", "Type", "2", "Diabetes", "Based", "on", "FTO", "Genotype", "The", "single", "nucleotide", "polymorphism", "rs9939609", "of", "the", "gene", "FTO", ",", "which", "encodes", "fat", "mass", "and", "obesity", "-associated", "protein", ",", "is", "strongly", "associated", "with", "obesity", "and", "type", "2", "diabetes", "(", "T2D", ")", "in", "multiple", "populations", ";", "however", ",", "the", "underlying", "mechanism", "of", "this", "association", "is", "unclear", ".", "The", "present", "study", "aimed", "to", "investigate", "FTO", "genotype", "-dependent", "metabolic", "changes", "in", "obesity", "and", "T2D", ".", "To", "elucidate", "metabolic", "dysregulation", "associated", "with", "disease", "risk", "genotype", ",", "genomic", "and", "metabolomic", "datasets", "were", "recruited", "from", "2,577", "participants", "of", "the", "Korean", "Association", "REsource", "(", "KARE", ")", "cohort", ",", "including", "40", "homozygous", "carriers", "of", "the", "FTO", "risk", "allele", "(", "AA", ")", ",", "570", "heterozygous", "carriers", "(", "AT", ")", ",", "and", "1,967", "participants", "carrying", "no", "risk", "allele", "(", "TT", ")", ".", "A", "total", "of", "134", "serum", "metabolites", "were", "quantified", "using", "a", "targeted", "metabolomics", "approach", ".", "Through", "comparison", "of", "various", "statistical", "methods", ",", "seven", "metabolites", "were", "identified", "that", "are", "significantly", "altered", "in", "obesity", "and", "T2D", "based", "on", "the", "FTO", "risk", "allele", "(", "adjusted", "p", "<", "0.05", ")", ".", "These", "identified", "metabolites", "are", "relevant", "to", "phosphatidylcholine", "metabolic", "pathway", ",", "and", "previously", "reported", "to", "be", "metabolic", "markers", "of", "obesity", "and", "T2D", ".", "In", "conclusion", ",", "using", "metabolomics", "with", "the", "information", "from", "genome-wide", "association", "studies", "revealed", "significantly", "altered", "metabolites", "depending", "on", "the", "FTO", "genotype", "in", "complex", "disorders", ".", "This", "study", "may", "contribute", "to", "a", "better", "understanding", "of", "the", "biological", "mechanisms", "linking", "obesity", "and", "T2D", "." ]	[ "O", "O", "B-Biologically Active Substance", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Disease or Syndrome", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Organism Function", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Organism Attribute", "O", "B-Intellectual Product", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Population Group", "O", "O", "B-Population Group", "B-Population Group", "B-Population Group", "B-Population Group", "B-Population Group", "B-Population Group", "B-Population Group", "O", "O", "O", "B-Organism Attribute", "B-Finding", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Organism Attribute", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Body Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Gene or Genome", "B-Organism Attribute", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O" ]
[ "Anthology", "of", "Venezuelan", "psychiatry", "Reception", "of", "Psychiatry", "in", "Venezuela", "since", "the", "19th", "Century", "to", "the", "late", "20th", "Century", "merits", "a", "historical", "approach", ".", "The", "following", "work", "proposes", "to", "research", "some", "of", "the", "very", "origins", "of", "Venezuelan", "psychiatry", "and", "its", "possible", "influence", "on", "contemporary", "mental", "health", "practice", ".", "Through", "documental", "research", ",", "the", "early", "works", "of", "local", "authors", "from", "the", "19th", "Century", "through", "20th", "Century", "finals", ":", "Carlos", "Arvelo", ",", "Lisandro", "Alvarado", ",", "Francisco", "Herrera", "Luque", ",", "Jose", "Luis", "Vethencourt", "and", "Jose", "Solanes", ",", "are", "subjected", "to", "study", ".", "This", "journey", "illustrates", "a", "descriptive", "panoramic", "view", "which", "allows", "to", "better", "comprenhend", "the", "current", "state", "of", "our", "psychiatry", ".", "In", "a", "brief", "introduction", "the", "most", "important", "events", "are", "described", ",", "since", "the", "arrival", "of", "Pinel", "'s", "ideas", ",", "followed", "by", "the", "early", "research", "paperworks", "published", "and", "the", "beginnings", "of", "the", "academic", "teachings", "of", "this", "specialty", "in", "Venezuela", "and", "displaying", "the", "main", "contemporary", "research", "groups", "thorough", "the", "country", "." ]	[ "B-Intellectual Product", "O", "B-Population Group", "B-Biomedical Occupation or Discipline", "B-Qualitative Concept", "O", "B-Biomedical Occupation or Discipline", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Biomedical Occupation or Discipline", "O", "O", "O", "B-Conceptual Entity", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Human", "B-Human", "O", "B-Human", "B-Human", "O", "B-Human", "B-Human", "B-Human", "O", "B-Human", "B-Human", "B-Human", "O", "B-Human", "B-Human", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Event", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Human", "B-Human", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O" ]
[ "Study", "of", "the", "Microfocus", "X-Ray", "Tube", "Based", "on", "a", "Point-Like", "Target", "Used", "for", "Micro-Computed", "Tomography", "For", "a", "micro-Computed", "Tomography", "(", "Micro-CT", ")", "system", ",", "the", "microfocus", "X-ray", "tube", "is", "an", "essential", "component", "because", "the", "spatial", "resolution", "of", "CT", "images", ",", "in", "theory", ",", "is", "mainly", "determined", "by", "the", "size", "and", "stability", "of", "the", "X-ray", "focal", "spot", "of", "the", "microfocus", "X-ray", "tube", ".", "However", ",", "many", "factors", ",", "including", "voltage", "fluctuations", ",", "mechanical", "vibrations", ",", "and", "temperature", "changes", ",", "can", "cause", "the", "size", "and", "the", "stability", "of", "the", "X-ray", "focal", "spot", "to", "degrade", ".", "A", "new", "microfocus", "X-ray", "tube", "based", "on", "a", "point-like", "micro-target", "in", "which", "the", "X-ray", "target", "is", "irradiated", "with", "an", "unfocused", "electron", "beam", "was", "investigated", ".", "EGS4", "Monte", "Carlo", "simulation", "code", "was", "employed", "for", "the", "calculation", "of", "the", "X-ray", "intensity", "produced", "from", "the", "point-like", "micro-target", "and", "the", "substrate", ".", "The", "effects", "of", "several", "arrangements", "of", "the", "target", "material", ",", "target", "and", "beam", "size", "were", "studied", ".", "The", "simulation", "results", "demonstrated", "that", "if", "the", "intensity", "of", "X-rays", "generated", "at", "the", "point-like", "target", "is", "greater", "than", "half", "of", "the", "X-ray", "intensity", "produced", "on", "the", "substrate", ",", "the", "X-ray", "focal", "spot", "is", "determined", "in", "part", "by", "the", "point-like", "target", "rather", "than", "by", "the", "electron", "beam", "in", "the", "conventional", "X-ray", "tube", ".", "In", "theory", ",", "since", "it", "is", "able", "to", "reduce", "those", "unfavorable", "effects", "such", "as", "the", "electron", "beam", "trajectory", "swinging", "and", "the", "beam", "size", "changing", "for", "the", "microfocus", "X-ray", "tube", ",", "it", "could", "alleviate", "CT", "image", "artifacts", "caused", "by", "the", "X-ray", "focal", "spot", "shift", "and", "size", "change", "." ]	[ "B-Laboratory Procedure", "O", "O", "B-Spatial Concept", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Spatial Concept", "B-Medical Device", "B-Medical Device", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Spatial Concept", "B-Quantitative Concept", "O", "B-Diagnostic Procedure", "B-Intellectual Product", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "O", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Spatial Concept", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Temporal Concept", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Spatial Concept", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Diagnostic Procedure", "B-Functional Concept", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Diagnostic Procedure", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Functional Concept", "B-Substance", "O", "B-Functional Concept", "O", "B-Manufactured Object", "B-Spatial Concept", "O", "B-Laboratory Procedure", "O", "O", "B-Research Activity", "B-Functional Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Diagnostic Procedure", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Diagnostic Procedure", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Substance", "O", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "B-Qualitative Concept", "B-Medical Device", "B-Medical Device", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Manufactured Object", "B-Spatial Concept", "B-Functional Concept", "O", "O", "B-Spatial Concept", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Qualitative Concept", "B-Diagnostic Procedure", "B-Intellectual Product", "B-Human-caused Phenomenon or Process", "B-Idea or Concept", "O", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "B-Spatial Concept", "B-Finding", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O" ]
[ "How", "variation", "between", "individuals", "affects", "species", "coexistence", "Although", "the", "effects", "of", "variation", "between", "individuals", "within", "species", "are", "traditionally", "ignored", "in", "studies", "of", "species", "coexistence", ",", "the", "magnitude", "of", "intraspecific", "variation", "in", "nature", "is", "forcing", "ecologists", "to", "reconsider", ".", "Compelling", "intuitive", "arguments", "suggest", "that", "individual", "variation", "may", "provide", "a", "previously", "unrecognised", "route", "to", "diversity", "maintenance", "by", "blurring", "species", "-", "level", "competitive", "differences", "or", "substituting", "for", "species", "-", "level", "niche", "differences", ".", "These", "arguments", ",", "which", "are", "motivating", "a", "large", "body", "of", "empirical", "work", ",", "have", "rarely", "been", "evaluated", "with", "quantitative", "theory", ".", "Here", "we", "incorporate", "intraspecific", "variation", "into", "a", "common", "model", "of", "competition", "and", "identify", "three", "pathways", "by", "which", "this", "variation", "affects", "coexistence", ":", "(", "1", ")", "changes", "in", "competitive", "dynamics", "because", "of", "nonlinear", "averaging", ",", "(", "2", ")", "changes", "in", "species", "'", "mean", "interaction", "strengths", "because", "of", "variation", "in", "underlying", "traits", "(", "also", "via", "nonlinear", "averaging", ")", "and", "(", "3", ")", "effects", "on", "stochastic", "demography", ".", "As", "a", "consequence", "of", "the", "first", "two", "mechanisms", ",", "we", "find", "that", "intraspecific", "variation", "in", "competitive", "ability", "increases", "the", "dominance", "of", "superior", "competitors", ",", "and", "intraspecific", "niche", "variation", "reduces", "species", "-", "level", "niche", "differentiation", ",", "both", "of", "which", "make", "coexistence", "more", "difficult", ".", "In", "addition", ",", "individual", "variation", "can", "exacerbate", "the", "effects", "of", "demographic", "stochasticity", ",", "and", "this", "further", "destabilises", "coexistence", ".", "Our", "work", "provides", "a", "theoretical", "foundation", "for", "emerging", "empirical", "interests", "in", "the", "effects", "of", "intraspecific", "variation", "on", "species", "diversity", "." ]	[ "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Population Group", "B-Qualitative Concept", "B-Classification", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Population Group", "O", "B-Classification", "O", "B-Functional Concept", "B-Idea or Concept", "O", "B-Research Activity", "O", "B-Classification", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "B-Functional Concept", "B-Professional or Occupational Group", "O", "B-Functional Concept", "O", "O", "B-Individual Behavior", "B-Social Behavior", "B-Idea or Concept", "O", "B-Population Group", "B-Qualitative Concept", "O", "B-Activity", "O", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "B-Activity", "O", "B-Qualitative Concept", "B-Classification", "O", "B-Qualitative Concept", "B-Social Behavior", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Classification", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "B-Social Behavior", "O", "O", "O", "B-Mental Process", "O", "B-Quantitative Concept", "B-Spatial Concept", "O", "B-Qualitative Concept", "B-Occupational Activity", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "B-Intellectual Product", "O", "B-Social Behavior", "O", "B-Qualitative Concept", "O", "B-Conceptual Entity", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Social Behavior", "B-Intellectual Product", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Classification", "O", "B-Quantitative Concept", "B-Functional Concept", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Finding", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Social Behavior", "B-Organism Attribute", "B-Functional Concept", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Population Group", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Classification", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Population Group", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Functional Concept", "B-Quantitative Concept", "O", "O", "B-Occupational Activity", "B-Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "B-Mental Process", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Classification", "B-Qualitative Concept", "O" ]
[ "Intracellular", "Metabolism", "of", "α", ",", "β-Unsaturated", "Carbonyl", "Compounds", ",", "Acrolein", ",", "Crotonaldehyde", "and", "Methyl", "Vinyl", "Ketone", ",", "Active", "Toxicants", "in", "Cigarette", "Smoke", ":", "Participation", "of", "Glutathione", "Conjugation", "Ability", "and", "Aldehyde-Ketone", "Sensitive", "Reductase", "Activity", "The", "major", "toxicants", "in", "cigarette", "smoke", ",", "α", ",", "β-unsaturated", "aldehydes", ",", "such", "as", "acrolein", "(", "ACR", ")", "and", "crotonaldehyde", "(", "CA", ")", ",", "and", "α", ",", "β-unsaturated", "ketone", ",", "methyl", "vinyl", "ketone", "(", "MVK", ")", ",", "are", "known", "to", "form", "Michael-type", "adducts", "with", "glutathione", "(", "GSH", ")", "and", "consequently", "cause", "intracellular", "GSH", "depletion", ",", "which", "is", "involved", "in", "cigarette", "smoke", "-", "induced", "cytotoxicity", ".", "We", "have", "previously", "clarified", "that", "exposure", "to", "cigarette", "smoke", "extract", "(", "CSE", ")", "of", "a", "mouse", "melanoma", "cell", "culture", "medium", "causes", "rapid", "reduction", "of", "intracellular", "GSH", "levels", ",", "and", "that", "the", "GSH", "-", "MVK", "adduct", "can", "be", "detected", "by", "LC/MS", "analysis", "while", "the", "GSH", "-", "CA", "adduct", "is", "hardly", "detected", ".", "In", "the", "present", "study", ",", "to", "clarify", "why", "the", "GSH", "-", "CA", "adduct", "is", "difficult", "to", "detect", "in", "the", "cell", "medium", ",", "we", "conducted", "detailed", "investigation", "of", "the", "structures", "of", "the", "reaction", "products", "of", "ACR", ",", "CA", ",", "MVK", "and", "CSE", "in", "the", "GSH", "solution", "or", "the", "cell", "culture", "medium", ".", "The", "mass", "spectra", "indicated", "that", "in", "the", "presence", "of", "the", "cells", ",", "the", "GSH", "-", "CA", "and", "GSH", "-", "ACR", "adducts", "were", "almost", "not", "detected", "while", "their", "corresponding", "alcohols", "were", "detected", ".", "On", "the", "other", "hand", ",", "both", "the", "GSH", "-", "MVK", "adducts", "and", "their", "reduced", "products", "were", "detected", ".", "In", "the", "absence", "of", "the", "cells", ",", "the", "reaction", "of", "GSH", "with", "all", "α", ",", "β-unsaturated", "carbonyls", "produced", "only", "their", "corresponding", "adducts", ".", "These", "results", "show", "that", "the", "GSH", "adducts", "of", "α", ",", "β-unsaturated", "aldehydes", ",", "CA", "and", "ACR", ",", "are", "quickly", "reduced", "by", "certain", "intracellular", "carbonyl", "reductase", "(", "s", ")", "and", "excreted", "from", "the", "cells", ",", "unlike", "the", "GSH", "adduct", "of", "α", ",", "β-unsaturated", "ketone", ",", "MVK", ".", "Such", "a", "difference", "in", "reactivity", "to", "the", "carbonyl", "reductase", "might", "be", "related", "to", "differences", "in", "the", "cytotoxicity", "of", "α", ",", "β-unsaturated", "aldehydes", "and", "ketones", "." ]	[ "B-Cell Function", "B-Cell Function", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "B-Hazardous or Poisonous Substance", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Functional Concept", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Molecular Function", "O", "O", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "O", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "O", "O", "O", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Spatial Concept", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Functional Concept", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Mammal", "B-Cell", "B-Cell", "B-Indicator, Reagent, or Diagnostic Aid", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Organic Chemical", "B-Chemical Viewed Structurally", "O", "O", "B-Finding", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Biologically Active Substance", "O", "B-Hazardous or Poisonous Substance", "B-Chemical Viewed Structurally", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Hazardous or Poisonous Substance", "B-Chemical Viewed Structurally", "O", "O", "O", "B-Finding", "O", "O", "B-Cell", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Spatial Concept", "O", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "B-Hazardous or Poisonous Substance", "O", "B-Organic Chemical", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Biologically Active Substance", "B-Substance", "O", "O", "B-Cell", "B-Indicator, Reagent, or Diagnostic Aid", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Cell", "O", "O", "B-Biologically Active Substance", "O", "B-Hazardous or Poisonous Substance", "O", "B-Biologically Active Substance", "O", "B-Indicator, Reagent, or Diagnostic Aid", "B-Chemical Viewed Structurally", "O", "O", "O", "B-Finding", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Organic Chemical", "B-Chemical Viewed Structurally", "O", "O", "B-Entity", "B-Entity", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "B-Functional Concept", "O", "B-Biologically Active Substance", "O", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "O", "O", "O", "B-Chemical Viewed Structurally", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Chemical Viewed Structurally", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Hazardous or Poisonous Substance", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Spatial Concept", "B-Enzyme", "B-Enzyme", "B-Enzyme", "B-Enzyme", "B-Enzyme", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "B-Biologically Active Substance", "B-Chemical Viewed Structurally", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "O", "O", "O", "B-Cell or Molecular Dysfunction", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O" ]
[ "Diagnostic", "utility", "of", "additional", "conventional", "techniques", "after", "endobronchial", "ultrasonography", "guidance", "during", "transbronchial", "biopsy", "Endobronchial", "ultrasonography", "with", "a", "guide", "sheath", "transbronchial", "biopsy", "(", "EBUS", "-", "GS", "TBB", ")", "has", "been", "used", "to", "diagnose", "peripheral", "pulmonary", "lesions", "(", "PPLs", ")", ".", "In", "this", "study", ",", "we", "evaluated", "the", "diagnostic", "utility", "of", "conventional", "TBB", "after", "EBUS", "-", "GS", "TBB", ".", "A", "retrospective", "analysis", "of", "patients", "who", "underwent", "conventional", "TBB", "after", "EBUS", "-", "GS", "TBB", "for", "PPL", "between", "August", "1", ",", "2012", "and", "December", "31", ",", "2014", ".", "We", "performed", "multivariate", "analysis", "to", "examine", "the", "association", "of", "various", "clinical", "factors", ",", "including", "EBUS", "probe", "distance", "and", "sample", "size", "area", ",", "with", "diagnostic", "yield", ".", "Of", "88", "eligible", "patients", ",", "57", "(", "65", "%", ")", "were", "successfully", "diagnosed", "by", "EBUS", "-", "GS", "TBB", ".", "In", "31", "patients", "not", "diagnosed", "by", "EBUS", "-", "GS", "TBB", ",", "15", "(", "48", "%", ")", "were", "successfully", "diagnosed", "by", "additional", "conventional", "TBB", ".", "Ground", "glass", "opacity", "(", "GGO", ")", "was", "a", "significant", "factor", "associated", "with", "the", "diagnostic", "yield", "of", "additional", "conventional", "TBB", "following", "EBUS", "-", "GS", "TBB", ".", "Multivariate", "analysis", "and", "receiver", "operator", "curves", "revealed", "that", "distance", "between", "the", "PPL", "and", "the", "EBUS", "probe", "of", "less", "than", "2.55", "mm", "favored", "the", "utility", "of", "conventional", "TBB", ".", "Additional", "conventional", "TBB", "after", "EBUS", "-", "GS", "TBB", "could", "be", "a", "useful", "procedure", "for", "the", "diagnosis", "of", "ground", "glass", "opacity", "PPLs", "and", "in", "cases", "of", "a", "distance", "of", "less", "than", "2.55", "mm", "between", "the", "EBUS", "probe", "and", "the", "lesion", "." ]	[ "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Health Care Activity", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Medical Device", "B-Medical Device", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "O", "B-Research Activity", "B-Research Activity", "O", "B-Patient or Disabled Group", "O", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "B-Diagnostic Procedure", "B-Medical Device", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Finding", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "B-Idea or Concept", "B-Functional Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "O", "B-Finding", "O", "O", "B-Diagnostic Procedure", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "O", "O", "O", "B-Diagnostic Procedure", "O", "O", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Medical Device", "O", "O", "B-Finding", "O" ]
[ "Strategies", "for", "Assaying", "Lysosomal", "Membrane", "Permeabilization", "Late", "endosomal", "organelles", "have", "an", "acidic", "pH", "and", "contain", "hydrolytic", "enzymes", "to", "degrade", "cargo", "delivered", "either", "from", "the", "extracellular", "environment", "by", "endocytosis", "or", "from", "within", "the", "cell", "itself", "by", "autophagy", ".", "In", "the", "event", "of", "lysosomal", "membrane", "permeabilization", "(", "LMP", ")", ",", "the", "contents", "of", "late", "endosomes", "and", "lysosomes", "can", "be", "released", "into", "the", "cytosol", "and", "then", "initiate", "apoptosis", ".", "Compounds", "that", "can", "trigger", "LMP", "are", "therefore", "candidates", "for", "the", "induction", "of", "apoptosis", ",", "in", "particular", "in", "anticancer", "therapy", ".", "Alternatively", ",", "drug-delivery", "systems", ",", "such", "as", "nanoparticles", ",", "can", "have", "side", "effects", "that", "can", "include", "LMP", ",", "which", "has", "toxic", "consequences", "for", "the", "cells", ".", "To", "determine", "when", ",", "to", "what", "extent", ",", "and", "with", "what", "consequences", "LMP", "occurs", "is", "therefore", "of", "paramount", "importance", "for", "the", "evaluation", "of", "new", "potentially", "LMP", "-", "inducing", "compounds", ".", "In", "this", "introduction", ",", "we", "provide", "an", "overview", "of", "some", "basic", "assays", "for", "assessing", "LMP", ",", "such", "as", "staining", "with", "lysosomotropic", "dyes", "and", "measurement", "of", "cysteine", "cathepsin", "activity", ",", "and", "discuss", "additional", "strategies", "for", "the", "detection", "of", "the", "release", "of", "endogenous", "lysosomal", "molecules", "or", "preloaded", "exogenous", "tracers", "into", "the", "cytosol", "." ]	[ "B-Therapeutic or Preventive Procedure", "O", "B-Laboratory Procedure", "B-Cell Component", "B-Cell Component", "B-Cell Function", "B-Cell Component", "B-Cell Component", "B-Cell Component", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Enzyme", "B-Enzyme", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Cell Component", "B-Spatial Concept", "O", "B-Cell Function", "O", "O", "O", "O", "B-Cell", "O", "O", "B-Cell Function", "O", "O", "O", "O", "O", "B-Cell Component", "B-Cell Component", "B-Cell Function", "O", "B-Cell Function", "O", "O", "O", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Cell Component", "O", "O", "O", "O", "O", "B-Cell Component", "O", "O", "O", "B-Cell Function", "O", "B-Qualitative Concept", "O", "O", "O", "B-Cell Function", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Cell Function", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell Function", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Cell Function", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Cell Function", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Health Care Activity", "B-Cell Function", "O", "O", "O", "O", "O", "B-Indicator, Reagent, or Diagnostic Aid", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "O", "B-Biologically Active Substance", "B-Enzyme", "B-Molecular Function", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "B-Cell Component", "B-Substance", "O", "O", "B-Functional Concept", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Cell Component", "O" ]
[ "Active", "diffusion", "and", "microtubule-based", "transport", "oppose", "myosin", "forces", "to", "position", "organelles", "in", "cells", "Even", "distribution", "of", "peroxisomes", "(", "POs", ")", "and", "lipid", "droplets", "(", "LDs", ")", "is", "critical", "to", "their", "role", "in", "lipid", "and", "reactive", "oxygen", "species", "homeostasis", ".", "How", "even", "distribution", "is", "achieved", "remains", "elusive", ",", "but", "diffusive", "motion", "and", "directed", "motility", "may", "play", "a", "role", ".", "Here", "we", "show", "that", "in", "the", "fungus", "Ustilago", "maydis", "~95", "%", "of", "POs", "and", "LDs", "undergo", "diffusive", "motions", ".", "These", "movements", "require", "ATP", "and", "involve", "bidirectional", "early", "endosome", "motility", ",", "indicating", "that", "microtubule", "-", "associated", "membrane", "trafficking", "enhances", "diffusion", "of", "organelles", ".", "When", "early", "endosome", "transport", "is", "abolished", ",", "POs", "and", "LDs", "drift", "slowly", "towards", "the", "growing", "cell", "end", ".", "This", "pole-ward", "drift", "is", "facilitated", "by", "anterograde", "delivery", "of", "secretory", "cargo", "to", "the", "cell", "tip", "by", "myosin-5", ".", "Modelling", "reveals", "that", "microtubule-based", "directed", "transport", "and", "active", "diffusion", "support", "distribution", ",", "mobility", "and", "mixing", "of", "POs", ".", "In", "mammalian", "COS-7", "cells", ",", "microtubules", "and", "F-actin", "also", "counteract", "each", "other", "to", "distribute", "POs", ".", "This", "highlights", "the", "importance", "of", "opposing", "cytoskeletal", "forces", "in", "organelle", "positioning", "in", "eukaryotes", "." ]	[ "B-Functional Concept", "B-Natural Phenomenon or Process", "O", "B-Cell Function", "B-Cell Function", "O", "B-Biologically Active Substance", "B-Phenomenon or Process", "O", "B-Spatial Concept", "B-Cell Component", "O", "B-Cell", "O", "B-Functional Concept", "O", "B-Cell Component", "O", "B-Cell Component", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Cell Component", "O", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Organic Chemical", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Biologic Function", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Organism Function", "O", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "O", "B-Fungus", "B-Fungus", "B-Fungus", "O", "O", "O", "B-Cell Component", "O", "B-Cell Component", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Organism Function", "O", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "O", "B-Cell Component", "B-Organism Function", "O", "O", "O", "B-Cell Component", "O", "B-Qualitative Concept", "B-Cell Component", "B-Cell Function", "B-Activity", "B-Natural Phenomenon or Process", "O", "B-Cell Component", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "O", "O", "B-Cell Component", "O", "B-Cell Component", "O", "O", "O", "O", "B-Cell Component", "B-Cell Component", "B-Cell Component", "O", "O", "B-Cell Function", "B-Cell Function", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Enzyme", "O", "B-Research Activity", "O", "O", "B-Cell Function", "B-Cell Function", "B-Cell Function", "O", "B-Functional Concept", "B-Natural Phenomenon or Process", "O", "B-Functional Concept", "O", "B-Cell Function", "O", "O", "O", "B-Cell Component", "O", "O", "B-Mammal", "B-Cell", "B-Cell", "O", "B-Cell Component", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Cell Component", "O", "O", "O", "O", "O", "O", "O", "B-Cell Component", "B-Phenomenon or Process", "O", "B-Cell Component", "B-Spatial Concept", "O", "B-Eukaryote", "O" ]
[ "Stimulation", "of", "cell", "proliferation", "by", "glutathione", "monoethyl", "ester", "in", "aged", "bone", "marrow", "stromal", "cells", "is", "associated", "with", "the", "assistance", "of", "TERT", "gene", "expression", "and", "telomerase", "activity", "The", "proliferation", "and", "differentiation", "potential", "of", "aged", "bone", "marrow", "stromal", "cells", "(", "BMSCs", ")", "are", "significantly", "reduced", ".", "In", "order", "to", "improve", "the", "performance", "of", "the", "aged", "BMSCs", ",", "these", "cells", "were", "treated", "with", "2", "mM", "glutathione", "monoethyl", "ester", "(", "GSH-MEE", ")", "for", "24", "h.", "Proliferation", "rate", ",", "telomerase", "activity", ",", "telomere", "length", ",", "and", "differentiation", "to", "cholinergic", "neuron-like", "cells", "(", "CNLCs", ")", "were", "observed", "to", "increase", ".", "Though", ",", "the", "expression", "level", "of", "telomerase", "reverse", "transcriptase", "gene", "increased", ",", "but", "CTC1", "and", "TEN1", "genes", "from", "Ctc1-Stn1-Ten1", "complex", "encoding", "proteins", "with", "regulatory", "function", "significantly", "decreased", ".", "Trypan", "blue", "exclusion", "assay", "was", "used", "to", "analyze", "the", "proliferation", "and", ",", "while", "telomere", "length", ",", "its", "several", "related", "gene", "expressions", ",", "and", "telomerase", "activity", "were", "measured", "using", "the", "real", "time", "reverse", "transcription-polymerase", "chain", "reaction", "and", "polymerase", "chain", "reaction", "enzyme-linked", "immunosorbent", "assay", "techniques", ",", "respectively", ".", "CNLCs", "differentiation", "potential", "was", "evaluated", "by", "estimating", "the", "percentage", "of", "choline", "acetyltransferase", "immunereactive", "cells", ".The", "results", "suggested", "that", "GSH-MEE", "could", "improve", "aged", "rat", "BMSC", "properties", "and", "would", "be", "of", "potential", "benefit", "for", "enhancing", "the", "performance", "of", "aged", "people", "'s", "BMSCs", "." ]	[ "B-Functional Concept", "O", "B-Cell Function", "B-Cell Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Gene or Genome", "B-Genetic Function", "B-Genetic Function", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Cell Function", "O", "B-Cell Function", "B-Qualitative Concept", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Organism Attribute", "B-Cell", "O", "O", "B-Cell", "O", "B-Functional Concept", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "B-Cell Function", "B-Quantitative Concept", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Cell Component", "B-Quantitative Concept", "O", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Functional Concept", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Cell Component", "B-Cell Component", "B-Activity", "B-Biologically Active Substance", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Quantitative Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Cell Function", "O", "O", "O", "B-Cell Component", "B-Quantitative Concept", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "B-Cell", "B-Cell Function", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Finding", "O", "B-Mammal", "B-Cell", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Activity", "O", "O", "O", "B-Population Group", "B-Population Group", "B-Population Group", "B-Cell", "O" ]
[ "Wild", "food", "plants", "and", "fungi", "used", "in", "the", "mycophilous", "Tibetan", "community", "of", "Zhagana", "(", "Tewo", "County", ",", "Gansu", ",", "China", ")", "The", "aim", "of", "the", "study", "was", "to", "investigate", "knowledge", "and", "use", "of", "wild", "food", "plants", "and", "fungi", "in", "a", "highland", "valley", "in", "the", "Gannan", "Tibetan", "Autonomous", "Region", "on", "the", "north-eastern", "edges", "of", "the", "Tibetan", "Plateau", ".", "Field", "research", "was", "carried", "out", "in", "four", "neighbouring", "villages", "in", "a", "mountain", "valley", "of", "the", "Diebu", "(", "Tewo", ")", "county", ",", "surrounded", "by", "spruce", "forests", ".", "The", "study", "consisted", "of", "30", "interviews", "with", "single", "informants", ",", "or", "group", "interviews", "(", "altogether", "63", "informants", ")", ".", "Apart", "from", "collecting", "voucher", "specimens", ",", "we", "also", "identified", "fungi", "using", "DNA", "barcoding", ".", "We", "recorded", "the", "use", "of", "54", "species", "of", "vascular", "plants", ".", "We", "also", "recorded", "the", "use", "of", "22", "mushroom", "taxa", ",", "which", "made", "up", "the", "largest", "category", "of", "wild", "foods", ".", "Fruits", "formed", "the", "largest", "category", "of", "food", "plants", ",", "with", "21", "species", ",", "larger", "than", "the", "wild", "greens", "category", ",", "which", "consisted", "of", "20", "species", "eaten", "after", "boiling", "or", "frying", "and", "7", "as", "raw", "snacks", ".", "We", "also", "recorded", "the", "alimentary", "use", "of", "10", "species", "of", "edible", "flowers", "and", "3", "species", "with", "underground", "edible", "organs", ".", "On", "average", ",", "20.8", "edible", "taxa", "were", "listed", "per", "interview", "(", "median", "-", "21", ")", ".", "The", "most", "listed", "category", "of", "wild", "foods", "was", "green", "vegetables", "(", "mean", "-", "7.5", "species", ",", "median", "-", "8", "species", ")", ",", "but", "fruits", "and", "mushrooms", "were", "listed", "nearly", "as", "frequently", "(", "mean", "-", "6.3", ",", "median", "-", "6", "and", "mean", "-", "5.8", ",", "-", "median", "6", "respectively", ")", ".", "Other", "category", "lists", "were", "very", "short", ",", "e.g.", ",", "flowers", "(", "mean", "-", "1.3", ",", "median", "-", "1", ")", "and", "underground", "edible", "parts", "(", "mean", "-", "0.7", ",", "median", "-", "1", ")", ".", "Wild", "vegetables", "are", "usually", "boiled", "and/or", "fried", "and", "served", "as", "side-dishes", ",", "or", "their", "green", "parts", "are", "eaten", "as", "snacks", "during", "mountain", "treks", "(", "e.g.", ",", "peeled", "rhubarb", "shoots", ")", ".", "Wild", "fruits", "are", "mainly", "collected", "by", "children", "and", "eaten", "raw", ",", "they", "are", "not", "stored", "for", "further", "use", ".", "The", "most", "widely", "used", "wild", "staple", "foods", "are", "Potetilla", "anserina", "roots", ",", "an", "important", "ceremonial", "food", "served", "on", "such", "occasions", "as", "New", "Year", "or", "at", "funerals", ".", "They", "are", "boiled", "and", "served", "with", "sugar", "and", "butter", ".", "The", "most", "important", "famine", "plants", "remembered", "by", "people", "are", "the", "aerial", "bulbils", "of", "Persicaria", "vivipara", ".", "Flowers", "are", "used", "as", "children", "'s", "snacks", "-", "their", "nectar", "is", "sucked", ".", "The", "number", "of", "wild", "taxa", "eaten", "in", "the", "studied", "valley", "is", "similar", "to", "that", "of", "other", "Tibetan", "areas", ".", "The", "structure", "of", "wild", "food", "plant", "taxa", "is", "also", "very", "typical", "for", "Tibetan", "speaking", "areas", "(", "e.g.", ",", "the", "use", "of", "rhubarb", "shoots", ",", "Potentilla", "anserina", ",", "Persicaria", "vivipara", ")", ".", "The", "studied", "community", "show", "a", "high", "level", "of", "mycophilia", "." ]	[ "B-Food", "B-Food", "B-Food", "O", "B-Fungus", "O", "O", "O", "B-Food", "B-Geographic Area", "B-Group", "O", "B-Geographic Area", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Functional Concept", "B-Intellectual Product", "O", "O", "O", "B-Food", "B-Food", "B-Food", "O", "B-Fungus", "O", "O", "O", "B-Spatial Concept", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "O", "B-Geographic Area", "B-Spatial Concept", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Research Activity", "O", "O", "O", "B-Activity", "O", "O", "B-Functional Concept", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "O", "B-Fungus", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "B-Food", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "O", "B-Classification", "O", "O", "O", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Organism Function", "O", "B-Occupational Activity", "O", "B-Occupational Activity", "O", "O", "O", "B-Qualitative Concept", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "O", "B-Plant", "B-Plant", "O", "O", "B-Classification", "O", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "B-Food", "B-Food", "O", "O", "O", "O", "B-Classification", "O", "O", "O", "O", "B-Classification", "O", "O", "O", "B-Food", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "B-Occupational Activity", "O", "O", "O", "O", "O", "B-Plant", "B-Plant", "O", "B-Organism Function", "O", "B-Food", "O", "B-Geographic Area", "B-Daily or Recreational Activity", "O", "O", "O", "B-Plant", "B-Plant", "B-Plant", "O", "O", "B-Food", "B-Food", "O", "O", "O", "O", "B-Age Group", "O", "B-Organism Function", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "B-Food", "O", "B-Plant", "B-Plant", "B-Plant", "O", "O", "O", "B-Food", "B-Food", "B-Occupational Activity", "O", "O", "B-Event", "O", "O", "O", "O", "O", "B-Social Behavior", "O", "O", "O", "B-Qualitative Concept", "O", "B-Occupational Activity", "O", "B-Pharmacologic Substance", "O", "B-Food", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Plant", "O", "O", "B-Population Group", "O", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Plant", "O", "B-Plant", "O", "O", "O", "B-Age Group", "B-Age Group", "B-Food", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "B-Plant", "B-Plant", "B-Organism Function", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "B-Food", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "B-Language", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "B-Food", "O" ]
[ "Early", "assessment", "of", "bilateral", "inguinal", "hernia", "repair", ":", "A", "comparison", "between", "the", "laparoscopic", "total", "extraperitoneal", "and", "Stoppa", "approaches", "The", "present", "clinical", "trial", "was", "designed", "to", "compare", "the", "results", "of", "bilateral", "inguinal", "hernia", "repair", "between", "patients", "who", "underwent", "the", "conventional", "Stoppa", "technique", "and", "laparoscopic", "total", "extraperitoneal", "repair", "(", "LTE", ")", "with", "a", "single", "mesh", "and", "without", "staple", "fixation", ".", "This", "controlled", ",", "randomised", "clinical", "trial", "was", "conducted", "at", "General", "Surgery", "and", "Trauma", "of", "the", "Clinics", "Hospital", ",", "Medical", "School", ",", "the", "University", "of", "Sγo", "Paulo", "between", "September", "2010", "and", "February", "2011", ".", "Totally", ",", "50", "male", "patients", ",", "with", "a", "bilateral", "inguinal", "hernia", ",", "older", "than", "25", "years", "were", "considered", "eligible", "for", "the", "study", ".", "The", "following", "parameters", "were", "analysed", "during", "the", "early", "post-operative", "period", ":", "(", "1", ")", "The", "intensity", "of", "surgical", "trauma", ",", "operation", "time", ",", "C-reactive", "protein", "(", "CRP", ")", "levels", ",", "white", "blood", "cell", "count", ",", "bleeding", "and", "pain", "intensity", ";", "(", "2", ")", "quality", "of", "life", "assessment", ";", "and", "(", "3", ")", "post-operative", "complications", ".", "LTE", "procedure", "was", "longer", "than", "the", "Stoppa", "procedure", "(", "134.6", "min", "΁", "38.3", "vs.", "90.6", "min", "΁", "41.3", ";", "P", "<", "0.05", ")", ".", "The", "levels", "of", "CRP", "were", "higher", "in", "the", "Stoppa", "group", "(", "P", "<", "0.05", ")", "but", "the", "number", "of", "leucocytes", ",", "haematocrit", ",", "and", "haemoglobin", "were", "similar", "between", "the", "groups", "(", "P", ">", "0.05", ")", ".", "There", "was", "no", "difference", "in", "pain", "during", "the", "1", "st", "and", "7", "th", "post-operative", ",", "physical", "functioning", ",", "physical", "limitation", ",", "the", "impact", "of", "pain", "on", "daily", "activities", ",", "and", "the", "Carolinas", "Comfort", "Scale", "during", "the", "7", "th", "and", "15", "th", "post-operative", "(", "P", ">", "0.05", ")", ".", "Complications", "occurred", "in", "88", "%", "of", "Stoppa", "group", "(", "22", "patients", ")", "and", "64", "%", "in", "LTE", "group", "(", "16", "patients", ")", "(", "P", "<", "0.05", ")", ".", "The", "comparative", "study", "between", "the", "Stoppa", "and", "LTE", "approaches", "for", "the", "bilateral", "inguinal", "hernia", "repair", "demonstrated", "that", ":", "(", "1", ")", "The", "LTE", "approach", "showed", "less", "surgical", "trauma", "despite", "the", "longer", "operation", "time", ";", "(", "2", ")", "Quality", "of", "life", "during", "the", "early", "post-operative", "period", "were", "similar", ";", "and", "(", "3", ")", "Complication", "rates", "were", "higher", "in", "the", "Stoppa", "group", "." ]	[ "B-Temporal Concept", "B-Health Care Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Temporal Concept", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Medical Device", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "B-Patient or Disabled Group", "O", "O", "O", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Research Activity", "O", "O", "O", "B-Conceptual Entity", "O", "B-Research Activity", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Qualitative Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Pathologic Function", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "B-Health Care Activity", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Immunologic Factor", "O", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "B-Finding", "O", "O", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "B-Sign or Symptom", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Idea or Concept", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Idea or Concept", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Quantitative Concept", "O", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Idea or Concept", "O" ]
[ "The", "role", "of", "catheter", "ablation", "in", "the", "management", "of", "atrial", "fibrillation", "Atrial", "fibrillation", "is", "driven", "by", "spontaneous", "electrical", "activation", "emerging", "from", "the", "pulmonary", "veins", ".", "Catheter", "ablation", "using", "either", "radiofrequency", "or", "cryothermal", "energy", "electrically", "isolates", "these", "veins", "from", "the", "left", "atrium", ",", "both", "reducing", "the", "burden", "of", "atrial", "fibrillation", "episodes", "and", "improving", "the", "patient", "'s", "symptoms", ".", "Catheter", "ablation", "is", "superior", "to", "antiarryhthmic", "drugs", "when", "patients", "are", "carefully", "selected", ".", "Underlying", "medical", "problems", "-", "including", "obesity", ",", "hypertension", "and", "obstructive", "sleep", "apnoea", "-", "should", "be", "optimally", "treated", "before", "considering", "ablation", ".", "Although", "this", "treatment", "has", "the", "potential", "to", "cure", "patients", "of", "their", "symptoms", ",", "they", "should", "be", "aware", "of", "the", "important", "associated", "procedural", "complications", "." ]	[ "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Health Care Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Organism Function", "B-Organism Function", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Temporal Concept", "O", "O", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "B-Sign or Symptom", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "O", "B-Conceptual Entity", "B-Patient or Disabled Group", "O", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O" ]
[ "The", "Chinese", "Herbal", "Mixture", "Tien-Hsien", "Liquid", "Augments", "the", "Anticancer", "Immunity", "in", "Tumor", "Cell", "-", "Vaccinated", "Mice", "Background", "The", "Chinese", "herbal", "mixture", ",", "Tien-Hsien", "liquid", "(", "THL", ")", ",", "has", "been", "used", "as", "an", "anticancer", "dietary", "supplement", "for", "more", "than", "20", "years", ".", "Our", "previous", "studies", "have", "shown", "that", "THL", "can", "modulate", "immune", "response", "and", "inhibit", "tumor", "growth", ".", "In", "this", "study", ",", "we", "further", "evaluated", "the", "effect", "of", "THL", "on", "anticancer", "immune", "response", "in", "mice", "vaccinated", "with", "γ-ray", "-", "irradiated", "tumor", "cells", ".", "Methods", "The", "antitumor", "effect", "of", "THL", "was", "determined", "in", "mice", "vaccinated", "with", "low-tumorigenic", "CT-26-low", "colon", "cancer", "cells", "or", "γ-ray-irradiated", "high-tumorigenic", "CT-26-high", "colon", "cancer", "cells", ".", "The", "number", "of", "natural", "killer", "(", "NK", ")", "cells", "and", "T", "lymphocytes", "in", "the", "spleen", "was", "analyzed", "by", "flow", "cytometry", ".", "The", "tumor", "-", "killing", "activities", "of", "NK", "cells", "and", "cytotoxic", "T", "lymphocytes", "(", "CTLs", ")", "were", "analyzed", "by", "flow", "cytometry", "using", "YAC-1", "and", "CT-26-high", "cells", ",", "respectively", ",", "as", "target", "cells", ".", "The", "levels", "of", "IFN-γ", ",", "IL-2", ",", "and", "TNF-α", "were", "determined", "by", "ELISA", ".", "Results", "THL", "suppressed", "the", "growth", "of", "CT-26-high", "tumor", "in", "mice", "previously", "vaccinated", "with", "low-tumorigenic", "CT-26-low", "cells", "or", "γ-irradiated", "CT-26-high", "cells", ".", "THL", "increased", "the", "populations", "of", "NK", "cells", "and", "CD4+", "T", "lymphocytes", "in", "the", "spleen", "and", "enhanced", "the", "tumor", "-", "killing", "activities", "of", "NK", "cells", "and", "CTL", "in", "mice", "vaccinated", "with", "γ-irradiated", "CT-26-high", "cells", ".", "THL", "increased", "the", "production", "of", "IFN-γ", ",", "IL-2", ",", "and", "TNF-α", "in", "mice", "vaccinated", "with", "γ-irradiated", "CT-26-high", "cells", ".", "Conclusion", "THL", "can", "enhance", "the", "antitumor", "immune", "responses", "in", "mice", "vaccinated", "with", "killed", "tumor", "cells", ".", "These", "results", "suggest", "that", "THL", "may", "be", "used", "as", "a", "complementary", "medicine", "for", "cancer", "patients", "previously", "treated", "with", "killed", "tumor", "cell", "vaccines", ",", "radiotherapy", ",", "or", "chemotherapy", "." ]	[ "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Physiologic Function", "O", "B-Cell", "B-Cell", "O", "B-Finding", "B-Mammal", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Substance", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Food", "B-Food", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "B-Research Activity", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Spatial Concept", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "B-Activity", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Research Activity", "O", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "B-Mammal", "B-Finding", "O", "B-Natural Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "B-Cell", "B-Cell", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "O", "B-Mammal", "B-Finding", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Therapeutic or Preventive Procedure", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Quantitative Concept", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "B-Cell", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Research Activity", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Neoplastic Process", "O", "B-Cell Function", "B-Activity", "O", "B-Cell", "B-Cell", "O", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "O", "O", "B-Research Activity", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Cell", "O", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Functional Concept", "B-Cell", "O", "O", "B-Qualitative Concept", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "O", "B-Immunologic Factor", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Laboratory Procedure", "O", "O", "B-Pharmacologic Substance", "B-Functional Concept", "O", "B-Organism Function", "O", "B-Cell", "B-Cell", "O", "B-Mammal", "O", "B-Finding", "O", "B-Cell", "B-Cell", "B-Cell", "O", "B-Therapeutic or Preventive Procedure", "B-Cell", "B-Cell", "O", "B-Pharmacologic Substance", "B-Quantitative Concept", "O", "O", "O", "B-Cell", "B-Cell", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Activity", "O", "B-Neoplastic Process", "O", "B-Cell Function", "B-Activity", "O", "B-Cell", "B-Cell", "O", "B-Cell", "O", "B-Mammal", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "B-Cell", "B-Cell", "O", "B-Pharmacologic Substance", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "O", "B-Immunologic Factor", "O", "B-Mammal", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "B-Cell", "B-Cell", "O", "O", "B-Pharmacologic Substance", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "B-Mammal", "B-Finding", "O", "B-Functional Concept", "B-Cell", "B-Cell", "O", "O", "B-Functional Concept", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Biomedical Occupation or Discipline", "O", "B-Neoplastic Process", "B-Patient or Disabled Group", "B-Temporal Concept", "B-Functional Concept", "O", "B-Immunologic Factor", "B-Immunologic Factor", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O" ]
[ "Comparison", "of", "Head", "Elevation", "Protocols", "Following", "Femoral", "Artery", "Sheath", "Removal", "After", "Coronary", "Angiography", "To", "compare", "2", "standard", "protocols", "for", "head", "elevation", "following", "removal", "of", "a", "femoral", "artery", "sheath", "after", "coronary", "angiography", "and", "their", "effects", "on", "bleeding", "complications", "and", "reported", "levels", "of", "back", "pain", ".", "One", "protocol", "involved", "flat", "supine", "bed", "rest", ";", "the", "other", "allowed", "progressive", "head", "elevation", ".", "A", "prospective", "comparative", "study", "of", "80", "adult", "patients", "undergoing", "coronary", "angiography", "via", "the", "femoral", "approach", ".", "The", "Numeric", "Rating", "Scale", "was", "used", "as", "the", "measure", "of", "reported", "pain", ".", "No", "bleeding", "complications", "occurred", "in", "either", "group", ".", "Both", "groups", "had", "very", "low", "mean", "pain", "scores", ".", "Repeated-", "measures", "analysis", "demonstrated", "that", "the", "experience", "of", "pain", "differed", "significantly", "over", "time", "by", "location", "(", "F5,70", "=", "3.864", ",", "P", "=", ".004", ")", ",", "with", "a", "notable", "decrease", "in", "pain", "scores", "more", "than", "1", "hour", "after", "sheath", "removal", "at", "the", "location", "that", "used", "the", "progressive", "head", "elevation", "protocol", ".", "Patients", "'", "satisfaction", "scores", "after", "discharge", "did", "not", "differ", "significantly", "between", "the", "2", "groups", ".", "Patients", "with", "a", "history", "of", "chronic", "back", "pain", "had", "consistently", "higher", "pain", "scores", ",", "but", "those", "pain", "scores", "did", "not", "differ", "significantly", "by", "location", "(", "or", "protocol", ")", ".", "It", "appears", "that", "using", "a", "progressive", "head", "-", "elevation", "protocol", "within", "the", "first", "3", "hours", "after", "diagnostic", "angiography", "is", "not", "associated", "with", "an", "increased", "risk", "of", "bleeding", "complications", "at", "the", "access", "site", "and", "warrants", "further", "exploration", "in", "the", "mitigation", "of", "back", "pain", "associated", "with", "prolonged", "supine", "bed", "rest", "." ]	[ "B-Activity", "O", "B-Body Location or Region", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Therapeutic or Preventive Procedure", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body Location or Region", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Qualitative Concept", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Body Location or Region", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Age Group", "B-Patient or Disabled Group", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Spatial Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Sign or Symptom", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "B-Research Activity", "O", "O", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "B-Temporal Concept", "O", "B-Body Location or Region", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Temporal Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Body Location or Region", "O", "O", "O", "O", "B-Body Location or Region", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Patient or Disabled Group", "O", "O", "B-Finding", "O", "B-Temporal Concept", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Body Location or Region", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Location or Region", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Temporal Concept", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O" ]
[ "Morphological", "characteristics", "regulating", "phallic", "glans", "engorgement", "in", "the", "American", "alligator", "The", "distal", "part", "of", "the", "crocodilian", "phallus", "consists", "of", "a", "bulbous", "glans", "containing", "well-developed", "vascular", "tissues", "that", "can", "inflate", "before", "or", "during", "sexual", "activity", ",", "enlarging", "and", "elaborating", "the", "glans", "into", "a", "complex", ",", "though", "still", "functionally", "undefined", ",", "copulatory", "structure", ".", "An", "enlarged", "glans", "putatively", "interacts", "with", "the", "female", "cloaca", "and", "may", "change", "the", "shape", "of", "her", "reproductive", "tract", "to", "facilitate", "insemination", "and", "increase", "the", "probability", "of", "fertilization", ".", "Here", ",", "we", "investigated", "the", "cellular-level", "properties", "of", "the", "glans", "and", "other", "inflatable", "phallic", "tissues", "associated", "with", "the", "sperm", "-conducting", "sulcus", "spermaticus", "in", "the", "American", "alligator", "(", "Alligator", "mississippiensis", ")", ".", "Using", "histochemical", "staining", ",", "we", "visualized", "and", "defined", "collagen", "and", "elastin", "fiber", "densities", "and", "orientations", "in", "these", "tissues", ".", "Extracellular", "matrix", "architectures", "provided", "insights", "about", "phallic", "glans", "material", "properties", "and", "how", "they", "may", "affect", "tissue", "strength", "and", "flexibility", "during", "inflation", "and", "in", "response", "to", "copulatory", "forces", ".", "We", "also", "investigated", "the", "potential", "sources", "of", "fluids", "that", "induce", "inflation", "in", "alligator", "phalli", ".", "Combining", "serial", "sectioning", "and", "three-dimensional", "reconstruction", ",", "we", "identified", "a", "pair", "of", "supracrucal", "plexus", "vascular", "bodies", "at", "the", "proximal", "end", "of", "the", "alligator", "phallus", "that", "extend", "distally", "adjacent", "to", "ventro-medial", "sulcus", "tissues", ".", "Together", ",", "our", "gross", "and", "histological", "examination", "of", "the", "American", "alligator", "phallic", "glans", "suggests", "that", "its", "tissues", "are", "arranged", "in", "a", "manner", "that", "would", "allow", "vascular", "inflation", "to", "expand", "the", "glans", "to", "a", "specific", "and", "repeatable", "shape", ",", "and", "potentially", "release", "secretory", "products", "into", "the", "female", "reproductive", "tract", ".", "Both", "elements", "could", "play", "roles", "in", "postcopulatory", "sexual", "selection", ",", "by", "mechanically", "and/or", "chemically", "affecting", "female", "reproductive", "physiology", "." ]	[ "B-Spatial Concept", "B-Qualitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Disease or Syndrome", "O", "O", "B-Reptile", "B-Reptile", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Reptile", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "O", "O", "O", "B-Behavior", "B-Behavior", "O", "B-Qualitative Concept", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "B-Idea or Concept", "O", "B-Social Behavior", "O", "O", "O", "B-Qualitative Concept", "B-Body Part, Organ, or Organ Component", "O", "B-Functional Concept", "O", "O", "B-Organism Attribute", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Functional Concept", "O", "B-Spatial Concept", "O", "B-Body System", "B-Body System", "B-Body System", "O", "O", "B-Organ or Tissue Function", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "B-Organism Function", "O", "O", "O", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Tissue", "B-Tissue", "B-Tissue", "O", "O", "O", "B-Cell", "O", "B-Body Space or Junction", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Reptile", "B-Reptile", "O", "B-Reptile", "B-Reptile", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "B-Tissue", "B-Tissue", "B-Quantitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Tissue", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Tissue", "B-Quantitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Social Behavior", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Substance", "O", "B-Functional Concept", "O", "O", "B-Reptile", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Cell Component", "O", "O", "O", "O", "O", "O", "B-Reptile", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "B-Tissue", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "B-Reptile", "B-Reptile", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "O", "B-Cell Component", "B-Cell Component", "O", "O", "B-Body System", "B-Body System", "B-Body System", "O", "O", "O", "O", "O", "O", "O", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "O", "B-Functional Concept", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "B-Physiologic Function", "B-Physiologic Function", "O" ]
[ "Heterogeneous", "Mechanisms", "of", "Primary", "and", "Acquired", "Resistance", "to", "Third-Generation", "EGFR", "Inhibitors", "To", "identify", "novel", "mechanisms", "of", "resistance", "to", "third-generation", "EGFR", "inhibitors", "in", "patients", "with", "lung", "adenocarcinoma", "that", "progressed", "under", "therapy", "with", "either", "AZD9291", "or", "rociletinib", "(", "CO-1686", ")", ".", "We", "analyzed", "tumor", "biopsies", "from", "seven", "patients", "obtained", "before", ",", "during", ",", "and/or", "after", "treatment", "with", "AZD9291", "or", "rociletinib", "(", "CO-1686", ")", ".", "Targeted", "sequencing", "and", "FISH", "analyses", "were", "performed", ",", "and", "the", "relevance", "of", "candidate", "genes", "was", "functionally", "assessed", "in", "in", "vitro", "models", ".", "We", "found", "recurrent", "amplification", "of", "either", "MET", "or", "ERBB2", "in", "tumors", "that", "were", "resistant", "or", "developed", "resistance", "to", "third-generation", "EGFR", "inhibitors", "and", "show", "that", "ERBB2", "and", "MET", "activation", "can", "confer", "resistance", "to", "these", "compounds", ".", "Furthermore", ",", "we", "identified", "a", "KRAS", "(", "G12S", ")", "mutation", "in", "a", "patient", "with", "acquired", "resistance", "to", "AZD9291", "as", "a", "potential", "driver", "of", "acquired", "resistance", ".", "Finally", ",", "we", "show", "that", "dual", "inhibition", "of", "EGFR", "/MEK", "might", "be", "a", "viable", "strategy", "to", "overcome", "resistance", "in", "EGFR-mutant", "cells", "expressing", "mutant", "KRAS", "CONCLUSIONS", ":", "Our", "data", "suggest", "that", "heterogeneous", "mechanisms", "of", "resistance", "can", "drive", "primary", "and", "acquired", "resistance", "to", "third-generation", "EGFR", "inhibitors", "and", "provide", "a", "rationale", "for", "potential", "combination", "strategies", ".", "Clin", "Cancer", "Res", ";", "1-11", ".", "©2016", "AACR", "." ]	[ "B-Functional Concept", "B-Functional Concept", "O", "B-Biologic Function", "B-Biologic Function", "B-Biologic Function", "B-Biologic Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "I-Biologic Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Research Activity", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Quantitative Concept", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Activity", "B-Activity", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Neoplastic Process", "O", "O", "B-Biologic Function", "O", "B-Biologic Function", "B-Biologic Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "O", "B-Genetic Function", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Biologic Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Patient or Disabled Group", "O", "B-Biologic Function", "B-Biologic Function", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Biologic Function", "B-Biologic Function", "O", "O", "O", "O", "O", "O", "B-Activity", "B-Activity", "O", "I-Enzyme", "B-Enzyme", "O", "O", "O", "B-Mental Process", "B-Mental Process", "O", "O", "B-Biologic Function", "O", "B-Cell", "B-Cell", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "I-Biologic Function", "O", "O", "B-Biologic Function", "B-Biologic Function", "B-Biologic Function", "B-Biologic Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Nax", "signaling", "evoked", "by", "an", "increase", "in", "[", "Na+", "]", "in", "CSF", "induces", "water", "intake", "via", "EET", "-mediated", "TRPV4", "activation", "Water-intake", "behavior", "is", "under", "the", "control", "of", "brain", "systems", "that", "sense", "body-fluid", "conditions", "at", "sensory", "circumventricular", "organs", "(", "sCVOs", ")", ";", "however", ",", "the", "underlying", "mechanisms", "have", "not", "yet", "been", "elucidated", "in", "detail", ".", "Nax", "is", "a", "sodium", "(", "Na", "(", "+", ")", ")", "level", "sensor", "in", "the", "brain", ",", "and", "the", "transient", "receptor", "potential", "vanilloid", "(", "TRPV", ")", "channels", ",", "TRPV1", "and", "TRPV4", ",", "have", "been", "proposed", "to", "function", "as", "osmosensors", ".", "We", "herein", "investigated", "voluntary", "water", "intake", "immediately", "induced", "after", "an", "intracerebroventricular", "(", "icv", ")", "administration", "of", "a", "hypertonic", "NaCl", "solution", "in", "TRPV1-", ",", "TRPV4-", ",", "Nax-", ",", "and", "their", "double-gene", "knockout", "(", "KO", ")", "mice", ".", "The", "induction", "of", "water", "intake", "by", "TRPV1", "-", "KO", "mice", "was", "normal", ",", "whereas", "that", "by", "TRPV4", "-", "KO", "and", "Nax", "-", "KO", "mice", "was", "significantly", "less", "than", "that", "by", "WT", "mice", ".", "Water", "intake", "by", "Nax", "/", "TRPV4", "-", "double", "KO", "mice", "was", "similar", "to", "that", "by", "the", "respective", "single", "KO", "mice", ".", "When", "TRPV4", "activity", "was", "blocked", "with", "a", "specific", "antagonist", "HC-067047", ",", "water", "intake", "by", "WT", "mice", "was", "significantly", "reduced", ",", "whereas", "that", "by", "TRPV4", "-", "KO", "and", "Nax", "-", "KO", "mice", "was", "not", ".", "Similar", "results", "were", "obtained", "with", "the", "administration", "of", "miconazole", ",", "which", "inhibits", "the", "biosynthesis", "of", "epoxyeicosatrienoic", "acids", "(", "EETs", ")", ",", "endogenous", "agonists", "for", "TRPV4", ",", "from", "arachidonic", "acid", "(", "AA", ")", ".", "Icv", "injection", "of", "hypertonic", "NaCl", "with", "AA", "or", "5,6-EET", "restored", "water", "intake", "by", "Nax", "-", "KO", "mice", "to", "the", "WT", "level", ",", "but", "not", "that", "by", "TRPV4", "-", "KO", "mice", ".", "These", "results", "suggest", "that", "the", "Na", "(", "+", ")", "signal", "generated", "in", "Nax", "-", "positive", "glial", "cells", "leads", "to", "the", "activation", "of", "TRPV4", "-", "positive", "neurons", "in", "sCVOs", "in", "order", "to", "stimulate", "water", "intake", "by", "using", "EETs", "as", "gliotransmitters", "." ]	[ "B-Biologically Active Substance", "B-Cell Function", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "B-Element, Ion, or Isotope", "O", "O", "B-Body Substance", "B-Functional Concept", "B-Organism Function", "B-Organism Function", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "B-Genetic Function", "B-Organism Function", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Substance", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Element, Ion, or Isotope", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "O", "B-Qualitative Concept", "B-Molecular Function", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Receptor", "B-Receptor", "B-Receptor", "B-Receptor", "B-Receptor", "B-Receptor", "B-Receptor", "B-Receptor", "O", "B-Receptor", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Molecular Function", "O", "O", "O", "B-Functional Concept", "B-Individual Behavior", "B-Organism Function", "B-Organism Function", "O", "B-Functional Concept", "O", "O", "B-Spatial Concept", "O", "B-Spatial Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "B-Inorganic Chemical", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "B-Functional Concept", "O", "B-Organism Function", "B-Organism Function", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Mammal", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Mammal", "B-Mammal", "O", "B-Organism Function", "B-Organism Function", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "B-Mammal", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Mammal", "B-Mammal", "O", "O", "B-Biologically Active Substance", "B-Molecular Function", "O", "B-Functional Concept", "O", "O", "B-Chemical Viewed Functionally", "B-Chemical Viewed Functionally", "B-Pharmacologic Substance", "O", "B-Organism Function", "B-Organism Function", "O", "B-Mammal", "B-Mammal", "O", "B-Idea or Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Mammal", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "O", "O", "O", "B-Qualitative Concept", "B-Finding", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Pharmacologic Substance", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "B-Functional Concept", "B-Pharmacologic Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "O", "B-Organism Function", "B-Organism Function", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "O", "O", "B-Gene or Genome", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "O", "O", "B-Finding", "O", "O", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Phenomenon or Process", "O", "O", "B-Biologically Active Substance", "O", "B-Finding", "B-Cell", "B-Cell", "O", "O", "O", "B-Genetic Function", "O", "B-Biologically Active Substance", "O", "B-Finding", "B-Cell", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Organism Function", "B-Organism Function", "O", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "O" ]
[ "Timing", "of", "False", "Ring", "Formation", "in", "Pinus", "halepensis", "and", "Arbutus", "unedo", "in", "Southern", "Italy", ":", "Outlook", "from", "an", "Analysis", "of", "Xylogenesis", "and", "Tree-Ring", "Chronologies", "Mediterranean", "tree", "rings", "are", "characterized", "by", "intra-annual", "density", "fluctuations", "(", "IADFs", ")", "due", "to", "partly", "climate-driven", "cambial", "activity", ".", "IADFs", "are", "used", "as", "structural", "signals", "to", "gain", "information", "on", "relations", "between", "environmental", "conditions", "and", "eco-physiological", "processes", "during", "xylogenesis", ",", "with", "intra-annual", "resolution", ".", "To", "reach", "an", "unbiased", "synchronization", "of", "the", "IADF", "position", "within", "tree", "rings", "and", "seasonal", "fluctuations", "in", "environmental", "conditions", ",", "it", "is", "necessary", "to", "know", "the", "timing", "of", "cambial", "activity", "and", "wood", "formation", ",", "which", "are", "species-", "and", "site-specific", "processes", ".", "We", "applied", "the", "microcoring", "technique", "to", "analyze", "xylogenesis", "in", "Pinus", "halepensis", "and", "Arbutus", "unedo", ".", "To", "the", "best", "of", "our", "knowledge", ",", "this", "is", "the", "first", "attempt", "to", "study", "xylogenesis", "in", "a", "hardwood", "species", "forming", "frequent", "IADFs", ".", "Both", "species", "co-occur", "at", "a", "site", "in", "southern", "Italy", "characterized", "by", "a", "Mediterranean", "climate", ".", "To", "facilitate", "tree-ring", "dating", "and", "identification", "of", "IADFs", ",", "we", "performed", "traditional", "dendroecological", "analysis", ".", "We", "analyzed", "xylogenesis", "during", "summer", ",", "which", "is", "considered", "a", "constraint", "for", "xylogenesis", "and", "a", "trigger", "for", "IADF", "formation", ".", "We", "followed", "the", "different", "phases", "of", "cell", "development", "in", "the", "current", "wood", "increment", "with", "the", "aim", "of", "evaluating", "whether", "and", "which", "type", "of", "IADFs", "were", "formed", ".", "We", "additionally", "analyzed", "the", "same", "phases", "again", "in", "September", "and", "in", "winter", "to", "verify", "the", "possible", "formation", "of", "IADFs", "in", "fall", "and", "whether", "cell", "production", "and", "differentiation", "was", "completed", "by", "the", "end", "of", "the", "calendar", "year", ".", "Both", "species", "formed", "the", "same", "type", "of", "IADFs", "(", "earlywood", "-like", "cells", "within", "latewood", ")", ",", "due", "to", "temporary", "growth", "restoration", "triggered", "by", "rain", "events", "during", "the", "period", "of", "summer", "drought", ".", "At", "the", "end", "of", "the", "calendar", "year", ",", "no", "cells", "in", "the", "phases", "of", "enlargement", "and", "secondary", "cell", "wall", "deposition", "occurred", ".", "A.", "unedo", "was", "more", "sensitive", "than", "P.", "halepensis", "because", "IADF", "s", "were", "formed", "earlier", "in", "the", "season", "and", "were", "more", "frequent", "in", "the", "tree-ring", "series", ".", "The", "dendro-anatomical", "approach", ",", "combining", "analysis", "of", "tree-ring", "series", "and", "of", "xylogenesis", ",", "helped", "to", "detect", "the", "period", "of", "IADF", "formation", "in", "the", "two", "species", ".", "Results", "are", "discussed", "in", "functional", "terms", ",", "highlighting", "the", "environmental", "conditions", "triggering", "IADFs", ",", "and", "also", "in", "methodological", "terms", ",", "evaluating", "the", "applicability", "of", "xylogenesis", "analysis", "in", "Mediterranean", "woods", ",", "especially", "when", "the", "formation", "of", "IADFs", "is", "not", "uniform", "around", "the", "stem", "." ]	[ "B-Temporal Concept", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Plant", "O", "B-Spatial Concept", "B-Geographic Area", "O", "B-Clinical Attribute", "O", "O", "B-Research Activity", "O", "B-Physiologic Function", "O", "B-Plant", "B-Intellectual Product", "B-Geographic Area", "B-Plant", "B-Plant", "O", "B-Activity", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Temporal Concept", "O", "O", "O", "B-Spatial Concept", "B-Idea or Concept", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Spatial Concept", "B-Qualitative Concept", "O", "B-Physiologic Function", "B-Phenomenon or Process", "B-Temporal Concept", "B-Physiologic Function", "O", "O", "B-Temporal Concept", "B-Conceptual Entity", "O", "O", "O", "O", "B-Research Activity", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "B-Spatial Concept", "O", "B-Plant", "B-Spatial Concept", "O", "B-Temporal Concept", "B-Sign or Symptom", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Substance", "B-Functional Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Research Activity", "B-Physiologic Function", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Event", "O", "B-Research Activity", "B-Physiologic Function", "O", "O", "B-Substance", "B-Classification", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "B-Classification", "B-Activity", "O", "O", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Geographic Area", "B-Activity", "O", "O", "B-Geographic Area", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "B-Qualitative Concept", "O", "B-Temporal Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Qualitative Concept", "B-Research Activity", "O", "O", "B-Research Activity", "B-Physiologic Function", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "B-Idea or Concept", "O", "B-Functional Concept", "O", "B-Physiologic Function", "O", "O", "O", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Temporal Concept", "O", "B-Cell Function", "B-Cell Function", "O", "O", "B-Temporal Concept", "B-Substance", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Research Activity", "O", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "O", "B-Finding", "B-Functional Concept", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "B-Cell", "B-Physiologic Function", "O", "B-Cell Function", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "B-Classification", "B-Functional Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Substance", "O", "B-Cell", "O", "B-Substance", "O", "O", "O", "O", "B-Temporal Concept", "B-Phenomenon or Process", "B-Finding", "B-Qualitative Concept", "B-Qualitative Concept", "B-Natural Phenomenon or Process", "B-Event", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "B-Cell", "O", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "B-Cell Component", "B-Cell Component", "B-Cell Component", "B-Functional Concept", "B-Activity", "O", "B-Plant", "B-Plant", "O", "O", "B-Functional Concept", "O", "B-Plant", "B-Plant", "O", "B-Temporal Concept", "O", "O", "B-Functional Concept", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Plant", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Research Activity", "O", "B-Plant", "O", "O", "O", "B-Physiologic Function", "O", "O", "O", "B-Finding", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "O", "B-Classification", "O", "B-Functional Concept", "O", "O", "O", "B-Functional Concept", "B-Idea or Concept", "O", "O", "O", "B-Spatial Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Physiologic Function", "B-Research Activity", "O", "B-Geographic Area", "B-Substance", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Temporal Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Plant", "O" ]
[ "An", "Accessible", "and", "Pragmatic", "Experimental", "Model", "of", "Nonalcoholic", "Fatty", "Liver", "Disease", "BACKGROUND", "There", "is", "no", "convenient", "cheap", "pragmatic", "experimental", "model", "for", "Nonalcoholic", "Fatty", "Liver", "Disease", "(", "NAFLD", ")", "/", "Nonalcoholic", "Steatohepatitis", "(", "NASH", ")", ".", "Our", "objective", "was", "to", "create", "a", "pragmatic", "model", "of", "NAFLD", "/", "NASH", ".", "METHODS", "Sprague-Dawley", "rats", "were", "fed", "a", "high-fat", ",", "high", "sugar", "homemade", "diet", "ad", "libitum", "for", "seven", "weeks", ".", "The", "high-fat", ",", "high", "sugar", "diet", "included", "59", "%", "of", "energy", "derived", "from", "fat", ",", "30", "%", "from", "carbohydrates", ",", "and", "11", "%", "from", "protein", ".", "Serum", "levels", "of", "fasting", "glucose", ",", "triglyceride", ",", "cholesterol", ",", "liver", "enzymes", ",", "insulin", ",", "and", "hepatic", "tumor", "necrosis", "factor-alpha", "(", "TNF-α", ")", "gene", "expression", "were", "determined", ".", "Hepatic", "histology", "was", "examined", "by", "H", "&", "E", "stain", ".", "RESULTS", "Rats", "fed", "the", "high-fat", ",", "high", "sugar", "diet", "developed", "hepatic", "steatosis", ",", "and", "a", "moderate", "inflammation", ",", "which", "was", "associated", "with", "increased", "serum", "levels", "of", "liver", "enzymes", ",", "glucose", ",", "insulin", ",", "triglyceride", ",", "cholesterol", ",", "and", "hepatic", "TNF-α", "gene", "expression", ".", "CONCLUSION", "This", "rat", "model", "resembles", "the", "key", "features", "of", "human", "NAFLD", "/", "NASH", "and", "provides", "a", "simple", "pragmatic", "experimental", "model", "for", "elucidating", "the", "disease", "prevention", "and", "treatment", "." ]	[ "O", "O", "O", "B-Animal", "B-Animal", "B-Animal", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Animal", "B-Animal", "B-Animal", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Animal", "B-Animal", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "B-Mammal", "B-Mammal", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Food", "O", "O", "O", "O", "B-Food", "O", "O", "O", "O", "O", "B-Food", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Body Location or Region", "B-Immunologic Factor", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "B-Body Location or Region", "B-Laboratory Procedure", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Mammal", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Laboratory or Test Result", "O", "B-Laboratory or Test Result", "O", "B-Laboratory or Test Result", "O", "B-Laboratory or Test Result", "O", "O", "B-Body Location or Region", "B-Immunologic Factor", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "B-Mammal", "B-Animal", "O", "O", "O", "O", "O", "B-Human", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Animal", "B-Animal", "B-Animal", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O" ]
[ "Comparison", "of", "the", "Effects", "of", "Subcutaneous", "Versus", "Continuous", "Infusion", "of", "Heparin", "on", "Key", "Inflammatory", "Parameters", "Following", "Sepsis", "Sepsis", "is", "the", "result", "of", "the", "interaction", "between", "inflammatory", "mediators", "and", "coagulation", "pathway", ".", "Unfractionated", "heparin", "may", "play", "a", "role", "as", "an", "anti-inflammatory", "agent", "beyond", "its", "anticoagulatory", "effect", "in", "sepsis", ".", "As", "a", "result", ",", "it", "may", "cause", "reduction", "in", "organ", "failure", "rate", "in", "patients", "with", "sepsis", "due", "to", "its", "impact", "on", "both", "inflammatory", "and", "coagulation", "process", ".", "The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "anti-inflammatory", "effects", "of", "heparin", "in", "sepsis", ".", "Plasma", "plasminogen", "activator", "inhibitor-1", "(", "PAI-1", ")", "as", "an", "inflammatory", "mediator", "and", "urinary", "necoutrophil", "gelatinase-associated", "lipocalin", "(", "NGAL", ")", "as", "a", "marker", "of", "kidney", "injury", "were", "investigated", ".", "This", "prospective", ",", "randomized", "controlled", "trial", "was", "conducted", "in", "a", "32-", "bed", "intensive", "care", "unit", ".", "Thirty", "patients", "with", "sepsis", "were", "randomized", "to", "receive", "heparin", "infusion", "of", "500", "units/hour", "or", "5000", "units", "of", "heparin", "three", "times", "a", "day", ",", "subcutaneously", ".", "The", "plasma", "level", "of", "PAI-1", "and", "urinary", "level", "of", "NGAL", "were", "determined", "at", "day", "0", ",", "2", "and", "7", ".", "The", "infusion", "group", "had", "a", "lower", "plasma", "PAI-1", "level", "compared", "to", "the", "subcutaneous", "group", "at", "day", "7", "(", "11.3", "±", "1.6", "vs.", "16.5", "±", "4.2", ";", "P", "=", "0.003", ")", ".", "The", "urinary", "NGAL", "level", "was", "lower", "in", "the", "infusion", "group", "at", "day", "2", "(", "131.3", "±", "11.9", "vs.", "151.2", "±", "20.6", ";", "P", "=", "0.014", ")", ";", "however", ",", "at", "day", "7", "the", "NGAL", "level", "was", "decreased", "in", "the", "subcutaneous", "group", "as", "much", "as", "the", "infusion", "group", "and", "there", "was", "no", "significant", "difference", "between", "the", "two", "groups", ".", "There", "was", "no", "significant", "difference", "in", "the", "acute", "physiology", "and", "chronic", "health", "evaluation", "(", "APACHE", ")", "II", "and", "sequential", "organ", "failure", "assessment", "(", "SOFA", ")", "scores", "between", "the", "two", "groups", "at", "day", "0", ",", "2", "and", "7", ".", "Low-dose", "heparin", "infusion", "compared", "to", "subcutaneous", "heparin", "can", "decrease", "the", "plasma", "PAI-1", "and", "urinary", "NGAL", "levels", "more", "rapidly", ".", "It", "can", "be", "related", "to", "anti-inflammatory", "effects", "of", "heparin", ",", "which", "may", "be", "more", "prominent", "in", "infusion", "route", "." ]	[ "B-Activity", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Biologically Active Substance", "O", "B-Functional Concept", "B-Functional Concept", "B-Conceptual Entity", "B-Temporal Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Molecular Function", "B-Molecular Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "O", "B-Conceptual Entity", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "B-Idea or Concept", "O", "O", "B-Research Activity", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Disease or Syndrome", "O", "B-Body Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Clinical Attribute", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Functional Concept", "O", "O", "B-Research Activity", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "B-Research Activity", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Finding", "O", "O", "B-Body Substance", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "O", "O", "B-Functional Concept", "B-Idea or Concept", "O", "O", "B-Spatial Concept", "B-Body Substance", "B-Biologically Active Substance", "B-Qualitative Concept", "B-Activity", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Functional Concept", "B-Idea or Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Functional Concept", "B-Idea or Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Idea or Concept", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "O", "B-Quantitative Concept", "B-Biologically Active Substance", "B-Functional Concept", "B-Activity", "O", "B-Spatial Concept", "B-Biologically Active Substance", "O", "B-Quantitative Concept", "O", "B-Body Substance", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O" ]
[ "The", "Spreading", "of", "Social", "Energy", ":", "How", "Exposure", "to", "Positive", "and", "Negative", "Social", "News", "Affects", "Behavior", "Social", "news", ",", "unlike", "video", "games", "or", "TV", "programs", ",", "conveys", "real-life", "interactions", ".", "Theoretically", ",", "social", "news", "in", "which", "people", "help", "or", "harm", "each", "other", "and", "violate", "rules", "should", "influence", "both", "prosocial", "and", "violation", "behaviors", ".", "In", "two", "experiments", ",", "we", "demonstrated", "the", "spreading", "effects", "of", "social", "news", "in", "a", "social", "interaction", "context", "emphasizing", "social", "conventions", "and", "a", "nonsocial", "interaction", "context", "emphasizing", "moral", "norms", ".", "Across", "the", "two", "studies", ",", "the", "results", "showed", "that", "positive", "social", "news", "increased", "cooperation", "(", "decreased", "defection", ")", "but", "had", "no", "effect", "on", "cheating", ",", "whereas", "negative", "social", "news", "increased", "cheating", "but", "with", "no", "change", "in", "cooperation", "(", "or", "defection", ")", ".", "We", "conclude", "that", "there", "is", "a", "spreading", "impact", "of", "positive", "social", "news", "in", "the", "conventional", "norm", "domain", "and", "of", "negative", "social", "news", "in", "the", "moral", "norm", "domain", "." ]	[ "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "O", "B-Finding", "B-Functional Concept", "B-Intellectual Product", "O", "B-Behavior", "B-Functional Concept", "B-Intellectual Product", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Finding", "O", "O", "O", "B-Functional Concept", "B-Intellectual Product", "O", "O", "B-Population Group", "B-Qualitative Concept", "O", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "B-Individual Behavior", "B-Regulation or Law", "O", "O", "O", "B-Social Behavior", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Intellectual Product", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "B-Human-caused Phenomenon or Process", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Finding", "B-Functional Concept", "B-Intellectual Product", "O", "B-Social Behavior", "O", "O", "B-Social Behavior", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Individual Behavior", "O", "O", "B-Finding", "B-Functional Concept", "B-Intellectual Product", "O", "B-Individual Behavior", "O", "O", "B-Finding", "B-Functional Concept", "O", "B-Social Behavior", "O", "O", "B-Social Behavior", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Finding", "B-Functional Concept", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Finding", "B-Functional Concept", "B-Intellectual Product", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O" ]
[ "Using", "Evolutionary", "Theory", "to", "Guide", "Mental", "Health", "Research", "Evolutionary", "approaches", "to", "medicine", "can", "shed", "light", "on", "the", "origins", "and", "etiology", "of", "disease", ".", "Such", "an", "approach", "may", "be", "especially", "useful", "in", "psychiatry", ",", "which", "frequently", "addresses", "conditions", "with", "heterogeneous", "presentation", "and", "unknown", "causes", ".", "We", "review", "several", "previous", "applications", "of", "evolutionary", "theory", "that", "highlight", "the", "ways", "in", "which", "psychiatric", "conditions", "may", "persist", "despite", "and", "because", "of", "natural", "selection", ".", "One", "lesson", "from", "the", "evolutionary", "approach", "is", "that", "some", "conditions", "currently", "classified", "as", "disorders", "(", "because", "they", "cause", "distress", "and", "impairment", ")", "may", "actually", "be", "caused", "by", "functioning", "adaptations", "operating", "``", "normally", "``", "(", "as", "designed", "by", "natural", "selection", ")", ".", "Such", "conditions", "suggest", "an", "alternative", "illness", "model", "that", "may", "generate", "alternative", "intervention", "strategies", ".", "Thus", ",", "the", "evolutionary", "approach", "suggests", "that", "psychiatry", "should", "sometimes", "think", "differently", "about", "distress", "and", "impairment", ".", "The", "complexity", "of", "the", "human", "brain", ",", "including", "normal", "functioning", "and", "potential", "for", "dysfunctions", ",", "has", "developed", "over", "evolutionary", "time", "and", "has", "been", "shaped", "by", "natural", "selection", ".", "Understanding", "the", "evolutionary", "origins", "of", "psychiatric", "conditions", "is", "therefore", "a", "crucial", "component", "to", "a", "complete", "understanding", "of", "etiology", "." ]	[ "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Mental Process", "B-Mental Process", "B-Research Activity", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Biomedical Occupation or Discipline", "O", "B-Activity", "B-Activity", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Classification", "O", "B-Mental or Behavioral Dysfunction", "O", "O", "O", "O", "B-Finding", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Biologic Function", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Experimental Model of Disease", "B-Experimental Model of Disease", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "O", "B-Pathologic Function", "O", "O", "B-Qualitative Concept", "O", "O", "B-Human", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "B-Organ or Tissue Function", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Qualitative Concept", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Functional Concept", "O" ]
[ "Transcriptomic", "and", "Physiological", "Responses", "of", "the", "Green", "Microalga", "Chlamydomonas", "reinhardtii", "during", "Short-Term", "Exposure", "to", "Subnanomolar", "Methylmercury", "Concentrations", "The", "effects", "of", "short-term", "exposure", "to", "subnanomolar", "methyl-mercury", "(", "MeHg", ")", "concentrations", ",", "representative", "of", "contaminated", "environments", ",", "on", "the", "microalga", "Chlamydomonas", "reinhardtii", "were", "assessed", "using", "both", "physiological", "end", "points", "and", "gene", "expression", "analysis", ".", "MeHg", "bioaccumulated", "and", "induced", "significant", "increase", "of", "the", "photosynthesis", "efficiency", ",", "while", "the", "algal", "growth", ",", "oxidative", "stress", ",", "and", "chlorophyll", "fluorescence", "were", "unaffected", ".", "At", "the", "molecular", "level", ",", "MeHg", "significantly", "dysregulated", "the", "expression", "of", "genes", "involved", "in", "motility", ",", "energy", "metabolism", ",", "lipid", "metabolism", ",", "metal", "transport", ",", "and", "antioxidant", "enzymes", ".", "Data", "suggest", "that", "the", "cells", "were", "able", "to", "cope", "with", "subnanomolar", "MeHg", "exposure", ",", "but", "this", "tolerance", "resulted", "in", "a", "significant", "cost", "to", "the", "cell", "energy", "and", "reserve", "metabolism", "as", "well", "as", "ample", "changes", "in", "the", "nutrition", "and", "motility", "of", "C.", "reinhardtii", ".", "The", "present", "results", "allowed", "gaining", "new", "insights", "on", "the", "effects", "and", "uptake", "mechanisms", "of", "MeHg", "at", "subnanomolar", "concentrations", "in", "aquatic", "primary", "producers", "." ]	[ "B-Genetic Function", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "B-Hazardous or Poisonous Substance", "B-Quantitative Concept", "O", "O", "O", "B-Temporal Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "O", "B-Quantitative Concept", "O", "O", "O", "B-Functional Concept", "B-Spatial Concept", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "O", "B-Activity", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Hazardous or Poisonous Substance", "B-Organ or Tissue Function", "O", "O", "B-Idea or Concept", "B-Functional Concept", "O", "O", "B-Natural Phenomenon or Process", "B-Quantitative Concept", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Genetic Function", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Organism Function", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Molecular Function", "B-Molecular Function", "O", "B-Cell Function", "B-Cell Function", "O", "O", "B-Pharmacologic Substance", "B-Enzyme", "O", "B-Idea or Concept", "O", "O", "O", "B-Cell", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "B-Hazardous or Poisonous Substance", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Organism Function", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Hazardous or Poisonous Substance", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "O" ]
[ "Emergence", "of", "family", "medicine", "in", "Ethiopia", "[", "corrected", "]", ":", "an", "international", "collaborative", "education", "model", "Family", "Medicine", "(", "FM", ")", "is", "a", "new", "specialty", "in", "Ethiopia", ".", "The", "first", "seven", "family", "physicians", "graduated", "in", "February", "2016", "from", "the", "inaugural", "residency", "programme", "at", "Addis", "Ababa", "University", ".", "Cooperation", "amongst", "Ethiopian", "and", "expatriate", "decision-makers", "and", "physicians", "was", "needed", "to", "begin", "the", "programme", ".", "Intentional", "replacement", "of", "expatriates", "with", "Ethiopian", "family", "physicians", "has", "begun", ".", "Barriers", "include", "lack", "of", "understanding", "of", "FM", "and", "the", "human", "and", "financial", "resources", "needed", "for", "scaling", "up", "the", "programme", ".", "Regular", "programme", "review", "with", "resident", "physician", "involvement", "has", "allowed", "the", "FM", "training", "programme", "to", "adapt", "and", "fit", "the", "Ethiopian", "context", ".", "Further", "successes", "will", "result", "from", "ongoing", "support", "and", "advocacy", "from", "the", "Federal", "Ministry", "of", "Health", "and", "other", "Ethiopian", ",", "African", ",", "and", "international", "primary", "care", "organisations", "." ]	[ "B-Qualitative Concept", "O", "B-Biomedical Occupation or Discipline", "B-Biomedical Occupation or Discipline", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Social Behavior", "B-Intellectual Product", "B-Intellectual Product", "B-Biomedical Occupation or Discipline", "B-Biomedical Occupation or Discipline", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "B-Geographic Area", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Population Group", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Educational Activity", "B-Intellectual Product", "O", "B-Organization", "B-Organization", "B-Organization", "O", "B-Social Behavior", "O", "B-Population Group", "O", "B-Finding", "B-Professional or Occupational Group", "O", "B-Professional or Occupational Group", "O", "O", "O", "B-Temporal Concept", "O", "B-Intellectual Product", "O", "B-Idea or Concept", "B-Functional Concept", "O", "B-Finding", "O", "B-Population Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Mental Process", "O", "B-Biomedical Occupation or Discipline", "O", "O", "B-Functional Concept", "O", "B-Finding", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Intellectual Product", "O", "B-Qualitative Concept", "B-Intellectual Product", "B-Qualitative Concept", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Social Behavior", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Educational Activity", "B-Educational Activity", "O", "B-Qualitative Concept", "O", "B-Activity", "O", "B-Population Group", "B-Idea or Concept", "O", "O", "B-Social Behavior", "O", "B-Functional Concept", "O", "O", "B-Social Behavior", "O", "B-Social Behavior", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Population Group", "O", "B-Population Group", "O", "O", "I-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O" ]
[ "Hierarchical", "Targeting", "Strategy", "for", "Enhanced", "Tumor", "Tissue", "Accumulation", "/", "Retention", "and", "Cellular", "Internalization", "Targeted", "delivery", "of", "therapeutic", "agents", "is", "an", "important", "way", "to", "improve", "the", "therapeutic", "index", "and", "reduce", "side", "effects", ".", "To", "design", "nanoparticles", "for", "targeted", "delivery", ",", "both", "enhanced", "tumor", "tissue", "accumulation", "/", "retention", "and", "enhanced", "cellular", "internalization", "should", "be", "considered", "simultaneously", ".", "So", "far", ",", "there", "have", "been", "very", "few", "nanoparticles", "with", "immutable", "structures", "that", "can", "achieve", "this", "goal", "efficiently", ".", "Hierarchical", "targeting", ",", "a", "novel", "targeting", "strategy", "based", "on", "stimuli", "responsiveness", ",", "shows", "good", "potential", "to", "enhance", "both", "tumor", "tissue", "accumulation", "/", "retention", "and", "cellular", "internalization", ".", "Here", ",", "the", "recent", "design", "and", "development", "of", "hierarchical", "targeting", "nanoplatforms", ",", "based", "on", "changeable", "particle", "sizes", ",", "switchable", "surface", "charges", "and", "activatable", "surface", "ligands", ",", "will", "be", "introduced", ".", "In", "general", ",", "the", "targeting", "moieties", "in", "these", "nanoplatforms", "are", "not", "activated", "during", "blood", "circulation", "for", "efficient", "tumor", "tissue", "accumulation", ",", "but", "re-activated", "by", "certain", "internal", "or", "external", "stimuli", "in", "the", "tumor", "microenvironment", "for", "enhanced", "cellular", "internalization", "." ]	[ "B-Functional Concept", "B-Functional Concept", "B-Research Activity", "O", "B-Functional Concept", "B-Tissue", "B-Tissue", "O", "O", "B-Physiologic Function", "O", "B-Cell Function", "B-Cell Function", "B-Functional Concept", "B-Phenomenon or Process", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Activity", "B-Manufactured Object", "O", "B-Functional Concept", "B-Phenomenon or Process", "O", "O", "B-Functional Concept", "B-Tissue", "B-Tissue", "O", "O", "B-Physiologic Function", "O", "B-Functional Concept", "B-Cell Function", "B-Cell Function", "O", "O", "B-Idea or Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Manufactured Object", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "B-Idea or Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Research Activity", "O", "O", "B-Phenomenon or Process", "B-Organism Attribute", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Physiologic Function", "O", "B-Cell Function", "B-Cell Function", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Functional Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Spatial Concept", "B-Chemical", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Qualitative Concept", "B-Tissue", "B-Tissue", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Phenomenon or Process", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "B-Functional Concept", "B-Cell Function", "B-Cell Function", "O" ]
[ "Subsolid", "pulmonary", "nodule", "morphology", "and", "associated", "patient", "characteristics", "in", "a", "routine", "clinical", "population", "To", "determine", "the", "presence", "and", "morphology", "of", "subsolid", "pulmonary", "nodules", "(", "SSNs", ")", "in", "a", "non-screening", "setting", "and", "relate", "them", "to", "clinical", "and", "patient", "characteristics", ".", "A", "total", "of", "16,890", "reports", "of", "clinically", "obtained", "chest", "CT", "(", "06/2011", "to", "11/2014", ",", "single-centre", ")", "were", "searched", "describing", "an", "SSN", ".", "Subjects", "with", "a", "visually", "confirmed", "SSN", "and", "at", "least", "two", "thin-slice", "CTs", "were", "included", ".", "Nodule", "volumes", "were", "measured", ".", "Progression", "was", "defined", "as", "volume", "increase", "exceeding", "the", "software", "interscan", "variation", ".", "Nodule", "morphology", ",", "location", ",", "and", "patient", "characteristics", "were", "evaluated", ".", "Fifteen", "transient", "and", "74", "persistent", "SSNs", "were", "included", "(", "median", "follow-up", "19.6", "[", "8.3-36.8", "]", "months", ")", ".", "Subjects", "with", "an", "SSN", "were", "slightly", "older", "than", "those", "without", "(", "62", "vs.", "58", "years", ";", "p", "=", "0.01", ")", ",", "but", "no", "gender", "predilection", "was", "found", ".", "SSNs", "were", "mostly", "located", "in", "the", "upper", "lobes", ".", "Women", "showed", "significantly", "more", "often", "persistent", "lesions", "than", "men", "(", "94", "%", "vs.", "69", "%", ";", "p", "=", "0.002", ")", ".", "Part-solid", "lesions", "were", "larger", "(", "1638", "vs.", "383", "mm", "(", "3", ")", ";", "p", "<", "0.001", ")", "and", "more", "often", "progressive", "(", "68", "%", "vs.", "38", "%", ";", "p", "=", "0.02", ")", ",", "compared", "to", "pure", "ground-glass", "nodules", ".", "Progressive", "SSNs", "were", "rare", "under", "the", "age", "of", "50", "years", ".", "Logistic", "regression", "analysis", "did", "not", "identify", "additional", "nodule", "parameters", "of", "future", "progression", ",", "apart", "from", "part-solid", "nature", ".", "This", "study", "confirms", "previously", "reported", "characteristics", "of", "SSNs", "and", "associated", "factors", "in", "a", "European", ",", "routine", "clinical", "population", ".", "•", "SSNs", "in", "women", "are", "significantly", "more", "often", "persistent", "compared", "to", "men", ".", "•", "SSN", "persistence", "is", "not", "associated", "with", "age", "or", "prior", "malignancy", ".", "•", "The", "majority", "of", "(", "persistent", ")", "SSNs", "are", "located", "in", "the", "upper", "lung", "lobes", ".", "•", "A", "part-solid", "nature", "is", "associated", "with", "future", "nodule", "growth", ".", "•", "Progressive", "solitary", "SSNs", "are", "rare", "under", "the", "age", "of", "50", "years", "." ]	[ "B-Finding", "B-Finding", "B-Finding", "B-Qualitative Concept", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Population Group", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Clinical Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Qualitative Concept", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Population Group", "O", "O", "B-Functional Concept", "O", "B-Finding", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Acquired Abnormality", "B-Quantitative Concept", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Qualitative Concept", "O", "B-Acquired Abnormality", "B-Qualitative Concept", "O", "B-Body Location or Region", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Health Care Activity", "O", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Population Group", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "B-Idea or Concept", "O", "O", "O", "B-Finding", "O", "O", "B-Spatial Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Population Group", "O", "B-Idea or Concept", "O", "O", "B-Temporal Concept", "B-Finding", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Functional Concept", "B-Finding", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Acquired Abnormality", "B-Finding", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Research Activity", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "O", "O", "B-Functional Concept", "O", "O", "B-Population Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Population Group", "O", "O", "B-Finding", "O", "B-Population Group", "O", "B-Idea or Concept", "O", "O", "B-Temporal Concept", "O", "O", "B-Population Group", "O", "O", "B-Finding", "B-Temporal Concept", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Finding", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Acquired Abnormality", "B-Organ or Tissue Function", "O", "O", "B-Functional Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Qualitative Concept", "O", "O", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O" ]
[ "Dynamic", "CT", "myocardial", "perfusion", "imaging", "identifies", "early", "perfusion", "abnormalities", "in", "diabetes", "and", "hypertension", ":", "Insights", "from", "a", "multicenter", "registry", "To", "identify", "patients", "with", "early", "signs", "of", "myocardial", "perfusion", "reduction", ",", "a", "reference", "base", "for", "perfusion", "measures", "is", "needed", ".", "To", "analyze", "perfusion", "parameters", "derived", "from", "dynamic", "computed", "tomography", "perfusion", "imaging", "(", "CTPI", ")", "in", "patients", "with", "suspected", "coronary", "artery", "disease", "(", "CAD", ")", ",", "and", "relationship", "with", "risk", "factors", ".", "In", "this", "multicenter", "study", ",", "coronary", "CT", "angiography", "(", "cCTA", ")", "and", "dynamic", "CTPI", "were", "performed", "by", "second-generation", "dual-source", "CT", "in", "patients", "suspected", "of", "CAD", ".", "Risk", "factors", "were", "collected", "from", "hospital", "records", ".", "Patients", "with", "visual", "perfusion", "defects", "on", "CTPI", ",", "previous", "coronary", "intervention", ",", "or", "missing", "risk", "factor", "details", "were", "excluded", ".", "This", "analysis", "included", "98", "patients", "(", "mean", "age", "±", "standard", "deviation", "[", "SD", "]", ",", "59.0", "±", "8.6yrs", ";", "73", "male", ")", ".", "Global", "measures", "of", "left", "ventricular", "myocardial", "blood", "flow", "(", "MBF", ")", ",", "myocardial", "blood", "volume", "(", "MBV", ")", "and", "volume", "transfer", "constant", "(", "K", "(", "trans", ")", ")", "were", "calculated", ".", "Mean", "MBF", "was", "139.3", "±", "31.4", "mL/100", "mL/min", ",", "MBV", "19.1", "±", "2.7", "mL/100", "mL", ",", "and", "Ktrans", "85.0", "±", "17.5", "mL/100", "mL/min", ".", "No", "significant", "differences", "in", "perfusion", "parameters", "were", "found", "by", "gender", "or", "age", "category", ".", "Hypertension", "and", "diabetes", "mellitus", "resulted", "in", "lower", "perfusion", "parameters", "(", "hypertension", "vs", "normotension", ":", "MBV", "18.5", "±", "3.0", "vs", "19.7", "±", "2.3", "mL/100", "mL", "and", "K", "(", "trans", ")", "82.0", "±", "18.0", "vs", "89.0", "±", "16.0", ",", "p", "<", "0.05", ";", "diabetes", "vs", "no", "diabetes", ":", "MBF", "128.5", "±", "31.5", "vs", "144.0", "±", "30.5", "mL/100", "mL/min", "and", "MBV", "17.9", "±", "2.4", "vs", "19.4", "±", "2.8", "mL/100", "mL", ",", "p", "<", "0.05", ")", ".", "In", "patients", "with", "hyperlipidemia", ",", "MBF", "was", "higher", "(", "146.8", "±", "34.4", "vs", "130.7", "±", "24.3", "mL/100", "mL/min", ",", "p", "<", "0.05", ")", ".", "Smoking", "and", "family", "history", "did", "not", "show", "perfusion", "parameter", "differences", ".", "Dynamic", "CTPI", "identifies", "early", "perfusion", "disturbances", "in", "conditions", "like", "diabetes", "and", "hypertension", ".", "With", "further", "standardization", ",", "absolute", "perfusion", "measures", "may", "improve", "CAD", "risk", "stratification", "in", "patients", "without", "visual", "perfusion", "defects", "." ]	[ "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Temporal Concept", "B-Organ or Tissue Function", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Research Activity", "B-Intellectual Product", "O", "O", "B-Patient or Disabled Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Organism Attribute", "I-Organ or Tissue Function", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Organ or Tissue Function", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Organ or Tissue Function", "B-Finding", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "I-Organ or Tissue Function", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "B-Organ or Tissue Function", "B-Functional Concept", "O", "B-Diagnostic Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Quantitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "B-Organ or Tissue Function", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Organ or Tissue Function", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ or Tissue Function", "B-Finding", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Organ or Tissue Function", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Finding", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Finding", "B-Finding", "O", "B-Organ or Tissue Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "B-Organ or Tissue Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual Behavior", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Organ or Tissue Function", "B-Finding", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Organ or Tissue Function", "B-Qualitative Concept", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Research Activity", "O", "O", "B-Organ or Tissue Function", "B-Quantitative Concept", "O", "O", "B-Disease or Syndrome", "B-Idea or Concept", "B-Research Activity", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "B-Organ or Tissue Function", "B-Functional Concept", "O" ]
[ "Cognition", "Enhancing", "Activity", "of", "Sulforaphane", "Against", "Scopolamine", "Induced", "Cognitive", "Impairment", "in", "Zebra", "Fish", "(", "Danio", "rerio", ")", "Several", "epidemiological", "studies", "have", "shown", "that", "consumption", "of", "large", "quantities", "of", "vegetables", "especially", "cruciferous", "vegetables", "(", "Broccoli", "and", "Brussels", "sprouts", ")", "can", "protect", "against", "chronic", "diseases", ".", "Sulforaphane", ",", "an", "isothiocynate", "found", "in", "cruciferous", "vegetables", "has", "been", "demonstrated", "to", "have", "neuroprotective", "effects", "in", "several", "experimental", "paradigms", ".", "This", "study", "was", "undertaken", "to", "examine", "the", "effect", "of", "sulforaphane", "on", "cognitive", "impairment", "in", "zebra", "fish", "model", "using", "a", "novel", "method", "of", "fear", "conditioning", ".", "Initially", ",", "the", "normal", "behaviour", "of", "zebra", "fishes", "was", "studied", "in", "light-dark", "tank", "for", "10", "min", "daily", "for", "10", "days", ".", "Fishes", "were", "then", "divided", "into", "seven", "groups", "of", "twelve", "in", "each", ".", "Group", "I", "served", "as", "normal", ",", "group", "II", "served", "as", "fear", "conditioned", "control", ",", "group", "III", "and", "group", "IV", "were", "sulforaphane", "(", "25", "µM/L", ")", "and", "piracetam", "(", "200", "mg/L", ")", "treated", "respectively", ".", "Group", "V", "served", "as", "scopolamine", "(", "400", "µM/L", ")", "induced", "memory", "impairment", "fishes", ".", "Group", "VI", "and", "VII", "were", "sulforaphane", "(", "25", "µM/L", ")", "and", "piracetam", "(", "200", "mg/L", ")", "treated", "scopolamine", "induced", "memory", "impairment", "groups", "respectively", ".", "In", "normal", "behavioural", "analysis", ",", "fishes", "preferred", "to", "stay", "in", "dark", "compartment", ".", "The", "average", "number", "of", "entries", "into", "the", "dark", "and", "time", "spent", "in", "dark", "were", "significantly", "more", ".", "Fishes", "in", "group", "II", "to", "VII", "were", "individually", "subjected", "to", "fear", "conditioning", "passive", "avoidance", "task", "and", "evaluated", "for", "learned", "task", "memory", ".", "It", "was", "observed", "that", "the", "average", "number", "of", "entries", "into", "dark", "and", "time", "spent", "in", "dark", "were", "significantly", "decreased", ".", "After", "exposure", "to", "respective", "treatment", "fishes", "in", "group", "III", "to", "VII", "were", "subjected", "to", "cognitive", "evaluation", ".", "There", "was", "no", "significant", "difference", "in", "cognition", "of", "group", "III", "and", "IV", "fishes", "exposed", "to", "sulforaphane", "and", "piracetam", "alone", "respectively", ".", "Fishes", "exposed", "to", "scopolamine", "showed", "a", "significant", "cognitive", "impairment", ".", "Sulforaphane", "exposure", "prior", "to", "scopolamine", "significantly", "retained", "the", "memory", "of", "learned", "task", ".", "These", "findings", "suggest", "that", "sulforaphane", "might", "be", "a", "promising", "therapeutic", "agent", "for", "cognitive", "enhancement", "in", "Alzheimer", "'s", "disease", "." ]	[ "B-Mental Process", "B-Activity", "B-Idea or Concept", "O", "B-Pharmacologic Substance", "B-Qualitative Concept", "B-Pharmacologic Substance", "B-Functional Concept", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Fish", "B-Fish", "O", "B-Fish", "B-Fish", "O", "B-Quantitative Concept", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Activity", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Food", "O", "B-Food", "B-Food", "O", "B-Food", "O", "B-Food", "B-Food", "O", "O", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Pharmacologic Substance", "O", "O", "B-Organic Chemical", "B-Finding", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Research Activity", "B-Research Activity", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Pharmacologic Substance", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Fish", "B-Fish", "B-Experimental Model of Disease", "O", "O", "B-Qualitative Concept", "B-Intellectual Product", "O", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "B-Qualitative Concept", "B-Behavior", "O", "B-Fish", "B-Fish", "O", "B-Research Activity", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "B-Fish", "O", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "B-Functional Concept", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "B-Fish", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "B-Functional Concept", "B-Pharmacologic Substance", "B-Functional Concept", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "O", "O", "B-Qualitative Concept", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Fish", "O", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Entity", "O", "O", "B-Qualitative Concept", "O", "B-Temporal Concept", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Fish", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Mental Process", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Health Care Activity", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Entity", "O", "B-Qualitative Concept", "O", "B-Temporal Concept", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Fish", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Health Care Activity", "O", "O", "O", "B-Finding", "B-Finding", "B-Qualitative Concept", "O", "B-Mental Process", "O", "O", "O", "O", "O", "B-Fish", "B-Qualitative Concept", "B-Qualitative Concept", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Fish", "B-Qualitative Concept", "B-Qualitative Concept", "B-Pharmacologic Substance", "O", "O", "B-Quantitative Concept", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Pharmacologic Substance", "B-Quantitative Concept", "O", "O", "B-Mental Process", "O", "B-Mental Process", "B-Functional Concept", "O", "O", "B-Finding", "B-Idea or Concept", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Mental Process", "B-Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O" ]

[ "DCTN4", "as", "a", "modifier", "of", "chronic", "Pseudomonas", "aeruginosa", "infection", "in", "cystic", "fibrosis", "Pseudomonas", "aeruginosa", "(", "Pa", ")", "infection", "in", "cystic", "fibrosis", "(", "CF", ")", "patients", "is", "associated", "with", "worse", "long-term", "pulmonary", "disease", "and", "shorter", "survival", ",", "and", "chronic", "Pa", "infection", "(", "CPA", ")", "is", "associated", "with", "reduced", "lung", "function", ",", "faster", "rate", "of", "lung", "decline", ",", "increased", "rates", "of", "exacerbations", "and", "shorter", "survival", ".", "By", "using", "exome", "sequencing", "and", "extreme", "phenotype", "design", ",", "it", "was", "recently", "shown", "that", "isoforms", "of", "dynactin", "4", "(", "DCTN4", ")", "may", "influence", "Pa", "infection", "in", "CF", ",", "leading", "to", "worse", "respiratory", "disease", ".", "The", "purpose", "of", "this", "study", "was", "to", "investigate", "the", "role", "of", "DCTN4", "missense", "variants", "on", "Pa", "infection", "incidence", ",", "age", "at", "first", "Pa", "infection", "and", "chronic", "Pa", "infection", "incidence", "in", "a", "cohort", "of", "adult", "CF", "patients", "from", "a", "single", "centre", ".", "Polymerase", "chain", "reaction", "and", "direct", "sequencing", "were", "used", "to", "screen", "DNA", "samples", "for", "DCTN4", "variants", ".", "A", "total", "of", "121", "adult", "CF", "patients", "from", "the", "Cochin", "Hospital", "CF", "centre", "have", "been", "included", ",", "all", "of", "them", "carrying", "two", "CFTR", "defects", ":", "103", "developed", "at", "least", "1", "pulmonary", "infection", "with", "Pa", ",", "and", "68", "patients", "of", "them", "had", "CPA", ".", "DCTN4", "variants", "were", "identified", "in", "24", "%", "(", "29/121", ")", "CF", "patients", "with", "Pa", "infection", "and", "in", "only", "17", "%", "(", "3/18", ")", "CF", "patients", "with", "no", "Pa", "infection", ".", "Of", "the", "patients", "with", "CPA", ",", "29", "%", "(", "20/68", ")", "had", "DCTN4", "missense", "variants", "vs", "23", "%", "(", "8/35", ")", "in", "patients", "without", "CPA", ".", "Interestingly", ",", "p.Tyr263Cys", "tend", "to", "be", "more", "frequently", "observed", "in", "CF", "patients", "with", "CPA", "than", "in", "patients", "without", "CPA", "(", "4/68", "vs", "0/35", ")", ",", "and", "DCTN4", "missense", "variants", "tend", "to", "be", "more", "frequent", "in", "male", "CF", "patients", "with", "CPA", "bearing", "two", "class", "II", "mutations", "than", "in", "male", "CF", "patients", "without", "CPA", "bearing", "two", "class", "II", "mutations", "(", "P", "=", "0.06", ")", ".", "Our", "observations", "reinforce", "that", "DCTN4", "missense", "variants", ",", "especially", "p.Tyr263Cys", ",", "may", "be", "involved", "in", "the", "pathogenesis", "of", "CPA", "in", "male", "CF", "." ]

[ "B-Biologically Active Substance", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Temporal Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Activity", "B-Activity", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "B-Organism Attribute", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "B-Population Group", "O", "B-Age Group", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "B-Health Care Related Organization", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Biologically Active Substance", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "B-Age Group", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Bacterium", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Biologically Active Substance", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Organism Attribute", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Finding", "B-Amino Acid, Peptide, or Protein", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "B-Disease or Syndrome", "O", "B-Organism Attribute", "B-Disease or Syndrome", "O" ]

[ "Nonylphenol", "diethoxylate", "inhibits", "apoptosis", "induced", "in", "PC12", "cells", "Nonylphenol", "and", "short-chain", "nonylphenol", "ethoxylates", "such", "as", "NP2", "EO", "are", "present", "in", "aquatic", "environment", "as", "wastewater", "contaminants", ",", "and", "their", "toxic", "effects", "on", "aquatic", "species", "have", "been", "reported", ".", "Apoptosis", "has", "been", "shown", "to", "be", "induced", "by", "serum", "deprivation", "or", "copper", "treatment", ".", "To", "understand", "the", "toxicity", "of", "nonylphenol", "diethoxylate", ",", "we", "investigated", "the", "effects", "of", "NP2", "EO", "on", "apoptosis", "induced", "by", "serum", "deprivation", "and", "copper", "by", "using", "PC12", "cell", "system", ".", "Nonylphenol", "diethoxylate", "itself", "showed", "no", "toxicity", "and", "recovered", "cell", "viability", "from", "apoptosis", ".", "In", "addition", ",", "nonylphenol", "diethoxylate", "decreased", "DNA", "fragmentation", "caused", "by", "apoptosis", "in", "PC12", "cells", ".", "This", "phenomenon", "was", "confirmed", "after", "treating", "apoptotic", "PC12", "cells", "with", "nonylphenol", "diethoxylate", ",", "whereas", "the", "cytochrome", "c", "release", "into", "the", "cytosol", "decreased", "as", "compared", "to", "that", "in", "apoptotic", "cells", "not", "treated", "with", "nonylphenol", "diethoxylate", "s.", "Furthermore", ",", "Bax", "contents", "in", "apoptotic", "cells", "were", "reduced", "after", "exposure", "to", "nonylphenol", "diethoxylate", ".", "Thus", ",", "nonylphenol", "diethoxylate", "has", "the", "opposite", "effect", "on", "apoptosis", "in", "PC12", "cells", "compared", "to", "nonylphenol", ",", "which", "enhances", "apoptosis", "induced", "by", "serum", "deprivation", ".", "The", "difference", "in", "structure", "of", "the", "two", "compounds", "is", "hypothesized", "to", "be", "responsible", "for", "this", "phenomenon", ".", "These", "results", "indicated", "that", "nonylphenol", "diethoxylate", "has", "capability", "to", "affect", "cell", "differentiation", "and", "development", "and", "has", "potentially", "harmful", "effect", "on", "organisms", "because", "of", "its", "unexpected", "impact", "on", "apoptosis", ".", "©", "2015", "Wiley", "Periodicals", ",", "Inc.", "Environ", "Toxicol", "31", ":", "1389-1398", ",", "2016", "." ]

[ "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Activity", "B-Cell Function", "B-Functional Concept", "O", "B-Cell", "B-Cell", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Finding", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Environmental Effect of Humans", "B-Substance", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Organism", "B-Organism", "O", "O", "O", "O", "B-Cell Function", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "B-Element, Ion, or Isotope", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Cell Function", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "B-Element, Ion, or Isotope", "O", "O", "B-Cell", "B-Cell", "B-Cell", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Cell Function", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Quantitative Concept", "B-Molecular Function", "B-Molecular Function", "O", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "O", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Cell", "B-Cell", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Enzyme", "B-Enzyme", "O", "O", "O", "B-Cell Component", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "B-Functional Concept", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Conceptual Entity", "O", "B-Cell", "B-Cell", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Activity", "B-Cell Function", "B-Functional Concept", "O", "B-Body Substance", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "O", "O", "B-Chemical", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Finding", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Qualitative Concept", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Physiologic Function", "O", "O", "B-Qualitative Concept", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Organism", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Cell Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Prevascularized", "silicon", "membranes", "for", "the", "enhancement", "of", "transport", "to", "implanted", "medical", "devices", "Recent", "advances", "in", "drug", "delivery", "and", "sensing", "devices", "for", "in", "situ", "applications", "are", "limited", "by", "the", "diffusion", "-limiting", "foreign", "body", "response", "of", "fibrous", "encapsulation", ".", "In", "this", "study", ",", "we", "fabricated", "prevascularized", "synthetic", "device", "ports", "to", "help", "mitigate", "this", "limitation", ".", "Membranes", "with", "rectilinear", "arrays", "of", "square", "pores", "with", "widths", "ranging", "from", "40", "to", "200", "μm", "were", "created", "using", "materials", "(", "50", "μm", "thick", "double-sided", "polished", "silicon", ")", "and", "processes", "(", "photolithography", "and", "directed", "reactive", "ion", "etching", ")", "common", "in", "the", "manufacturing", "of", "microfabricated", "sensors", ".", "Vascular", "endothelial", "cells", "responded", "to", "membrane", "geometry", "by", "either", "forming", "vascular", "tubes", "that", "extended", "through", "the", "pore", "or", "completely", "filling", "membrane", "pores", "after", "4", "days", "in", "culture", ".", "Although", "tube", "formation", "began", "to", "predominate", "overgrowth", "around", "75", "μm", "and", "continued", "to", "increase", "at", "even", "larger", "pore", "sizes", ",", "tubes", "formed", "at", "these", "large", "pore", "sizes", "were", "not", "completely", "round", "and", "had", "relatively", "thin", "walls", ".", "Thus", ",", "the", "optimum", "range", "of", "pore", "size", "for", "prevascularization", "of", "these", "membranes", "was", "estimated", "to", "be", "75-100", "μm", ".", "This", "study", "lays", "the", "foundation", "for", "creating", "a", "prevascularized", "port", "that", "can", "be", "used", "to", "reduce", "fibrous", "encapsulation", "and", "thus", "enhance", "diffusion", "to", "implanted", "medical", "devices", "and", "sensors", ".", "©", "2015", "Wiley", "Periodicals", ",", "Inc.", "J", "Biomed", "Mater", "Res", "Part", "B", ":", "Appl", "Biomater", ",", "104B", ":", "1602-1609", ",", "2016", "." ]

[ "B-Functional Concept", "B-Biomedical or Dental Material", "B-Manufactured Object", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Health Care Activity", "O", "B-Functional Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Manufactured Object", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "B-Phenomenon or Process", "O", "B-Functional Concept", "O", "B-Manufactured Object", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "B-Phenomenon or Process", "O", "B-Occupational Activity", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Occupational Activity", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Spatial Concept", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "I-Activity", "B-Manufactured Object", "B-Spatial Concept", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "B-Manufactured Object", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "O", "B-Activity", "B-Natural Phenomenon or Process", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Seated", "maximum", "flexion", ":", "An", "alternative", "to", "standing", "maximum", "flexion", "for", "determining", "presence", "of", "flexion", "-", "relaxation", "?", "The", "flexion", "-", "relaxation", "phenomenon", "(", "FRP", ")", "in", "standing", "is", "a", "specific", "and", "sensitive", "diagnostic", "tool", "for", "low", "back", "pain", ".", "Seated", "flexion", "as", "an", "alternative", "could", "be", "beneficial", "for", "certain", "populations", ",", "yet", "the", "behavior", "of", "the", "trunk", "extensors", "during", "seated", "maximum", "flexion", "compared", "to", "standing", "flexion", "remains", "unclear", ".", "Compare", "FRP", "occurrences", "and", "spine", "angles", "between", "seated", "and", "standing", "flexion", "postures", "in", "three", "levels", "of", "the", "erector", "spinae", "muscles", ".", "Thirty-one", "participants", "free", "of", "back", "pain", "performed", "seated", "and", "standing", "maximum", "trunk", "flexion", ".", "Electromyographical", "signals", "were", "recorded", "from", "the", "bilateral", "lumbar", "(", "L3", ")", ",", "lower-thoracic", "(", "T9", ")", ",", "and", "upper-thoracic", "(", "T4", ")", "erector", "spinae", "and", "assessed", "for", "the", "occurrence", "of", "FRP", ".", "Spine", "angles", "corresponding", "to", "FRP", "onset", "and", "cessation", "were", "determined", ",", "and", "FRP", "occurrences", "and", "angles", "were", "compared", "between", "posture", "and", "muscle", ".", "FRP", "occurrence", "was", "similar", "in", "standing", "and", "seated", "maximum", "flexion", "across", "all", "muscles", ",", "with", "the", "lumbar", "muscles", "showing", "the", "greatest", "consistency", ".", "Standing", "FRP", "onset", "and", "cessation", "angles", "were", "consistently", "greater", "than", "the", "corresponding", "seated", "FRP", "angles", ".", "Considering", "the", "similar", "number", "of", "FRP", "occurrences", ",", "seated", "maximum", "flexion", "may", "constitute", "an", "objective", "criterion", "for", "low", "back", "pain", "diagnosis", ".", "Future", "work", "should", "seek", "to", "confirm", "the", "utility", "of", "this", "test", "in", "individuals", "with", "low", "back", "pain", "." ]

[ "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Conceptual Entity", "O", "B-Spatial Concept", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Organ or Tissue Function", "O", "B-Activity", "O", "O", "B-Organ or Tissue Function", "O", "B-Activity", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Spatial Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Spatial Concept", "O", "B-Finding", "O", "B-Spatial Concept", "B-Organ or Tissue Function", "B-Organism Attribute", "O", "O", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Population Group", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Finding", "O", "B-Spatial Concept", "B-Quantitative Concept", "B-Body Location or Region", "B-Organ or Tissue Function", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Activity", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Activity", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "B-Activity", "O", "B-Organism Attribute", "O", "B-Tissue", "O", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "B-Tissue", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Phenomenon or Process", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Finding", "B-Quantitative Concept", "B-Organ or Tissue Function", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Population Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O" ]

[ "The", "Relationship", "Between", "Distance", "and", "Post-operative", "Visit", "Attendance", "Following", "Medical", "Male", "Circumcision", "in", "Nyanza", "Province", ",", "Kenya", "To", "date", ",", "there", "is", "no", "research", "on", "voluntary", "medical", "male", "circumcision", "(", "VMMC", ")", "catchment", "areas", "or", "the", "relationship", "between", "distance", "to", "a", "VMMC", "facility", "and", "attendance", "at", "a", "post-operative", "follow-up", "visit", ".", "We", "analyzed", "data", "from", "a", "randomly", "selected", "subset", "of", "males", "self-seeking", "circumcision", "at", "one", "of", "16", "participating", "facilities", "in", "Nyanza", "Province", ",", "Kenya", "between", "2008", "and", "2010", ".", "Among", "1437", "participants", ",", "46.7", "%", "attended", "follow-up", ".", "The", "median", "distance", "from", "residence", "to", "utilized", "facility", "was", "2.98", "km", "(", "IQR", "1.31-5.38", ")", ".", "Nearly", "all", "participants", "(", "98.8", "%", ")", "lived", "within", "5", "km", "from", "a", "facility", ",", "however", ",", "26.3", "%", "visited", "a", "facility", "more", "than", "5", "km", "away", ".", "Stratified", "results", "demonstrated", "that", "among", "those", "utilizing", "fixed", "facilities", ",", "greater", "distance", "was", "associated", "with", "higher", "odds", "of", "follow-up", "non-attendance", "(", "OR", "5.01-10km", "vs.", "0-1km", "=", "1.71", ",", "95", "%", "CI", "1.08", ",", "2.70", ",", "p", "=", "0.02", ";", "OR", ">", "10km", "vs.", "0-1", "km", "=", "2.80", ",", "95", "%", "CI", "1.26", ",", "6.21", ",", "p", "=", "0.01", ")", ",", "adjusting", "for", "age", "and", "district", "of", "residence", ".", "We", "found", "5", "km", "marked", "the", "threshold", "distance", "beyond", "which", "follow-up", "attendance", "significantly", "dropped", ".", "These", "results", "demonstrate", "distance", "is", "an", "important", "predictor", "of", "attending", "follow-up", ",", "and", "this", "relationship", "appears", "to", "be", "modified", "by", "facility", "type", "." ]

[ "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Behavior", "B-Activity", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Individual Behavior", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Health Care Related Organization", "O", "B-Activity", "O", "O", "B-Finding", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Research Activity", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "B-Activity", "B-Classification", "O", "B-Population Group", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Functional Concept", "B-Health Care Activity", "O", "O", "B-Spatial Concept", "B-Quantitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "B-Behavior", "O", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Health Care Activity", "B-Activity", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Health Care Activity", "B-Activity", "B-Idea or Concept", "B-Quantitative Concept", "O", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "O", "O", "B-Idea or Concept", "O", "B-Functional Concept", "B-Health Care Activity", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Health Care Related Organization", "B-Qualitative Concept", "O" ]

[ "Promoting", "lifestyle", "behaviour", "change", "and", "well-being", "in", "hospital", "patients", ":", "a", "pilot", "study", "of", "an", "evidence-based", "psychological", "intervention", "Lifestyle", "risk", "behaviours", "show", "an", "inverse", "social", "gradient", ",", "clustering", "in", "vulnerable", "groups", ".", "We", "designed", "and", "piloted", "an", "intervention", "to", "address", "barriers", "to", "lifestyle", "behaviour", "change", "among", "hospital", "patients", ".", "We", "designed", "our", "intervention", "using", "effective", "components", "of", "behaviour", "change", "interventions", "informed", "by", "psychological", "theory", ".", "Delivered", "by", "a", "health", "psychologist", "based", "at", "the", "Royal", "Free", "London", "NHS", "Foundation", "Trust", ",", "the", "4-week", "intervention", "included", "detailed", "baseline", "assessment", ",", "personalized", "goal", "setting", ",", "psychological", "skills", "development", ",", "motivation", "support", "and", "referral", "to", "community", "services", ".", "Primary", "outcomes", "were", "feasibility", "and", "patient", "acceptability", ".", "We", "also", "evaluated", "changes", "to", "health", "and", "well-being", ".", "From", "1", "July", "2013", "to", "31", "September", "2014", ",", "686", "patients", "were", "referred", ",", "338", "(", "49.3", "%", ")", "attended", "a", "first", "appointment", "and", "172", "(", "25.1", "%", ")", "completed", "follow-up", ".", "Furthermore", ",", "72.1", "%", "of", "attenders", "were", "female", "with", "the", "median", "age", "55", "years", "and", "poor", "self-reported", "baseline", "health", ".", "After", "4", "weeks", ",", "self-efficacy", ",", "health", "and", "well-being", "scores", "significantly", "improved", ":", "63", "%", "of", "lifestyle", "goals", "and", "89", "%", "of", "health", "management", "goals", "were", "fully", "achieved", ";", "58", "%", "of", "referrals", "to", "community", "lifestyle", "behaviour", "change", "services", "and", "79", "%", "of", "referrals", "to", "other", "services", "(", "e.g", ".", "Citizen", "'s", "Advice", "Bureau", ")", "were", "accepted", ";", "99", "%", "were", "satisfied", "/", "very", "satisfied", "with", "the", "service", ".", "Our", "hospital-based", "intervention", "was", "feasible", ",", "acceptable", "and", "showed", "preliminary", "health", "and", "well-being", "gains", "." ]

[ "B-Activity", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "B-Finding", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Individual Behavior", "B-Individual Behavior", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Self-help or Relief Organization", "B-Self-help or Relief Organization", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Patient or Disabled Group", "B-Qualitative Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "O", "B-Finding", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "B-Organism Attribute", "O", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Mental Process", "O", "B-Idea or Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Intellectual Product", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Self-help or Relief Organization", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Finding", "B-Finding", "O", "O", "B-Health Care Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O" ]

[ "The", "Impact", "of", "Deployment", "on", "Parental", ",", "Family", "and", "Child", "Adjustment", "in", "Military", "Families", "Since", "9/11", ",", "military", "service", "in", "the", "United", "States", "has", "been", "characterized", "by", "wartime", "deployments", "and", "reintegration", "challenges", "that", "contribute", "to", "a", "context", "of", "stress", "for", "military", "families", ".", "Research", "indicates", "the", "negative", "impact", "of", "wartime", "deployment", "on", "the", "well", "being", "of", "service", "members", ",", "military", "spouses", ",", "and", "children", ".", "Yet", ",", "few", "studies", "have", "considered", "how", "parental", "deployments", "may", "affect", "adjustment", "in", "young", "children", "and", "their", "families", ".", "Using", "deployment", "records", "and", "parent", "-", "reported", "measures", "from", "primary", "caregiving", "(", "N", "=", "680", ")", "and", "military", "(", "n", "=", "310", ")", "parents", ",", "we", "examined", "the", "influence", "of", "deployment", "on", "adjustment", "in", "military", "families", "with", "children", "ages", "0-10", "years", ".", "Greater", "deployment", "exposure", "was", "related", "to", "impaired", "family", "functioning", "and", "marital", "instability", ".", "Parental", "depressive", "and", "posttraumatic", "stress", "symptoms", "were", "associated", "with", "impairments", "in", "social", "emotional", "adjustment", "in", "young", "children", ",", "increased", "anxiety", "in", "early", "childhood", ",", "and", "adjustment", "problems", "in", "school-age", "children", ".", "Conversely", ",", "parental", "sensitivity", "was", "associated", "with", "improved", "social", "and", "emotional", "outcomes", "across", "childhood", ".", "These", "findings", "provide", "guidance", "to", "developing", "preventive", "approaches", "for", "military", "families", "with", "young", "children", "." ]

[ "O", "O", "O", "B-Activity", "O", "B-Family Group", "O", "B-Family Group", "O", "B-Age Group", "B-Individual Behavior", "O", "B-Family Group", "B-Family Group", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "B-Temporal Concept", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Family Group", "B-Family Group", "O", "B-Research Activity", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Activity", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Professional or Occupational Group", "B-Population Group", "O", "B-Professional or Occupational Group", "B-Family Group", "O", "O", "B-Age Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Family Group", "B-Activity", "O", "O", "B-Individual Behavior", "O", "B-Age Group", "B-Age Group", "O", "O", "B-Family Group", "O", "O", "I-Intellectual Product", "B-Intellectual Product", "O", "B-Family Group", "O", "B-Intellectual Product", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "B-Family Group", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Individual Behavior", "O", "B-Family Group", "B-Family Group", "O", "B-Age Group", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "B-Functional Concept", "B-Social Behavior", "B-Social Behavior", "O", "B-Finding", "B-Finding", "O", "B-Family Group", "B-Mental or Behavioral Dysfunction", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Functional Concept", "O", "B-Social Behavior", "B-Finding", "B-Individual Behavior", "O", "B-Age Group", "B-Age Group", "O", "O", "B-Finding", "O", "O", "B-Temporal Concept", "O", "O", "B-Individual Behavior", "O", "O", "B-Age Group", "B-Age Group", "O", "O", "O", "B-Family Group", "B-Mental Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Social Behavior", "O", "B-Finding", "B-Finding", "O", "B-Temporal Concept", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Family Group", "B-Family Group", "O", "O", "B-Age Group", "O" ]

[ "Combining", "electrostatic", "powder", "with", "an", "insecticide", ":", "effect", "on", "stored", "-", "product", "beetles", "and", "on", "the", "commodity", "The", "opportunity", "to", "reduce", "the", "amount", "of", "pirimiphos-methyl", "applied", "to", "grain", "by", "formulating", "it", "in", "an", "electrostatic", "powder", "was", "investigated", ".", "The", "insecticidal", "efficacy", "of", "pirimiphos-methyl", "in", "EC", "formulation", "or", "formulated", "using", "electrostatic", "powder", "(", "EP", ")", "as", "an", "inert", "carrier", "was", "investigated", "against", "Sitophilus", "oryzae", "(", "L.", ")", ",", "Oryzaephilus", "surinamensis", "(", "L.", ")", ",", "Rhyzopertha", "dominica", "(", "F.", ")", "and", "Tribolium", "confusum", "Jacquelin", "du", "Val", ".", "Furthermore", ",", "the", "adhesive", "properties", "of", "EP", "to", "rice", ",", "corn", "and", "wheat", ",", "together", "with", "the", "effect", "on", "bulk", "density", "and", "bread", "-", "and", "pasta", "-", "making", "properties", ",", "were", "investigated", ".", "The", "results", "showed", "that", "pirimiphos-methyl", "formulated", "with", "EP", "provided", "better", "efficacy", "against", "adults", "when", "compared", "with", "EC", "formulation", "for", "O.", "surinamensis", "and", "T.", "confusum", ",", "but", "there", "was", "no", "difference", "for", "R.", "dominica", ".", "Progeny", "production", "was", "consistently", "lower", "in", "grain", "treated", "with", "the", "EP", "formulation", "than", "in", "grain", "treated", "with", "the", "EC", ".", "Tests", "showed", "that", "EP", "adhered", "to", "the", "kernels", "for", "longer", "on", "hard", "wheat", "than", "on", "maize", "or", "rice", ".", "In", "most", "commodities", ",", "EP", "did", "not", "alter", "the", "bulk", "density", ".", "Finally", ",", "the", "addition", "of", "EP", "did", "not", "affect", "flour", "-", "and", "bread", "-", "making", "properties", ",", "nor", "the", "pasta", "-making", "properties", ".", "The", "results", "of", "the", "present", "study", "suggest", "that", "an", "EP", "could", "be", "used", "to", "reduce", "the", "amount", "of", "pirimiphos-methyl", "applied", "to", "grain", "for", "effective", "pest", "control", ",", "with", "no", "detrimental", "effects", "on", "grain", "quality", ".", "©", "2016", "Society", "of", "Chemical", "Industry", "." ]

[ "O", "B-Substance", "B-Substance", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Functional Concept", "O", "B-Entity", "B-Eukaryote", "O", "O", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Food", "O", "O", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Qualitative Concept", "O", "B-Pharmacologic Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Substance", "B-Substance", "O", "B-Substance", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Substance", "O", "B-Food", "O", "B-Food", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Food", "O", "O", "B-Food", "O", "B-Activity", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Substance", "O", "O", "B-Qualitative Concept", "O", "B-Eukaryote", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Family Group", "O", "O", "O", "O", "O", "B-Food", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Substance", "O", "O", "O", "B-Food", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "B-Substance", "B-Phenomenon or Process", "O", "O", "B-Food", "O", "O", "O", "O", "B-Food", "O", "O", "B-Food", "O", "B-Food", "O", "O", "O", "B-Food", "O", "B-Substance", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "B-Food", "O", "O", "B-Food", "O", "B-Activity", "B-Qualitative Concept", "O", "O", "O", "B-Food", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Food", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Food", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Radiofrequency", "ablation", "of", "posteroseptal", "accessory", "pathways", "associated", "with", "coronary", "sinus", "diverticula", "Posteroseptal", "accessory", "pathways", "may", "be", "associated", "with", "a", "coronary", "sinus", "(", "CS", ")", "diverticulum", ".", "Our", "purpose", "was", "to", "describe", "the", "clinical", "characteristics", ",", "mapping", "and", "ablation", "of", "these", "pathways", ".", "This", "was", "a", "retrospective", "study", "of", "all", "patients", "who", "underwent", "ablation", "of", "posteroseptal", "accessory", "pathways", "in", "a", "single", "centre", ".", "Patients", "with", "a", "diverticulum", "of", "the", "CS", "or", "one", "of", "its", "tributaries", "were", "included", "in", "group", "I", ",", "while", "the", "other", "patients", "formed", "group", "II", ".", "Clinical", "presentation", ",", "ablation", "procedure", "and", "outcome", "were", "compared", "between", "the", "two", "groups", ".", "A", "total", "of", "51", "patients", "were", "included", ",", "16", "in", "group", "I", "and", "35", "in", "group", "II", ".", "There", "were", "no", "significant", "differences", "in", "age", "or", "sex", "distribution", ".", "Atrial", "fibrillation", "(", "AF", ")", "and", "previous", "unsuccessful", "ablation", "were", "more", "common", "in", "group", "I", ".", "A", "negative", "delta", "wave", "in", "lead", "II", "was", "the", "ECG", "finding", "with", "best", "sensitivity", "and", "specificity", "for", "the", "presence", "of", "a", "diverticulum", ".", "A", "pathway", "potential", "was", "common", "at", "the", "successful", "site", "in", "group", "I", ",", "and", "the", "interval", "between", "local", "ventricular", "electrogram", "and", "delta", "wave", "onset", "was", "shorter", "(", "19.5", "±", "8", "vs", "33.1", "±", "7.6", "ms", ",", "p", "<", "0.001", ")", ".", "There", "was", "a", "trend", "toward", "lower", "procedural", "success", "rate", "and", "higher", "recurrence", "rate", "in", "group", "I", ",", "although", "this", "was", "not", "significant", ".", "CS", "diverticula", "should", "be", "suspected", "in", "patients", "with", "manifest", "posteroseptal", "accessory", "pathways", "who", "have", "a", "previous", "failed", "ablation", ",", "documented", "AF", "or", "typical", "electrocardiographic", "signs", ".", "A", "discrete", "potential", "is", "frequently", "seen", "at", "the", "successful", "site", ",", "but", "the", "local", "ventricular", "electrogram", "is", "not", "as", "early", "as", "in", "other", "accessory", "pathways", "." ]

[ "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Diagnostic Procedure", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Finding", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "B-Quantitative Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Disease or Syndrome", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O" ]

[ "Association", "of", "RBP4", "levels", "with", "increased", "arterial", "stiffness", "in", "adolescents", "with", "family", "history", "of", "type", "2", "diabetes", "The", "aim", "of", "this", "study", "was", "to", "explore", "the", "impact", "of", "family", "history", "of", "type", "2", "diabetes", "(", "FH2D", ")", "on", "arterial", "stiffness", "in", "young", "people", "and", "its", "relationship", "to", "adipocytokines", ".", "This", "case-control", "study", "included", "52", "adolescents", "(", "male", "/", "female", "28/24", ")", "with", "FH2D", "(", "FH2D+", ")", "and", "40", "adolescents", "(", "male", "/", "female", "21/19", ")", "without", "FH2D", "(", "FH2D-", ")", ".", "Anthropometric", "measurements", ",", "including", "height", ",", "weight", ",", "waist", "circumference", "(", "WC", ")", ",", "and", "blood", "pressure", ",", "were", "obtained", ".", "Blood", "samples", "were", "collected", ",", "fasting", "plasma", "glucose", "(", "FPG", ")", ",", "serum", "lipids", ",", "Retinol", "Binding", "Protein", "4", "(", "RBP4", ")", ",", "C", "reactive", "protein", "(", "CRP", ")", ",", "adiponectin", "and", "visfatin", "were", "examined", ".", "Brachial-ankle", "pulse", "wave", "velocity", "(", "baPWV", ")", "was", "used", "to", "evaluate", "arterial", "stiffness", ".", "Visceral", "fat", "area", "(", "VFA", ")", "was", "measured", "by", "computerized", "tomography", ".", "Compared", "with", "FH2D-", "group", ",", "FH2D+", "group", "had", "a", "significantly", "higher", "oral", "glucose", "tolerance", "test", "(", "OGTT", ")", "2-hour", "insulin", ",", "RBP4", "and", "baPWV", "levels", ",", "a", "lower", "adiponectin", "and", "glucose", "infusing", "rate", "(", "GIR", ")", "(", "P", "<", "0.05", ")", ".", "BaPWV", "was", "positively", "correlated", "with", "age", ",", "systolic", "blood", "pressure", "(", "SBP", ")", ",", "diastolic", "blood", "pressure", "(", "DBP", ")", ",", "2-hour", "(", "OGTT", ")", "insulin", ",", "RBP4", ",", "and", "VFA", ",", "and", "negatively", "correlated", "with", "GIR", "in", "FH2D+", "group", ".", "After", "multivariate", "analysis", ",", "age", ",", "SBP", ",", "RBP4", "and", "VFA", "maintained", "an", "independent", "association", "with", "baPWV", "in", "FH2D+", "group", "(", "P", "<", "0.05", ")", ",", "while", "only", "age", ",", "SBP", ",", "and", "VFA", "were", "independent", "predictors", "of", "baPWV", "in", "FH2D-", "group", "(", "P", "<", "0.05", ")", ".", "These", "findings", "led", "to", "the", "conclusion", "that", "RBP4", "level", "was", "associated", "with", "increased", "arterial", "stiffness", "in", "young", "subjects", "with", "family", "history", "of", "type", "2", "diabetes", "." ]

[ "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Age Group", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Temporal Concept", "B-Population Group", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Age Group", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "B-Finding", "O", "B-Finding", "O", "O", "O", "B-Age Group", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "B-Finding", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "B-Organism Function", "B-Organism Function", "O", "O", "O", "O", "B-Body Substance", "B-Body Substance", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Laboratory Procedure", "O", "B-Enzyme", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Finding", "B-Population Group", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Population Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "O", "B-Biologically Active Substance", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Clinical Attribute", "O", "O", "B-Idea or Concept", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Temporal Concept", "B-Population Group", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O" ]

[ "EZH2", "and", "ZFX", "oncogenes", "in", "malignant", "behaviour", "of", "parathyroid", "neoplasms", "Several", "studies", "reported", "somatic", "mutations", "of", "many", "genes", "(", "MEN1", ",", "CTNNB1", ",", "CDKIs", "and", "others", ")", "in", "parathyroid", "adenoma", ",", "although", "with", "different", "prevalence", ".", "Recently", ",", "activating", "mutations", "of", "the", "EZH2", "and", "ZFX", "oncogenes", "were", "identified", "in", "benign", "parathyroid", "adenoma", "by", "whole", "exome", "sequencing", ".", "The", "same", "mutations", "had", "been", "found", "in", "blood", "and", "ovary", "malignant", "tumours", ".", "On", "one", "hand", ",", "this", "result", "raised", "the", "hypothesis", "that", "these", "oncogenes", "may", "play", "a", "role", "in", "the", "onset", "of", "parathyroid", "tumour", ",", "but", "it", "would", "also", "suggest", "they", "may", "be", "involved", "in", "malignant", ",", "rather", "benign", ",", "parathyroid", "neoplasm", ".", "Our", "aim", "was", "to", "verify", "the", "occurrence", "of", "selected", "mutations", "of", "the", "EZH2", "and", "ZFX", "genes", "in", "an", "Italian", "cohort", "of", "23", "sporadic", "parathyroid", "carcinomas", ",", "12", "atypical", "and", "45", "typical", "adenomas", ".", "DNA", "was", "extracted", "from", "paraffin-embedded", "tissues", ",", "PCR", "amplified", "and", "directly", "sequenced", ".", "No", "mutations", "were", "detected", "in", "the", "coding", "sequence", "and", "boundaries", "of", "both", "genes", "in", "any", "of", "the", "samples", ".", "Two", "polymorphisms", "of", "the", "EZH2", "gene", "were", "identified", "with", "different", "prevalence", ":", "the", "rs2072407", "variant", "was", "present", "in", "the", "30", "%", "of", "the", "samples", ",", "in", "keeping", "with", "the", "overall", "frequency", "in", "larger", "populations", ",", "while", "the", "rs78589034", "variant", ",", "located", "close", "to", "the", "5", "'", "end", "of", "the", "exon", "16", ",", "was", "detected", "in", "only", "one", "proband", "with", "familial", "isolated", "hyperparathyroidism", ";", "we", "investigated", "the", "possible", "outcome", "on", "the", "splicing", "process", ".", "EZH2", "and", "ZFX", "genes", "do", "not", "seem", "to", "have", "an", "impact", "on", "the", "onset", "of", "most", "parathyroid", "tumours", ",", "both", "benign", "and", "malignant", ",", "though", "further", "studies", "on", "larger", "cohorts", "of", "different", "ethnicity", "are", "needed", "." ]

[ "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Research Activity", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Activity", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Body Substance", "O", "B-Body Part, Organ, or Organ Component", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Neoplastic Process", "O", "B-Biologically Active Substance", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Tissue", "B-Tissue", "O", "B-Molecular Biology Research Technique", "B-Phenomenon or Process", "O", "O", "B-Functional Concept", "O", "B-Finding", "B-Genetic Function", "O", "B-Finding", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Substance", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Temporal Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Finding", "O", "O", "O", "B-Family Group", "O", "B-Functional Concept", "B-Functional Concept", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Population Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O" ]

[ "The", "effect", "of", "total", "hip", "arthroplasty", "on", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "and", "low", "back", "pain", "in", "patients", "with", "severe", "hip", "osteoarthritis", "Sagittal", "spinopelvic", "malalignment", "has", "been", "reported", "in", "spinal", "disorders", "such", "as", "low", "back", "pain", "(", "LBP", ")", ",", "and", "restoration", "of", "normal", "alignment", "is", "targeted", "when", "treating", "these", "disorders", ".", "Abnormal", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "has", "been", "reported", "in", "patients", "with", "severe", "hip", "osteoarthritis", "(", "OA", ")", ",", "who", "have", "a", "high", "prevalence", "of", "associated", "LBP", ".", "This", "prospective", "longitudinal", "study", "aimed", "to", "investigate", "changes", "in", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "after", "total", "hip", "arthroplasty", "(", "THA", ")", "in", "patients", "with", "severe", "hip", "OA", ",", "and", "whether", "these", "changes", "contribute", "to", "LBP", "relief", ".", "Patients", "undergoing", "primary", "THA", "due", "to", "severe", "unilateral", "hip", "OA", "were", "recruited", ".", "Physical", "examination", "and", "X-ray", "films", "were", "taken", "to", "rule", "out", "any", "spinal", "disorder", ".", "Sagittal", "alignment", "of", "pelvis", ",", "hip", ",", "and", "spine", "was", "analyzed", "on", "lateral", "radiographs", "taken", "before", "(", "baseline", ")", "and", "1", "year", "after", "(", "follow-up", ")", "THA", ".", "Functional", "instruments", "were", "completed", "by", "patients", "including", ":", "visual", "analog", "scale", "(", "VAS", ")", "for", "LBP", ",", "Roland-Morris", "Disability", "Questionnaire", "(", "RMDQ", ")", ",", "and", "Harris", "Hip", "Score", "(", "HHS", ")", ".", "Comparisons", "were", "carried", "out", "at", "baseline", "and", "follow-up", ",", "and", "between", "patients", "with", "and", "without", "LBP", ".", "The", "recruited", "69", "patients", "showed", "significantly", "reduced", "hip", "flexion", "and", "improved", "global", "spinal", "balance", "at", "follow-up", "compared", "with", "baseline", ".", "LBP", "was", "reported", "by", "39", "patients", "(", "56.5", "%", ")", "before", "surgery", ";", "at", "follow-up", ",", "17", "reported", "complete", "resolution", ",", "while", "22", "reported", "significant", "relief", ".", "Significant", "decreases", "in", "VAS", "and", "RMDQ", "scores", "in", "lumbar", "spine", "and", "increase", "in", "hip", "HHS", "were", "observed", ".", "THA", "in", "patients", "with", "severe", "hip", "OA", "could", "help", "correct", "abnormal", "sagittal", "spinal", "-", "pelvic-leg", "alignment", "and", "relieve", "comorbid", "LBP", ".", "Improvements", "in", "hip", "flexion", "and", "global", "spinal", "balance", "might", "be", "involved", "in", "the", "mechanism", "of", "LBP", "relief", "." ]

[ "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Body Location or Region", "B-Body Part, Organ, or Organ Component", "B-Pathologic Function", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "O", "B-Finding", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Sign or Symptom", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Sign or Symptom", "B-Finding", "O", "B-Patient or Disabled Group", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Body Location or Region", "B-Finding", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Health Care Activity", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "B-Sign or Symptom", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Health Care Activity", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Health Care Activity", "O", "O", "B-Quantitative Concept", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "O", "B-Clinical Attribute", "O", "B-Intellectual Product", "B-Quantitative Concept", "O", "B-Body Location or Region", "B-Body Location or Region", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Body Location or Region", "B-Spatial Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "B-Finding", "B-Sign or Symptom", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "B-Sign or Symptom", "B-Finding", "O" ]

[ "Beyond", "neutral", "and", "forbidden", "links", ":", "morphological", "matches", "and", "the", "assembly", "of", "mutualistic", "hawkmoth", "-", "plant", "networks", "A", "major", "challenge", "in", "evolutionary", "ecology", "is", "to", "understand", "how", "co-evolutionary", "processes", "shape", "patterns", "of", "interactions", "between", "species", "at", "community", "level", ".", "Pollination", "of", "flowers", "with", "long", "corolla", "tubes", "by", "long-tongued", "hawkmoths", "has", "been", "invoked", "as", "a", "showcase", "model", "of", "co-evolution", ".", "Recently", ",", "optimal", "foraging", "models", "have", "predicted", "that", "there", "might", "be", "a", "close", "association", "between", "mouthparts", "'", "length", "and", "the", "corolla", "depth", "of", "the", "visited", "flowers", ",", "thus", "favouring", "trait", "convergence", "and", "specialization", "at", "community", "level", ".", "Here", ",", "we", "assessed", "whether", "hawkmoths", "more", "frequently", "pollinate", "plants", "with", "floral", "tube", "lengths", "similar", "to", "their", "proboscis", "lengths", "(", "morphological", "match", "hypothesis", ")", "against", "abundance", "-based", "processes", "(", "neutral", "hypothesis", ")", "and", "ecological", "trait", "mismatches", "constraints", "(", "forbidden", "links", "hypothesis", ")", ",", "and", "how", "these", "processes", "structure", "hawkmoth", "-", "plant", "mutualistic", "networks", "from", "five", "communities", "in", "four", "biogeographical", "regions", "of", "South", "America", ".", "We", "found", "convergence", "in", "morphological", "traits", "across", "the", "five", "communities", "and", "that", "the", "distribution", "of", "morphological", "differences", "between", "hawkmoths", "and", "plants", "is", "consistent", "with", "expectations", "under", "the", "morphological", "match", "hypothesis", "in", "three", "of", "the", "five", "communities", ".", "In", "the", "two", "remaining", "communities", ",", "which", "are", "ecotones", "between", "two", "distinct", "biogeographical", "areas", ",", "interactions", "are", "better", "predicted", "by", "the", "neutral", "hypothesis", ".", "Our", "findings", "are", "consistent", "with", "the", "idea", "that", "diffuse", "co-evolution", "drives", "the", "evolution", "of", "extremely", "long", "proboscises", "and", "flower", "tubes", ",", "and", "highlight", "the", "importance", "of", "morphological", "traits", ",", "beyond", "the", "forbidden", "links", "hypothesis", ",", "in", "structuring", "interactions", "between", "mutualistic", "partners", ",", "revealing", "that", "the", "role", "of", "niche-based", "processes", "can", "be", "much", "more", "complex", "than", "previously", "known", "." ]

[ "O", "B-Conceptual Entity", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "B-Phenomenon or Process", "B-Eukaryote", "O", "B-Plant", "B-Functional Concept", "O", "O", "O", "O", "B-Occupation or Discipline", "B-Occupation or Discipline", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Spatial Concept", "O", "B-Functional Concept", "O", "B-Classification", "O", "B-Group", "B-Qualitative Concept", "O", "B-Organism Function", "O", "B-Plant", "O", "B-Plant", "B-Plant", "B-Plant", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "O", "O", "O", "B-Research Device", "O", "B-Genetic Function", "O", "O", "O", "O", "O", "B-Research Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Plant", "B-Spatial Concept", "O", "O", "O", "B-Plant", "O", "O", "O", "B-Organism Attribute", "B-Activity", "O", "B-Occupation or Discipline", "O", "B-Group", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Eukaryote", "O", "O", "B-Plant", "B-Plant", "O", "B-Classification", "B-Classification", "B-Quantitative Concept", "O", "O", "O", "B-Eukaryote", "B-Quantitative Concept", "O", "B-Spatial Concept", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "O", "B-Phenomenon or Process", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Qualitative Concept", "B-Occupational Activity", "O", "B-Conceptual Entity", "B-Conceptual Entity", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Spatial Concept", "B-Eukaryote", "O", "B-Plant", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Group", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "B-Activity", "O", "B-Spatial Concept", "B-Organism Attribute", "O", "O", "O", "B-Group", "O", "O", "O", "B-Functional Concept", "O", "B-Spatial Concept", "O", "O", "B-Eukaryote", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "B-Genetic Function", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Organism Attribute", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "B-Idea or Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Impact", "of", "totally", "laparoscopic", "combined", "management", "of", "colorectal", "cancer", "with", "synchronous", "hepatic", "metastases", "on", "severity", "of", "complications", ":", "a", "propensity-score", "-based", "analysis", "Thanks", "to", "widespread", "diffusion", "of", "minimally", "invasive", "approach", "in", "the", "setting", "of", "both", "colorectal", "and", "hepatic", "surgeries", ",", "the", "interest", "in", "combined", "resections", "for", "colorectal", "cancer", "and", "synchronous", "liver", "metastases", "(", "SCLM", ")", "by", "totally", "laparoscopic", "approach", "(", "TLA", ")", "has", "increased", ".", "Aim", "of", "this", "study", "was", "to", "compare", "outcome", "of", "combined", "resections", "for", "SCLM", "performed", "by", "TLA", "or", "by", "open", "approach", ",", "in", "a", "propensity-score-based", "study", ".", "All", "25", "patients", "undergoing", "combined", "TLA", "for", "SCLM", "at", "San", "Raffaele", "Hospital", "in", "Milano", "were", "compared", "in", "a", "case-matched", "analysis", "with", "25", "out", "of", "91", "patients", "undergoing", "totally", "open", "approach", "(", "TOA", "group", ")", ".", "Groups", "were", "matched", "with", "1:2", "ratio", "using", "propensity", "scores", "based", "on", "covariates", "representing", "disease", "severity", ".", "Main", "endpoints", "were", "postoperative", "morbidity", "and", "long-term", "outcome", ".", "The", "Modified", "Accordion", "Severity", "Grading", "System", "was", "used", "to", "quantify", "complications", ".", "The", "groups", "resulted", "comparable", "in", "terms", "of", "patients", "and", "disease", "characteristics", ".", "The", "TLA", "group", ",", "as", "compared", "to", "the", "TOA", "group", ",", "had", "lower", "blood", "loss", "(", "350", "vs", "600", "mL", ")", ",", "shorter", "postoperative", "stay", "(", "9", "vs", "12", "days", ")", ",", "lower", "postoperative", "morbidity", "index", "(", "0.14", "vs", "0.20", ")", "and", "severity", "score", "for", "complicated", "patients", "(", "0.60", "vs", "0.85", ")", ".", "Colonic", "anastomosis", "leakage", "had", "the", "highest", "fractional", "complication", "burden", "in", "both", "groups", ".", "In", "spite", "of", "comparable", "long-term", "overall", "survival", ",", "the", "TLA", "group", "had", "better", "recurrence-free", "survival", ".", "TLA", "for", "combined", "resections", "is", "feasible", ",", "and", "its", "indications", "can", "be", "widened", "to", "encompass", "a", "larger", "population", "of", "patients", ",", "provided", "its", "benefits", "in", "terms", "of", "reduced", "overall", "risk", "and", "severity", "of", "complications", ",", "rapid", "functional", "recovery", "and", "favorable", "long-term", "outcomes", "." ]

[ "O", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Diagnostic Procedure", "O", "B-Neoplastic Process", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Quantitative Concept", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "I-Population Group", "B-Population Group", "O", "O", "B-Finding", "B-Finding", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Temporal Concept", "B-Functional Concept", "O" ]

[ "Application", "of", "an", "Analytical", "Solution", "as", "a", "Screening", "Tool", "for", "Sea", "Water", "Intrusion", "Sea", "water", "intrusion", "into", "aquifers", "is", "problematic", "in", "many", "coastal", "areas", ".", "The", "physics", "and", "chemistry", "of", "this", "issue", "are", "complex", ",", "and", "sea", "water", "intrusion", "remains", "challenging", "to", "quantify", ".", "Simple", "assessment", "tools", "like", "analytical", "models", "offer", "advantages", "of", "rapid", "application", ",", "but", "their", "applicability", "to", "field", "situations", "is", "unclear", ".", "This", "study", "examines", "the", "reliability", "of", "a", "popular", "sharp-interface", "analytical", "approach", "for", "estimating", "the", "extent", "of", "sea", "water", "in", "a", "homogeneous", "coastal", "aquifer", "subjected", "to", "pumping", "and", "regional", "flow", "effects", "and", "under", "steady-state", "conditions", ".", "The", "analytical", "model", "is", "tested", "against", "observations", "from", "Canada", ",", "the", "United", "States", ",", "and", "Australia", "to", "assess", "its", "utility", "as", "an", "initial", "approximation", "of", "sea", "water", "extent", "for", "the", "purposes", "of", "rapid", "groundwater", "management", "decision", "making", ".", "The", "occurrence", "of", "sea", "water", "intrusion", "resulting", "in", "increased", "salinity", "at", "pumping", "wells", "was", "correctly", "predicted", "in", "approximately", "60", "%", "of", "cases", ".", "Application", "of", "a", "correction", "to", "account", "for", "dispersion", "did", "not", "markedly", "improve", "the", "results", ".", "Failure", "of", "the", "analytical", "model", "to", "provide", "correct", "predictions", "can", "be", "attributed", "to", "mismatches", "between", "its", "simplifying", "assumptions", "and", "more", "complex", "field", "settings", ".", "The", "best", "results", "occurred", "where", "the", "toe", "of", "the", "salt", "water", "wedge", "is", "expected", "to", "be", "the", "closest", "to", "the", "coast", "under", "predevelopment", "conditions", ".", "Predictions", "were", "the", "poorest", "for", "aquifers", "where", "the", "salt", "water", "wedge", "was", "expected", "to", "extend", "further", "inland", "under", "predevelopment", "conditions", "and", "was", "therefore", "more", "dispersive", "prior", "to", "pumping", ".", "Sharp-interface", "solutions", "remain", "useful", "tools", "to", "screen", "for", "the", "vulnerability", "of", "coastal", "aquifers", "to", "sea", "water", "intrusion", ",", "although", "the", "significant", "sources", "of", "uncertainty", "identified", "in", "this", "study", "require", "careful", "consideration", "to", "avoid", "misinterpreting", "sharp-interface", "results", "." ]

[ "B-Functional Concept", "O", "O", "B-Intellectual Product", "B-Conceptual Entity", "O", "O", "B-Health Care Activity", "B-Intellectual Product", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "O", "B-Finding", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Occupation or Discipline", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Quantitative Concept", "O", "O", "O", "B-Substance", "B-Substance", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Natural Phenomenon or Process", "O", "O", "B-Functional Concept", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Qualitative Concept", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Functional Concept", "O", "B-Idea or Concept", "O", "B-Geographic Area", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Geographic Area", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Substance", "B-Substance", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Occupational Activity", "B-Mental Process", "B-Mental Process", "O", "O", "B-Temporal Concept", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "B-Quantitative Concept", "B-Laboratory or Test Result", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Finding", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "B-Spatial Concept", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "B-Intellectual Product", "O", "B-Health Care Activity", "O", "O", "B-Finding", "O", "B-Spatial Concept", "B-Natural Phenomenon or Process", "O", "B-Substance", "B-Substance", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O" ]

[ "Patient", "-", "Physician", "Discordance", "in", "Global", "Assessment", "in", "Rheumatoid", "Arthritis", ":", "A", "Systematic", "Literature", "Review", "With", "Meta-Analysis", "The", "integration", "of", "the", "patient", "in", "therapeutic", "decision-making", "is", "important", "in", "the", "management", "of", "rheumatoid", "arthritis", "(", "RA", ")", ",", "but", "the", "patient", "opinion", "regarding", "disease", "status", "may", "differ", "from", "the", "physician", "'s", "opinion", ".", "The", "aim", "of", "this", "study", "was", "to", "assess", "in", "the", "published", "literature", "the", "frequency", "and", "drivers", "of", "patient", "-", "physician", "discordance", "in", "global", "assessment", "in", "RA", ".", "A", "systematic", "literature", "review", "of", "all", "articles", "published", "up", "to", "January", "2015", "in", "Medline", "or", "Embase", ",", "reporting", "discordance", "in", "RA", ",", "was", "conducted", "by", "2", "investigators", ".", "Discordance", "was", "defined", "based", "on", "the", "absolute", "difference", "of", "patient", "global", "(", "PGA", ")", "and", "physician", "global", "assessments", "(", "PhGA", ")", "on", "0-10-cm", "scales", ".", "The", "frequency", "of", "discordance", "and", "its", "predictors", "were", "collected", "in", "each", "study", ".", "Frequencies", "of", "discordance", "were", "pooled", "by", "meta-analysis", "using", "random", "effect", ".", "In", "all", ",", "12", "studies", "were", "selected", "(", "i.e.", ",", "11,879", "patients", ")", ":", "weighted", "mean", "±", "SD", "age", "was", "55.1", "±", "13.9", "years", ",", "weighted", "mean", "±", "SD", "disease", "duration", "was", "10.4", "±", "9.3", "years", ",", "and", "80.7", "%", "were", "women", ".", "The", "value", "of", "the", "difference", "|", "PGA", "-", "PhGA", "|", "defining", "discordance", "varied", "between", "≥0.5", "cm", "(", "n", "=", "2", "studies", ")", "to", "≥3", "cm", "(", "n", "=", "5", "studies", ")", ";", "the", "weighted", "mean", "value", "was", "2.7", "cm", ".", "The", "pooled", "percentage", "of", "patients", "with", "discordance", "was", "43", "%", "(", "95", "%", "confidence", "interval", "36", "%", "-51", "%", ";", "range", "25", "%", "-76", "%", ")", ".", "PGA", "was", "usually", "higher", "than", "PhGA", ".", "The", "drivers", "of", "PGA", "were", "pain", "and", "functional", "incapacity", ",", "whereas", "drivers", "of", "PhGA", "were", "joint", "counts", "and", "acute-phase", "reactants", ".", "Discordance", "in", "global", "assessment", "was", "most", "frequently", "defined", "as", "a", "difference", "of", "3", "points", "or", "more", ";", "even", "with", "such", "a", "stringent", "definition", ",", "up", "to", "half", "the", "patients", "were", "found", "to", "be", "discordant", ".", "The", "long-term", "consequences", "of", "this", "discordance", "remain", "to", "be", "determined", "." ]

[ "B-Patient or Disabled Group", "O", "B-Professional or Occupational Group", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Research Activity", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "B-Mental Process", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Patient or Disabled Group", "B-Mental Process", "O", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Mental Process", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Activity", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Temporal Concept", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Professional or Occupational Group", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Occupational Activity", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Research Activity", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Intellectual Product", "O", "B-Research Activity", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "O", "B-Research Activity", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Sign or Symptom", "O", "B-Functional Concept", "B-Clinical Attribute", "O", "O", "O", "O", "B-Research Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O" ]

[ "Nosocomial", "pneumonia", "caused", "by", "methicillin-resistant", "Staphylococcus", "aureus", "treated", "with", "linezolid", "or", "vancomycin", ":", "A", "secondary", "economic", "analysis", "of", "resource", "use", "from", "a", "Spanish", "perspective", "Adopting", "a", "unique", "Spanish", "perspective", ",", "this", "study", "aims", "to", "assess", "healthcare", "resource", "utilization", "(", "HCRU", ")", "and", "the", "costs", "of", "treating", "nosocomial", "pneumonia", "(", "NP", ")", "produced", "by", "methicillin-resistant", "Staphylococcus", "aureus", "(", "MRSA", ")", "in", "hospitalized", "adults", "using", "linezolid", "or", "vancomycin", ".", "An", "evaluation", "is", "also", "made", "of", "the", "renal", "failure", "rate", "and", "related", "economic", "outcomes", "between", "study", "groups", ".", "An", "economic", "post", "hoc", "evaluation", "of", "a", "randomized", ",", "double-blind", ",", "multicenter", "phase", "4", "study", "was", "carried", "out", ".", "Nosocomial", "pneumonia", "due", "to", "MRSA", "in", "hospitalized", "adults", ".", "The", "modified", "intent", "to", "treat", "(", "mITT", ")", "population", "comprised", "224", "linezolid", "-", "and", "224", "vancomycin", "-", "treated", "patients", ".", "Costs", "and", "HCRU", "were", "evaluated", "between", "patients", "administered", "either", "linezolid", "or", "vancomycin", ",", "and", "between", "patients", "who", "developed", "renal", "failure", "and", "those", "who", "did", "not", ".", "Analysis", "of", "HCRU", "outcomes", "and", "costs", ".", "Total", "costs", "were", "similar", "between", "the", "linezolid", "-", "(", "€17,782±€9,615", ")", "and", "vancomycin", "-", "treated", "patients", "(", "€17,423±€9,460", ")", "(", "P=.69", ")", ".", "The", "renal", "failure", "rate", "was", "significantly", "lower", "in", "the", "linezolid", "-", "treated", "patients", "(", "4", "%", "vs.", "15", "%", ";", "P", "<", ".001", ")", ".", "The", "total", "costs", "tended", "to", "be", "higher", "in", "patients", "who", "developed", "renal", "failure", "(", "€19,626±€10,840", "vs.", "€17,388±€9,369", ";", "P=.14", ")", ".", "Among", "the", "patients", "who", "developed", "renal", "failure", ",", "HCRU", "(", "days", "on", "mechanical", "ventilation", ":", "13.2±10.7", "vs.", "7.6±3.6", "days", ";", "P=.21", ";", "ICU", "stay", ":", "14.4±10.5", "vs.", "9.9±6.6", "days", ";", "P=.30", ";", "hospital", "stay", ":", "19.5±9.5", "vs.", "16.1±11.0", "days", ";", "P=.26", ")", "and", "cost", "(", "€17,219±€8,792", "vs.", "€20,263±€11,350", ";", "P=.51", ")", "tended", "to", "be", "lower", "in", "the", "linezolid", "-", "vs.", "vancomycin", "-", "treated", "patients", ".", "There", "were", "no", "statistically", "significant", "differences", "in", "costs", "per", "patient", "-", "day", "between", "cohorts", "after", "correcting", "for", "mortality", "(", "€1000", "vs.", "€1,010", ";", "P=.98", ")", ".", "From", "a", "Spanish", "perspective", ",", "there", "were", "no", "statistically", "significant", "differences", "in", "total", "costs", "between", "the", "linezolid", "and", "vancomycin", "pneumonia", "cohorts", ".", "The", "drug", "cost", "corresponding", "to", "linezolid", "was", "partially", "offset", "by", "fewer", "renal", "failure", "adverse", "events", "." ]

[ "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Geographic Area", "O", "O", "O", "O", "B-Geographic Area", "O", "O", "O", "B-Research Activity", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Idea or Concept", "O", "O", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "B-Bacterium", "O", "O", "B-Finding", "B-Finding", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Research Activity", "O", "B-Research Activity", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Bacterium", "O", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Population Group", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "B-Quantitative Concept", "O", "B-Idea or Concept", "O", "O", "O", "B-Patient or Disabled Group", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Idea or Concept", "O", "B-Temporal Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Antibiotic", "O", "B-Therapeutic or Preventive Procedure", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "B-Temporal Concept", "O", "B-Population Group", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Pharmacologic Substance", "O", "B-Antibiotic", "B-Disease or Syndrome", "B-Population Group", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Quantitative Concept", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Pathologic Function", "B-Pathologic Function", "O" ]

[ "The", "Role", "of", "TRAF4", "and", "B3GAT1", "Gene", "Expression", "in", "the", "Food", "Hypersensitivity", "and", "Insect", "Venom", "Allergy", "in", "Mastocytosis", "Mastocytosis", "is", "an", "uncommon", "disease", "classified", "as", "a", "myeloproliferative", "neoplasm", ",", "however", ",", "its", "symptoms", "are", "broad", "and", "place", "patients", "at", "crossroads", "between", "dermatology", ",", "hematology", "and", "allergology", ".", "Patients", "with", "mastocytosis", "often", "suffer", "from", "symptoms", "resulting", "from", "the", "activation", "and", "release", "of", "mediators", "from", "the", "mast", "cells", ",", "such", "as", "generalized", "itching", ",", "redness", ",", "headache", ",", "abdominal", "cramps", ",", "diarrhea", ",", "bone", "pain", "or", "arthritis", ",", "hypotension", "and", "shock", ".", "The", "possible", "severe", ",", "fatal", "or", "near", "fatal", "reactions", "caused", "by", "food", "hypersensitivity", "are", "reasons", "for", "the", "research", "focused", "on", "marker", "identification", ".", "The", "aim", "of", "the", "study", "was", "to", "analyse", "the", "gene", "expression", "differences", "in", "mastocytosis", "patients", "with", "and", "without", "food", "and", "drug", "hypersensitivity", "and", "insect", "venom", "allergy", "(", "IVA", ")", ".", "A", "total", "of", "57", "Caucasian", "patients", "with", "mastocytosis", "were", "studied", "[", "median", "age", "41.8", ";", "range", "18-77", "years", ";", "15", "(", "26.3", "%", ")", "males", "and", "42", "(", "73.7", "%", ")", "females", "]", ".", "Quantitative", "RT-PCRs", "of", "11", "genes", "plus", "ribosomal", "18S", "RNA", "were", "run", ".", "Symptoms", "of", "food", "hypersensitivity", "were", "found", "in", "12", "patients", "(", "21", "%", ")", ",", "including", "3", "patients", "(", "13", "%", ")", "with", "cutaneous", "mastocytosis", "(", "CM", ")", ",", "and", "9", "(", "28", "%", ")", "with", "indolent", "systemic", "mastocytosis", "(", "ISM", ")", ".", "IVA", "was", "confirmed", "in", "13", "patients", "(", "22.8", "%", ")", "including", "6", "patients", "(", "10.5", "%", ")", "with", "CM", ",", "and", "7", "patients", "(", "12.3", "%", ")", "with", "ISM", ".", "Drug", "hypersensitivity", "was", "diagnosed", "in", "10", "patients", "(", "17.5", "%", ")", ".", "Significant", "differences", "in", "the", "gene", "expression", "were", "found", "for", "TRAF4", "(", "p", "=", "0.008", ")", "in", "the", "comparison", "of", "the", "mastocytosis", "patients", "with", "and", "without", "concomitant", "food", "hypersensitivity", ".", "Furthermore", "significant", "differences", "were", "found", "in", "gene", "expression", "for", "B3GAT1", "(", "p", "=", "0.003", ")", "in", "patients", "with", "IVA", "compared", "to", "patients", "without", "insect", "sting", "anaphylaxis", "in", "the", "medical", "history", ".", "The", "expression", "of", "studied", "genes", "did", "not", "differ", "according", "to", "the", "presence", "of", "drug", "hypersensitivity", ".", "The", "TRAF4", "expression", "was", "higher", "in", "mastocytosis", "patients", "with", "food", "hypersensitivity", "in", "their", "medical", "history", ",", "the", "B3GAT1", "expression", "was", "lower", "in", "mastocytosis", "patients", "with", "IVA", "in", "history", "." ]

[ "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Finding", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "B-Gene or Genome", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "B-Sign or Symptom", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "B-Pathologic Function", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Finding", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "O", "O", "B-Patient or Disabled Group", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Pathologic Function", "O", "O", "O" ]

[ "Generalized", "Weakness", "in", "a", "Transplant", "Patient", ":", "A", "Case", "Presentation", "Generalized", "weakness", "in", "transplant", "patients", "is", "a", "major", "complaint", "in", "tertiary", "rehabilitation", "hospitals", ".", "The", "diagnosis", "and", "management", "of", "generalized", "weakness", "in", "this", "population", "pose", "challenges", "for", "physicians", ".", "We", "present", "the", "case", "of", "a", "transplant", "patient", "with", "generalized", "weakness", "who", "was", "eventually", "diagnosed", "with", "calciphylaxis", "using", "a", "multidisciplinary", "diagnostic", "approach", "of", "electrodiagnostics", ",", "vascular", "study", ",", "and", "skin", "biopsy", ".", "Calciphylaxis", "is", "a", "rare", "cutaneous", "disorder", "that", "mimics", "other", "collagen", "vascular", "diseases", "in", "its", "presentation", "and", "fulminant", "course", ".", "Physiatrists", "should", "be", "cognizant", "of", "calciphylaxis", ",", "as", "it", "signals", "a", "poor", "prognosis", "if", "not", "correctly", "diagnosed", "and", "treated", "in", "a", "timely", "manner", ",", "with", "high", "incidence", "of", "sepsis", ",", "wound", "pain", ",", "and", "disability", ".", "V", "." ]

[ "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Finding", "B-Patient or Disabled Group", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Finding", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Population Group", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Patient or Disabled Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "O", "B-Finding", "O", "B-Disease or Syndrome", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Diagnostic Procedure", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Finding", "O", "O", "O" ]

[ "Use", "of", "ecoacoustics", "to", "determine", "biodiversity", "patterns", "across", "ecological", "gradients", "The", "variety", "of", "local", "animal", "sounds", "characterizes", "a", "landscape", ".", "We", "used", "ecoacoustics", "to", "noninvasively", "assess", "the", "species", "richness", "of", "various", "biotopes", "typical", "of", "an", "ecofriendly", "forest", "plantation", "with", "diverse", "ecological", "gradients", "and", "both", "nonnative", "and", "indigenous", "vegetation", ".", "The", "reference", "area", "was", "an", "adjacent", "large", "World", "Heritage", "Site", "protected", "area", "(", "PA", ")", ".", "All", "sites", "were", "in", "a", "global", "biodiversity", "hotspot", ".", "Our", "results", "showed", "how", "taxa", "segregated", "into", "various", "biotopes", ".", "We", "identified", "65", "singing", "species", ",", "including", "birds", ",", "frogs", ",", "crickets", ",", "and", "katydids", ".", "Large", ",", "natural", ",", "protected", "grassland", "sites", "in", "the", "PA", "had", "the", "highest", "mean", "acoustic", "diversity", "(", "14.1", "species", "/", "site", ")", ".", "Areas", "covered", "in", "nonnative", "timber", "or", "grass", "species", "were", "devoid", "of", "acoustic", "species", ".", "Sites", "grazed", "by", "native", "and", "domestic", "megaherbivores", "were", "fairly", "rich", "(", "5.1", ")", "in", "acoustic", "species", "but", "none", "were", "unique", "to", "this", "habitat", "type", ",", "where", "acoustic", "diversity", "was", "greater", "than", "in", "intensively", "managed", "grassland", "sites", "(", "0.04", ")", ".", "Natural", "vegetation", "patches", "inside", "the", "plantation", "mosaic", "supported", "high", "mean", "acoustic", "diversity", "(", "indigenous", "forests", "7.6", ",", "grasslands", "8.0", ",", "wetlands", "9.1", ")", ",", "which", "increased", "as", "plant", "heterogeneity", "and", "patch", "size", "increased", ".", "Indigenous", "forest", "patches", "within", "the", "plantation", "mosaic", "contained", "a", "highly", "characteristic", "acoustic", "species", "assemblage", ",", "emphasizing", "their", "complementary", "contribution", "to", "local", "biodiversity", ".", "Overall", ",", "acoustic", "signals", "determined", "spatial", "biodiversity", "patterns", "and", "can", "be", "a", "useful", "tool", "for", "guiding", "conservation", "." ]

[ "O", "O", "B-Occupational Activity", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "O", "B-Spatial Concept", "B-Animal", "B-Natural Phenomenon or Process", "B-Idea or Concept", "O", "B-Spatial Concept", "O", "O", "O", "B-Occupational Activity", "O", "O", "B-Functional Concept", "O", "B-Classification", "O", "O", "B-Quantitative Concept", "B-Geographic Area", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "B-Finding", "O", "B-Group Attribute", "B-Plant", "O", "O", "B-Conceptual Entity", "B-Geographic Area", "O", "O", "B-Spatial Concept", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Functional Concept", "O", "O", "B-Conceptual Entity", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "O", "B-Individual Behavior", "B-Classification", "O", "O", "B-Bird", "O", "B-Amphibian", "O", "B-Eukaryote", "O", "O", "B-Eukaryote", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Geographic Area", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Classification", "O", "B-Spatial Concept", "O", "O", "B-Spatial Concept", "O", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Classification", "O", "O", "O", "B-Classification", "B-Classification", "O", "B-Spatial Concept", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Animal", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Group Attribute", "B-Natural Phenomenon or Process", "O", "O", "B-Spatial Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Plant", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Quantitative Concept", "O", "B-Group Attribute", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "B-Qualitative Concept", "B-Classification", "B-Classification", "B-Idea or Concept", "O", "O", "O", "O", "B-Activity", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O" ]

[ "A", "Randomized", "Controlled", "Noninferiority", "Trial", "of", "Single", "Dose", "of", "Oral", "Dexamethasone", "Versus", "5", "Days", "of", "Oral", "Prednisone", "in", "Acute", "Adult", "Asthma", "Oral", "dexamethasone", "demonstrates", "bioavailability", "similar", "to", "that", "of", "oral", "prednisone", "but", "has", "a", "longer", "half-life", ".", "We", "evaluate", "whether", "a", "single", "dose", "of", "oral", "dexamethasone", "plus", "4", "days", "of", "placebo", "is", "not", "inferior", "to", "5", "days", "of", "oral", "prednisone", "in", "treatment", "of", "adults", "with", "mild", "to", "moderate", "asthma", "exacerbations", "to", "prevent", "relapse", "defined", "as", "an", "unscheduled", "return", "visit", "for", "additional", "treatment", "for", "persistent", "or", "worsening", "asthma", "within", "14", "days", ".", "Adult", "emergency", "department", "patients", "(", "aged", "18", "to", "55", "years", ")", "were", "randomized", "to", "receive", "either", "a", "single", "dose", "of", "12", "mg", "of", "oral", "dexamethasone", "with", "4", "days", "of", "placebo", "or", "a", "5-", "day", "course", "of", "oral", "prednisone", "60", "mg", "a", "day", ".", "Outcomes", "including", "relapse", "were", "assessed", "by", "a", "follow-up", "telephone", "interview", "at", "2", "weeks", ".", "One", "hundred", "seventy-three", "dexamethasone", "and", "203", "prednisone", "subjects", "completed", "the", "study", "regimen", "and", "telephone", "follow-up", ".", "The", "dexamethasone", "group", "by", "a", "small", "margin", "surpassed", "the", "preset", "8", "%", "difference", "between", "groups", "for", "noninferiority", "in", "relapse", "rates", "within", "14", "days", "(", "12.1", "%", "versus", "9.8", "%", ";", "difference", "2.3", "%", ";", "95", "%", "confidence", "interval", "-4.1", "%", "to", "8.6", "%", ")", ".", "Subjects", "in", "the", "2", "groups", "had", "similar", "rates", "of", "hospitalization", "for", "their", "relapse", "visit", "(", "dexamethasone", "3.4", "%", "versus", "prednisone", "2.9", "%", ";", "difference", "0.5", "%", ";", "95", "%", "confidence", "interval", "-4.1", "%", "to", "3.1", "%", ")", ".", "Adverse", "effect", "rates", "were", "generally", "the", "same", "in", "the", "2", "groups", ".", "A", "single", "dose", "of", "oral", "dexamethasone", "did", "not", "demonstrate", "noninferiority", "to", "prednisone", "for", "5", "days", "by", "a", "very", "small", "margin", "for", "treatment", "of", "adults", "with", "mild", "to", "moderate", "asthma", "exacerbations", ".", "Enhanced", "compliance", "and", "convenience", "may", "support", "the", "use", "of", "dexamethasone", "regardless", "." ]

[ "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Age Group", "B-Disease or Syndrome", "B-Clinical Drug", "B-Clinical Drug", "B-Activity", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "B-Functional Concept", "O", "B-Temporal Concept", "O", "B-Biomedical or Dental Material", "O", "O", "B-Spatial Concept", "O", "O", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "B-Functional Concept", "O", "B-Age Group", "O", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Functional Concept", "B-Phenomenon or Process", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "O", "B-Temporal Concept", "O", "B-Age Group", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Patient or Disabled Group", "O", "B-Organism Attribute", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Research Activity", "O", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Temporal Concept", "O", "B-Biomedical or Dental Material", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "B-Functional Concept", "B-Phenomenon or Process", "O", "B-Activity", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Temporal Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Pharmacologic Substance", "O", "O", "B-Hormone", "B-Group", "B-Qualitative Concept", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Phenomenon or Process", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Health Care Activity", "O", "O", "B-Phenomenon or Process", "B-Health Care Activity", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Hormone", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Clinical Drug", "B-Clinical Drug", "O", "O", "B-Activity", "B-Qualitative Concept", "O", "B-Hormone", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Age Group", "O", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Activity", "B-Finding", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O", "O" ]

[ "Relationship", "between", "XspI", "Site", "Polymorphisms", "of", "LDL-R", "Gene", "and", "Serum", "IL-2", "and", "IL-10", "in", "Patients", "with", "Hypercholesterolemia", "Relationship", "has", "been", "identified", "in", "sporadic", "reports", "between", "polymorphisms", "and", "hypercholesterolemia", ".", "However", ",", "the", "relationship", "between", "inflammatory", "cytokines", "and", "polymorphism", "of", "low-density", "lipoprotein", "receptor", "(", "LDL-R", ")", "gene", "in", "hypercholesterolemia", "is", "unclear", ".", "This", "study", "aimed", "to", "explore", "the", "relationship", "and", "significance", "between", "polymorphisms", "of", "LDL-R", "gene", "and", "serum", "Interleukin-2", "(", "IL-2", ")", ",", "IL-10", "in", "patients", "with", "hypercholesterolemia", ".", "PCR-RFLP", "and", "direct", "DNA", "sequencing", "assay", "were", "employed", "to", "determine", "polymorphism", "of", "LDL-R", "gene", "in", "900", "patients", "with", "hypercholesterolemia", "and", "400", "healthy", "cases", ".", "ELISA", "was", "applied", "to", "assay", "serum", "concentration", "of", "IL-2", "and", "IL-10", ".", "Blood", "lipid", "indexes", "were", "tested", "in", "all", "cases", ".", "Compared", "with", "the", "healthy", "controls", ",", "level", "of", "IL-2", "increased", "significantly", ",", "while", "IL-10", "decreased", "significantly", "(", "P", "<", "0.05", ")", ".", "Correlation", "analysis", "showed", "that", "IL-2", "was", "positively", "correlated", "with", "total", "cholesterol", "(", "TC", ")", ",", "LDL-c", ",", "and", "genotype", "(", "r", "=", "0.542", ",", "0.410", ",", "0.598", ",", "P", "<", "0.05", ")", "and", "negatively", "correlated", "with", "HDL-c", "(", "r", "=", "-0.352", ",", "P", "<", "0.05", ")", ".", "Negative", "relationship", "also", "was", "found", "between", "TC", ",", "LDL-c", ",", "genotype", ",", "and", "IL-10", "(", "r", "=", "-0.452", ",", "-0.390", ",", "-0.613", ",", "P", "<", "0.05", ")", ",", "and", "positive", "correlation", "between", "HDL-c", "and", "IL-10", "(", "r", "=", "0.398", ",", "P", "<", "0.05", ")", ".", "Multiple", "linear", "regression", "showed", "that", "genotypes", "and", "TC", "were", "independent", "factors", "affecting", "the", "levels", "of", "IL-2", "and", "IL-10", "(", "P", "<", "0.05", ")", ".", "IL-2", "and", "IL-10", "were", "related", "to", "gene", "polymorphisms", "of", "LDL-R", ",", "which", "might", "be", "involved", "in", "the", "development", "and", "progress", "of", "hypercholesterolemia", "." ]

[ "B-Qualitative Concept", "O", "B-Enzyme", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Genetic Function", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Immunologic Factor", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Disease or Syndrome", "O", "B-Finding", "O", "O", "B-Research Activity", "B-Idea or Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "O", "B-Immunologic Factor", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Finding", "O", "O", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "B-Laboratory Procedure", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Intellectual Product", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "B-Immunologic Factor", "B-Quantitative Concept", "B-Idea or Concept", "O", "O", "B-Immunologic Factor", "B-Quantitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Immunologic Factor", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "O", "O", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "O", "B-Organism Attribute", "O", "O", "B-Immunologic Factor", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Immunologic Factor", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Organism Attribute", "O", "B-Organic Chemical", "O", "B-Idea or Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "I-Immunologic Factor", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Qualitative Concept", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O" ]

[ "HERG1", "potassium", "channel", "expression", "in", "potentially", "malignant", "disorders", "of", "the", "oral", "mucosa", "and", "prognostic", "relevance", "in", "oral", "squamous", "cell", "carcinoma", "HERG1", "potassium", "channel", "plays", "a", "critical", "role", "in", "the", "cell", "proliferation", ".", "HERG1", "protein", "expression", "was", "analyzed", "by", "immunohistochemistry", "(", "IHC", ")", "in", "62", "patients", "with", "oral", "leukoplakias", "and", "100", "patients", "with", "oral", "squamous", "cell", "carcinomas", "(", "OSCC", ")", ".", "HERG1", "mRNA", "levels", "were", "assessed", "by", "real-time", "reverse", "transcriptase-polymerase", "chain", "reaction", "(", "RT-PCR", ")", "in", "22", "patients", "with", "primary", "head", "and", "neck", "squamous", "cell", "carcinoma", "(", "HNSCC", ")", ".", "Statistically", "significant", "associations", "were", "found", "between", "HERG1", "expression", "and", "tobacco", "consumption", ",", "disease", "stage", ",", "tumor", "differentiation", ",", "tumor", "recurrence", ",", "and", "reduced", "survival", ".", "There", "was", "no", "association", "between", "HERG1", "expression", "and", "the", "risk", "of", "progression", "from", "oral", "leukoplakia", "to", "OSCC", ".", "In", "addition", ",", "a", "high", "proportion", "of", "tumors", "(", "80", "%", ")", "showed", "increased", "HERG1", "mRNA", "levels", "compared", "to", "normal", "mucosa", "from", "nononcologic", "patients", ".", "Aberrant", "HERG1", "expression", "increases", "as", "oral", "tumorigenesis", "progresses", "from", "oral", "hyperplasia", "to", "OSCC", ".", "Increased", "HERG1", "mRNA", "levels", "were", "also", "frequently", "detected", "in", "OSCC", "and", "other", "HNSCC", "subsites", ".", "HERG1", "expression", "emerges", "as", "a", "clinically", "relevant", "feature", "during", "tumor", "progression", "and", "a", "potential", "poor", "prognostic", "biomarker", "for", "OSCC", ".", "©", "2016", "Wiley", "Periodicals", ",", "Inc.", "Head", "Neck", "38", ":", "1708-1716", ",", "2016", "." ]

[ "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Intellectual Product", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "B-Conceptual Entity", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Research Activity", "O", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Activity", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Neoplastic Process", "B-Cell Function", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "B-Activity", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "O", "B-Idea or Concept", "O", "B-Neoplastic Process", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "B-Activity", "O", "B-Tissue", "B-Tissue", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Genetic Function", "B-Functional Concept", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Neoplastic Process", "O", "B-Quantitative Concept", "B-Gene or Genome", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "O", "O", "B-Finding", "O", "B-Neoplastic Process", "O", "O", "B-Neoplastic Process", "B-Spatial Concept", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Intellectual Product", "B-Clinical Attribute", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Malignancy", "is", "associated", "with", "microcalcification", "and", "higher", "AP/T", "ratio", "in", "ultrasonography", ",", "but", "not", "with", "Hashimoto", "'s", "thyroiditis", "in", "histopathology", "in", "patients", "with", "thyroid", "nodules", "evaluated", "as", "Bethesda", "Category", "III", "(", "AUS", "/", "FLUS", ")", "in", "cytology", "The", "predictors", "of", "malignancy", "are", "important", "for", "the", "decision", "of", "appropriate", "management", "in", "nodules", "with", "atypia", "of", "undetermined", "significance", "/", "follicular", "lesion", "of", "undetermined", "significance", "(", "AUS", "/", "FLUS", ")", ".", "Our", "aim", "was", "to", "determine", "the", "ultrasonographical", ",", "clinical", ",", "and", "biochemical", "predictors", "of", "malignancy", "in", "these", "patients", ".", "A", "total", "of", "427", "patients", "with", "cytologically", "Bethesda", "Category", "III", "(", "AUS", "/", "FLUS", ")", "thyroid", "nodules", "were", "included", "in", "this", "retrospective", "study", ".", "We", "divided", "the", "nodules", "into", "two", "subgroups", "according", "to", "the", "histopathology", "as", "benign", "and", "malignant", ",", "and", "compared", "the", "preoperative", "ultrasonographical", ",", "clinical", ",", "and", "biochemical", "findings", ".", "In", "overall", ",", "427", "patients", "with", "449", "AUS", "/", "FLUS", "nodules", "who", "had", "undergone", "surgery", ",", "the", "rate", "of", "malignancy", "was", "23.4", "%", "(", "105/449", ")", ".", "When", "evaluated", "separately", ",", "the", "rate", "of", "malignancy", "was", "25.8", "%", "in", "nodules", "with", "AUS", "(", "82/318", ")", "and", "17.6", "%", "in", "nodules", "with", "FLUS", "(", "23/131", ")", "(", "p", "=", "0.061", ")", ".", "The", "vast", "majority", "of", "malignant", "specimens", "in", "histopathology", "consisted", "of", "papillary", "thyroid", "carcinoma", "(", "PTC", ")", "(", "n", "=", "91", ",", "86.7", "%", ")", ".", "Preoperative", "ultrasonographic", "features", "of", "105", "malignant", "nodules", "in", "histopathology", "were", "compared", "with", "the", "344", "benign", "nodules", "in", "histopathology", ".", "Anteroposterior/Transverse", "(", "AP/T", ")", "ratio", "was", "significantly", "higher", "in", "malignant", "group", "compared", "to", "benign", "group", "(", "p", "=", "0.013", ")", ".", "In", "multiple", "logistic", "analysis", ",", "we", "found", "that", "higher", "AP/T", "ratio", "and", "microcalcification", "were", "independently", "associated", "with", "malignancy", "(", "p", "<", "0.05", ")", ".", "The", "malignancy", "-associated", "cut-off", "value", "of", "AP/T", "ratio", "at", "maximum", "sensitivity", "and", "specificity", "was", "≥0.81", ".", "We", "did", "not", "find", "any", "correlation", "between", "malignancy", "and", "Hashimoto", "'s", "thyroiditis", "in", "histopathology", "in", "multivariate", "analysis", "(", "p", ">", "0.05", ")", ".", "In", "Bethesda", "Category", "III", "nodules", "with", "higher", "AP/T", "ratio", "and", "microcalcification", ",", "surgery", "might", "be", "considered", "as", "a", "first", "therapeutic", "option", "instead", "of", "repeat", "fine-needle", "aspiration", "biopsy", "or", "observation", "." ]

[ "B-Neoplastic Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Pathologic Function", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "O", "B-Laboratory Procedure", "O", "B-Intellectual Product", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Neoplastic Process", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "B-Population Group", "O", "O", "O", "B-Laboratory Procedure", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Temporal Concept", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Cell or Molecular Dysfunction", "O", "B-Finding", "B-Neoplastic Process", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "B-Laboratory Procedure", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Pathologic Function", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Neoplastic Process", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Pathologic Function", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Research Activity", "O" ]

[ "Low", "serum", "vitamin", "D", "is", "associated", "with", "higher", "cortical", "porosity", "in", "elderly", "men", "Bone", "loss", "at", "peripheral", "sites", "in", "the", "elderly", "is", "mainly", "cortical", "and", "involves", "increased", "cortical", "porosity", ".", "However", ",", "an", "association", "between", "bone", "loss", "at", "these", "sites", "and", "25-hydroxyvitamin", "D", "has", "not", "been", "reported", ".", "To", "investigate", "the", "association", "between", "serum", "levels", "of", "25-hydroxyvitamin", "D", ",", "bone", "microstructure", "and", "areal", "bone", "mineral", "density", "(", "BMD", ")", "in", "elderly", "men", ".", "A", "population", "-based", "cohort", "of", "444", "elderly", "men", "(", "mean", "±", "SD", "age", "80.2", "±", "3.5", "years", ")", "was", "investigated", ".", "Bone", "microstructure", "was", "measured", "by", "high-resolution", "peripheral", "quantitative", "computed", "tomography", ",", "areal", "BMD", "by", "dual-energy", "X-ray", "absorptiometry", "and", "serum", "25-hydroxyvitamin", "D", "and", "parathyroid", "hormone", "levels", "by", "immunoassay", ".", "Mean", "cortical", "porosity", "at", "the", "distal", "tibia", "was", "14.7", "%", "higher", "(", "12.5", "±", "4.3", "%", "vs.", "10.9", "±", "4.1", "%", ",", "P", "<", "0.05", ")", "whilst", "cortical", "volumetric", "BMD", ",", "area", ",", "trabecular", "bone", "volume", "fraction", "and", "femoral", "neck", "areal", "BMD", "were", "lower", "in", "men", "in", "the", "lowest", "quartile", "of", "vitamin", "D", "levels", "compared", "to", "the", "highest", ".", "In", "men", "with", "vitamin", "D", "deficiency", "(", "<", "25", "nmol", "L", "(", "-1", ")", ")", "or", "insufficiency", "[", "25-49", "nmol", "L", "(", "-1", ")", ",", "in", "combination", "with", "an", "elevated", "serum", "level", "of", "parathyroid", "hormone", "(", ">", "6.8", "pmol", "L", "(", "-1", ")", ")", "]", ",", "cortical", "porosity", "was", "17.2", "%", "higher", "than", "in", "vitamin", "D", "-", "sufficient", "men", "(", "P", "<", "0.01", ")", ".", "A", "linear", "regression", "model", "including", "age", ",", "weight", ",", "height", ",", "daily", "calcium", "intake", ",", "physical", "activity", ",", "smoking", "vitamin", "D", "supplementation", "and", "parathyroid", "hormone", "showed", "that", "25-hydroxyvitamin", "D", "independently", "predicted", "cortical", "porosity", "(", "standardized", "β", "=", "-0.110", ",", "R", "(", "2", ")", "=", "1.1", "%", ",", "P", "=", "0.024", ")", ",", "area", "(", "β", "=", "0.123", ",", "R", "(", "2", ")", "=", "1.4", "%", ",", "P", "=", "0.007", ")", "and", "cortical", "volumetric", "BMD", "(", "β", "=", "0.125", ",", "R", "(", "2", ")", "=", "1.4", "%", ",", "P", "=", "0.007", ")", "of", "the", "tibia", "as", "well", "as", "areal", "BMD", "of", "the", "femoral", "neck", "(", "β", "=", "0.102", ",", "R", "(", "2", ")", "=", "0.9", "%", ",", "P", "=", "0.04", ")", ".", "Serum", "vitamin", "D", "is", "associated", "with", "cortical", "porosity", ",", "area", "and", "density", ",", "indicating", "that", "bone", "fragility", "as", "a", "result", "of", "low", "vitamin", "D", "could", "be", "due", "to", "changes", "in", "cortical", "bone", "microstructure", "and", "geometry", "." ]

[ "B-Qualitative Concept", "B-Body Substance", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "B-Population Group", "B-Population Group", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Spatial Concept", "B-Body Location or Region", "O", "O", "B-Population Group", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Quantitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Body Location or Region", "O", "B-Vitamin", "B-Vitamin", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Population Group", "O", "B-Population Group", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Qualitative Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Body Substance", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Intellectual Product", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Individual Behavior", "B-Vitamin", "B-Vitamin", "B-Pharmacologic Substance", "O", "B-Hormone", "B-Hormone", "O", "O", "B-Vitamin", "B-Vitamin", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Substance", "B-Vitamin", "B-Vitamin", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "B-Clinical Attribute", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "B-Qualitative Concept", "B-Vitamin", "B-Vitamin", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Spatial Concept", "O" ]

[ "Nationwide", "reduction", "in", "the", "number", "of", "corneal", "transplantations", "for", "keratoconus", "following", "the", "implementation", "of", "cross-linking", "Keratoconus", "is", "characterized", "by", "corneal", "ectasia", "and", "irregular", "astigmatism", ",", "which", "can", "lead", "to", "diminished", "vision", "and", "corneal", "scarring", ".", "Approximately", "10-20", "%", "of", "patients", "with", "keratoconus", "eventually", "require", "a", "corneal", "transplant", ".", "Corneal", "cross-linking", "(", "CXL", ")", "is", "a", "relatively", "new", "treatment", "that", "may", "help", "prevent", "the", "need", "for", "corneal", "transplantation", ".", "Here", ",", "we", "investigated", "whether", "the", "introduction", "of", "CXL", "has", "reduced", "the", "number", "of", "corneal", "transplants", "performed", "annually", ".", "Data", "regarding", "the", "transplantation", "procedures", "performed", "in", "patients", "under", "the", "age", "of", "50", "years", "were", "extracted", "from", "the", "Dutch", "National", "Organ", "Transplant", "Registry", ".", "The", "number", "of", "corneal", "transplants", "performed", "prior", "to", "(", "i.e", ".", "in", "2005", "through", "2007", ")", "and", "following", "the", "introduction", "of", "CXL", "(", "i.e", ".", "in", "2012", "through", "2014", ")", "were", "compared", ".", "Furthermore", ",", "a", "trend", "analysis", "on", "annual", "keratoplasties", "over", "time", "was", "performed", ".", "Approximately", "25", "%", "fewer", "corneal", "transplants", "were", "performed", "in", "the", "3-", "year", "period", "following", "the", "introduction", "of", "CXL", "compared", "to", "the", "3-", "year", "period", "prior", "to", "the", "introduction", "of", "CXL", "(", "201", "versus", "269", "transplants", ",", "respectively", ";", "p", "=", "0.005", ")", ".", "Age", ",", "gender", "and", "visual", "acuity", "were", "similar", "between", "the", "patient", "groups", "in", "the", "two", "time", "periods", ".", "Trend", "analysis", "also", "demonstrated", "a", "significant", "decrease", "in", "the", "amount", "of", "corneal", "transplants", "(", "p", "=", "0.001", ")", ".", "Significantly", "fewer", "corneal", "transplants", "were", "performed", "for", "treating", "keratoconus", "following", "the", "nationwide", "introduction", "of", "CXL", ".", "This", "reduction", "suggests", "that", "corneal", "cross-linking", "can", "significantly", "reduce", "the", "need", "for", "corneal", "transplantation", "." ]

[ "B-Spatial Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "O", "O", "B-Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "B-Temporal Concept", "O", "B-Idea or Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "O", "B-Patient or Disabled Group", "O", "O", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Functional Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Activity", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "B-Spatial Concept", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Quantitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O" ]

[ "Rapid", "Fabrication", "of", "a", "Cell", "-", "Seeded", "Collagen", "Gel", "-Based", "Tubular", "Construct", "that", "Withstands", "Arterial", "Pressure", ":", "Rapid", "Fabrication", "of", "a", "Gel", "-Based", "Media", "Equivalent", "Based", "on", "plastically", "compressed", "cell", "-", "seeded", "collagen", "gels", ",", "we", "fabricated", "a", "small-diameter", "tubular", "construct", "that", "withstands", "arterial", "pressure", "without", "prolonged", "culture", "in", "vitro", ".", "Specifically", ",", "to", "mimic", "the", "microstructure", "of", "vascular", "media", ",", "the", "cell", "-", "seeded", "collagen", "gel", "was", "uniaxially", "stretched", "prior", "to", "plastic", "compression", "to", "align", "collagen", "fibers", "and", "hence", "cells", "in", "the", "gel", ".", "The", "resulting", "gel", "sheet", "was", "then", "wrapped", "around", "a", "custom-made", "multi-layered", "braided", "tube", "to", "form", "aligned", "tubular", "constructs", "whereas", "the", "gel", "sheet", "prepared", "similarly", "but", "without", "uniaxial", "stretching", "formed", "control", "constructs", ".", "With", "the", "braided", "tube", ",", "fluid", "in", "the", "gel", "construct", "was", "further", "removed", "by", "vacuum", "suction", "aiming", "to", "consolidate", "the", "concentric", "layers", "of", "the", "construct", ".", "The", "construct", "was", "finally", "treated", "with", "transglutaminase", ".", "Both", "SEM", "and", "histology", "confirmed", "the", "absence", "of", "gaps", "in", "the", "wall", "of", "the", "construct", ".", "Particularly", ",", "cells", "in", "the", "wall", "of", "the", "aligned", "tubular", "construct", "were", "circumferentially", "aligned", ".", "The", "enzyme", "-mediated", "crosslinking", "increased", "burst", "pressure", "of", "both", "the", "constructs", "significantly", ";", "the", "extent", "of", "the", "increase", "of", "burst", "pressure", "for", "the", "aligned", "tubular", "construct", "was", "greater", "than", "that", "for", "the", "control", "counterpart", ".", "Increasing", "crosslinking", "left", "the", "compliance", "of", "the", "aligned", "tubular", "construct", "unchanged", "but", "reduced", "that", "of", "the", "control", "construct", ".", "Cells", "remained", "viable", "in", "transglutaminase", "-treated", "plastically", "compressed", "gels", "after", "6", "days", "in", "culture", ".", "This", "study", "demonstrated", "that", "by", "combining", "stretch-induced", "fiber", "alignment", ",", "plastic", "compression", ",", "and", "enzyme", "-mediated", "crosslinking", ",", "a", "cell", "-", "seeded", "collagen", "gel", "-based", "tubular", "construct", "with", "potential", "to", "be", "used", "as", "vascular", "media", "can", "be", "made", "within", "3", "days", "." ]

[ "O", "B-Activity", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Activity", "O", "O", "B-Biomedical or Dental Material", "O", "B-Substance", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "O", "B-Activity", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "B-Laboratory Procedure", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "B-Substance", "B-Natural Phenomenon or Process", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Cell", "O", "O", "B-Biomedical or Dental Material", "O", "O", "O", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "B-Substance", "O", "O", "B-Biomedical or Dental Material", "B-Medical Device", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "B-Medical Device", "O", "O", "O", "O", "B-Enzyme", "O", "O", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "B-Cell", "O", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Biomedical or Dental Material", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Tissue", "B-Quantitative Concept", "O", "B-Substance", "B-Natural Phenomenon or Process", "O", "O", "B-Enzyme", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Cell", "O", "B-Laboratory Procedure", "B-Amino Acid, Peptide, or Protein", "B-Biomedical or Dental Material", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "O", "O", "B-Temporal Concept", "O" ]

[ "Impact", "of", "cofactor", "-", "binding", "loop", "mutations", "on", "thermotolerance", "and", "activity", "of", "E.", "coli", "transketolase", "Improvement", "of", "thermostability", "in", "engineered", "enzymes", "can", "allow", "biocatalysis", "on", "substrates", "with", "poor", "aqueous", "solubility", ".", "Denaturation", "of", "the", "cofactor", "-", "binding", "loops", "of", "Escherichia", "coli", "transketolase", "(", "TK", ")", "was", "previously", "linked", "to", "the", "loss", "of", "enzyme", "activity", "under", "conditions", "of", "high", "pH", "or", "urea", ".", "Incubation", "at", "temperatures", "just", "below", "the", "thermal", "melting", "transition", ",", "above", "which", "the", "protein", "aggregates", ",", "was", "also", "found", "to", "anneal", "the", "enzyme", "to", "give", "an", "increased", "specific", "activity", ".", "The", "potential", "role", "of", "cofactor", "-", "binding", "loop", "instability", "in", "this", "process", "remained", "unclear", ".", "In", "this", "work", ",", "the", "two", "cofactor", "-", "binding", "loops", "(", "residues", "185-192", "and", "382-392", ")", "were", "progressively", "mutated", "towards", "the", "equivalent", "sequence", "from", "the", "thermostable", "Thermus", "thermophilus", "TK", "and", "variants", "assessed", "for", "their", "impact", "on", "both", "thermostability", "and", "activity", ".", "Cofactor-binding", "loop", "2", "variants", "had", "detrimental", "effects", "on", "specific", "activity", "at", "elevated", "temperatures", ",", "whereas", "the", "H192P", "mutation", "in", "cofactor-binding", "loop", "1", "resulted", "in", "a", "two-fold", "improved", "stability", "to", "inactivation", "at", "elevated", "temperatures", ",", "and", "increased", "the", "critical", "onset", "temperature", "for", "aggregation", ".", "The", "specific", "activity", "of", "H192P", "was", "3-fold", "and", "19-fold", "higher", "than", "that", "for", "wild-type", "at", "60°C", "and", "65°C", "respectively", ",", "and", "also", "remained", "2.7-4", "fold", "higher", "after", "re-cooling", "from", "pre-incubations", "at", "either", "55°C", "or", "60°C", "for", "1h", ".", "Interestingly", ",", "H192P", "was", "also", "2-times", "more", "active", "than", "wild-type", "TK", "at", "25°C", ".", "Optimal", "activity", "was", "achieved", "at", "60°C", "for", "H192P", "compared", "to", "55°C", "for", "wild", "type", ".", "These", "results", "show", "that", "cofactor-binding", "loop", "1", ",", "plays", "a", "pivotal", "role", "in", "partial", "denaturation", "and", "aggregation", "at", "elevated", "temperatures", ".", "Furthermore", ",", "a", "single", "rigidifying", "mutation", "within", "this", "loop", "can", "significantly", "improve", "the", "enzyme", "specific", "activity", ",", "as", "well", "as", "the", "stability", "to", "thermal", "denaturation", "and", "aggregation", ",", "to", "give", "an", "increased", "temperature", "optimum", "for", "activity", "." ]

[ "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "B-Genetic Function", "O", "B-Physiologic Function", "O", "B-Molecular Function", "O", "B-Bacterium", "B-Bacterium", "B-Enzyme", "B-Conceptual Entity", "O", "B-Natural Phenomenon or Process", "O", "B-Enzyme", "B-Enzyme", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Molecular Function", "O", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Bacterium", "B-Bacterium", "B-Enzyme", "O", "B-Enzyme", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Molecular Function", "B-Molecular Function", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "O", "B-Laboratory Procedure", "O", "B-Quantitative Concept", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Enzyme", "O", "O", "O", "B-Quantitative Concept", "O", "B-Molecular Function", "O", "O", "O", "B-Conceptual Entity", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "B-Amino Acid Sequence", "O", "O", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "O", "O", "B-Qualitative Concept", "B-Bacterium", "B-Bacterium", "B-Enzyme", "O", "B-Gene or Genome", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Activity", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Gene or Genome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Activity", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Natural Phenomenon or Process", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Gene or Genome", "B-Enzyme", "O", "O", "O", "B-Qualitative Concept", "B-Activity", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Quantitative Concept", "B-Molecular Function", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Nucleotide Sequence", "O", "O", "O", "O", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "B-Molecular Function", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Molecular Function", "O" ]

[ "Expression", "and", "Purification", "of", "E2", "Glycoprotein", "from", "Insect", "Cells", "(", "Sf9", ")", "for", "Use", "in", "Serology", "Chikungunya", "virus", "(", "CHIKV", ")", "is", "a", "mosquito", "-", "borne", "arbovirus", "which", "poses", "a", "major", "threat", "to", "global", "public", "health", ".", "Definitive", "CHIKV", "diagnosis", "is", "crucial", ",", "especially", "in", "distinguishing", "the", "disease", "from", "dengue", "virus", ",", "which", "co-circulates", "in", "endemic", "areas", "and", "shares", "the", "same", "mosquito", "vectors", ".", "Laboratory", "diagnosis", "is", "mainly", "based", "on", "serological", "or", "molecular", "approaches", ".", "The", "E2", "glycoprotein", "is", "a", "good", "candidate", "for", "serological", "diagnosis", "since", "it", "is", "the", "immunodominant", "antigen", "during", "the", "course", "of", "infection", ",", "and", "reacts", "with", "seropositive", "CHIKV", "sera", ".", "In", "this", "chapter", ",", "we", "describe", "the", "generation", "of", "stable", "clone", "Sf9", "(", "Spodoptera", "frugiperda", ")", "cells", "expressing", "secreted", ",", "soluble", ",", "and", "native", "recombinant", "CHIKV", "E2", "glycoprotein", ".", "We", "use", "direct", "plasmid", "expression", "in", "insect", "cells", ",", "rather", "than", "the", "traditional", "technique", "of", "generating", "recombinant", "baculovirus", ".", "This", "recombinant", "protein", "is", "useful", "for", "serological", "diagnosis", "of", "CHIKV", "infection", "." ]

[ "B-Genetic Function", "O", "B-Laboratory Procedure", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Eukaryote", "B-Cell", "O", "B-Cell", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Virus", "B-Virus", "O", "B-Virus", "O", "O", "O", "B-Eukaryote", "O", "B-Finding", "B-Virus", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Temporal Concept", "B-Virus", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Virus", "B-Virus", "O", "O", "B-Functional Concept", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Immunologic Factor", "B-Immunologic Factor", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "B-Pathologic Function", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Virus", "B-Body Substance", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Idea or Concept", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Cell", "B-Cell", "O", "B-Eukaryote", "B-Eukaryote", "O", "B-Cell", "B-Genetic Function", "B-Cell Function", "O", "B-Cell Component", "O", "O", "B-Functional Concept", "B-Organism", "B-Virus", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Therapeutic or Preventive Procedure", "O", "B-Eukaryote", "B-Cell", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Activity", "B-Virus", "B-Virus", "O", "O", "B-Amino Acid, Peptide, or Protein", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Virus", "B-Pathologic Function", "O" ]

[ "Acute", "risk", "factors", "for", "suicide", "attempts", "and", "death", ":", "prospective", "findings", "from", "the", "STEP", "-", "BD", "study", "Suicide", "is", "unfortunately", "common", "in", "psychiatric", "practice", ",", "but", "difficult", "to", "predict", ".", "The", "present", "study", "sought", "to", "assess", "which", "clinical", "symptoms", "increase", "in", "the", "months", "before", "suicidal", "behavior", "in", "a", "sample", "of", "psychiatric", "outpatients", "with", "bipolar", "disorder", ".", "Data", "from", "the", "Systematic", "Treatment", "Enhancement", "Program", "for", "Bipolar", "Disorder", "(", "STEP", "-", "BD", ")", "trial", "were", "used", ".", "A", "total", "of", "103", "participants", "who", "attempted", "suicide", "or", "died", "by", "suicide", "during", "the", "trial", "were", "included", ";", "a", "15", "%", "random", "sample", "of", "the", "remaining", "participants", "(", "n", "=", "427", ")", "was", "used", "as", "a", "comparison", "sample", ".", "Linear", "mixed", "models", "in", "the", "six", "months", "before", "suicidal", "behavior", "were", "conducted", "for", "each", "of", "five", "proposed", "acute", "risk", "factors", "for", "suicidal", "behavior", ".", "Participants", "were", "assessed", "using", "the", "Clinical", "Monitoring", "Form", "(", "CMF", ")", "at", "each", "visit", "for", "the", "following", "potential", "acute", "risk", "factors", "for", "suicidal", "behavior", ":", "suicidal", "ideation", ",", "loss", "of", "interest", ",", "anxiety", ",", "psychomotor", "agitation", ",", "and", "high-risk", "behavior", ".", "Each", "of", "the", "five", "symptoms", "was", "elevated", "overall", "in", "individuals", "who", "engaged", "in", "suicidal", "behavior", "(", "p", "<", "0.05", ")", ".", "The", "severity", "of", "both", "suicidal", "ideation", "and", "loss", "of", "interest", "significantly", "increased", "in", "the", "months", "before", "suicidal", "behavior", "(", "p", "<", "0.001", ")", ".", "Anxiety", "demonstrated", "comparable", "effect", "sizes", "across", "multiple", "models", ".", "Psychomotor", "agitation", "and", "high-risk", "behavior", "were", "not", "significantly", "elevated", "before", "suicidal", "behavior", ".", "Suicidal", "ideation", ",", "loss", "of", "interest", "and", ",", "to", "a", "lesser", "extent", ",", "anxiety", "may", "represent", "acute", "suicide", "risk", "factors", "up", "to", "four", "months", "before", "suicidal", "behavior", "in", "outpatients", "with", "bipolar", "disorder", ".", "Further", "investigation", "of", "these", "potential", "acute", "risk", "factors", "in", "prospective", "analyses", "is", "warranted", "." ]

[ "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "B-Research Activity", "B-Finding", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Mental Process", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Research Activity", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Sign or Symptom", "B-Functional Concept", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "B-Substance", "O", "B-Biomedical Occupation or Discipline", "B-Patient or Disabled Group", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Idea or Concept", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Health Care Activity", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Substance", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "B-Substance", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Population Group", "O", "B-Activity", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "B-Finding", "O", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "O", "O", "B-Sign or Symptom", "O", "B-Qualitative Concept", "O", "O", "B-Population Group", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Finding", "B-Finding", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "B-Finding", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Temporal Concept", "O", "B-Finding", "B-Finding", "O", "B-Patient or Disabled Group", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O" ]

[ "Measurement", "of", "Outcomes", "of", "Upper", "Limb", "Reconstructive", "Surgery", "for", "Tetraplegia", "Reconstructive", "arm/hand", "surgery", "for", "tetraplegia", "is", "performed", "to", "improve", "arm/hand", "function", "and", "therefore", "personal", "well-being", "for", "individuals", "who", "accept", "such", "elective", "surgeries", ".", "However", ",", "changes", "at", "an", "impairment", "level", "do", "not", "always", "translate", "into", "functional", "or", "quality", "of", "life", "changes", ".", "Therefore", ",", "multiple", "outcome", "tools", "should", "be", "used", "that", "incorporate", "sufficient", "responsiveness", "to", "detect", "changes", "in", "arm/hand", "function", ",", "activity", "and", "participation", ",", "and", "quality", "of", "life", "of", "the", "individuals", "involved", ".", "This", "narrative", "review", "aims", "to", "assist", "clinicians", "to", "choose", "the", "most", "appropriate", "tools", "to", "assess", "the", "need", "for", "reconstructive", "surgery", "and", "to", "evaluate", "its", "outcomes", ".", "Our", "specific", "objectives", "are", "(", "1", ")", "to", "describe", "aspects", "to", "consider", "when", "choosing", "a", "measure", "and", "(", "2", ")", "to", "describe", "the", "measures", "advised", "by", "an", "international", "therapist", "consensus", "group", "established", "in", "2007", ".", "All", "advised", "measures", "are", "appraised", "in", "terms", "of", "the", "underlying", "construct", ",", "administration", ",", "and", "clinical", "relevance", "to", "arm/hand", "reconstructions", ".", "Essentially", "there", "are", "currently", "no", "criterion", "standard", "measures", "to", "evaluate", "the", "consequences", "of", "reconstructive", "arm/hand", "surgery", ".", "However", ",", "with", "judicious", "use", "of", "available", "measures", "it", "is", "possible", "to", "ensure", "the", "questions", "asked", "or", "tasks", "completed", "are", "relevant", "to", "the", "surgical", "reconstruction", "(", "s", ")", "undertaken", ".", "Further", "work", "in", "this", "field", "is", "required", ".", "This", "would", "be", "best", "met", "by", "immediate", "collaboration", "between", "2", "outcome", "'s", "tool", "developers", "and", "by", "analysis", "of", "pre", "-", "and", "postoperative", "data", "already", "held", "in", "various", "international", "sites", ",", "which", "would", "allow", "further", "evaluation", "of", "the", "measures", "already", "in", "use", ",", "or", "components", "thereof", "." ]

[ "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "B-Finding", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Functional Concept", "O", "B-Finding", "B-Organism Function", "B-Organism Function", "O", "O", "B-Finding", "B-Finding", "O", "B-Population Group", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "B-Functional Concept", "O", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "B-Functional Concept", "B-Finding", "B-Finding", "O", "B-Finding", "B-Functional Concept", "O", "B-Organism Function", "B-Organism Function", "O", "B-Activity", "O", "B-Functional Concept", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Health Care Activity", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Qualitative Concept", "B-Manufactured Object", "O", "B-Activity", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Idea or Concept", "B-Professional or Occupational Group", "O", "B-Idea or Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Idea or Concept", "B-Quantitative Concept", "B-Functional Concept", "O", "B-Health Care Activity", "O", "B-Functional Concept", "B-Functional Concept", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Occupational Activity", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "B-Conceptual Entity", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Social Behavior", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Occupational Activity", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Manufactured Object", "O", "O" ]

[ "Basal", "and", "maximal", "metabolic", "rates", "differ", "in", "their", "response", "to", "rapid", "temperature", "change", "among", "avian", "species", "In", "birds", ",", "acclimation", "and", "acclimatization", "to", "temperature", "are", "associated", "with", "changes", "in", "basal", "(", "BMR", ")", ",", "summit", "(", "Msum", ")", "and", "maximal", "(", "MMR", ")", "metabolic", "rates", "but", "little", "is", "known", "about", "the", "rate", "at", "which", "species", "adjust", "their", "phenotype", "to", "short-term", "temperature", "variations", ".", "Our", "aims", "were", "(", "1", ")", "to", "determine", "the", "pattern", "of", "metabolic", "adjustments", "following", "a", "rapid", "temperature", "change", ",", "(", "2", ")", "to", "determine", "whether", "performance", "varies", "at", "similar", "rates", "during", "exposure", "to", "warm", "or", "cold", "environments", ",", "and", "(", "3", ")", "to", "determine", "if", "BMR", ",", "Msum", "and", "MMR", "change", "at", "comparable", "rates", "during", "thermal", "acclimation", ".", "We", "measured", "these", "parameters", "in", "white-throated", "sparrows", "(", "Zonotrichia", "albicollis", ")", ",", "black-capped", "chickadees", "(", "Poecile", "atricapillus", ")", ",", "and", "snow", "buntings", "(", "Plectrophenax", "nivalis", ")", "after", "acclimation", "to", "10", "°C", "(", "day", "0", ")", "and", "on", "the", "4th", "and", "8th", "days", "of", "acclimation", "to", "either", "-5", "or", "28", "°C", ".", "Birds", "changed", "their", "metabolic", "phenotype", "within", "8", "days", "with", "patterns", "differing", "among", "species", ".", "Sparrows", "expressed", "the", "expected", "metabolic", "increases", "in", "the", "cold", "and", "decreases", "at", "thermoneutrality", "while", "performance", "in", "chickadees", "and", "buntings", "was", "not", "influenced", "by", "temperature", "but", "changed", "over", "time", "with", "inverse", "patterns", ".", "Our", "results", "suggest", "that", "BMR", "varies", "at", "comparable", "rates", "in", "warm", "and", "cold", "environments", "but", "changes", "faster", "than", "Msum", "and", "MMR", ",", "likely", "due", "to", "limitations", "in", "the", "rate", "of", "change", "in", "organ", "size", "and", "function", ".", "They", "also", "suggest", "that", "maximal", "metabolic", "capacity", "is", "lost", "faster", "in", "a", "warm", "environment", "than", "it", "is", "gained", "in", "a", "cold", "environment", ".", "With", "the", "expected", "increase", "in", "temperature", "stochasticity", "at", "northern", "latitudes", ",", "a", "loss", "of", "thermogenic", "capacity", "during", "warm", "winter", "days", "could", ",", "therefore", ",", "be", "detrimental", "if", "birds", "are", "slow", "to", "readjust", "their", "phenotype", "with", "the", "return", "of", "cold", "days", "." ]

[ "B-Organism Function", "O", "B-Qualitative Concept", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Bird", "B-Classification", "O", "B-Bird", "O", "B-Organism Function", "O", "B-Organism Function", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Organism Function", "O", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "B-Qualitative Concept", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "O", "O", "O", "O", "B-Physiologic Function", "O", "O", "B-Classification", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Physiologic Function", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "O", "B-Physiologic Function", "O", "B-Natural Phenomenon or Process", "B-Organism Function", "O", "O", "O", "O", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "O", "O", "B-Organism Function", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "B-Bird", "O", "O", "B-Functional Concept", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O", "B-Spatial Concept", "O", "O", "B-Classification", "O", "B-Bird", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Bird", "O", "B-Bird", "O", "O", "B-Conceptual Entity", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "B-Finding", "O", "O", "B-Organism Function", "O", "O", "O", "B-Physiologic Function", "O", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Physiologic Function", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "B-Quantitative Concept", "O", "B-Natural Phenomenon or Process", "B-Quantitative Concept", "O", "B-Phenomenon or Process", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "B-Bird", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Temporal Concept", "O" ]

[ "Factors", "preventing", "kneeling", "in", "a", "group", "of", "pre-educated", "patients", "post", "total", "knee", "arthroplasty", "Difficulties", "in", "kneeling", ",", "one", "of", "the", "poorest", "scoring", "functional", "outcomes", "post", "total", "knee", "arthroplasty", "(", "TKA", ")", ",", "have", "been", "attributed", "to", "a", "lack", "of", "patient", "education", ".", "This", "is", "the", "first", "study", "to", "investigate", "specific", "factors", "affecting", "a", "patient", "'s", "perceived", "ability", "to", "kneel", "post", "TKA", ",", "following", "exposure", "to", "a", "preoperative", "kneeling", "education", "session", ".", "A", "cross-sectional", "study", "was", "conducted", "following", "TKA", "with", "patients", "who", "had", "been", "educated", "about", "kneeling", "prior", "to", "the", "operation", ".", "Patients", "completed", "kneeling", "questionnaires", "at", "6", "(", "n", "=", "115", ")", "and", "12", "(", "n", "=", "82", ")", "months", "post", "TKA", ".", "In", "addition", "to", "the", "12-month", "kneeling", "questionnaire", ",", "patients", "also", "completed", "the", "Oxford", "knee", "score", "(", "OKS", ")", "survey", ".", "Seventy-two", "percent", "of", "patients", "perceived", "they", "could", "kneel", "at", "12", "months", "post", "TKA", ".", "Overall", ",", "pain", "and", "discomfort", "were", "the", "most", "common", "factors", "deterring", "patients", "from", "kneeling", ".", "Perceived", "kneeling", "ability", "was", "the", "poorest", "scored", "outcome", "on", "the", "OKS", "with", "patients", "reporting", "mild", "to", "moderate", "difficulty", "with", "this", "task", ".", "Kneeling", "scores", "were", "strongly", "correlated", "with", "overall", "knee", "function", "scores", "(", "R", "=", "0.70", ")", ",", "strongly", "correlated", "with", "pain", "scores", "(", "R", "=", "0.45", ")", "and", "weakly", "correlated", "with", "knee", "stability", "scores", "(", "R", "=", "0.29", ")", ".", "When", "asked", "about", "other", "factors", "preventing", "kneeling", "other", "than", "pain", "or", "discomfor", "t", ",", "75", "%", "had", "reasons", "unrelated", "to", "the", "knee", "or", "TKA", ".", "The", "most", "common", "reason", "was", "'problems", "with", "the", "other", "knee", "'", "(", "n", "=", "19", ")", ".", "Patients", "in", "this", "study", "were", "provided", "with", "education", "regarding", "their", "kneeling", "ability", "post", "TKA", ",", "yet", "still", "experienced", "limitations", "in", "perceived", "kneeling", "ability", "post", "operatively", ".", "Contrary", "to", "previous", "research", ",", "our", "study", "suggests", "that", "factors", "other", "than", "patient", "education", "affect", "a", "patient", "'s", "perceived", "kneeling", "ability", "post", "TKA", "." ]

[ "B-Functional Concept", "B-Functional Concept", "B-Physiologic Function", "O", "O", "B-Idea or Concept", "O", "B-Educational Activity", "B-Patient or Disabled Group", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "O", "B-Patient or Disabled Group", "B-Educational Activity", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "B-Mental Process", "B-Organism Attribute", "B-Organism Attribute", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Temporal Concept", "B-Physiologic Function", "B-Educational Activity", "B-Educational Activity", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Educational Activity", "O", "B-Physiologic Function", "B-Temporal Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "B-Physiologic Function", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Physiologic Function", "B-Intellectual Product", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "B-Mental Process", "O", "O", "B-Physiologic Function", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Patient or Disabled Group", "O", "B-Physiologic Function", "O", "B-Mental Process", "B-Physiologic Function", "B-Organism Attribute", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Clinical Attribute", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "O", "O", "O", "O", "B-Physiologic Function", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Physiologic Function", "O", "O", "B-Sign or Symptom", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Educational Activity", "O", "O", "B-Physiologic Function", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Physiologic Function", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Patient or Disabled Group", "B-Educational Activity", "B-Health Care Activity", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "B-Mental Process", "B-Physiologic Function", "B-Organism Attribute", "B-Temporal Concept", "B-Therapeutic or Preventive Procedure", "O" ]

[ "Improved", "diagnostic", "yield", "of", "neuromuscular", "disorders", "applying", "clinical", "exome", "sequencing", "in", "patients", "arising", "from", "a", "consanguineous", "population", "Neuromuscular", "diseases", "(", "NMDs", ")", "include", "a", "broad", "range", "of", "disorders", "affecting", "muscles", ",", "nerves", "and", "neuromuscular", "junctions", ".", "Their", "overlapping", "phenotypes", "and", "heterogeneous", "genetic", "nature", "have", "created", "challenges", "in", "diagnosis", "which", "calls", "for", "the", "implementation", "of", "massive", "parallel", "sequencing", "as", "a", "candidate", "strategy", "to", "increase", "the", "diagnostic", "yield", ".", "In", "this", "study", ",", "total", "of", "45", "patients", ",", "mostly", "offspring", "of", "consanguineous", "marriages", "were", "examined", "using", "whole", "exome", "sequencing", ".", "Data", "analysis", "was", "performed", "to", "identify", "the", "most", "probable", "pathogenic", "rare", "variants", "in", "known", "NMD", "genes", "which", "led", "to", "identification", "of", "causal", "variants", "for", "33", "out", "of", "45", "patients", "(", "73.3", "%", ")", "in", "the", "following", "known", "genes", ":", "CAPN3", ",", "Col6A1", ",", "Col6A3", ",", "DMD", ",", "DYSF", ",", "FHL1", ",", "GJB1", ",", "ISPD", ",", "LAMA2", ",", "LMNA", ",", "PLEC1", ",", "RYR1", ",", "SGCA", ",", "SGCB", ",", "SYNE1", ",", "TNNT1", "and", "22", "novel", "pathogenic", "variants", "were", "detected", ".", "Today", ",", "the", "advantage", "of", "whole", "exome", "sequencing", "in", "clinical", "diagnostic", "strategies", "of", "heterogeneous", "disorders", "is", "clear", ".", "In", "this", "cohort", ",", "a", "diagnostic", "yield", "of", "73.3", "%", "was", "achieved", "which", "is", "quite", "high", "compared", "to", "the", "overall", "reported", "diagnostic", "yield", "of", "25", "%", "to", "50", "%", ".", "This", "could", "be", "explained", "by", "the", "consanguineous", "background", "of", "these", "patients", "and", "is", "another", "strong", "advantage", "of", "offering", "clinical", "exome", "sequencing", "in", "diagnostic", "laboratories", ",", "especially", "in", "populations", "with", "high", "rate", "of", "consanguinity", "." ]

[ "B-Finding", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Population Group", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Tissue", "O", "B-Tissue", "O", "B-Cell Component", "B-Cell Component", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Organism Attribute", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Activity", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Family Group", "O", "B-Social Behavior", "B-Social Behavior", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Disease or Syndrome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "B-Finding", "B-Gene or Genome", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Functional Concept", "B-Health Care Related Organization", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Finding", "O" ]

[ "Safety", "of", "transradial", "diagnostic", "cardiac", "catheterization", "in", "patients", "under", "oral", "anticoagulant", "therapy", "Cardiac", "catheterization", "in", "anticoagulated", "patients", "is", "usually", "performed", "after", "the", "anticoagulation", "has", "been", "withdrawn", ",", "at", "least", "in", "the", "previous", "48h", ",", "and", "sometimes", "bridging", "therapy", "with", "heparin", "is", "used", ".", "A", "prospective", "observational", "study", "including", "489", "patients", "undergoing", "transradial", "catheterization", "was", "conducted", ".", "A", "total", "of", "140", "patients", "were", "under", "acenocoumarol", "(", "group", "A", ")", "and", "they", "were", "compared", "with", "the", "remainder", "(", "group", "B", ")", "for", "complications", "after", "the", "procedure", "(", "bleeding", "and", "vascular", "access", "complications", ")", ".", "Patients", "in", "group", "A", "were", "older", "(", "74±12", "years", "vs.", "68±17", "years", ",", "p", "<", "0.01", ")", "and", "the", "main", "indication", "for", "anticoagulation", "was", "atrial", "fibrillation", "(", "58.6", "%", ")", ".", "No", "complications", "occurred", "during", "the", "procedures", ".", "There", "were", "no", "acute", "bleedings", "just", "after", "the", "bandage", "removal", ".", "During", "the", "first", "24h", ",", "only", "3", "(", "2.1", "%", ")", "radial", "occlusions", "in", "group", "A", "and", "2", "(", "0.6", "%", ")", "in", "group", "B", "(", "p=0.14", ")", "were", "recorded", ".", "Hematomas", "between", "5", "and", "10cm", "appeared", "in", "5", "%", "of", "the", "group", "A", "vs.", "4.6", "%", "in", "group", "B", ".", "During", "the", "1-month", "follow-up", "period", ",", "one", "more", "radial", "occlusion", "in", "each", "group", "was", "recorded", "and", "there", "were", "4", "(", "1.1", "%", ")", "additional", "mild", "hematomas", "in", "group", "B", "and", "none", "in", "group", "A", "(", "p=0.48", ")", ".", "Performing", "a", "transradial", "diagnostic", "cardiac", "catheterization", "without", "removal", "of", "the", "oral", "chronic", "anticoagulation", "appears", "safe", "in", "patients", "under", "acenocumarol", "therapy", "." ]

[ "B-Research Activity", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Patient or Disabled Group", "O", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Functional Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Patient or Disabled Group", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Pharmacologic Substance", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Qualitative Concept", "O", "B-Classification", "B-Classification", "O", "O", "B-Pathologic Function", "O", "O", "B-Health Care Activity", "O", "B-Pathologic Function", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Patient or Disabled Group", "O", "B-Classification", "B-Classification", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Finding", "B-Pathologic Function", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Finding", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Temporal Concept", "O", "B-Medical Device", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Temporal Concept", "B-Health Care Activity", "B-Temporal Concept", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Pathologic Function", "O", "B-Classification", "B-Classification", "O", "O", "O", "B-Classification", "B-Classification", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Qualitative Concept", "B-Activity", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Finding", "O", "B-Patient or Disabled Group", "O", "B-Pharmacologic Substance", "B-Therapeutic or Preventive Procedure", "O" ]

[ "Does", "infrared", "visualization", "improve", "selection", "of", "venipuncture", "sites", "for", "indwelling", "needle", "at", "the", "forearm", "in", "second-year", "nursing", "students", "?", "To", "evaluate", "the", "effectiveness", "of", "a", "vein", "visualization", "display", "system", "using", "near-infrared", "light", "(", "``", "Vein", "Display", "``", ")", "for", "the", "safe", "and", "proper", "selection", "of", "venipuncture", "sites", "for", "indwelling", "needle", "placement", "in", "the", "forearm", ".", "Ten", "second", "year", "nursing", "students", "were", "recruited", "to", "apply", "an", "indwelling", "needle", "line", "with", "and", "without", "Vein", "Display", ".", "Another", "ten", "participants", "were", "recruited", "from", "various", "faculty", "to", "serve", "as", "patients", ".", "The", "quality", "of", "the", "venipuncture", "procedure", "at", "various", "selected", "sites", "was", "evaluated", "according", "to", "a", "scale", "developed", "by", "the", "authors", ".", "Time", ",", "scores", "and", "patterns", "of", "puncture", "-", "site", "selection", "were", "compared", "with", "respect", "to", "three", "different", "methods", ":", "[", "1", "]", "attempt", "1", "(", "tourniquet", "only", ")", ",", "[", "2", "]", "attempt", "2", "(", "Vein", "Display", "only", ")", "and", "[", "3", "]", "attempt", "3", "(", "both", ")", ".", "To", "validate", "the", "effectiveness", "of", "Vein", "Display", ",", "52", "trials", "were", "conducted", "in", "total", ".", "We", "found", "that", "venipuncture", "site", "selection", "time", "was", "significantly", "improved", "with", "the", "Vein", "Display", ",", "particularly", "in", "the", "case", "of", "difficult", "to", "administer", "venipuncture", "sites", ".", "Overall", ",", "we", "found", "no", "significant", "difference", "with", "respect", "to", "venipuncture", "quality", ",", "as", "determined", "by", "our", "scale", ".", "These", "results", "suggest", "that", "equipment", "such", "as", "the", "Vein", "Display", "can", "contribute", "immensely", "to", "the", "improvement", "of", "practical", "skills", ",", "such", "as", "venipuncture", ",", "especially", "in", "the", "context", "of", "elderly", "patients", "." ]

[ "O", "B-Medical Device", "B-Functional Concept", "O", "B-Activity", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "O", "B-Functional Concept", "B-Medical Device", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Medical Device", "B-Medical Device", "B-Medical Device", "B-Medical Device", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "O", "B-Functional Concept", "B-Medical Device", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Medical Device", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Functional Concept", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "B-Professional or Occupational Group", "O", "B-Temporal Concept", "O", "B-Quantitative Concept", "O", "B-Qualitative Concept", "O", "B-Diagnostic Procedure", "O", "B-Spatial Concept", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "B-Activity", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Diagnostic Procedure", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Patient or Disabled Group", "O" ]

[ "Elective", "Nephron", "Sparing", "Surgery", "Decreases", "Other", "Cause", "Mortality", "Relative", "to", "Radical", "Nephrectomy", "Only", "in", "Specific", "Subgroups", "of", "Patients", "with", "Renal", "Cell", "Carcinoma", "There", "is", "no", "consensus", "regarding", "a", "protective", "effect", "on", "mortality", "due", "to", "a", "cause", "other", "than", "cancer", "in", "patients", "treated", "with", "elective", "nephron", "sparing", "surgery", "relative", "to", "their", "radical", "nephrectomy", "counterparts", ".", "We", "test", "whether", "the", "protective", "effect", "of", "nephron", "sparing", "surgery", "relative", "to", "radical", "nephrectomy", "is", "universal", "or", "present", "in", "specific", "subgroups", "of", "patients", ".", "A", "collaborative", "database", "of", "5", "institutions", "was", "queried", "to", "evaluate", "1,783", "patients", "without", "chronic", "kidney", "disease", "diagnosed", "with", "a", "clinical", "T1", "renal", "mass", "that", "was", "treated", "with", "nephron", "sparing", "surgery", "or", "radical", "nephrectomy", ".", "Multivariable", "Cox", "regression", "analysis", "was", "done", "to", "assess", "the", "impact", "of", "surgery", "type", "(", "nephron", "sparing", "surgery", "vs", "radical", "nephrectomy", ")", "on", "other", "cause", "mortality", "after", "adjustment", "for", "patient", "and", "cancer", "characteristics", ".", "Interaction", "terms", "were", "used", "to", "test", "the", "hypothesis", "that", "the", "impact", "of", "surgery", "type", "varies", "according", "to", "specific", "subcohorts", "of", "patients", ".", "Ten-year", "other", "cause", "mortality", "-free", "survival", "rates", "were", "90", "%", "and", "88", "%", "after", "nephron", "sparing", "surgery", "and", "radical", "nephrectomy", ",", "respectively", ".", "In", "the", "overall", "population", "radical", "nephrectomy", "was", "not", "associated", "with", "an", "increased", "risk", "of", "other", "cause", "mortality", "on", "multivariable", "analysis", "compared", "to", "nephron", "sparing", "surgery", "(", "HR", "0.91", ",", "95", "%", "CI", "0.6-1.38", ",", "p", "=", "0.6", ")", ".", "However", ",", "radical", "nephrectomy", "increased", "the", "risk", "of", "other", "cause", "mortality", "according", "to", "the", "increasing", "baseline", "Charlson", "comorbidity", "index", "(", "interaction", "test", "p", "=", "0.0008", ")", ".", "For", "example", ",", "in", "a", "patient", "with", "a", "Charlson", "comorbidity", "index", "of", "4", "the", "probability", "of", "10-year", "other", "cause", "mortality", "-free", "survival", "was", "86", "%", "after", "nephron", "sparing", "surgery", "and", "60", "%", "after", "radical", "nephrectomy", ".", "Elective", "nephron", "sparing", "surgery", "does", "not", "improve", "other", "cause", "survival", "relative", "to", "radical", "nephrectomy", "consistently", "in", "all", "patients", "with", "kidney", "cancer", ".", "Patients", "who", "are", "more", "ill", "with", "relevant", "comorbidities", "are", "those", "who", "benefit", "the", "most", "from", "nephron", "sparing", "surgery", "in", "terms", "of", "other", "cause", "mortality", "." ]

[ "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Quantitative Concept", "B-Finding", "B-Finding", "B-Finding", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Classification", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Social Behavior", "O", "O", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Patient or Disabled Group", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Finding", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "B-Classification", "O", "B-Patient or Disabled Group", "O", "O", "B-Quantitative Concept", "B-Intellectual Product", "O", "O", "B-Idea or Concept", "O", "B-Intellectual Product", "O", "B-Health Care Activity", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Qualitative Concept", "B-Population Group", "O", "B-Patient or Disabled Group", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Population Group", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Idea or Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Quantitative Concept", "O", "B-Idea or Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "B-Quantitative Concept", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "B-Finding", "O", "B-Activity", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "O", "O", "B-Activity", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Sign or Symptom", "O", "B-Qualitative Concept", "B-Idea or Concept", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O" ]

[ "A", "prime", "a", "day", "keeps", "calories", "away", ":", "The", "effects", "of", "supraliminal", "priming", "on", "food", "consumption", "and", "the", "moderating", "role", "of", "gender", "and", "eating", "restraint", "The", "link", "between", "intentions", "and", "action", "in", "weight", "control", "is", "weaker", "than", "previously", "thought", ",", "so", "recent", "research", "has", "called", "for", "further", "investigation", "of", "ways", "to", "improve", "weight", "control", "that", "bypass", "conscious", "intentions", ".", "Priming", "has", "been", "shown", "to", "have", "effects", "on", "individual", "behavior", "in", "a", "variety", "of", "contexts", "by", "influencing", "subconscious", "cognition", ".", "This", "paper", "investigates", "the", "effects", "of", "semantic", "priming", "using", "healthy", "body", "image", ",", "goal-oriented", "words", "on", "food", "consumption", ".", "The", "moderating", "role", "of", "both", "restrained", "eating", "and", "gender", "is", "investigated", ".", "161", "participants", "were", "involved", "in", "an", "experiment", "using", "a", "novel", "version", "of", "a", "scrambled", "sentence", "priming", "game", ".", "The", "outcome", "measure", "was", "the", "number", "of", "kilocalories", "consumed", ",", "examined", "using", "a", "between", "subjects", "ANCOVA", "with", "priming", ",", "gender", ",", "restrained", "eating", "index", ",", "self-reported", "BMI", ",", "and", "two", "interaction", "terms", "(", "priming", "x", "gender", ",", "and", "priming", "x", "restrained", "eating", "index", ")", ".", "There", "was", "no", "main", "effect", "of", "priming", "but", "there", "was", "an", "interaction", "of", "priming", "with", "gender", ".", "Females", "consumed", "significantly", "fewer", "kilocalories", "after", "being", "exposed", "to", "priming", "words", "related", "to", "a", "healthy", "body", "image", "(", "i.e", ".", "``", "slim", "''", ",", "``", "fit", ",", "''", ")", "compared", "to", "females", "receiving", "the", "neutral", "prime", ",", "with", "a", "medium", "effect", "size", "(", "d", "=", "0.58", ")", ".", "The", "body", "image", "prime", "did", "not", "significantly", "affect", "food", "intake", "for", "males", ",", "nor", "did", "it", "have", "a", "differential", "effect", "on", "restrained", "eaters", ".", "This", "study", "shows", "that", "priming", "can", "be", "an", "effective", "method", "for", "influencing", "females", "to", "reduce", "food", "intake", ",", "regardless", "of", "whether", "they", "are", "restrained", "or", "unrestrained", "eaters", ".", "Future", "studies", "could", "investigate", "whether", "different", "priming", "words", "related", "to", "a", "male", "'s", "healthy", "body", "image", "goal", "(", "i.e", ".", "``", "buff", ",", "''", "``", "muscles", ",", "''", "etc", ".", ")", "would", "similarly", "reduce", "food", "intake", "for", "males", "." ]

[ "O", "B-Mental Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Mental Process", "B-Mental Process", "O", "B-Activity", "B-Activity", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Organism Attribute", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "B-Mental Process", "O", "B-Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Mental Process", "B-Mental Process", "O", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Mental Process", "B-Mental Process", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Activity", "B-Activity", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Mental Process", "B-Daily or Recreational Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Mental Process", "O", "B-Organism Attribute", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Research Activity", "B-Clinical Attribute", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Mental Process", "O", "B-Organism Attribute", "O", "O", "B-Mental Process", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Mental Process", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Mental Process", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Mental Process", "B-Intellectual Product", "O", "O", "O", "B-Qualitative Concept", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "O", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "B-Organism Function", "B-Organism Function", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Organism Function", "B-Organism Function", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Intellectual Product", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Qualitative Concept", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "B-Organism Function", "O", "B-Organism Attribute", "O" ]

[ "Neurotrophins", "and", "specific", "receptors", "in", "the", "oviduct", "tracts", "of", "Japanese", "quail", "(", "Coturnix", "coturnix", "japonica", ")", "Neurotrophins", "(", "NGF", ",", "BDNF", "and", "NT-3", ")", "and", "their", "specific", "receptors", "(", "TrkA", ",", "TrkB", "and", "TrkC", ")", "were", "studied", "in", "the", "oviduct", "of", "egg", "laying", "quails", ".", "Neurotrophins", "(", "NTs", ")", "are", "mainly", "involved", "in", "the", "development", "and", "maintenance", "of", "neuronal", "populations", "in", "the", "central", "and", "peripheral", "nervous", "system", ",", "but", "also", "in", "reproductive", "system", ".", "In", "this", "survey", ",", "we", "first", "studied", "the", "morphological", "organization", "of", "the", "quail", "oviduct", ",", "distinguished", "in", "infundibulum", ",", "magnum", ",", "isthmus", ",", "uterus", "and", "vagina", ",", "and", "then", "we", "analyzed", "the", "expression", "and", "localization", "of", "NTs", "and", "Trks", "receptors", "in", "the", "whole", "tracts", ".", "By", "western", "blotting", "we", "detected", "that", "the", "investigated", "NTs", "and", "Trks", "receptors", "are", "expressed", "in", "all", "oviductal", "tracts", ".", "By", "immunohistochemistry", "we", "were", "able", "to", "define", "the", "distribution", "of", "NTs", "and", "Trks", ".", "Specifically", ",", "NGF", ",", "BDNF", "and", "NT3", "were", "localized", "in", "lining", "and", "ductal", "epithelial", "cells", ",", "and", "NGF", "was", "also", "detected", "in", "secretory", "cells", "of", "tubular", "glands", "and", "in", "nervous", "fibers", "of", "vessel", "wall", ".", "TrkA", "and", "TrkB", "were", "present", "in", "the", "lining", "and", "ductal", "epithelium", ";", "TrkA", "and", "TrkC", "were", "present", "in", "nervous", "fibers", "of", "vessel", "wall", "in", "all", "oviductal", "tracts", ".", "Furthermore", ",", "we", "also", "observed", "NGF", "and", "BDNF", "co-localized", "with", "TrkA", "and", "TrkB", "in", "cells", "of", "the", "lining", "and", "ductal", "epithelium", ",", "suggesting", "an", "autocrine", "mechanism", "of", "action", "." ]

[ "B-Biologically Active Substance", "O", "B-Receptor", "B-Receptor", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Bird", "B-Bird", "O", "B-Bird", "B-Bird", "B-Bird", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Receptor", "B-Receptor", "O", "B-Receptor", "O", "B-Receptor", "O", "B-Receptor", "O", "O", "B-Research Activity", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Organism Function", "B-Organism Function", "B-Bird", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Cell", "B-Cell", "O", "O", "B-Body System", "O", "B-Body System", "B-Body System", "B-Body System", "O", "O", "O", "O", "B-Body System", "B-Body System", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Qualitative Concept", "B-Physiologic Function", "O", "O", "B-Bird", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "B-Research Activity", "O", "B-Genetic Function", "O", "B-Cell Function", "O", "B-Biologically Active Substance", "O", "B-Receptor", "B-Receptor", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "B-Functional Concept", "B-Biologically Active Substance", "O", "B-Receptor", "B-Receptor", "O", "B-Genetic Function", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "B-Cell Function", "O", "B-Biologically Active Substance", "O", "B-Receptor", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Spatial Concept", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Receptor", "O", "B-Receptor", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "O", "B-Receptor", "O", "B-Receptor", "O", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Receptor", "O", "B-Receptor", "O", "B-Cell", "O", "O", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Activity", "O" ]

[ "Laser", "-facilitated", "epicutaneous", "immunotherapy", "to", "IgE-mediated", "allergy", "Allergen", "specific", "immunotherapy", "has", "been", "shown", "to", "be", "the", "only", "effective", "treatment", "for", "long-lasting", "clinical", "benefit", "to", "IgE-mediated", "allergic", "diseases", ",", "but", "a", "fewer", "than", "5", "%", "of", "patients", "choose", "the", "treatment", "because", "of", "inconvenience", "and", "a", "high", "risk", "of", "anaphylaxis", ".", "Recently", ",", "epicutaneous", "allergen-specific", "immunotherapy", "(", "EPIT", ")", "has", "proven", "effective", ",", "yet", "with", "limitations", "owing", "to", "strong", "skin", "reactions", ".", "We", "demonstrate", "here", "safer", "and", "faster", "EPIT", ",", "named", "μEPIT", ",", "by", "delivering", "powdered", "allergen", "and", "adjuvants", "into", "many", "micropores", "in", "the", "epidermis", ".", "We", "fabricated", "a", "microarray", "patch", "fractionally", "coated", "with", "a", "powder", "mixture", "of", "ovalbumin", "(", "OVA", ")", "model", "allergen", ",", "CpG", ",", "and", "1,25-dihydroxyvitamin", "D3", "(", "VD3", ")", ".", "Topical", "application", "of", "the", "patch", "onto", "laser-microperforated", "skin", "resulted", "in", "a", "high", "level", "of", "epidermal", "delivery", "while", "greatly", "minimizing", "allergen", "leakage", "into", "circulation", "system", "as", "compared", "to", "current", "subcutaneous", "immunotherapy", "(", "SCIT", ")", ".", "Moreover", ",", "only", "three", "times", "of", "μEPIT", "over", "two", "weeks", "could", "sufficiently", "inhibit", "allergen-specific", "IgE", "responses", "in", "mice", "suffering", "OVA", "-induced", "airway", "hyperresponsivness", "(", "AHR", ")", ",", "which", "was", "unattainable", "by", "eight", "times", "of", "SCIT", "over", "three", "weeks", ".", "Mechanistically", ",", "μEPIT", "preferably", "enhanced", "IgG2a", "production", "suggesting", "TH1-biased", "immune", "responses", "and", "induced", "a", "high", "level", "of", "T-regulatory", "(", "Treg", ")", "cells", "against", "repeated", "allergen", "sensitization", ".", "The", "immune", "tolerance", "was", "confirmed", "by", "marked", "reduction", "in", "airway", "wall", "thickness", "as", "well", "as", "eosinophil", "and", "neutrophil", "infiltration", "into", "the", "respiratory", "airway", ".", "The", "μEPIT", "represents", "a", "novel", "and", "painless", "technology", "to", "treat", "IgE-mediated", "allergic", "diseases", "with", "little", "local", "skin", "reaction", "and", "a", "minimal", "risk", "of", "anaphylaxis", "." ]

[ "B-Manufactured Object", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Temporal Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Pathologic Function", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Functional Concept", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "O", "B-Cell Component", "O", "O", "B-Tissue", "O", "O", "O", "O", "B-Manufactured Object", "B-Medical Device", "O", "B-Qualitative Concept", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Immunologic Factor", "O", "B-Biologically Active Substance", "O", "O", "B-Vitamin", "B-Vitamin", "O", "B-Vitamin", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Medical Device", "O", "B-Finding", "B-Body System", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "B-Tissue", "B-Functional Concept", "O", "O", "O", "B-Immunologic Factor", "B-Finding", "O", "B-Body System", "B-Body System", "O", "B-Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Activity", "B-Immunologic Factor", "B-Immunologic Factor", "B-Organism Attribute", "O", "B-Mammal", "O", "B-Biologically Active Substance", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Activity", "B-Immunologic Factor", "B-Biologic Function", "O", "B-Cell", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "B-Cell", "O", "B-Cell", "O", "B-Cell", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Finding", "O", "O", "O", "B-Cell", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Activity", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Occupation or Discipline", "O", "B-Therapeutic or Preventive Procedure", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "O", "B-Pathologic Function", "O" ]

[ "Predicting", "real", "-", "world", "functional", "milestones", "in", "schizophrenia", "Schizophrenia", "is", "a", "severe", "disorder", "that", "often", "causes", "impairments", "in", "major", "areas", "of", "functioning", ",", "and", "most", "patients", "do", "not", "achieve", "expected", "real", "-", "world", "functional", "milestones", ".", "The", "aim", "of", "this", "study", "was", "to", "identify", "which", "variables", "of", "demography", ",", "illness", "activity", ",", "and", "functional", "capacity", "predict", "patients", "'", "ability", "to", "attain", "real", "-", "world", "functional", "milestones", ".", "Participants", "were", "235", "outpatients", ",", "149", "men", "and", "86", "women", ",", "diagnosed", "with", "schizophrenia", "spectrum", "disorder", ".", "Our", "results", "showed", "that", "younger", "patients", "managed", "to", "achieve", "a", "higher", "level", "of", "functioning", "in", "educational", "level", ",", "marital", "status", ",", "and", "social", "contacts", ".", "Patients", "'", "functional", "capacity", "was", "primarily", "associated", "with", "educational", "level", "and", "housing", "situation", ".", "We", "also", "found", "that", "women", "needed", "less", "support", "regarding", "housing", "and", "obtained", "a", "higher", "level", "of", "marital", "status", "as", "compared", "with", "men", ".", "Our", "findings", "demonstrate", "the", "importance", "of", "considering", "current", "symptoms", ",", "especially", "negative", "symptoms", ",", "and", "remission", "stability", "over", "time", ",", "together", "with", "age", ",", "duration", "of", "illness", ",", "gender", ",", "educational", "level", ",", "and", "current", "functional", "capacity", ",", "when", "predicting", "patients", "'", "future", "real", "-", "world", "functioning", ".", "We", "also", "conclude", "that", "there", "is", "an", "advantage", "in", "exploring", "symptoms", "divided", "into", "positive", ",", "negative", ",", "and", "general", "domains", "considering", "their", "probable", "impact", "on", "functional", "achievements", "." ]

[ "B-Idea or Concept", "B-Qualitative Concept", "O", "B-Population Group", "B-Functional Concept", "B-Conceptual Entity", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Population Group", "B-Functional Concept", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Occupation or Discipline", "O", "B-Sign or Symptom", "B-Activity", "O", "O", "B-Finding", "B-Finding", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Population Group", "B-Functional Concept", "B-Conceptual Entity", "O", "B-Population Group", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Population Group", "O", "O", "B-Population Group", "O", "B-Finding", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Finding", "B-Finding", "O", "B-Group Attribute", "B-Group Attribute", "O", "O", "B-Finding", "B-Finding", "O", "B-Patient or Disabled Group", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Manufactured Object", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Group Attribute", "B-Group Attribute", "O", "O", "O", "B-Population Group", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Sign or Symptom", "O", "O", "B-Finding", "B-Sign or Symptom", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Temporal Concept", "O", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Organism Attribute", "O", "B-Finding", "B-Finding", "O", "O", "B-Temporal Concept", "B-Finding", "B-Finding", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Qualitative Concept", "O", "B-Population Group", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Sign or Symptom", "O", "O", "B-Finding", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Behavior", "O" ]

[ "LDLR", ",", "ApoB", "and", "ApoE", "genes", "polymorphisms", "and", "classical", "risk", "factors", "in", "premature", "coronary", "artery", "disease", "Lipoproteins", "play", "a", "central", "role", "in", "the", "development", "of", "atherosclerotic", "disease", ".", "So", ",", "with", "their", "ability", "to", "affect", "lipid", "levels", ",", "the", "LDLR", ",", "ApoB", "and", "ApoE", "polymorphisms", "could", "be", "one", "of", "the", "factors", "influencing", "development", "of", "atherosclerosis", ".", "This", "hypothesis", "has", "been", "tested", "in", "different", "populations", "with", "conflicting", "results", ".", "The", "purpose", "of", "the", "present", "study", "was", "to", "investigate", "the", "association", "between", "the", "LDLR", ",", "ApoB", "and", "ApoE", "genes", "polymorphisms", "with", "premature", "CAD", "(", "PCAD", ")", "in", "Egyptians", ".", "One", "hundred", "thirty-five", "patients", "of", "PCAD", "and", "one", "hundred", "thirty-two", "ages", "and", "sex", "matched", "control", "subjects", "were", "included", "in", "the", "study", ".", "LDLR", "and", "ApoB", "genes", "polymorphisms", "were", "analyzed", "by", "polymerase", "chain", "reaction", "(", "PCR", ")", ".", "The", "ApoE", "genotypes", "were", "identified", "by", "multiplex", "amplification", "refractory", "mutation", "system", "(", "multi-AMRS", ")", ".", "We", "found", "that", "LDLR", "A", "(", "+", ")", "A", "(", "+", ")", "genotype", ",", "ApoB", "X", "(", "+", ")", "allele", "and", "ApoE", "E4", "allele", "increased", "the", "risk", "of", "PCAD", "by", "1.8", ",", "2.1", "and", "12.1", "respectively", ".", "The", "present", "study", "proved", "that", "smoking", ",", "metabolic", "syndrome", ",", "ApoB", "X", "(", "+", ")", "X", "(", "+", ")", "genotype", "and", "ApoE", "E4", "allele", "were", "independent", "risk", "factors", "for", "the", "development", "of", "PCAD", ".", "This", "is", "the", "first", "study", "investigate", "the", "association", "between", "low", "density", "lipoprotein", "receptor", ",", "apolipoprotein", "B", "and", "apolipoprotein", "E", "genes", "polymorphisms", "with", "PCAD", "and", "lipid", "levels", "in", "Egyptians", "and", "we", "concluded", "that", "the", "LDLR", "A", "(", "+", ")", "A", "(", "+", ")", "genotype", ",", "ApoB", "X", "(", "+", ")", "allele", "and", "ApoE", "E4", "allele", "may", "be", "associated", "with", "an", "increased", "risk", "for", "development", "of", "PCAD", "by", "elevated", "levels", "of", "total", "cholesterol", "(", "TC", ")", "and", "low", "density", "lipoprotein", "(", "LDLc", ")", ".", "The", "coexistence", "of", "CAD", "risk", "factors", "with", "LDLR", "A", "(", "+", ")", "A", "(", "+", ")", "genotype", ",", "ApoB", "X", "(", "+", ")", "allele", "and", "ApoE", "E4", "allele", "may", "increase", "the", "risk", "of", "the", "development", "of", "PCAD", "in", "Egyptian", "patients", "." ]

[ "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Genetic Function", "O", "O", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "O", "B-Idea or Concept", "O", "O", "B-Intellectual Product", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Genetic Function", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "B-Population Group", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Genetic Function", "O", "B-Research Activity", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Gene or Genome", "B-Organism Attribute", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual Behavior", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Genetic Function", "O", "B-Disease or Syndrome", "O", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "O", "B-Population Group", "O", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Finding", "B-Finding", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "B-Population Group", "B-Patient or Disabled Group", "O" ]

[ "The", "influence", "of", "liposomal", "formulation", "on", "the", "incorporation", "and", "retention", "of", "PNA", "oligomers", "Liposomal", "formulations", "composed", "of", "phospholipids", "with", "different", "unsaturation", "degrees", ",", "head", "groups", "and", "at", "different", "cholesterol", "content", "have", "been", "tested", "for", "the", "encapsulation", "of", "Peptide", "Nucleic", "Acid", "(", "PNA", ")", "oligomers", ".", "The", "best", "loading", "capability", "(", "177μg", ",", "ER", "%", "=87.2", ")", "was", "obtained", "for", "pure", "liposomes", "of", "phosphatidylglycerol", "(", "DOPG", ")", "with", "negatively", "charged", "head", "group", ".", "The", "insertion", "of", "a", "10-20", "%", "of", "cholesterol", "in", "DOPG", "based", "liposomes", "provides", "a", "slight", "decrease", "(", "∼160μg", ")", "of", "the", "PNA", "loading", ".", "On", "the", "other", "hand", ",", "the", "cholesterol", "addition", "(", "20-30", "%", ")", "slows", "down", "the", "PNA", "'s", "release", "(", "∼27", "%", ")", "in", "fetal", "bovine", "serum", "from", "the", "liposomal", "formulation", ".", "Based", "on", "the", "encapsulation", "and", "the", "release", "properties", ",", "PEGylated", "DOPG", "liposomes", "with", "a", "percentage", "of", "cholesterol", "of", "10-20", "%", "are", "the", "optimal", "formulation", "for", "the", "loading", "of", "PNA-a210", "." ]

[ "O", "O", "O", "B-Organic Chemical", "B-Conceptual Entity", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Organic Chemical", "B-Conceptual Entity", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Phenomenon or Process", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "B-Indicator, Reagent, or Diagnostic Aid", "B-Indicator, Reagent, or Diagnostic Aid", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Organic Chemical", "B-Conceptual Entity", "O", "O", "O", "O", "B-Phenomenon or Process", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "B-Biomedical or Dental Material", "B-Organic Chemical", "B-Organic Chemical", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Activity", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "O" ]

[ "Mandibular", "kinesiographic", "pattern", "of", "women", "with", "chronic", "TMD", "after", "management", "with", "educational", "and", "self-care", "therapies", ":", "A", "double-blind", ",", "randomized", "clinical", "trial", "Limited", "mandibular", "movements", "are", "one", "of", "the", "most", "important", "signs", "of", "temporomandibular", "disorders", "(", "TMDs", ")", "and", "may", "cause", "functional", "difficulties", ".", "The", "purpose", "of", "this", "double-blind", ",", "randomized", "clinical", "trial", "was", "to", "evaluate", "the", "effect", "of", "treatment", "with", "only", "educational", "or", "education", "associated", "with", "self-care", "therapies", "on", "the", "pattern", "of", "mandibular", "movements", "of", "women", "with", "chronic", "painful", "TMDs", ".", "Forty-two", "women", "were", "selected", "and", "randomly", "divided", "into", "3", "groups", ",", "control", "group", "(", "CG", ",", "n=13", ")", ",", "education", "group", "(", "EG", ",", "n=16", ")", ",", "and", "education", "and", "self-care", "group", "(", "ESG", ",", "n=13", ")", ",", "according", "to", "the", "sequence", "of", "treatment", "they", "received", ".", "A", "kinesiograph", "device", "recorded", "mandibular", "movements", "during", "maximum", "mouth", "opening", "and", "mastication", "at", "baseline", "(", "T0", ")", "and", "at", "30-day", "(", "T1", ")", "and", "60-day", "(", "T2", ")", "follow-up", ".", "Kinesiographic", "data", "were", "statistically", "analyzed", "using", "1-way", "ANOVA", ",", "followed", "by", "the", "Bonferroni", "test", "for", "multiple", "comparisons", "of", "means", "(", "α=.05", ")", ".", "The", "ESG", "group", "demonstrated", "an", "improvement", "in", "the", "maximum", "vertical", "opening", "(", "MVO", "=", "5.1", "±3.4", "mm", ";", "P=.012", ")", "and", "anteroposterior", "mandibular", "movement", "(", "MAM", ")", "during", "maximum", "opening", "(", "7.4", "±9.5", ";", "P=.019", ")", ",", "significantly", "higher", "than", "that", "of", "the", "EG", "(", "MVO", "=1.8", "±3.5", "mm", ";", "MAM", "=0.8", "±5.0", "mm", ")", "and", "the", "CG", "(", "MVO", "=0.9", "±3.8", "mm", ";", "MAM", "=0.8", "±4.4", "mm", ")", "after", "30", "days", "of", "follow-up", ".", "Moreover", ",", "at", "T1", ",", "vertical", "mandibular", "movement", "during", "mastication", "was", "significantly", "higher", "in", "the", "ESG", "group", "(", "17.4", "±1.7", "mm", ")", "than", "in", "the", "EG", "group", "(", "15.0", "±2.8", ",", "P=.027", ")", ".", "No", "significant", "differences", "were", "found", "between", "the", "women", "who", "received", "treatment", "with", "educational", "and", "self-care", "therapies", "for", "60", "days", "and", "the", "women", "who", "received", "this", "treatment", "for", "30", "days", ".", "In", "the", "short-term", ",", "education", "and", "self-care", "treatment", "positively", "influenced", "the", "mandibular", "movement", "pattern", "of", "women", "with", "chronic", "painful", "TMDs", "." ]

[ "B-Body Part, Organ, or Organ Component", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Population Group", "O", "B-Temporal Concept", "B-Disease or Syndrome", "O", "B-Health Care Activity", "O", "B-Classification", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Research Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Classification", "O", "B-Classification", "B-Qualitative Concept", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Intellectual Product", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "O", "B-Population Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Disease or Syndrome", "O", "B-Quantitative Concept", "B-Population Group", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Group", "B-Group", "O", "B-Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "O", "B-Medical Device", "B-Medical Device", "B-Qualitative Concept", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "B-Temporal Concept", "B-Quantitative Concept", "B-Body Space or Junction", "B-Organism Function", "O", "B-Organ or Tissue Function", "O", "B-Quantitative Concept", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "B-Health Care Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Research Activity", "B-Research Activity", "B-Functional Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Activity", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Conceptual Entity", "O", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "B-Organism Function", "O", "B-Temporal Concept", "B-Quantitative Concept", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "O", "O", "O", "B-Organism Function", "O", "O", "O", "O", "O", "O", "B-Group", "O", "B-Organism Function", "O", "O", "O", "O", "B-Organism Function", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Spatial Concept", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "B-Temporal Concept", "B-Organ or Tissue Function", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Qualitative Concept", "O", "B-Finding", "O", "O", "B-Population Group", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Classification", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "B-Population Group", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "O", "B-Classification", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Finding", "B-Conceptual Entity", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "B-Intellectual Product", "O", "B-Population Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "B-Disease or Syndrome", "O" ]

[ "Histopathology", "of", "the", "filum", "terminale", "in", "children", "with", "and", "without", "tethered", "cord", "syndrome", "with", "attention", "to", "the", "elastic", "tissue", "within", "the", "filum", "To", "compare", "histologically", "transected", "fila", "from", "pediatric", "patients", "with", "tethered", "cord", "syndrome", "(", "TCS", ")", ",", "with", "and", "without", "a", "low", "conus", ",", "with", "controls", ",", "focusing", "on", "collagenous", "and", "elastic", "tissue", ".", "Thirty", "fila", "from", "patients", "with", "TCS", ",", "including", "5", "where", "minimal", "cautery", "was", "used", "prior", "to", "filum", "section", ",", "were", "compared", "with", "fila", "from", "27", "pediatric", "cadavers", "without", "TCS", "(", "controls", ")", ".", "Sections", "of", "fila", "were", "stained", "with", "H", "&", "E", ",", "Masson", "trichrome", "and", "Verhoeff", "von", "Gieson", "elastic", "stains", ",", "and", "7", "with", "Gordon", "and", "Sweet", "'s", "reticulin", "stain", ".", "Fila", "from", "controls", "showed", "loose", "fibrous", "connective", "tissue", "(", "FCT", ")", "with", "thin", "and", "evenly", "dispersed", "elastic", "fibers", "(", "EFs", ")", ".", "Reticulin", "fibers", "(", "RFs", ")", "were", "seen", "in", "blood", "vessel", "walls", "and", "nerve", "twigs", ".", "Fat", "was", "identified", "microscopically", "in", "2", "fila", ".", "All", "fila", "from", "patients", "with", "TCS", "had", "dense", "FCT", ".", "The", "EFs", "were", "in", "normal", "numbers", "in", "17", ",", "and", "focally", "or", "diffusely", "decreased", "in", "13", ".", "All", "25", "patients", "where", "the", "fila", "were", "cauterized", "during", "resection", "had", "thick", "and", "coiled", "EFs", ".", "Coiling", "was", "not", "seen", "when", "minimal", "cautery", "was", "applied", ".", "RFs", "were", "seen", "in", "blood", "vessel", "walls", "and", "nerve", "twigs", ".", "Fat", "was", "identified", "in", "19", "patients", ".", "Findings", "were", "similar", ",", "whether", "the", "conus", "termination", "was", "normal", "or", "low", ".", "The", "fila", "of", "all", "patients", "with", "TCS", ",", "whether", "or", "not", "the", "conus", "was", "low", ",", "showed", "abnormal", "FCT", ".", "EFs", "were", "decreased", "in", "48", "%", "of", "patients", ";", "however", ",", "there", "were", "thick", "and", "coiled", "EFs", "in", "all", "patients", ".", "Coiling", "of", "EFs", ",", "initially", "thought", "to", "be", "an", "abnormality", "in", "patients", ",", "is", "considered", "most", "likely", "to", "be", "a", "result", "of", "cautery", "(", "i.e.", ",", "artifactual", "/", "iatrogenic", "coiling", ")", "." ]

[ "B-Biomedical Occupation or Discipline", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Age Group", "O", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Activity", "B-Functional Concept", "B-Functional Concept", "B-Body Part, Organ, or Organ Component", "O", "B-Qualitative Concept", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Body Location or Region", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Laboratory Procedure", "O", "O", "B-Activity", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "B-Anatomical Structure", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "B-Group", "O", "O", "B-Substance", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Group", "O", "B-Qualitative Concept", "B-Tissue", "B-Tissue", "B-Tissue", "O", "B-Tissue", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "B-Tissue", "B-Tissue", "O", "B-Tissue", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Tissue", "O", "O", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Tissue", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Tissue", "O", "B-Spatial Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "O", "O", "B-Patient or Disabled Group", "O", "B-Finding", "O", "B-Qualitative Concept", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Spatial Concept", "O", "O", "B-Finding", "B-Tissue", "O", "B-Tissue", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Tissue", "O", "O", "B-Patient or Disabled Group", "O", "B-Spatial Concept", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Human-caused Phenomenon or Process", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O" ]

[ "Clinical", "value", "of", "pathologic", "examination", "of", "non-neoplastic", "kidney", "in", "patients", "with", "upper", "urinary", "tract", "malignancies", "While", "surgical", "resection", "remains", "the", "standard", "of", "care", "in", "the", "treatment", "of", "upper", "urinary", "tract", "malignancies", ",", "nephrectomy", "is", "a", "risk", "factor", "for", "the", "development", "of", "chronic", "kidney", "disease", "(", "CKD", ")", ".", "The", "aim", "of", "this", "study", "was", "to", "determine", "whether", "histologic", "evaluation", "of", "non-neoplastic", "kidney", "could", "enable", "early", "identification", "of", "unrecognized", "kidney", "disease", "and", "could", "be", "of", "prognostic", "value", "in", "predicting", "postoperative", "renal", "outcomes", ".", "We", "retrospectively", "analyzed", "51", "patients", "with", "upper", "urinary", "tract", "malignancies", "who", "received", "uninephrectomy", "or", "uninephroureterectomy", ".", "A", "thorough", "pathologic", "evaluation", "of", "non-neoplastic", "kidney", "including", "special", "stains", ",", "immunofluorescence", ",", "and", "electron", "microscopic", "studies", "was", "performed", ".", "The", "degree", "of", "parenchymal", "changes", "was", "graded", "from", "0", "to", "15", ".", "Of", "51", "patients", ",", "only", "13", "showed", "normal", "kidney", "pathology", ".", "Fifteen", "patients", "showed", "glomerular", "abnormalities", ",", "14", "showed", "diabetic", "nephropathy", ",", "and", "11", "showed", "vascular", "nephropathy", ".", "There", "was", "one", "case", "each", "of", "reflux", "nephropathy", "and", "chronic", "pyelonephritis", ".", "The", "median", "histologic", "score", "was", "5", "points", ".", "Only", "25.4", "%", "of", "patients", "had", "≤", "3", "points", ".", "Score", "more", "than", "5", "was", "observed", "in", "47.1", "%", "of", "patients", ".", "Postoperative", "estimated", "glomerular", "filtration", "rate", "(", "eGFR", ")", "at", "3", "to", "36", "months", "were", "obtained", "from", "90.2", "%", "of", "patients", ",", "and", "of", "those", ",", "34.8", "%", "had", "de", "novo", "CKD", ".", "Since", "no", "one", "had", "CKD", "in", "partial", "nephrectomized", "patients", ",", "we", "determined", "risk", "factors", "for", "CKD", "in", "radical", "nephrectomized", "patients", ".", "Cox", "regression", "analysis", "revealed", "that", "postoperative", "AKI", ",", "preoperative", "eGFR", ",", "and", "histologic", "score", "of", "non-neoplastic", "kidney", "were", "the", "independent", "predictors", "for", "CKD", ".", "We", "conclude", "that", "routine", "pathologic", "evaluation", "of", "non-neoplastic", "kidney", "provides", "valuable", "diagnostic", "and", "prognostic", "information", "." ]

[ "B-Finding", "B-Finding", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Patient or Disabled Group", "O", "B-Body System", "B-Body System", "B-Body System", "B-Neoplastic Process", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body System", "B-Body System", "B-Body System", "B-Neoplastic Process", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Activity", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "B-Temporal Concept", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "O", "B-Research Activity", "B-Research Activity", "O", "B-Patient or Disabled Group", "O", "B-Body System", "B-Body System", "B-Body System", "B-Neoplastic Process", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Functional Concept", "B-Health Care Activity", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Biomedical Occupation or Discipline", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Temporal Concept", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Disease or Syndrome", "O", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Temporal Concept", "B-Injury or Poisoning", "O", "B-Temporal Concept", "B-Laboratory Procedure", "O", "O", "B-Functional Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Idea or Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Health Care Activity", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Functional Concept", "O", "B-Intellectual Product", "O", "O" ]

[ "Prospective", "study", "of", "dietary", "Non", "Enzymatic", "Antioxidant", "Capacity", "on", "the", "risk", "of", "hip", "fracture", "in", "the", "elderly", "Dietary", "antioxidants", "may", "play", "an", "important", "role", "in", "the", "prevention", "of", "bone", "loss", "and", "associated", "fractures", "by", "reducing", "levels", "of", "oxidative", "stress", ".", "We", "prospectively", "investigated", "the", "association", "between", "dietary", "Non", "Enzymatic", "Antioxidant", "Capacity", "(", "NEAC", ")", "and", "the", "risk", "of", "hip", "fracture", "and", "whether", "this", "effect", "was", "modified", "by", "smoking", ".", "In", "the", "Swedish", "National", "March", "Cohort", "13,409", "men", "and", "women", "over", "the", "age", "of", "55", "who", "had", "not", "experienced", "cancer", ",", "cardiovascular", "disease", "or", "hip", "fracture", ",", "were", "followed", "through", "record-linkages", "from", "1997", "through", "2010", ".", "NEAC", "was", "assessed", "by", "a", "validated", "food", "frequency", "questionnaire", "collected", "at", "baseline", ".", "We", "categorized", "the", "distribution", "of", "NEAC", "into", "sex", "-", "specific", "quartiles", "and", "used", "multivariable", "adjusted", "Cox", "proportional", "hazards", "regression", "models", "to", "estimate", "hazard", "ratios", "(", "HRs", ")", "with", "95", "%", "confidence", "intervals", "(", "95", "%", "CI", ")", ".", "During", "a", "mean", "follow-up", "time", "of", "12.4years", ",", "we", "identified", "491", "incident", "cases", "of", "first", "hip", "fracture", ".", "Subjects", "in", "the", "highest", "quartile", "of", "dietary", "NEAC", "had", "a", "39", "%", "lower", "risk", "of", "incident", "hip", "fracture", "compared", "to", "those", "in", "the", "lowest", "quartile", "(", "HR", ":", "0.61", ";", "95", "%", "CI", ":", "0.44-0.85", ")", ".", "The", "association", "was", "non-linear", "(", "p", "for", "non-linearity", ":", "0.004", ")", "with", "a", "potential", "threshold", "between", "the", "first", "and", "the", "second", "quartile", "and", "no", "further", "risk", "reduction", "at", "higher", "levels", "of", "dietary", "NEAC", ".", "Due", "to", "a", "low", "smoking", "prevalence", "in", "our", "study", "population", ",", "we", "had", "limited", "power", "to", "detect", "effect", "modification", "between", "dietary", "NEAC", "and", "smoking", "on", "a", "multiplicative", "or", "additive", "scale", ".", "Higher", "dietary", "NEAC", "intake", "is", "associated", "with", "lower", "risk", "of", "hip", "fracture", "in", "the", "elderly", "." ]

[ "O", "O", "O", "B-Food", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Idea or Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "B-Population Group", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Injury or Poisoning", "O", "O", "O", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "O", "B-Idea or Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "O", "B-Individual Behavior", "O", "O", "O", "B-Population Group", "B-Population Group", "B-Population Group", "B-Population Group", "O", "B-Population Group", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "O", "B-Organism Attribute", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Food", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "O", "B-Food", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Laboratory Procedure", "O", "B-Individual Behavior", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O" ]

[ "MiR-211", "is", "epigenetically", "regulated", "by", "DNMT1", "mediated", "methylation", "and", "inhibits", "EMT", "of", "melanoma", "cells", "by", "targeting", "RAB22A", "MiR-211", "has", "strong", "inhibitive", "effects", "on", "melanoma", "cell", "growth", ",", "invasion", "and", "metastasis", ".", "However", ",", "how", "it", "is", "downregulated", "and", "whether", "other", "genes", "are", "involved", "its", "downstream", "regulation", "in", "melanoma", "are", "not", "clear", ".", "In", "this", "study", ",", "we", "firstly", "verified", "the", "expression", "of", "miR-211", "in", "melanoma", "cell", "lines", "and", "observed", "that", "its", "downregulation", "is", "associated", "with", "increased", "DNMT1", "expression", ".", "By", "performing", "qRT-PCR", "and", "MSP", "analysis", ",", "we", "confirmed", "that", "DNMT1", "is", "negatively", "correlated", "with", "miR-211", "expression", "and", "can", "modulate", "DNA", "methylation", "in", "the", "promoter", "region", "of", "miR-211", ".", "By", "performing", "bioinformatics", "analysis", ",", "we", "found", "that", "RAB22A", "is", "a", "possible", "target", "of", "miR-211", ",", "which", "has", "two", "broadly", "conversed", "binding", "sites", "with", "miR-211", "in", "the", "3'UTR", ".", "Following", "dual", "luciferase", "assay", ",", "qRT-PCR", "and", "western", "blot", "analysis", "confirmed", "the", "direct", "binding", "between", "miR-211", "and", "RAB22A", "and", "the", "suppressive", "effect", "of", "miR-211", "on", "RAB22A", "expression", ".", "Knockdown", "of", "RAB22A", "increased", "epithelial", "properties", "and", "impaired", "mesenchymal", "properties", "of", "the", "melanoma", "cells", ",", "suggesting", "that", "miR-211", "modulates", "epithelial", "mesenchymal", "transition", "(", "EMT", ")", "of", "melanoma", "cells", "via", "downregulating", "RAB22A", ".", "In", "summary", ",", "the", "present", "study", "firstly", "demonstrated", "that", "DNMT1", "mediated", "promoter", "methylation", "is", "a", "mechanism", "of", "miRNA", "suppression", "in", "melanoma", "and", "revealed", "a", "new", "tumor", "suppressor", "role", "of", "the", "miR-211", "by", "targeting", "RAB22A", "in", "melanoma", ".", "The", "DNMT1", "/", "miR-211", "/", "RAB22A", "axis", "provides", "a", "novel", "insight", "into", "the", "pathogenesis", "of", "melanoma", ",", "particularly", "in", "the", "EMT", "process", "." ]

[ "B-Gene or Genome", "O", "B-Cell Function", "B-Cell Function", "O", "B-Gene or Genome", "O", "B-Molecular Function", "O", "B-Activity", "B-Cell Function", "O", "B-Cell", "B-Cell", "O", "B-Molecular Biology Research Technique", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Activity", "O", "O", "B-Neoplastic Process", "B-Cell Function", "B-Cell Function", "O", "B-Pathologic Function", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Molecular Function", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "B-Spatial Concept", "B-Molecular Function", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Genetic Function", "O", "B-Gene or Genome", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Molecular Function", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "B-Molecular Biology Research Technique", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "B-Spatial Concept", "B-Molecular Function", "B-Molecular Function", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Gene or Genome", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Biomedical Occupation or Discipline", "O", "O", "O", "O", "B-Gene or Genome", "O", "O", "O", "B-Functional Concept", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "B-Receptor", "B-Receptor", "O", "B-Gene or Genome", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Indicator, Reagent, or Diagnostic Aid", "B-Laboratory Procedure", "O", "B-Molecular Biology Research Technique", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "B-Molecular Function", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Genetic Function", "O", "B-Molecular Biology Research Technique", "O", "B-Gene or Genome", "O", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "O", "B-Cell", "B-Cell", "O", "O", "O", "B-Gene or Genome", "B-Spatial Concept", "B-Cell Function", "B-Cell Function", "B-Cell Function", "O", "B-Cell Function", "O", "O", "B-Cell", "B-Cell", "O", "B-Molecular Function", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Biologically Active Substance", "B-Molecular Function", "O", "O", "B-Functional Concept", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "B-Gene or Genome", "O", "B-Molecular Biology Research Technique", "B-Gene or Genome", "O", "B-Neoplastic Process", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "B-Neoplastic Process", "O", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O" ]

[ "Concordant", "but", "Varied", "Phenotypes", "among", "Duchenne", "Muscular", "Dystrophy", "Patient", "-Specific", "Myoblasts", "Derived", "using", "a", "Human", "iPSC", "-Based", "Model", "Duchenne", "muscular", "dystrophy", "(", "DMD", ")", "remains", "an", "intractable", "genetic", "disease", ".", "Althogh", "there", "are", "several", "animal", "models", "of", "DMD", ",", "there", "is", "no", "human", "cell", "model", "that", "carries", "patient", "-specific", "DYSTROPHIN", "mutations", ".", "Here", ",", "we", "present", "a", "human", "DMD", "model", "using", "human", "induced", "pluripotent", "stem", "cells", "(", "hiPSCs", ")", ".", "Our", "model", "reveals", "concordant", "disease", "-", "related", "phenotypes", "with", "patient", "-", "dependent", "variation", ",", "which", "are", "partially", "reversed", "by", "genetic", "and", "pharmacological", "approaches", ".", "Our", "``", "chemical-compound", "-based", "''", "strategy", "successfully", "directs", "hiPSCs", "into", "expandable", "myoblasts", ",", "which", "exhibit", "a", "myogenic", "transcriptional", "program", ",", "forming", "striated", "contractile", "myofibers", "and", "participating", "in", "muscle", "regeneration", "in", "vivo", ".", "DMD", "-", "hiPSC", "-derived", "myoblasts", "show", "disease", "-", "related", "phenotypes", "with", "patient", "-to-", "patient", "variability", ",", "including", "aberrant", "expression", "of", "inflammation", "or", "immune-response", "genes", "and", "collagens", ",", "increased", "BMP", "/", "TGFβ", "signaling", ",", "and", "reduced", "fusion", "competence", ".", "Furthermore", ",", "by", "genetic", "correction", "and", "pharmacological", "``", "dual-", "SMAD", "``", "inhibition", ",", "the", "DMD", "-", "hiPSC", "-derived", "myoblasts", "and", "genetically", "corrected", "isogenic", "myoblasts", "form", "``", "rescued", "''", "multi", "-", "nucleated", "myotubes", ".", "In", "conclusion", ",", "our", "findings", "demonstrate", "the", "feasibility", "of", "establishing", "a", "human", "``", "DMD", "-in-a-dish", "''", "model", "using", "hiPSC", "-based", "disease", "modeling", "." ]

[ "O", "O", "O", "B-Organism Attribute", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Cell", "O", "O", "O", "B-Human", "B-Cell", "O", "B-Experimental Model of Disease", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Experimental Model of Disease", "B-Experimental Model of Disease", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Gene or Genome", "B-Genetic Function", "O", "O", "O", "O", "O", "O", "B-Human", "B-Disease or Syndrome", "B-Experimental Model of Disease", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Functional Concept", "B-Organism Attribute", "O", "B-Patient or Disabled Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Chemical", "O", "O", "B-Research Activity", "O", "O", "B-Cell", "O", "O", "B-Cell", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Cell Component", "B-Cell Component", "O", "O", "O", "B-Finding", "B-Finding", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Disease or Syndrome", "O", "B-Cell", "O", "B-Cell", "O", "B-Disease or Syndrome", "O", "B-Functional Concept", "B-Organism Attribute", "O", "B-Patient or Disabled Group", "O", "B-Patient or Disabled Group", "B-Conceptual Entity", "O", "O", "B-Qualitative Concept", "O", "O", "B-Pathologic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "B-Molecular Function", "O", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Biologically Active Substance", "O", "B-Cell Function", "O", "O", "B-Disease or Syndrome", "O", "B-Cell", "O", "B-Cell", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Cell", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Human", "O", "B-Disease or Syndrome", "O", "O", "B-Experimental Model of Disease", "O", "B-Cell", "O", "B-Disease or Syndrome", "B-Experimental Model of Disease", "O" ]

[ "SNAI1", "promotes", "the", "development", "of", "HCC", "through", "the", "enhancement", "of", "proliferation", "and", "inhibition", "of", "apoptosis", "SNAI1", ",", "a", "zinc-finger", "transcription", "factor", ",", "plays", "an", "important", "role", "in", "the", "induction", "of", "epithelial-mesenchymal", "transition", "(", "EMT", ")", "in", "various", "cancers", ".", "However", ",", "the", "possible", "functions", "of", "SNAI1", "in", "the", "proliferation", "and", "apoptosis", "of", "hepatocellular", "carcinoma", "have", "not", "been", "clearly", "identified", ".", "In", "this", "study", ",", "we", "investigated", "the", "effects", "and", "mechanisms", "of", "SNAI1", "in", "the", "proliferation", "and", "apoptosis", "of", "hepatocellular", "carcinoma", "using", "clinical", "samples", "and", "cell", "lines", ".", "We", "found", "that", "SNAI1", "is", "highly", "expressed", "in", "the", "tissues", "of", "liver", "cancer", "compared", "with", "adjacent", "nontumor", "tissues", ".", "SNAI1", "is", "also", "highly", "expressed", "in", "the", "hepatoma", "cell", "lines", "HepG2", ",", "SMMC-7721", ",", "and", "BEL-7402", "compared", "with", "the", "human", "normal", "liver", "cell", "line", "L02", ".", "We", "also", "observed", "that", "SNAI1", "expression", "was", "correlated", "with", "distal", "metastasis", ",", "incomplete", "tumor", "capsule", "formation", ",", "and", "histological", "differentiation", "in", "hepatocellular", "carcinoma", "(", "HCC", ")", ".", "Moreover", ",", "we", "demonstrated", "that", "knockdown", "of", "SNAI1", "via", "lentiviral", "vectors", "of", "RNAi", "against", "SNAI", "inhibited", "cell", "proliferation", "by", "inducing", "G1", "arrest", ",", "which", "was", "accompanied", "by", "the", "downregulation", "of", "cyclin", "D1", "but", "not", "that", "of", "cyclin", "A", ".", "In", "addition", ",", "knockdown", "of", "SNAI1", "promoted", "apoptosis", "by", "decreasing", "the", "expression", "of", "Bcl-2", ".", "In", "conclusion", ",", "our", "findings", "revealed", "that", "SNAI1", "is", "involved", "in", "the", "development", "of", "hepatocellular", "carcinoma", "via", "regulating", "the", "growth", "and", "apoptosis", "of", "tumor", "cells", "." ]

[ "B-Biologically Active Substance", "B-Activity", "O", "B-Functional Concept", "O", "B-Neoplastic Process", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Cell Function", "B-Cell Function", "B-Cell Function", "B-Biologically Active Substance", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Cell Function", "B-Cell Function", "O", "B-Cell Function", "O", "O", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Functional Concept", "O", "B-Cell Function", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Biologically Active Substance", "O", "O", "B-Functional Concept", "O", "B-Cell Function", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Qualitative Concept", "B-Substance", "O", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Genetic Function", "O", "O", "B-Tissue", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Tissue", "B-Tissue", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Genetic Function", "O", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "O", "O", "B-Cell", "O", "O", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Genetic Function", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "O", "B-Gene or Genome", "O", "B-Virus", "B-Pharmacologic Substance", "O", "B-Genetic Function", "O", "B-Biologically Active Substance", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Cell Function", "B-Cell Function", "O", "O", "O", "O", "O", "O", "B-Molecular Function", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "O", "B-Gene or Genome", "B-Activity", "B-Cell Function", "O", "O", "O", "B-Genetic Function", "O", "B-Amino Acid, Peptide, or Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "O" ]

[ "Function", "and", "clinical", "meaningfulness", "of", "treatments", "for", "mild", "Alzheimer", "'s", "disease", "Effectiveness", "of", "Alzheimer", "'s", "disease", "(", "AD", ")", "treatments", "is", "commonly", "evaluated", "with", "coprimary", "outcomes", ";", "cognition", "with", "function", "to", "ensure", "clinical", "meaningfulness", "of", "a", "cognitive", "effect", ".", "We", "reviewed", "the", "literature", "for", "functional", "outcomes", "in", "mild", "AD", "or", "mild", "cognitive", "impairment", "(", "MCI", ")", "patients", "(", "distinct", "from", "combined", "mild-moderate", "/", "severe", "AD", ")", "treated", "with", "approved", "AD", "drugs", ".", "Cognitive", "and", "functional", "treatment", "differences", "in", "mild", "AD", "patients", "in", "solanezumab", "EXPEDITION", "/", "EXPEDITION2", "studies", "were", "compared", "across", "time", ".", "Seven", "publications", "provided", "MCI", "/", "mild", "AD", "functional", "outcomes", ",", "one", "of", "which", "reported", "a", "significant", "functional", "treatment", "effect", ".", "Secondary", "analyses", "of", "EXPEDITION", "studies", "suggested", "a", "smaller", "functional", "effect", "of", "solanezumab", "relative", "to", "cognition", ".", "An", "increasing", "effect", "of", "solanezumab", "over", "18", "months", "was", "shown", "for", "cognition", "and", "function", ".", "Function", "as", "the", "sole", "measure", "to", "demonstrate", "clinical", "meaningfulness", "of", "cognitive", "effects", "in", "mild", "AD", "may", "have", "limitations", ".", "For", "disease", "-", "modifying", "treatments", ",", "point", "differences", "on", "cognitive", "and", "functional", "scales", "should", "be", "qualified", "with", "duration", "of", "treatment", "." ]

[ "B-Mental Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Mental Process", "O", "B-Mental Process", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Mental Process", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Intellectual Product", "O", "B-Mental Process", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Pharmacologic Substance", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Mental Process", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "B-Immunologic Factor", "B-Activity", "O", "B-Activity", "B-Research Activity", "O", "B-Activity", "O", "B-Temporal Concept", "O", "O", "B-Intellectual Product", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Mental Process", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Activity", "B-Research Activity", "O", "O", "O", "B-Mental Process", "B-Qualitative Concept", "O", "B-Immunologic Factor", "O", "O", "B-Mental Process", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Immunologic Factor", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Mental Process", "O", "B-Mental Process", "O", "B-Mental Process", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Mental Process", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "O", "O", "B-Disease or Syndrome", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Mental Process", "O", "B-Mental Process", "B-Intellectual Product", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O" ]

[ "Body", "mass", "index", "and", "suicide", "methods", "Overweight", "and", "obesity", "is", "associated", "with", "lower", "rates", "of", "suicide", ".", "However", ",", "little", "is", "known", "about", "the", "association", "with", "different", "suicide", "methods", ".", "We", "studied", "the", "association", "between", "groups", "of", "body", "mass", "index", "and", "suicide", "methods", ".", "We", "identified", "all", "medicolegal", "autopsy", "cases", "with", "a", "cause", "of", "death", "due", "to", "external", "causes", "in", "Sweden", "during", "1999-2013", "(", "N", "=", "39,368", ")", "and", "included", "11,715", "suicides", "and", "13,316", "accidents", "or", "homicides", "as", "controls", ".", "We", "applied", "multinomial", "regression", "models", "adjusted", "for", "age", ",", "sex", ",", "year", "and", "season", "of", "death", ".", "Obesity", "was", "associated", "with", "suicidal", "intoxication", ",", "OR", "1.15", "[", "95", "%", "confidence", "interval", "(", "CI", ")", "1.02", ",", "1.30", "]", "and", "negatively", "associated", "with", "all", "other", "suicide", "methods", "studied", ".", "Underweight", "showed", "a", "negative", "association", "with", "suicidal", "drowning", "and", "there", "was", "an", "indication", "towards", "a", "negative", "association", "with", "hanging", "in", "men", "OR", "0.81", "(", "95", "%", "CI", "0.65", ",", "1.01", ")", ".", "We", "conclude", "that", "body", "mass", "index", "(", "BMI", ")", "is", "associated", "with", "the", "choice", "of", "suicide", "method", ".", "This", "may", "be", "of", "importance", "in", "a", "public", "health", "perspective", ",", "e.g", ".", "potential", "for", "prevention", "of", "intoxications", ".", "In", "the", "practice", "of", "forensic", "medicine", ",", "the", "physician", "'s", "level", "of", "suspicion", "may", "rise", "if", "the", "apparent", "suicidal", "method", "is", "less", "common", "for", "the", "individual", "characteristics", "of", "the", "deceased", ",", "such", "as", "BMI", "." ]

[ "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Finding", "B-Functional Concept", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Finding", "B-Functional Concept", "O", "O", "O", "O", "B-Regulation or Law", "B-Diagnostic Procedure", "B-Functional Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Finding", "B-Finding", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Finding", "O", "O", "B-Phenomenon or Process", "O", "B-Individual Behavior", "O", "B-Group", "O", "O", "O", "B-Quantitative Concept", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Functional Concept", "O", "O", "B-Finding", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Finding", "B-Injury or Poisoning", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Injury or Poisoning", "O", "B-Population Group", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Finding", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Finding", "O", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Biomedical Occupation or Discipline", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "B-Mental Process", "O", "O", "O", "O", "B-Idea or Concept", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Organism Function", "O", "O", "O", "B-Clinical Attribute", "O" ]

[ "Quantitative", "assessment", "of", "fluorescent", "proteins", "The", "advent", "of", "fluorescent", "proteins", "(", "FPs", ")", "for", "genetic", "labeling", "of", "molecules", "and", "cells", "has", "revolutionized", "fluorescence", "microscopy", ".", "Genetic", "manipulations", "have", "created", "a", "vast", "array", "of", "bright", "and", "stable", "FPs", "spanning", "blue", "to", "red", "spectral", "regions", ".", "Common", "to", "autofluorescent", "FPs", "is", "their", "tight", "β-barrel", "structure", ",", "which", "provides", "the", "rigidity", "and", "chemical", "environment", "needed", "for", "effectual", "fluorescence", ".", "Despite", "the", "common", "structure", ",", "each", "FP", "has", "unique", "properties", ".", "Thus", ",", "there", "is", "no", "single", "'best", "'", "FP", "for", "every", "circumstance", ",", "and", "each", "FP", "has", "advantages", "and", "disadvantages", ".", "To", "guide", "decisions", "about", "which", "FP", "is", "right", "for", "a", "given", "application", ",", "we", "have", "quantitatively", "characterized", "the", "brightness", ",", "photostability", ",", "pH", "stability", "and", "monomeric", "properties", "of", "more", "than", "40", "FPs", "to", "enable", "straightforward", "and", "direct", "comparison", "between", "them", ".", "We", "focus", "on", "popular", "and/or", "top-performing", "FPs", "in", "each", "spectral", "region", "." ]

[ "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Substance", "O", "B-Cell", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Spatial Concept", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "B-Laboratory Procedure", "B-Biologically Active Substance", "O", "O", "O", "B-Amino Acid Sequence", "B-Amino Acid Sequence", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Chemical", "B-Spatial Concept", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "B-Molecular Sequence", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Finding", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Chemical Viewed Structurally", "B-Qualitative Concept", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O" ]

[ "Cognitive", "impairment", "in", "HIV", "and", "HCV", "co-infected", "patients", ":", "a", "systematic", "review", "and", "meta-analysis", "Cognitive", "impairment", "has", "been", "well", "documented", "in", "human", "immunodeficiency", "virus", "(", "HIV", ")", "and", "hepatitis", "C", "virus", "(", "HCV", ")", "mono-infections", ".", "However", ",", "in", "the", "context", "of", "HIV", "/", "HCV", "co-infection", "the", "research", "is", "more", "limited", ".", "The", "aim", "of", "this", "systematic", "review", "was", "to", "describe", "the", "characteristics", "of", "cognitive", "impairment", "in", "HIV", "/", "HCV", "co-infection", "and", "to", "examine", "the", "differences", "in", "cognitive", "performance", "between", "HIV", "/", "HCV", "and", "HIV", "and", "HCV", "mono-infected", "patients", ".", "Of", "the", "437", "records", "initially", "screened", ",", "24", "papers", "met", "the", "inclusion", "criteria", "and", "were", "included", "in", "the", "systematic", "review", ".", "Four", "studies", "were", "included", "in", "the", "meta-analysis", ".", "Most", "studies", "indicated", "that", "HIV", "/", "HCV", "co-infected", "patients", "had", "a", "higher", "level", "of", "cognitive", "impairment", "than", "HIV", "mono-infected", "patients", ".", "Meta-analysis", "also", "indicated", "that", "HIV", "mono-infected", "patients", "had", "a", "significantly", "lower", "global", "deficit", "score", "than", "co-infected", "patients", ".", "The", "results", "also", "indicated", "that", "co-infected", "patients", "were", "more", "likely", "to", "be", "impaired", "in", "information", "processing", "speed", "than", "HIV", "mono-infected", "patients", ".", "These", "findings", "can", "be", "challenged", "by", "biasing", "factors", "such", "as", "the", "small", "number", "of", "included", "studies", ",", "heterogeneity", "of", "the", "samples", "and", "a", "large", "diversity", "of", "methodological", "procedures", ".", "Future", "research", "with", "consistent", "and", "comprehensive", "neuropsychological", "batteries", "and", "covering", "a", "greater", "diversity", "of", "risk", "factors", "is", "needed", ",", "in", "order", "to", "clarify", "the", "effects", "of", "both", "viruses", "on", "cognitive", "function", "and", "the", "mechanisms", "that", "underlie", "these", "effects", ".", "Because", "cognitive", "impairments", "may", "pose", "significant", "challenges", "to", "medication", "adherence", ",", "quality", "of", "life", "and", "overall", "functioning", ",", "such", "knowledge", "may", "have", "important", "implications", "to", "the", "planning", "and", "implementation", "of", "effective", "interventions", "aimed", "at", "optimising", "the", "clinical", "management", "of", "these", "infections", "." ]

[ "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Virus", "O", "B-Virus", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "B-Intellectual Product", "O", "B-Research Activity", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "O", "O", "O", "B-Virus", "B-Virus", "B-Virus", "O", "B-Virus", "O", "O", "B-Virus", "B-Virus", "B-Virus", "O", "B-Virus", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Virus", "O", "B-Virus", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Virus", "O", "B-Virus", "B-Disease or Syndrome", "O", "O", "B-Finding", "O", "O", "O", "B-Mental Process", "B-Mental Process", "O", "B-Virus", "O", "B-Virus", "O", "B-Virus", "O", "B-Virus", "B-Pathologic Function", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Research Activity", "O", "O", "B-Virus", "O", "B-Virus", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Virus", "B-Pathologic Function", "B-Patient or Disabled Group", "O", "B-Research Activity", "O", "O", "O", "B-Virus", "B-Pathologic Function", "B-Patient or Disabled Group", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "B-Virus", "B-Pathologic Function", "B-Patient or Disabled Group", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Group Attribute", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Virus", "O", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "O", "B-Health Care Activity", "O", "B-Finding", "B-Finding", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Pathologic Function", "O" ]

[ "Consumption", "of", "fruits", "and", "vegetables", "associated", "with", "other", "risk", "behaviors", "among", "adolescents", "in", "Northeast", "Brazil", "To", "determine", "the", "prevalence", "of", "consumption", "of", "fruits", "and", "vegetables", "and", "identify", "the", "association", "with", "low", "level", "of", "physical", "activity", ",", "exposure", "to", "sedentary", "behavior", ",", "consumption", "of", "soft", "drinks", "and", "overweight", "/", "obesity", "in", "adolescents", ".", "This", "is", "a", "cross-sectional", "school-based", "study", "with", "a", "representative", "sample", "of", "3992", "students", "aged", "14-19", "years", "from", "the", "state", "of", "Sergipe", ",", "Brazil", ".", "The", "outcome", "was", "low", "consumption", "of", "fruits", "and", "vegetables", "(", "<", "5", "servings/day", ")", ".", "Independent", "variables", "were", ":", "level", "of", "physical", "activity", ",", "sedentary", "behavior", ",", "consumption", "of", "soft", "drinks", ",", "and", "overweight", "/", "obesity", ".", "Global", "Student", "Health", "Survey", "questionnaire", "and", "body", "mass", "and", "height", "measurements", "were", "used", ",", "as", "well", "as", "chi-square", "test", "and", "crude", "and", "adjusted", "binary", "logistic", "regression", ".", "The", "significance", "level", "adopted", "was", "5", "%", ".", "The", "prevalence", "of", "inadequate", "consumption", "of", "fruits", "and", "vegetables", "was", "high", "-", "88.6", "%", "(", "95", "%", "CI", "=87.6-89.5", ")", ".", "Higher", "likelihood", "of", "low", "consumption", "of", "fruits", "and", "vegetables", "was", "verified", "among", "boys", "who", "were", "exposed", "to", "sedentary", "behavior", "(", "OR", "=1.63", ";", "95", "%", "CI", "=1.18-2.24", ")", ",", "who", "consumed", "soft", "drinks", "(", "OR", "=3.04", ";", "95", "%", "CI", "=2.10-4.40", ")", ",", "with", "insufficiently", "physical", "activity", "(", "OR", "=1.98", ";", "95", "%", "CI", "=1.43-2.73", ")", "and", "girls", "who", "consumed", "soft", "drinks", "(", "OR", "=1.88", ";", "95", "%", "CI", "=1.43-2.47", ")", "and", "those", "with", "overweight", "/", "obesity", "(", "OR", "=1.63", ";", "95", "%", "CI", "=1.19-2.23", ")", ".", "There", "is", "a", "need", "of", "public", "policies", "aimed", "at", "encouraging", "the", "consumption", "of", "healthy", "foods", "among", "adolescents", "." ]

[ "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "B-Age Group", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "B-Quantitative Concept", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "B-Activity", "O", "B-Food", "B-Food", "O", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Age Group", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Substance", "O", "O", "B-Population Group", "O", "O", "B-Temporal Concept", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Finding", "B-Finding", "O", "B-Activity", "O", "B-Food", "B-Food", "O", "O", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Organism Attribute", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "O", "O", "B-Age Group", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Activity", "B-Food", "B-Food", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Age Group", "O", "B-Activity", "B-Food", "B-Food", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Sign or Symptom", "O", "B-Disease or Syndrome", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Governmental or Regulatory Activity", "B-Governmental or Regulatory Activity", "O", "O", "O", "O", "B-Activity", "B-Activity", "B-Activity", "B-Activity", "O", "B-Age Group", "O" ]

[ "Usefulness", "of", "Embolization", "for", "Iatrogenic", "Dural", "Arteriovenous", "Fistula", "Associated", "with", "Recurrent", "Chronic", "Subdural", "Hematoma", ":", "A", "Case", "Report", "and", "Literature", "Review", "Refractory", "chronic", "subdural", "hematomas", "due", "to", "iatrogenic", "dural", "arteriovenous", "fistulas", "(", "dAVFs", ")", "are", "difficult", "to", "treat", ".", "We", "report", "our", "experience", "and", "propose", "a", "guideline", "on", "basis", "of", "a", "literature", "review", "for", "the", "usefulness", "of", "embolization", "of", "middle", "meningeal", "artery", "(", "MMA", ")", "for", "the", "treatment", "of", "the", "same", ".", "We", "report", "a", "case", "with", "right", "hemiparesis", "and", "aphasia", "1", "month", "after", "a", "fall", "from", "a", "bicycle", ".", "Computed", "tomography", "scan", "of", "the", "head", "showed", "left", "chronic", "subdural", "hematoma", ",", "which", "was", "evacuated", "by", "burr-hole", "drainage", ".", "The", "postoperative", "course", "was", "complicated", "by", "reaccumulation", "within", "short", "period", "of", "time", ".", "On", "superselective", "digital", "subtraction", "angiography", "of", "MMA", ",", "iatrogenic", "dAVF", "was", "found", "on", "left", "side", ".", "We", "embolized", "successfully", "it", "using", "n-butyl", "cyanoacrylate", "after", "a", "third", "irrigation", ".", "No", "reaccumulation", "found", "in", "the", "postoperative", "period", "or", "at", "last", "follow-up", ".", "We", "propose", "treatment", "protocol", "based", "on", "our", "experience", "and", "literature", "review", ".", "Refractory", "chronic", "subdural", "hematoma", "with", "reaccumulation", "within", "a", "short", "interval", "should", "be", "subjected", "to", "digital", "subtraction", "angiography", "of", "the", "MMA", ".", "Embolization", "of", "ipsilateral", "MMA", "is", "safe", ",", "effective", ",", "and", "a", "useful", "option", "for", "the", "treatment", "of", "iatrogenic", "dAVF", "and", "resolution", "of", "hematoma", "." ]

[ "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "B-Qualitative Concept", "B-Qualitative Concept", "B-Temporal Concept", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Functional Concept", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Disease or Syndrome", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "O", "B-Anatomical Abnormality", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Finding", "B-Finding", "O", "B-Mental or Behavioral Dysfunction", "O", "B-Temporal Concept", "O", "O", "B-Finding", "O", "O", "B-Manufactured Object", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Body Location or Region", "O", "B-Spatial Concept", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Functional Concept", "O", "B-Finding", "O", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Disease or Syndrome", "B-Anatomical Abnormality", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Qualitative Concept", "O", "O", "B-Biomedical or Dental Material", "B-Biomedical or Dental Material", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Qualitative Concept", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Functional Concept", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Finding", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Spatial Concept", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Anatomical Abnormality", "O", "B-Conceptual Entity", "O", "B-Pathologic Function", "O" ]

[ "In", "Search", "of", "the", "E.", "coli", "Compounds", "that", "Change", "the", "Antibiotic", "Production", "Pattern", "of", "Streptomyces", "coelicolor", "During", "Inter-species", "Interaction", "The", "aim", "of", "this", "work", "was", "to", "investigate", "the", "interaction", "between", "E.coli", "and", "Streptomyces", "coelicolor", "A3", "(", "2", ")", "for", "the", "increased", "production", "of", "undecylprodigiosin", "and", "identify", "the", "E.", "coli", "actives", "mediating", "this", "inter-species", "interaction", ".", "The", "antibiotics", "of", "interest", "were", "the", "red-pigmented", "undecylprodigiosin", "and", "blue-pigmented", "actinorhodin", ".", "Pure", "cultures", "of", "S.", "coelicolor", "in", "a", "defined", "medium", "produced", "higher", "concentrations", "of", "actinorhodin", "compared", "to", "those", "of", "undecylprodigiosin", ".", "The", "latter", "however", ",", "is", "more", "important", "due", "to", "its", "immunosuppressive", "and", "antitumor", "properties", ".", "As", "a", "strategy", "to", "increase", "undecylprodigiosin", "production", ",", "we", "added", "separately", ",", "live", "cells", "and", "heat-killed", "cells", "of", "E.", "coli", "C600", ",", "and", "the", "cell-free", "supernatant", "of", "E.", "coli", "culture", "to", "S.", "coelicolor", "cultures", "in", "shake", "flasks", ".", "The", "interaction", "with", "live", "cells", "of", "E.", "coli", "altered", "the", "antibiotic", "production", "pattern", "and", "undecylprodigiosin", "production", "was", "enhanced", "by", "3.5-fold", "compared", "to", "the", "pure", "cultures", "of", "S.", "coelicolor", "and", "actinorhodin", "decreased", "by", "15-fold", ".", "The", "heat-killed", "cells", "of", "E.", "coli", "however", ",", "had", "no", "effect", "on", "antibiotic", "production", ".", "In", "all", "cases", ",", "growth", "and", "glucose", "consumption", "of", "S.", "coelicolor", "remained", "almost", "the", "same", "as", "those", "observed", "in", "the", "pure", "culture", "indicating", "that", "the", "changes", "in", "antibiotic", "production", "were", "not", "due", "to", "nutritional", "stress", ".", "Results", "with", "cell-free", "supernatant", "of", "E.", "coli", "culture", "indicated", "that", "the", "interaction", "between", "S.", "coelicolor", "and", "E.", "coli", "was", "mediated", "via", "diffusible", "molecule", "(", "s", ")", ".", "Using", "a", "set", "of", "extraction", "procedures", "and", "agar-well", "diffusion", "bioassays", ",", "we", "isolated", "and", "preliminarily", "identified", "a", "class", "of", "compounds", ".", "For", "the", "preliminary", "verification", ",", "we", "added", "the", "compound", "which", "was", "the", "common", "chemical", "structural", "moiety", "in", "this", "class", "of", "compounds", "to", "the", "pure", "S.", "coelicolor", "cultures", ".", "We", "observed", "similar", "effects", "on", "antibiotic", "production", "as", "with", "the", "live", "E.", "coli", "cells", "and", "their", "supernatant", "indicating", "that", "this", "class", "of", "compounds", "secreted", "by", "E.", "coli", "indeed", "could", "act", "as", "actives", "during", "interspecies", "interaction", "and", "increase", "the", "production", "of", "undecylprodigiosin", "." ]

[ "O", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Biologically Active Substance", "O", "O", "O", "B-Antibiotic", "B-Functional Concept", "O", "O", "B-Bacterium", "B-Bacterium", "O", "B-Social Behavior", "B-Social Behavior", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Bacterium", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "B-Quantitative Concept", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Functional Concept", "B-Social Behavior", "O", "B-Social Behavior", "B-Social Behavior", "O", "O", "B-Antibiotic", "O", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "B-Antibiotic", "O", "O", "B-Laboratory Procedure", "O", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Quantitative Concept", "O", "B-Antibiotic", "B-Activity", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Pharmacologic Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Cell", "B-Cell", "O", "B-Phenomenon or Process", "B-Cell", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Body Substance", "B-Body Substance", "O", "B-Bacterium", "B-Bacterium", "B-Laboratory Procedure", "O", "B-Bacterium", "B-Bacterium", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Functional Concept", "O", "B-Cell", "B-Cell", "O", "B-Bacterium", "B-Bacterium", "O", "O", "B-Antibiotic", "B-Functional Concept", "O", "O", "B-Pharmacologic Substance", "B-Functional Concept", "O", "B-Activity", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Bacterium", "B-Bacterium", "O", "B-Antibiotic", "B-Quantitative Concept", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Cell", "O", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Antibiotic", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Finding", "B-Finding", "O", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "B-Functional Concept", "O", "B-Antibiotic", "B-Functional Concept", "O", "O", "O", "O", "B-Organism Function", "B-Finding", "O", "B-Functional Concept", "O", "B-Body Substance", "B-Body Substance", "O", "B-Bacterium", "B-Bacterium", "B-Laboratory Procedure", "O", "O", "O", "B-Functional Concept", "O", "B-Bacterium", "B-Bacterium", "O", "B-Bacterium", "B-Bacterium", "O", "B-Social Behavior", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Antibiotic", "B-Functional Concept", "O", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Cell", "O", "O", "B-Body Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Cell Function", "O", "B-Bacterium", "B-Bacterium", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Social Behavior", "B-Social Behavior", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Pharmacologic Substance", "O" ]

[ "Group", "III/IV", "muscle", "afferents", "limit", "the", "intramuscular", "metabolic", "perturbation", "during", "whole", "body", "exercise", "in", "humans", "The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "role", "of", "group", "III/IV", "muscle", "afferents", "in", "limiting", "the", "endurance", "exercise", "-", "induced", "metabolic", "perturbation", "assayed", "in", "muscle", "biopsy", "samples", "taken", "from", "locomotor", "muscle", ".", "Lumbar", "intrathecal", "fentanyl", "was", "used", "to", "attenuate", "the", "central", "projection", "of", "μ-opioid", "receptor", "-", "sensitive", "locomotor", "muscle", "afferents", "during", "a", "5", "km", "cycling", "time", "trial", ".", "The", "findings", "suggest", "that", "the", "central", "projection", "of", "group", "III/IV", "muscle", "afferent", "feedback", "constrains", "voluntary", "neural", "'", "drive", "'", "to", "working", "locomotor", "muscle", "and", "limits", "the", "exercise", "-", "induced", "intramuscular", "metabolic", "perturbation", ".", "Therefore", ",", "the", "CNS", "might", "regulate", "the", "degree", "of", "metabolic", "perturbation", "within", "locomotor", "muscle", "and", "thereby", "limit", "peripheral", "fatigue", ".", "It", "appears", "that", "the", "group", "III/IV", "muscle", "afferents", "are", "an", "important", "neural", "link", "in", "this", "regulatory", "mechanism", ",", "which", "probably", "serves", "to", "protect", "locomotor", "muscle", "from", "the", "potentially", "severe", "functional", "impairment", "as", "a", "consequence", "of", "severe", "intramuscular", "metabolic", "disturbance", ".", "To", "investigate", "the", "role", "of", "metabo", "-", "and", "mechanosensitive", "group", "III/IV", "muscle", "afferents", "in", "limiting", "the", "intramuscular", "metabolic", "perturbation", "during", "whole", "body", "endurance", "exercise", ",", "eight", "subjects", "performed", "5", "km", "cycling", "time", "trials", "under", "control", "conditions", "(", "CTRL", ")", "and", "with", "lumbar", "intrathecal", "fentanyl", "impairing", "lower", "limb", "muscle", "afferent", "feedback", "(", "FENT", ")", ".", "Vastus", "lateralis", "muscle", "biopsies", "were", "obtained", "before", "and", "immediately", "after", "exercise", ".", "Motoneuronal", "output", "was", "estimated", "through", "vastus", "lateralis", "surface", "electromyography", "(", "EMG", ")", ".", "Exercise", "-", "induced", "changes", "in", "intramuscular", "metabolites", "were", "determine", "d", "using", "liquid", "and", "gas", "chromatography-mass", "spectrometry", ".", "Quadriceps", "fatigue", "was", "quantified", "by", "pre", "-", "to", "post", "-", "exercise", "changes", "in", "potentiated", "quadriceps", "twitch", "torque", "(", "ΔQTsingle", ")", "evoked", "by", "electrical", "femoral", "nerve", "stimulation", ".", "Although", "motoneuronal", "output", "was", "21", "±", "12", "%", "higher", "during", "FENT", "compared", "to", "CTRL", "(", "P", "<", "0.05", ")", ",", "time", "to", "complete", "the", "time", "trial", "was", "similar", "(", "∼8.8", "min", ")", ".", "Compared", "to", "CTRL", ",", "power", "output", "during", "FENT", "was", "10", "±", "4", "%", "higher", "in", "the", "first", "half", "of", "the", "time", "trial", ",", "but", "11", "±", "5", "%", "lower", "in", "the", "second", "half", "(", "both", "P", "<", "0.01", ")", ".", "The", "exercise", "-", "induced", "increase", "in", "intramuscular", "inorganic", "phosphate", ",", "H", "(", "+", ")", ",", "adenosine", "diphosphate", ",", "lactate", "and", "phosphocreatine", "depletion", "was", "55", "±", "30", ",", "62", "±", "18", ",", "129", "±", "63", ",", "47", "±", "14", "(", "P", "<", "0.001", ")", "and", "27", "±", "14", "%", "(", "P", "<", "0.01", ")", "greater", "in", "FENT", "than", "CTRL", ".", "ΔQTsingle", "was", "greater", "following", "FENT", "than", "CTRL", "(", "-52", "±", "2", "vs", "-31", "±", "1", "%", ",", "P", "<", "0.001", ")", "and", "this", "difference", "was", "positively", "correlated", "with", "the", "difference", "in", "inorganic", "phosphate", "(", "r", "(", "2", ")", "=", "0.79", ";", "P", "<", "0.01", ")", "and", "H", "(", "+", ")", "(", "r", "(", "2", ")", "=", "0.92", ";", "P", "<", "0.01", ")", ".", "In", "conclusion", ",", "during", "whole", "body", "exercise", ",", "group", "III/IV", "muscle", "afferents", "provide", "feedback", "to", "the", "CNS", "which", ",", "in", "turn", ",", "constrains", "motoneuronal", "output", "to", "the", "active", "skeletal", "muscle", ".", "This", "regulatory", "mechanism", "limits", "the", "exercise", "-", "induced", "intramuscular", "metabolic", "perturbation", ",", "preventing", "an", "abnormal", "homeostatic", "challenge", "and", "excessive", "peripheral", "fatigue", "." ]

[ "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "B-Functional Concept", "O", "B-Spatial Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Anatomical Structure", "B-Anatomical Structure", "B-Daily or Recreational Activity", "O", "B-Human", "O", "B-Functional Concept", "O", "O", "B-Research Activity", "O", "O", "B-Laboratory Procedure", "O", "B-Conceptual Entity", "O", "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "O", "B-Functional Concept", "O", "B-Finding", "B-Daily or Recreational Activity", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "B-Laboratory Procedure", "O", "B-Tissue", "B-Tissue", "B-Tissue", "O", "O", "B-Organism Function", "B-Tissue", "O", "B-Body Location or Region", "B-Body Space or Junction", "B-Pharmacologic Substance", "O", "O", "O", "B-Activity", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Receptor", "B-Receptor", "O", "B-Functional Concept", "B-Organism Function", "B-Tissue", "B-Cell", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Research Activity", "O", "O", "B-Finding", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "B-Physiologic Function", "B-Conceptual Entity", "B-Individual Behavior", "B-Functional Concept", "O", "B-Mental Process", "O", "O", "B-Functional Concept", "B-Organism Function", "B-Tissue", "O", "B-Functional Concept", "O", "B-Daily or Recreational Activity", "O", "B-Functional Concept", "B-Spatial Concept", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Body System", "O", "B-Biologic Function", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Organism Function", "B-Tissue", "O", "O", "B-Functional Concept", "B-Spatial Concept", "B-Sign or Symptom", "O", "O", "B-Qualitative Concept", "O", "O", "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Body Space or Junction", "O", "O", "B-Biologic Function", "B-Functional Concept", "O", "O", "B-Idea or Concept", "O", "O", "B-Finding", "B-Organism Function", "B-Tissue", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "O", "B-Conceptual Entity", "O", "B-Organism Function", "O", "O", "B-Qualitative Concept", "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "O", "B-Functional Concept", "O", "B-Spatial Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Anatomical Structure", "B-Anatomical Structure", "B-Finding", "B-Daily or Recreational Activity", "O", "O", "B-Group", "B-Functional Concept", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Research Activity", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "B-Body Location or Region", "B-Body Space or Junction", "B-Pharmacologic Substance", "B-Functional Concept", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Tissue", "B-Cell", "B-Physiologic Function", "O", "B-Physiologic Function", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Tissue", "B-Tissue", "O", "B-Functional Concept", "B-Temporal Concept", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Daily or Recreational Activity", "O", "B-Cell", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "B-Daily or Recreational Activity", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Spatial Concept", "B-Biologically Active Substance", "O", "B-Laboratory Procedure", "O", "O", "B-Substance", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Sign or Symptom", "O", "B-Quantitative Concept", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "B-Daily or Recreational Activity", "B-Functional Concept", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Phenomenon or Process", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Cell", "B-Activity", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Physiologic Function", "B-Activity", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "B-Temporal Concept", "B-Research Activity", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Finding", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "B-Physiologic Function", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Temporal Concept", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Daily or Recreational Activity", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Spatial Concept", "B-Inorganic Chemical", "B-Inorganic Chemical", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Physiologic Function", "O", "B-Finding", "O", "B-Phenomenon or Process", "O", "B-Quantitative Concept", "O", "B-Physiologic Function", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Anatomical Structure", "B-Anatomical Structure", "B-Daily or Recreational Activity", "O", "B-Tissue", "B-Tissue", "B-Tissue", "B-Cell", "B-Activity", "B-Physiologic Function", "O", "O", "B-Body System", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Cell", "B-Activity", "O", "O", "B-Functional Concept", "B-Tissue", "B-Tissue", "O", "O", "B-Biologic Function", "B-Functional Concept", "B-Functional Concept", "O", "B-Daily or Recreational Activity", "O", "B-Functional Concept", "B-Spatial Concept", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Finding", "B-Finding", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Sign or Symptom", "O" ]

[ "Incidence", "of", "crown", "fracture", "and", "risk", "factors", "in", "the", "primary", "dentition", ":", "a", "prospective", "longitudinal", "study", "Few", "studies", "have", "assessed", "the", "incidence", "and", "risk", "factors", "to", "crown", "fractures", "in", "preschool", "children", ".", "The", "aim", "of", "this", "study", "was", "to", "estimate", "the", "incidence", "of", "crown", "fracture", "in", "the", "primary", "dentition", "over", "a", "1-year", "follow-up", "period", ",", "identify", "risk", "factors", ",", "and", "test", "the", "hypothesis", "that", "children", "with", "previous", "crown", "fracture", "are", "more", "prone", "to", "experience", "further", "cases", "of", "crown", "fracture", "independently", "of", "other", "risk", "factors", ".", "This", "study", "was", "developed", "in", "two", "phases", ":", "cross-sectional", "and", "prospective", "longitudinal", "study", ".", "The", "cross-sectional", "study", "was", "carried", "out", "261", "preschool", "children", ".", "The", "prospective", "longitudinal", "study", "was", "carried", "out", "194", "children", "allocated", "to", "two", "groups", ":", "exposed", "group", "(", "children", "with", "prior", "exposure", "to", "crown", "fracture", ")", "and", "non", "-", "exposed", "group", "(", "children", "without", "prior", "exposure", ")", ".", "On", "both", "occasions", ",", "children", "were", "examined", "for", "the", "diagnosis", "of", "crown", "fracture", "and", "evaluation", "of", "lip", "coverage", "and", "overjet", ".", "The", "parents", "were", "interviewed", "with", "regard", "to", "the", "socioeconomic", "indicators", ".", "New", "cases", "of", "crown", "fracture", "were", "identified", "based", "on", "the", "comparison", "of", "the", "two", "examinations", ".", "Data", "analysis", "involved", "Pearson", "'s", "chi-square", "test", ",", "McNemar", "'s", "test", ",", "and", "Poisson", "regression", "with", "robust", "variance", ".", "Among", "the", "261", "children", "who", "participated", "in", "the", "cross-sectional", "study", ",", "194", "were", "re-examined", "(", "65", "in", "the", "exposed", "group", "and", "129", "in", "the", "non", "-", "exposed", "group", ")", ".", "The", "overall", "incidence", "of", "crown", "fracture", "was", "55.7", "%", "(", "n", "=", "108", ")", ".", "The", "difference", "in", "percentage", "of", "increased", "risk", "of", "crown", "fracture", "in", "exposed", "and", "non", "-", "exposed", "groups", "was", "13.4", "%", ".", "A", "greater", "incidence", "of", "crown", "fracture", "was", "found", "in", "the", "exposed", "group", "(", "64.6", "%", ";", "P", "<", "0,001", ")", ".", "The", "children", "exposed", "(", "RR", ":", "1.30", ";", "95", "%", "CI", ":", "1.01-1.67", ")", "had", "a", "greater", "risk", "of", "developing", "new", "cases", "of", "crown", "fracture", "in", "comparison", "with", "the", "non", "-", "exposed", "group", ".", "The", "incidence", "of", "crown", "fracture", "was", "high", "and", "children", "with", "previous", "crown", "fracture", "had", "a", "greater", "risk", "of", "suffering", "new", "cases", "of", "crown", "fracture", "during", "the", "1-year", "follow-up", "period", "." ]

[ "B-Quantitative Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Finding", "B-Finding", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Age Group", "B-Age Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Health Care Activity", "B-Temporal Concept", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Age Group", "O", "B-Temporal Concept", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Age Group", "B-Age Group", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Age Group", "O", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "B-Age Group", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "B-Finding", "O", "B-Population Group", "B-Population Group", "O", "B-Age Group", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Age Group", "O", "O", "O", "O", "B-Finding", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Anatomical Abnormality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Age Group", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "B-Finding", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "B-Finding", "O", "B-Population Group", "B-Population Group", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Age Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "O", "B-Finding", "O", "B-Population Group", "B-Population Group", "O", "O", "B-Quantitative Concept", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "B-Age Group", "O", "B-Temporal Concept", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "O", "B-Health Care Activity", "B-Temporal Concept", "O" ]

[ "An", "Efficient", "and", "Reliable", "Statistical", "Method", "for", "Estimating", "Functional", "Connectivity", "in", "Large", "Scale", "Brain", "Networks", "Using", "Partial", "Correlation", "Currently", ",", "network-oriented", "analysis", "of", "fMRI", "data", "has", "become", "an", "important", "tool", "for", "understanding", "brain", "organization", "and", "brain", "networks", ".", "Among", "the", "range", "of", "network", "modeling", "methods", ",", "partial", "correlation", "has", "shown", "great", "promises", "in", "accurately", "detecting", "true", "brain", "network", "connections", ".", "However", ",", "the", "application", "of", "partial", "correlation", "in", "investigating", "brain", "connectivity", ",", "especially", "in", "large-scale", "brain", "networks", ",", "has", "been", "limited", "so", "far", "due", "to", "the", "technical", "challenges", "in", "its", "estimation", ".", "In", "this", "paper", ",", "we", "propose", "an", "efficient", "and", "reliable", "statistical", "method", "for", "estimating", "partial", "correlation", "in", "large-scale", "brain", "network", "modeling", ".", "Our", "method", "derives", "partial", "correlation", "based", "on", "the", "precision", "matrix", "estimated", "via", "Constrained", "L1-minimization", "Approach", "(", "CLIME", ")", ",", "which", "is", "a", "recently", "developed", "statistical", "method", "that", "is", "more", "efficient", "and", "demonstrates", "better", "performance", "than", "the", "existing", "methods", ".", "To", "help", "select", "an", "appropriate", "tuning", "parameter", "for", "sparsity", "control", "in", "the", "network", "estimation", ",", "we", "propose", "a", "new", "Dens-based", "selection", "method", "that", "provides", "a", "more", "informative", "and", "flexible", "tool", "to", "allow", "the", "users", "to", "select", "the", "tuning", "parameter", "based", "on", "the", "desired", "sparsity", "level", ".", "Another", "appealing", "feature", "of", "the", "Dens-based", "method", "is", "that", "it", "is", "much", "faster", "than", "the", "existing", "methods", ",", "which", "provides", "an", "important", "advantage", "in", "neuroimaging", "applications", ".", "Simulation", "studies", "show", "that", "the", "Dens-based", "method", "demonstrates", "comparable", "or", "better", "performance", "with", "respect", "to", "the", "existing", "methods", "in", "network", "estimation", ".", "We", "applied", "the", "proposed", "partial", "correlation", "method", "to", "investigate", "resting", "state", "functional", "connectivity", "using", "rs-fMRI", "data", "from", "the", "Philadelphia", "Neurodevelopmental", "Cohort", "(", "PNC", ")", "study", ".", "Our", "results", "show", "that", "partial", "correlation", "analysis", "removed", "considerable", "between-module", "marginal", "connections", "identified", "by", "full", "correlation", "analysis", ",", "suggesting", "these", "connections", "were", "likely", "caused", "by", "global", "effects", "or", "common", "connection", "to", "other", "nodes", ".", "Based", "on", "partial", "correlation", ",", "we", "find", "that", "the", "most", "significant", "direct", "connections", "are", "between", "homologous", "brain", "locations", "in", "the", "left", "and", "right", "hemisphere", ".", "When", "comparing", "partial", "correlation", "derived", "under", "different", "sparse", "tuning", "parameters", ",", "an", "important", "finding", "is", "that", "the", "sparse", "regularization", "has", "more", "shrinkage", "effects", "on", "negative", "functional", "connections", "than", "on", "positive", "connections", ",", "which", "supports", "previous", "findings", "that", "many", "of", "the", "negative", "brain", "connections", "are", "due", "to", "non-neurophysiological", "effects", ".", "An", "R", "package", "``", "DensParcorr", "''", "can", "be", "downloaded", "from", "CRAN", "for", "implementing", "the", "proposed", "statistical", "methods", "." ]

[ "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Research Activity", "B-Research Activity", "O", "B-Quantitative Concept", "B-Functional Concept", "B-Spatial Concept", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "B-Organism Function", "B-Research Activity", "O", "B-Diagnostic Procedure", "B-Idea or Concept", "O", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Physiologic Function", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "O", "O", "O", "O", "O", "B-Organism Function", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Body Part, Organ, or Organ Component", "B-Spatial Concept", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Research Activity", "B-Research Activity", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Organism Function", "B-Research Activity", "O", "O", "B-Intellectual Product", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Activity", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "B-Qualitative Concept", "O", "O", "B-Organism Function", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "O", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Organism Function", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "B-Intellectual Product", "O", "B-Functional Concept", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "B-Research Activity", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Location or Region", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Spatial Concept", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Finding", "B-Functional Concept", "B-Spatial Concept", "O", "O", "B-Finding", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Body Part, Organ, or Organ Component", "B-Spatial Concept", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O" ]

[ "Mitochondrial", "Ultrastructure", "and", "Glucose", "Signaling", "Pathways", "Attributed", "to", "the", "Kv1.3", "Ion", "Channel", "Gene-targeted", "deletion", "of", "the", "potassium", "channel", "Kv1.3", "(", "Kv1.3", "(", "-∕-", ")", ")", "results", "i", "n", "``", "S", "uper-smeller", "''", "mice", "with", "a", "se", "nsory", "p", "h", "enotype", "t", "hat", "includes", "an", "increased", "olfactory", "ability", "linked", "to", "changes", "in", "olfactory", "circuitry", ",", "increased", "abundance", "of", "olfactory", "cilia", ",", "and", "increased", "expression", "of", "odorant", "receptors", "and", "the", "G-protein", ",", "Golf", ".", "Kv1.3", "(", "-∕-", ")", "mice", "a", "lso", "have", "a", "metabolic", "p", "h", "enotype", "i", "ncluding", "lo", "wer", "b", "o", "dy", "weight", "a", "nd", "de", "creased", "a", "d", "iposity", ",", "in", "creased", "total", "energy", "expenditure", "(", "TEE", ")", ",", "increased", "locomotor", "activity", ",", "and", "resistance", "to", "both", "diet", "-", "and", "genetic-induced", "obesity", ".", "We", "explored", "two", "cellular", "aspects", "to", "elucidate", "the", "mechanism", "by", "which", "loss", "of", "Kv1.3", "channel", "in", "the", "olfactory", "bulb", "(", "OB", ")", "may", "enhance", "glucose", "utilization", "and", "metabolic", "rate", ".", "First", ",", "using", "in", "situ", "hybridization", "we", "find", "that", "Kv1.3", "and", "the", "insulin", "-", "dependent", "glucose", "transporter", "type", "4", "(", "GLUT4", ")", "are", "co-localized", "to", "the", "mitral", "cell", "layer", "of", "the", "OB", ".", "Disruption", "of", "Kv1.3", "conduction", "via", "construction", "of", "a", "pore", "mutation", "(", "W386F", "Kv1.3", ")", "was", "sufficient", "to", "independently", "translocate", "GLUT4", "to", "the", "plasma", "membrane", "in", "HEK", "293", "cells", ".", "Because", "olfactory", "sensory", "perception", "and", "the", "maintenance", "of", "action", "potential", "(", "AP", ")", "firing", "frequency", "by", "mitral", "cells", "of", "the", "OB", "is", "highly", "energy", "demanding", "and", "Kv1.3", "is", "also", "expressed", "in", "mitochondria", ",", "we", "next", "explored", "the", "structure", "of", "this", "organelle", "in", "mitral", "cells", ".", "We", "challenged", "wildtype", "(", "WT", ")", "and", "Kv1.3", "(", "-∕-", ")", "male", "mice", "with", "a", "m", "oderately", "high-fat", "diet", "(", "M", "HF", ",", "31.8", "%", "kcal", "fat", ")", "for", "4", "months", "and", "then", "examined", "OB", "ultrastructure", "using", "transmission", "electron", "microscopy", ".", "In", "WT", "mice", ",", "mitochondria", "were", "significantly", "enlarged", "following", "diet-induced", "obesity", "(", "DIO", ")", "and", "there", "were", "fewer", "mitochondria", ",", "likely", "due", "to", "mitophagy", ".", "Interestingly", ",", "mitochondria", "were", "significantly", "smaller", "in", "Kv1.3", "(", "-∕-", ")", "mice", "c", "ompared", "with", "that", "of", "W", "T", "mice", ".", "Similar", "to", "their", "m", "etabolic", "r", "esistance", "to", "D", "IO", ",", "the", "K", "v1.3", "(", "-∕-", ")", "mice", "ha", "d", "unchanged", "mit", "ochondria", "in", "terms", "of", "cros", "s", "sectional", "area", "and", "abundance", "following", "a", "challenge", "with", "modified", "diet", ".", "We", "are", "very", "interested", "to", "understand", "how", "targeted", "disruption", "of", "the", "Kv1.3", "channel", "in", "the", "OB", "can", "modify", "TEE", ".", "Our", "study", "demonstrates", "that", "Kv1.3", "regulates", "mitochondrial", "structure", "and", "alters", "glucose", "utilization", ";", "two", "important", "metabolic", "changes", "that", "could", "drive", "whole", "system", "changes", "in", "metabolism", "initiated", "at", "the", "OB", "." ]

[ "B-Cell Component", "B-Cell", "O", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Molecular Biology Research Technique", "B-Genetic Function", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "B-Laboratory or Test Result", "O", "O", "B-Molecular Function", "B-Mammal", "O", "B-Mammal", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "O", "O", "B-Quantitative Concept", "B-Organism Function", "B-Organism Attribute", "O", "O", "O", "O", "B-Organism Function", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Cell Component", "B-Cell Component", "O", "O", "B-Quantitative Concept", "B-Genetic Function", "O", "B-Receptor", "B-Receptor", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Organism Attribute", "B-Organism Attribute", "B-Organism Attribute", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Organism Function", "B-Organism Function", "O", "O", "B-Mental Process", "O", "O", "B-Food", "O", "O", "B-Genetic Function", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Molecular Function", "B-Molecular Function", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Hormone", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Cell", "B-Cell", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Functional Concept", "O", "B-Biologically Active Substance", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "O", "O", "B-Cell Function", "B-Biologically Active Substance", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "O", "B-Activity", "O", "B-Cell Function", "B-Cell Function", "B-Cell Function", "B-Cell Function", "B-Cell Function", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Cell", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Cell Component", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell Component", "O", "B-Body Part, Organ, or Organ Component", "B-Cell", "O", "O", "O", "B-Mammal", "O", "B-Mammal", "O", "O", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Cell", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Mammal", "B-Mammal", "O", "B-Cell Component", "O", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Cell Component", "O", "O", "O", "O", "B-Cell Function", "O", "O", "O", "B-Cell Component", "O", "O", "B-Qualitative Concept", "O", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "O", "O", "O", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "O", "B-Cell Component", "B-Cell Component", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Cell Component", "B-Cell Component", "O", "O", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O" ]

[ "Cobalamin", "Protection", "against", "Oxidative", "Stress", "in", "the", "Acidophilic", "Iron-oxidizing", "Bacterium", "Leptospirillum", "Group", "II", "CF-1", "Members", "of", "the", "genus", "Leptospirillum", "are", "aerobic", "iron-oxidizing", "bacteria", "belonging", "to", "the", "phylum", "Nitrospira", ".", "They", "are", "important", "members", "of", "microbial", "communities", "that", "catalyze", "the", "biomining", "of", "sulfidic", "ores", ",", "thereby", "solubilizing", "metal", "ions", ".", "These", "microorganisms", "live", "under", "extremely", "acidic", "and", "metal", "-loaded", "environments", "and", "thus", "must", "tolerate", "high", "concentrations", "of", "reactive", "oxygen", "species", "(", "ROS", ")", ".", "Cobalamin", "(", "vitamin", "B12", ")", "is", "a", "cobalt", "-containing", "tetrapyrrole", "cofactor", "involved", "in", "intramolecular", "rearrangement", "reactions", "and", "has", "recently", "been", "suggested", "to", "be", "an", "intracellular", "antioxidant", ".", "In", "this", "work", ",", "we", "investigated", "the", "effect", "of", "the", "exogenous", "addition", "of", "cobalamin", "on", "oxidative", "stress", "parameters", "in", "Leptospirillum", "group", "II", "strain", "CF-1", ".", "Our", "results", "revealed", "that", "the", "external", "supplementation", "of", "cobalamin", "reduces", "the", "levels", "of", "intracellular", "ROSs", "and", "the", "damage", "to", "biomolecules", ",", "and", "also", "stimulates", "the", "growth", "and", "survival", "of", "cells", "exposed", "to", "oxidative", "stress", "exerted", "by", "ferric", "ion", ",", "hydrogen", "peroxide", ",", "chromate", "and", "diamide", ".", "Furthermore", ",", "exposure", "of", "strain", "CF-1", "to", "oxidative", "stress", "elicitors", "resulted", "in", "the", "transcriptional", "activation", "of", "the", "cbiA", "gene", "encoding", "CbiA", "of", "the", "cobalamin", "biosynthetic", "pathway", ".", "Altogether", ",", "these", "data", "suggest", "that", "cobalamin", "plays", "an", "important", "role", "in", "redox", "protection", "of", "Leptospirillum", "strain", "CF-1", ",", "supporting", "survival", "of", "this", "microorganism", "under", "extremely", "oxidative", "environmental", "conditions", ".", "Understanding", "the", "mechanisms", "underlying", "the", "protective", "effect", "of", "cobalamin", "against", "oxidative", "stress", "may", "help", "to", "develop", "strategies", "to", "make", "biomining", "processes", "more", "effective", "." ]

[ "B-Vitamin", "B-Finding", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Functional Concept", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "O", "O", "B-Bacterium", "O", "B-Qualitative Concept", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Bacterium", "B-Bacterium", "O", "O", "O", "O", "O", "O", "B-Organism", "B-Natural Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "O", "B-Occupational Activity", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "O", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "O", "O", "B-Organism", "O", "O", "O", "O", "O", "B-Inorganic Chemical", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "O", "B-Element, Ion, or Isotope", "O", "O", "B-Vitamin", "O", "B-Vitamin", "B-Vitamin", "O", "O", "O", "B-Element, Ion, or Isotope", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "O", "O", "B-Vitamin", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Conceptual Entity", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Food", "B-Food", "O", "B-Vitamin", "O", "O", "O", "O", "B-Spatial Concept", "B-Element, Ion, or Isotope", "O", "O", "B-Functional Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Organism Function", "O", "B-Cell Function", "B-Cell Function", "B-Cell Function", "O", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "O", "B-Inorganic Chemical", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "O", "O", "O", "B-Bacterium", "B-Bacterium", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Biologically Active Substance", "O", "O", "B-Vitamin", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Vitamin", "O", "O", "O", "O", "O", "B-Molecular Function", "B-Finding", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "O", "O", "O", "B-Organism", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Vitamin", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "B-Phenomenon or Process", "O", "B-Qualitative Concept", "O" ]

[ "Metabolite", "Profiling", "of", "Italian", "Tomato", "Landraces", "with", "Different", "Fruit", "Types", "Increased", "interest", "toward", "traditional", "tomato", "varieties", "is", "fueled", "by", "the", "need", "to", "rescue", "desirable", "organoleptic", "traits", "and", "to", "improve", "the", "quality", "of", "fresh", "and", "processed", "tomatoes", "in", "the", "market", ".", "In", "addition", ",", "the", "phenotypic", "and", "genetic", "variation", "preserved", "in", "tomato", "landraces", "represents", "a", "means", "to", "understand", "the", "genetic", "basis", "of", "traits", "related", "to", "health", "and", "organoleptic", "aspects", "and", "improve", "them", "in", "modern", "varieties", ".", "To", "establish", "a", "framework", "for", "this", "approach", ",", "we", "studied", "the", "content", "of", "several", "metabolites", "in", "a", "panel", "of", "Italian", "tomato", "landraces", "categorized", "into", "three", "broad", "fruit", "type", "classes", "(", "flattened", "/", "ribbed", ",", "pear", "/", "oxheart", ",", "round", "/", "elongate", ")", ".", "Three", "modern", "hybrids", ",", "corresponding", "to", "the", "three", "fruit", "shape", "typologies", ",", "were", "included", "as", "reference", ".", "Red", "ripe", "fruits", "were", "morphologically", "characterized", "and", "biochemically", "analyzed", "for", "their", "content", "in", "glycoalkaloids", ",", "phenols", ",", "amino", "acids", ",", "and", "Amadori", "products", ".", "The", "round", "/", "elongate", "types", "showed", "a", "higher", "content", "in", "glycoalkaloids", ",", "whereas", "flattened", "types", "had", "higher", "levels", "of", "phenolic", "compounds", ".", "Flattened", "tomatoes", "were", "also", "rich", "in", "total", "amino", "acids", "and", "in", "particular", "in", "glutamic", "acid", ".", "Multivariate", "analysis", "of", "amino", "acid", "content", "clearly", "separated", "the", "three", "classes", "of", "fruit", "types", ".", "Making", "allowance", "of", "the", "very", "low", "number", "of", "genotypes", ",", "phenotype-marker", "relationships", "were", "analyzed", "after", "retrieving", "single", "nucleotide", "polymorphisms", "(", "SNPs", ")", "among", "the", "landraces", "available", "in", "the", "literature", ".", "Sixty-six", "markers", "were", "significantly", "associated", "with", "the", "studied", "traits", ".", "The", "positions", "of", "several", "of", "these", "SNPs", "showed", "correspondence", "with", "already", "described", "genomic", "regions", "and", "QTLs", "supporting", "the", "reliability", "of", "the", "association", ".", "Overall", "the", "data", "indicated", "that", "significant", "changes", "in", "quality", "-related", "metabolites", "occur", "depending", "on", "the", "genetic", "background", "in", "traditional", "tomato", "germplasm", ",", "frequently", "according", "to", "specific", "fruit", "shape", "categories", ".", "Such", "a", "variability", "is", "suitable", "to", "harness", "association", "mapping", "for", "metabolic", "quality", "traits", "using", "this", "germplasm", "as", "an", "experimental", "population", ",", "paving", "the", "way", "for", "investigating", "their", "genetic", "/", "molecular", "basis", ",", "and", "facilitating", "breeding", "for", "quality-related", "compounds", "in", "tomato", "fruits", "." ]

[ "B-Biologically Active Substance", "B-Functional Concept", "O", "B-Geographic Area", "B-Food", "B-Conceptual Entity", "O", "O", "B-Food", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "B-Food", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Finding", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "B-Food", "O", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Food", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Organism Attribute", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Geographic Area", "B-Food", "B-Conceptual Entity", "O", "O", "O", "O", "B-Food", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Food", "O", "B-Food", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "O", "O", "O", "B-Organism", "B-Organism", "O", "O", "O", "O", "O", "B-Food", "B-Spatial Concept", "B-Intellectual Product", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Food", "B-Food", "B-Food", "O", "B-Spatial Concept", "B-Activity", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Functional Concept", "B-Food", "O", "O", "B-Qualitative Concept", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "B-Qualitative Concept", "O", "B-Research Activity", "O", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "O", "B-Nucleotide Sequence", "O", "O", "O", "B-Conceptual Entity", "O", "O", "O", "B-Intellectual Product", "O", "O", "B-Nucleotide Sequence", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Research Activity", "B-Organism Attribute", "O", "O", "O", "O", "O", "O", "O", "B-Nucleotide Sequence", "O", "O", "O", "O", "O", "B-Conceptual Entity", "B-Conceptual Entity", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Functional Concept", "B-Food", "B-Cell Component", "O", "O", "O", "O", "O", "B-Food", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "B-Activity", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Organism Attribute", "O", "O", "B-Cell Component", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "B-Organism Function", "O", "B-Qualitative Concept", "B-Chemical", "O", "B-Food", "B-Food", "O" ]

[ "Cross-reactivity", "features", "of", "deoxynivalenol", "(", "DON", ")", "-targeted", "immunoaffinity", "columns", "aiming", "to", "achieve", "simultaneous", "analysis", "of", "DON", "and", "major", "conjugates", "in", "cereal", "samples", "Immunoafﬁnity", "columns", "(", "IACs", ")", "are", "a", "well-established", "tool", "in", "the", "determination", "of", "regulated", "mycotoxins", "in", "food", "and", "feed", "commodities", ".", "However", ",", "they", "also", "have", "the", "potential", "to", "become", "attractive", "pre-concentration", "and", "clean-up", "materials", "for", "the", "determination", "of", "masked", "(", "also", "called", "modified", ")", "mycotoxins", ",", "which", "have", "been", "recognised", "as", "important", "contributors", "to", "the", "toxicological", "hazard", "deriving", "from", "fungal", "spoilage", "of", "goods", ".", "However", ",", "the", "information", "available", "in", "the", "literature", "concerning", "the", "cross-reactivity", "of", "DON", "-", "IACs", "against", "the", "major", "conjugates", "(", "DON-3-G", ",", "15-AcDON", "and", "3-AcDON", ")", "is", "incomplete", "and", "often", "contradictory", ".", "We", "have", "carried", "out", "a", "detailed", "characterisation", "of", "the", "cross-reactivity", "of", "the", "four", "main", "IACs", "brands", "against", "DON", "and", "its", "conjugates", "as", "well", "as", "an", "assessment", "of", "the", "competition", "among", "the", "analytes", ".", "Only", "one", "IAC", "enabled", "the", "simultaneous", "analysis", "of", "all", "relevant", "DON", "forms", "while", "two", "missed", "15-AcDON", "and", "the", "fourth", "one", "missed", "DON-3-G", "and", "3-AcDON", ".", "In", "the", "case", "of", "the", "multivalent", "IAC", ",", "the", "analytes", "modified", "at", "the", "C-3", "position", "compete", "for", "the", "antibody", "binding", "with", "preference", "for", "3-AcDON", "(", "less", "spatially", "hindered", ")", "while", "DON-3-G", "has", "the", "more-hindered", "access", "to", "the", "active", "sites", ".", "Taking", "into", "consideration", "the", "levels", "of", "DON", "conjugates", "existing", "in", "real", "samples", ",", "the", "cross-reactivity", "of", "one", "DON", "-", "IAC", "allows", "a", "quantitative", "analysis", "of", "all", "of", "these", "analytes", ".", "Important", "but", "rather", "neglected", "aspects", "such", "as", "the", "continuous", "supply", "of", "IACs", "with", "identical", "characteristics", ",", "and", "of", "columns", "which", "are", "strictly", "blank", ",", "are", "also", "addressed", "in", "this", "paper", "." ]

[ "B-Molecular Function", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Laboratory Procedure", "B-Medical Device", "O", "O", "O", "B-Temporal Concept", "B-Laboratory Procedure", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Chemical Viewed Structurally", "O", "B-Food", "B-Substance", "B-Laboratory Procedure", "B-Medical Device", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Food", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologic Function", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "B-Phenomenon or Process", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Molecular Function", "O", "B-Hazardous or Poisonous Substance", "O", "B-Medical Device", "O", "O", "O", "B-Chemical Viewed Structurally", "O", "B-Organic Chemical", "O", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Molecular Function", "O", "O", "O", "O", "B-Medical Device", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Chemical Viewed Structurally", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Medical Device", "O", "O", "B-Temporal Concept", "B-Laboratory Procedure", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "B-Organic Chemical", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Receptor", "B-Receptor", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "B-Organic Chemical", "O", "O", "O", "O", "O", "O", "B-Receptor", "B-Receptor", "O", "O", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Chemical Viewed Structurally", "O", "O", "B-Substance", "B-Substance", "O", "O", "B-Molecular Function", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Medical Device", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "A", "longitudinal", "study", "assessing", "childcare", "services", "'", "adoption", "of", "obesity", "prevention", "policies", "and", "practices", "Despite", "ongoing", "investments", "to", "improve", "the", "obesogenic", "environments", "of", "childcare", "settings", ",", "little", "is", "known", "regarding", "how", "these", "services", "have", "changed", "their", "physical", "activity", "and", "nutrition-promoting", "practices", ".", "This", "study", "aims", "to", "describe", "changes", "in", "the", "proportion", "of", "Australian", "childcare", "services", "that", "have", "adopted", "best-practice", "healthy", "eating", "and", "physical", "activity", "practices", "between", "2006", "and", "2013", "and", "to", "assess", "whether", "adoption", "varied", "by", "socio-economic", "status", "and", "locality", ".", "A", "randomly", "selected", "sample", "of", "nominated", "supervisors", "(", "n", "=", "358", ")", "from", "childcare", "services", "located", "in", "New", "South", "Wales", ",", "Australia", ",", "participated", "in", "a", "telephone", "survey", "in", "2006", ",", "2009", ",", "2010", "and", "2013", ".", "Supervisors", "reported", "on", "their", "service", "'s", "adoption", "of", "six", "practices", ":", "(", "i", ")", "having", "written", "nutrition", "and", "physical", "activity", "policies", ";", "(", "ii", ")", "staff", "trained", "in", "physical", "activity", "and", "nutrition", "in", "the", "past", "year", ";", "(", "iii", ")", "scheduled", "time", "for", "fundamental", "movement", "skills", "and", "(", "iv", ")", "outdoor", "play", ";", "(", "v", ")", "weekly", "or", "less", "screen", "time", "opportunitie", "s", ";", "and", "(", "vi", ")", "serving", "only", "non-sweetened", "beverages", ".", "A", "significant", "increase", "in", "the", "prevalence", "of", "services", "adopting", "all", "but", "one", "practice", ",", "between", "2006", "and", "2013", "was", "identified", ".", "Ninety", "one", "percent", "of", "services", "adopted", "four", "or", "more", "practices", ",", "a", "significant", "increase", "from", "38", "%", "in", "2006", ".", "There", "were", "no", "differences", "in", "the", "proportion", "of", "services", "adopting", "each", "practice", "by", "locality", "and", "socio-economic", "status", ".", "Government", "investment", "in", "obesity", "prevention", "programmes", "can", "equitably", "improve", "childcare", "service", "'s", "adoption", "of", "healthy", "eating", "and", "physical", "activity", "promoting", "practices", "on", "a", "jurisdiction", "-wide", "basis", ".", "The", "establishment", "of", "a", "routine", "system", "to", "monitor", "adoption", "of", "a", "broader", "range", "of", "practices", "by", "childcare", "services", "is", "warranted", "." ]

[ "O", "B-Research Activity", "B-Research Activity", "O", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Disease or Syndrome", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Spatial Concept", "O", "B-Occupational Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "O", "B-Health Care Activity", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "B-Intellectual Product", "O", "O", "O", "O", "B-Professional or Occupational Group", "O", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Organism Function", "B-Individual Behavior", "O", "O", "O", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Occupational Activity", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "B-Health Care Activity", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Organization", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "B-Occupational Activity", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Health Care Activity", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "O" ]

[ "Improving", "Early", "Identification", "and", "Ongoing", "Care", "of", "Children", "With", "Autism", "Spectrum", "Disorder", "Poor", "adherence", "to", "recommended", "screening", "for", "autism", "spectrum", "disorder", "(", "ASD", ")", "and", "pediatricians", "'", "lack", "of", "confidence", "in", "providing", "care", "for", "children", "with", "ASD", "reflect", "quality", "gaps", "in", "primary", "care", ".", "This", "study", "aimed", "to", "increase", "the", "proportion", "of", "toddlers", "screened", "for", "ASD", "and", "improve", "physicians", "'", "self-efficacy", "in", "providing", "care", "to", "children", "with", "ASD", ".", "Twenty-six", "Utah", "primary", "care", "practices", "participated", "in", "a", "3", "to", "6", "month", "learning", "collaborative", "(", "LC", ")", "to", "improve", "identification", "and", "ongoing", "care", "of", "children", "with", "ASD", ".", "Monthly", "chart", "audits", "assessed", "whether", "an", "ASD", "screening", "tool", "was", "administered", "at", "18-", "and", "24-", "month", "visits", ".", "Physicians", "completed", "pre-LC", "and", "post-LC", "surveys", "to", "assess", "changes", "in", "self-efficacy", "in", "providing", "care", "and", "changes", "in", "perceived", "barriers", "to", "implementation", "of", "screening", "and", "caring", "for", "children", "with", "ASD", ".", "Before", "the", "LC", ",", "15", "%", "of", "18-", "and", "24-", "month", "visits", "had", "documented", "ASD", "screening", ",", "compared", "with", "91", "%", "during", "the", "last", "month", "of", "the", "LC", "(", "P", "<", ".001", ")", ".", "This", "rate", "of", "ASD", "screening", "was", "sustained", "4", "years", "after", "the", "LC", "by", "most", "practices", ".", "Compared", "with", "survey", "responses", "before", "the", "LC", ",", "physicians", "reported", "significant", "improvement", "in", "their", "ability", "to", "care", "for", "children", "with", "ASD", "and", "decreases", "in", "their", "perceived", "barriers", "to", "screening", "and", "caring", "for", "children", "with", "ASD", ".", "The", "LC", "was", "effective", "in", "increasing", "and", "sustaining", "recommended", "ASD", "screening", "of", "toddlers", "and", "improving", "physicians", "'", "perceived", "self-efficacy", "in", "caring", "for", "children", "with", "ASD", ".", "Improving", "primary", "care", "screening", ",", "skills", ",", "and", "knowledge", "may", "improve", "the", "timing", "of", "diagnosis", ",", "initiation", "of", "treatment", ",", "quality", "of", "care", ",", "and", "outcomes", "for", "children", "with", "ASD", "." ]

[ "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "B-Professional or Occupational Group", "O", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Age Group", "O", "O", "B-Finding", "O", "B-Finding", "B-Professional or Occupational Group", "O", "B-Mental Process", "O", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Organization", "B-Organization", "O", "B-Organization", "O", "O", "B-Finding", "B-Mental Process", "O", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Finding", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Health Care Activity", "O", "B-Professional or Occupational Group", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "B-Intellectual Product", "O", "O", "B-Functional Concept", "O", "B-Mental Process", "O", "O", "B-Activity", "O", "O", "O", "B-Mental Process", "B-Qualitative Concept", "O", "B-Activity", "O", "B-Health Care Activity", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "O", "O", "B-Organization", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Health Care Activity", "O", "B-Health Care Activity", "B-Finding", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Organization", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Health Care Activity", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Organization", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "B-Organization", "O", "B-Professional or Occupational Group", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "O", "O", "O", "B-Mental Process", "B-Qualitative Concept", "O", "B-Health Care Activity", "O", "B-Activity", "O", "B-Age Group", "O", "B-Finding", "O", "O", "B-Organization", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Health Care Activity", "O", "B-Age Group", "O", "O", "B-Professional or Occupational Group", "O", "O", "B-Mental Process", "O", "B-Individual Behavior", "O", "B-Age Group", "O", "B-Finding", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "O", "B-Finding", "O", "B-Temporal Concept", "O", "B-Research Activity", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Functional Concept", "O", "B-Age Group", "O", "B-Finding", "O" ]

[ "Describing", "Self-Care", "Self-Efficacy", ":", "Definition", ",", "Measurement", ",", "Outcomes", ",", "and", "Implications", "The", "pragmatic", "utility", "method", "of", "concept", "analysis", "was", "used", "to", "explore", "the", "usefulness", "of", "the", "concept", "self-care", "self-efficacy", ".", "Empirical", "studies", "across", "disciplines", "published", "between", "1996", "and", "2015", "were", "used", "as", "data", ".", "A", "data", "matrix", "was", "developed", ".", "Analytical", "questions", "and", "responses", "were", "derived", "from", "the", "data", "to", "understand", "patterns", ",", "develop", "new", "knowledge", "and", "achieve", "synthesis", ".", "Usefulness", "of", "the", "concept", "is", "contingent", "on", "how", "it", "is", "defined", "and", "measured", ".", "Self-care", "self-efficacy", "is", "associated", "with", "performance", "of", "self-care", "activities", "and", "positive", "health", "outcomes", "in", "diverse", "populations", ".", "Research", "can", "guide", "development", "of", "targeted", "interventions", "to", "increase", "patients", "'", "self-care", "self-efficacy", ",", "thus", "reducing", "costs", ",", "and", "assisting", "people", "to", "achieve", "optimal", "health", "." ]

[ "O", "B-Daily or Recreational Activity", "B-Mental Process", "O", "B-Intellectual Product", "O", "B-Functional Concept", "O", "B-Functional Concept", "O", "O", "B-Idea or Concept", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "B-Idea or Concept", "B-Research Activity", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "B-Daily or Recreational Activity", "B-Mental Process", "O", "B-Research Activity", "B-Research Activity", "O", "B-Occupation or Discipline", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Intellectual Product", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Daily or Recreational Activity", "B-Mental Process", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Activity", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "B-Finding", "B-Occupational Activity", "B-Occupational Activity", "O", "B-Qualitative Concept", "B-Population Group", "O", "B-Research Activity", "O", "O", "B-Functional Concept", "O", "O", "B-Health Care Activity", "O", "O", "B-Patient or Disabled Group", "O", "B-Daily or Recreational Activity", "B-Mental Process", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "B-Health Care Activity", "B-Population Group", "O", "O", "B-Qualitative Concept", "B-Idea or Concept", "O" ]

[ "Dynamics", "of", "intestinal", "metabolites", "and", "morphology", "in", "response", "to", "necrotic", "enteritis", "challenge", "in", "broiler", "chickens", "Despite", "the", "relatively", "small", "contribution", "to", "metabolizable", "energy", "that", "volatile", "fatty", "acids", "(", "VFAs", ")", "provide", "in", "chickens", ",", "these", "organic", "acids", "have", "been", "reported", "to", "play", "beneficial", "roles", "in", "the", "gastrointestinal", "tract", "(", "GIT", ")", "of", "birds", ",", "for", "example", ",", "inhibition", "of", "the", "growth", "of", "some", "pathogenic", "bacteria", ".", "However", ",", "information", "regarding", "the", "dynamics", "of", "these", "metabolites", "in", "the", "GIT", "of", "chickens", "is", "still", "scarce", ",", "especially", "under", "disease", "conditions", "such", "as", "necrotic", "enteritis", "(", "NE", ")", ".", "Here", ",", "we", "investigated", "the", "dynamics", "of", "VFAs", "and", "lactic", "acid", ",", "and", "intestinal", "morphology", "in", "response", "to", "NE", "predisposing", "factors", ",", "that", "is", ",", "excessive", "dietary", "fishmeal", "and", "Eimeria", "inoculation", ",", "and", "causative", "agent", "Clostridium", "perfringens", "producing", "NetB", "toxin", ".", "The", "experiment", "was", "designed", "in", "a", "2", "×", "2", "×", "2", "factorial", "arrangement", "of", "treatments", "with", "or", "without", ":", "fishmeal", "feeding", ",", "Eimeria", "inoculation", "and", "C.", "perfringens", "challenge", ".", "The", "results", "showed", "that", "these", "factors", "significantly", "influenced", "composition", "and", "concentration", "of", "VFAs", "and", "lactic", "acids", ",", "pH", "and", "histomorphometry", "in", "one", "way", "or", "another", ".", "These", "changes", "may", "be", "important", "for", "the", "onset", "of", "NE", "or", "only", "the", "synergetic", "responses", "to", "micro", "environmental", "stress", ".", "Eimeria", "appeared", "to", "be", "more", "important", "than", "fishmeal", "in", "predisposing", "birds", "to", "NE", ",", "thus", "the", "application", "of", "Eimeria", "in", "NE", "challenge", "provides", "more", "consistent", "success", "in", "inducing", "the", "disease", ".", "The", "metabolic", "responses", "to", "various", "adverse", "factors", "such", "as", "excessive", "dietary", "fishmeal", "and", "Eimeria", "infection", "are", "complex", ".", "Thus", ",", "intensive", "efforts", "are", "required", "to", "better", "understand", "NE", "so", "as", "to", "achieve", "the", "control", "of", "the", "disease", "in", "the", "absence", "of", "antibiotics", "." ]

[ "B-Natural Phenomenon or Process", "O", "B-Body Part, Organ, or Organ Component", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "O", "B-Organism Attribute", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Health Care Activity", "O", "B-Bird", "B-Bird", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "B-Activity", "O", "B-Functional Concept", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "B-Activity", "O", "B-Bird", "O", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "O", "B-Health Care Activity", "O", "O", "B-Quantitative Concept", "B-Conceptual Entity", "O", "O", "B-Body System", "B-Body System", "O", "B-Body System", "O", "O", "B-Bird", "O", "O", "O", "O", "B-Organism Function", "B-Organism Function", "B-Organism Function", "B-Organism Function", "O", "O", "B-Organism", "B-Bacterium", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Body System", "O", "B-Bird", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Natural Phenomenon or Process", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Qualitative Concept", "O", "B-Organism Attribute", "O", "B-Disease or Syndrome", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Food", "B-Substance", "O", "B-Eukaryote", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "B-Finding", "B-Bacterium", "B-Bacterium", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "B-Research Activity", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Substance", "B-Activity", "O", "B-Eukaryote", "B-Therapeutic or Preventive Procedure", "O", "B-Bacterium", "B-Bacterium", "B-Health Care Activity", "O", "O", "B-Finding", "O", "O", "O", "B-Functional Concept", "B-Idea or Concept", "B-Conceptual Entity", "B-Clinical Attribute", "O", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Disease or Syndrome", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Spatial Concept", "B-Spatial Concept", "B-Finding", "O", "B-Eukaryote", "O", "O", "O", "B-Quantitative Concept", "B-Qualitative Concept", "O", "B-Substance", "O", "B-Functional Concept", "B-Bird", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Functional Concept", "O", "B-Eukaryote", "O", "B-Disease or Syndrome", "B-Health Care Activity", "B-Activity", "O", "B-Idea or Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "B-Organism Attribute", "O", "O", "B-Pathologic Function", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Food", "B-Substance", "O", "B-Eukaryote", "B-Pathologic Function", "O", "B-Qualitative Concept", "O", "O", "O", "B-Qualitative Concept", "B-Organism Function", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Mental Process", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "B-Functional Concept", "O", "B-Antibiotic", "O" ]

[ "The", "effects", "of", "paternal", "high-fat", "diet", "exposure", "on", "offspring", "metabolism", "with", "epigenetic", "changes", "in", "the", "mouse", "adiponectin", "and", "leptin", "gene", "promoters", "Recent", "studies", "have", "demonstrated", "that", "epigenetic", "changes", "resulting", "from", "malnutrition", "might", "play", "important", "roles", "in", "transgenerational", "links", "with", "metabolic", "diseases", ".", "Previously", ",", "we", "observed", "that", "exposure", "to", "a", "high-fat", "diet", "(", "HFD", ")", "in", "utero", "caused", "a", "metabolic", "syndrome", "-like", "phenomenon", "through", "epigenetic", "modifications", "of", "the", "adiponectin", "and", "leptin", "genes", "that", "persisted", "for", "multiple", "generations", ".", "Recent", "etiological", "studies", "indicated", "that", "paternal", "BMI", "had", "effects", "on", "offspring", "BMI", "that", "were", "independent", "of", "but", "additive", "to", "maternal", "BMI", "effects", ".", "Thus", ",", "we", "examined", "whether", "paternal", "HFD", "-", "induced", "obesity", "affected", "the", "metabolic", "status", "of", "offspring", "through", "epigenetic", "changes", "in", "the", "adiponectin", "and", "leptin", "genes", ".", "Additionally", ",", "we", "investigated", "whether", "a", "normal", "diet", "during", "subsequent", "generations", "abolished", "the", "epigenetic", "changes", "associated", "with", "paternal", "HFD", "exposure", "before", "conception", ".", "We", "observed", "the", "effects", "of", "paternal", "HFD", "exposure", "before", "conception", "over", "multiple", "generations", "on", "offspring", "metabolic", "traits", ",", "including", "weight", "and", "fat", "gain", ",", "glucose", "intolerance", ",", "hypertriglyceridemia", ",", "abnormal", "adipocytokine", "levels", ",", "hypertension", ",", "and", "adiponectin", "and", "leptin", "gene", "expression", "and", "epigenetic", "changes", ".", "Normal", "diet", "consumption", "by", "male", "offspring", "during", "the", "subsequent", "generation", "following", "paternal", "HFD", "exposure", "diminished", "whereas", "consumption", "for", "two", "generations", "completely", "abolished", "the", "effect", "of", "paternal", "HFD", "exposure", "on", "metabolic", "traits", "and", "adipocytokine", "promoter", "epigenetic", "changes", "in", "the", "offspring", ".", "The", "effects", "of", "paternal", "HFD", "exposure", "on", "offspring", "were", "relatively", "weaker", "than", "those", "following", "HFD", "exposure", "in", "utero", ".", "However", ",", "paternal", "HFD", "exposure", "had", "an", "additive", "metabolic", "effect", "for", "two", "generations", ",", "suggesting", "that", "both", "paternal", "and", "maternal", "nutrition", "might", "affect", "offspring", "metabolism", "through", "epigenetic", "modifications", "of", "adipocytokine", "genes", "for", "multiple", "generations", "." ]

[ "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Food", "B-Food", "B-Qualitative Concept", "O", "B-Family Group", "B-Organism Function", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Research Activity", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Conceptual Entity", "O", "B-Group Attribute", "B-Group Attribute", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "O", "B-Food", "B-Food", "O", "B-Food", "O", "B-Age Group", "B-Age Group", "B-Functional Concept", "O", "B-Functional Concept", "B-Disease or Syndrome", "O", "B-Phenomenon or Process", "B-Functional Concept", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "B-Quantitative Concept", "B-Temporal Concept", "O", "O", "B-Functional Concept", "B-Research Activity", "B-Finding", "O", "B-Qualitative Concept", "B-Clinical Attribute", "O", "B-Qualitative Concept", "O", "B-Family Group", "B-Clinical Attribute", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Clinical Attribute", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Food", "O", "B-Functional Concept", "B-Disease or Syndrome", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Family Group", "B-Functional Concept", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "B-Temporal Concept", "B-Idea or Concept", "B-Idea or Concept", "B-Activity", "O", "B-Genetic Function", "B-Genetic Function", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "B-Temporal Concept", "B-Organism Function", "O", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "B-Temporal Concept", "B-Organism Function", "O", "B-Quantitative Concept", "B-Temporal Concept", "O", "B-Family Group", "B-Functional Concept", "B-Organism Attribute", "O", "B-Functional Concept", "B-Finding", "O", "B-Pharmacologic Substance", "B-Quantitative Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Genetic Function", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "O", "O", "B-Family Group", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "B-Quantitative Concept", "O", "B-Activity", "O", "O", "B-Temporal Concept", "O", "B-Activity", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Organism Attribute", "O", "B-Biologically Active Substance", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Family Group", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "O", "B-Family Group", "O", "O", "B-Qualitative Concept", "O", "O", "B-Temporal Concept", "B-Food", "B-Qualitative Concept", "B-Age Group", "B-Age Group", "O", "O", "O", "B-Qualitative Concept", "B-Food", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Organism Function", "O", "B-Qualitative Concept", "B-Family Group", "B-Organism Function", "B-Functional Concept", "B-Genetic Function", "B-Genetic Function", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Quantitative Concept", "B-Temporal Concept", "O" ]

[ "Ehlers-Danlos", "syndrome", "The", "Ehlers-Danlos", "syndromes", "(", "EDSs", ")", "were", "originally", "described", "by", "Ehlers", "in", "Denmark", "and", "Danlos", "in", "Paris", "in", "1898", "and", "1908", ",", "respectively", ".", "They", "had", "both", "published", "individual", "case", "studies", "in", "which", "the", "common", "factor", "was", "laxity", "of", "ligaments", "leading", "to", "joint", "hypermobility", "and", "hyperextensibility", "of", "the", "skin", ".", "The", "choice", "of", "the", "name", "of", "this", "eponymous", "disease", "had", "been", "made", "by", "Dr", "Parkes", "Weber", ",", "an", "eminent", "London", "physician", "in", "the", "1930s", ",", "who", "had", "a", "penchant", "for", "eponymous", "diseases", ",", "having", "had", "no", "less", "than", "seven", "attributed", "to", "himself", ",", "at", "least", "in", "part", ".", "Unfortunately", ",", "this", "was", "before", "the", "age", "of", "a", "computerised", "literature", "search", ",", "and", "Parkes", "Weber", "had", "inadvertently", "overlooked", "the", "very", "first", "description", "of", "EDS", "which", "had", "been", "made", "by", "Tchernabogov", ",", "a", "Russian", "dermatologist", ",", "whose", "description", "was", "published", "in", "1891", "and", "remains", "one", "of", "the", "best", "descriptions", "of", "EDS", "in", "the", "literature", "." ]

[ "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Intellectual Product", "O", "B-Human", "O", "B-Geographic Area", "O", "B-Human", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Human", "B-Human", "B-Human", "O", "O", "O", "B-Geographic Area", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "B-Individual Behavior", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Activity", "O", "O", "B-Human", "B-Human", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Human", "O", "O", "B-Population Group", "B-Professional or Occupational Group", "O", "O", "B-Intellectual Product", "O", "B-Occupational Activity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Disease or Syndrome", "O", "O", "B-Intellectual Product", "O" ]

[ "Assessment", "of", "laparoscopic", "stomach", "preserving", "surgery", "with", "sentinel", "basin", "dissection", "versus", "standard", "gastrectomy", "with", "lymphadenectomy", "in", "early", "gastric", "cancer", "-A", "multicenter", "randomized", "phase", "III", "clinical", "trial", "(", "SENORITA", "trial", ")", "protocol", "Along", "with", "the", "marked", "increase", "in", "early", "gastric", "cancer", "(", "EGC", ")", "in", "the", "Eastern", "countries", ",", "there", "has", "been", "an", "effort", "to", "adopt", "the", "sentinel", "node", "concept", "in", "EGC", "to", "preserve", "gastric", "function", "and", "reduce", "the", "occurrence", "of", "postoperative", "complications", ".", "Based", "on", "promising", "results", "from", "a", "previous", "quality", "control", "study", ",", "this", "prospective", "multicenter", "randomized", "controlled", "phase", "III", "clinical", "trial", "aims", "to", "elucidate", "the", "oncologic", "safety", "of", "laparoscopic", "stomach-preserving", "surgery", "with", "sentinel", "basin", "dissection", "(", "SBD", ")", "compared", "to", "a", "standard", "laparoscopic", "gastrectomy", ".", "This", "trial", "is", "an", "investigator-initiated", ",", "open-label", ",", "multicenter", "randomized", "controlled", "phase", "III", "trial", "with", "a", "non-inferiority", "design", ".", "Patients", "diagnosed", "with", "a", "single", "lesion", "of", "clinical", "stage", "T1N0M0", "gastric", "adenocarcinoma", ",", "with", "a", "diameter", "of", "3", "cm", "or", "less", "are", "eligible", "for", "the", "present", "study", ".", "A", "total", "of", "580", "patients", "(", "290", "per", "group", ")", "will", "be", "randomized", "to", "either", "laparoscopic", "stomach-preserving", "surgery", "with", "SBD", "or", "standard", "surgery", ".", "The", "primary", "end-point", "is", "3-year", "disease-free", "survival", "(", "DFS", ")", "and", "the", "secondary", "endpoints", "include", "postoperative", "morbidity", "and", "mortality", ",", "quality", "of", "life", ",", "5-year", "DFS", ",", "and", "overall", "survival", ".", "Qualified", "investigators", "who", "completed", "the", "prior", "quality", "control", "study", "are", "exclusively", "allowed", "to", "participate", "in", "this", "phase", "III", "clinical", "trial", ".", "The", "proposed", "trial", "is", "expected", "to", "verify", "whether", "laparoscopic", "stomach-preserving", "surgery", "with", "SBD", "achieves", "similar", "oncologic", "outcomes", "and", "improved", "quality", "of", "life", "compared", "to", "a", "standard", "gastrectomy", "in", "EGC", "patients", ".", "This", "study", "was", "registered", "at", "the", "NIH", "ClinicalTrial.gov", "database", "(", "NCT01804998", ")", "on", "March", "4th", ",", "2013", "." ]

[ "B-Health Care Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Neoplastic Process", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Neoplastic Process", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Neoplastic Process", "O", "O", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Research Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Neoplastic Process", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Isolation", "and", "characterization", "of", "Burkholderia", "sp", ".", "strain", "CCA53", "exhibiting", "ligninolytic", "potential", "Microbial", "degradation", "of", "lignin", "releases", "fermentable", "sugars", ",", "effective", "utilization", "of", "which", "could", "support", "biofuel", "production", "from", "lignocellulosic", "biomass", ".", "In", "the", "present", "study", ",", "a", "lignin-degrading", "bacterium", "was", "isolated", "from", "leaf", "soil", "and", "identified", "as", "Burkholderia", "sp", ".", "based", "on", "16S", "rRNA", "gene", "sequencing", ".", "This", "strain", "was", "named", "CCA53", ",", "and", "its", "lignin-degrading", "capability", "was", "assessed", "by", "observing", "its", "growth", "on", "medium", "containing", "alkali", "lignin", "or", "lignin", "-associated", "aromatic", "monomers", "as", "the", "sole", "carbon", "source", ".", "Alkali", "lignin", "and", "at", "least", "eight", "lignin", "-associated", "aromatic", "monomers", "supported", "growth", "of", "this", "strain", ",", "and", "the", "most", "effective", "utilization", "was", "observed", "for", "p-hydroxybenzene", "monomers", ".", "These", "findings", "indicate", "that", "Burkholderia", "sp", ".", "strain", "CCA53", "has", "fragmentary", "activity", "for", "lignin", "degradation", "." ]

[ "B-Functional Concept", "O", "B-Activity", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "B-Molecular Function", "B-Qualitative Concept", "B-Organism", "B-Organism Function", "O", "B-Biologically Active Substance", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Organic Chemical", "B-Occupational Activity", "O", "B-Organic Chemical", "B-Quantitative Concept", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Molecular Function", "B-Bacterium", "O", "B-Functional Concept", "O", "B-Plant", "B-Substance", "O", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "O", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Nucleic Acid, Nucleoside, or Nucleotide", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Qualitative Concept", "O", "O", "B-Bacterium", "O", "O", "O", "B-Molecular Function", "B-Qualitative Concept", "O", "B-Activity", "O", "O", "O", "B-Organism Function", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "O", "O", "B-Element, Ion, or Isotope", "B-Finding", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "B-Organism Function", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "O", "B-Finding", "O", "O", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "B-Bacterium", "O", "B-Activity", "B-Activity", "O", "B-Molecular Function", "B-Molecular Function", "O" ]

[ "Association", "of", "Metabolites", "with", "Obesity", "and", "Type", "2", "Diabetes", "Based", "on", "FTO", "Genotype", "The", "single", "nucleotide", "polymorphism", "rs9939609", "of", "the", "gene", "FTO", ",", "which", "encodes", "fat", "mass", "and", "obesity", "-associated", "protein", ",", "is", "strongly", "associated", "with", "obesity", "and", "type", "2", "diabetes", "(", "T2D", ")", "in", "multiple", "populations", ";", "however", ",", "the", "underlying", "mechanism", "of", "this", "association", "is", "unclear", ".", "The", "present", "study", "aimed", "to", "investigate", "FTO", "genotype", "-dependent", "metabolic", "changes", "in", "obesity", "and", "T2D", ".", "To", "elucidate", "metabolic", "dysregulation", "associated", "with", "disease", "risk", "genotype", ",", "genomic", "and", "metabolomic", "datasets", "were", "recruited", "from", "2,577", "participants", "of", "the", "Korean", "Association", "REsource", "(", "KARE", ")", "cohort", ",", "including", "40", "homozygous", "carriers", "of", "the", "FTO", "risk", "allele", "(", "AA", ")", ",", "570", "heterozygous", "carriers", "(", "AT", ")", ",", "and", "1,967", "participants", "carrying", "no", "risk", "allele", "(", "TT", ")", ".", "A", "total", "of", "134", "serum", "metabolites", "were", "quantified", "using", "a", "targeted", "metabolomics", "approach", ".", "Through", "comparison", "of", "various", "statistical", "methods", ",", "seven", "metabolites", "were", "identified", "that", "are", "significantly", "altered", "in", "obesity", "and", "T2D", "based", "on", "the", "FTO", "risk", "allele", "(", "adjusted", "p", "<", "0.05", ")", ".", "These", "identified", "metabolites", "are", "relevant", "to", "phosphatidylcholine", "metabolic", "pathway", ",", "and", "previously", "reported", "to", "be", "metabolic", "markers", "of", "obesity", "and", "T2D", ".", "In", "conclusion", ",", "using", "metabolomics", "with", "the", "information", "from", "genome-wide", "association", "studies", "revealed", "significantly", "altered", "metabolites", "depending", "on", "the", "FTO", "genotype", "in", "complex", "disorders", ".", "This", "study", "may", "contribute", "to", "a", "better", "understanding", "of", "the", "biological", "mechanisms", "linking", "obesity", "and", "T2D", "." ]

[ "O", "O", "B-Biologically Active Substance", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Nucleotide Sequence", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "B-Organism Attribute", "B-Organism Attribute", "O", "B-Disease or Syndrome", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "B-Gene or Genome", "B-Organism Attribute", "O", "B-Organism Function", "B-Functional Concept", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Organism Attribute", "O", "B-Intellectual Product", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Population Group", "O", "O", "B-Population Group", "B-Population Group", "B-Population Group", "B-Population Group", "B-Population Group", "B-Population Group", "B-Population Group", "O", "O", "O", "B-Organism Attribute", "B-Finding", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "B-Organism Attribute", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "O", "O", "O", "O", "O", "B-Body Substance", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Gene or Genome", "B-Organism Attribute", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O" ]

[ "Anthology", "of", "Venezuelan", "psychiatry", "Reception", "of", "Psychiatry", "in", "Venezuela", "since", "the", "19th", "Century", "to", "the", "late", "20th", "Century", "merits", "a", "historical", "approach", ".", "The", "following", "work", "proposes", "to", "research", "some", "of", "the", "very", "origins", "of", "Venezuelan", "psychiatry", "and", "its", "possible", "influence", "on", "contemporary", "mental", "health", "practice", ".", "Through", "documental", "research", ",", "the", "early", "works", "of", "local", "authors", "from", "the", "19th", "Century", "through", "20th", "Century", "finals", ":", "Carlos", "Arvelo", ",", "Lisandro", "Alvarado", ",", "Francisco", "Herrera", "Luque", ",", "Jose", "Luis", "Vethencourt", "and", "Jose", "Solanes", ",", "are", "subjected", "to", "study", ".", "This", "journey", "illustrates", "a", "descriptive", "panoramic", "view", "which", "allows", "to", "better", "comprenhend", "the", "current", "state", "of", "our", "psychiatry", ".", "In", "a", "brief", "introduction", "the", "most", "important", "events", "are", "described", ",", "since", "the", "arrival", "of", "Pinel", "'s", "ideas", ",", "followed", "by", "the", "early", "research", "paperworks", "published", "and", "the", "beginnings", "of", "the", "academic", "teachings", "of", "this", "specialty", "in", "Venezuela", "and", "displaying", "the", "main", "contemporary", "research", "groups", "thorough", "the", "country", "." ]

[ "B-Intellectual Product", "O", "B-Population Group", "B-Biomedical Occupation or Discipline", "B-Qualitative Concept", "O", "B-Biomedical Occupation or Discipline", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "O", "B-Population Group", "B-Biomedical Occupation or Discipline", "O", "O", "O", "B-Conceptual Entity", "O", "O", "B-Health Care Activity", "B-Health Care Activity", "B-Health Care Activity", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Human", "B-Human", "O", "B-Human", "B-Human", "O", "B-Human", "B-Human", "B-Human", "O", "B-Human", "B-Human", "B-Human", "O", "B-Human", "B-Human", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Event", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Human", "B-Human", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "B-Occupational Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O" ]

[ "Study", "of", "the", "Microfocus", "X-Ray", "Tube", "Based", "on", "a", "Point-Like", "Target", "Used", "for", "Micro-Computed", "Tomography", "For", "a", "micro-Computed", "Tomography", "(", "Micro-CT", ")", "system", ",", "the", "microfocus", "X-ray", "tube", "is", "an", "essential", "component", "because", "the", "spatial", "resolution", "of", "CT", "images", ",", "in", "theory", ",", "is", "mainly", "determined", "by", "the", "size", "and", "stability", "of", "the", "X-ray", "focal", "spot", "of", "the", "microfocus", "X-ray", "tube", ".", "However", ",", "many", "factors", ",", "including", "voltage", "fluctuations", ",", "mechanical", "vibrations", ",", "and", "temperature", "changes", ",", "can", "cause", "the", "size", "and", "the", "stability", "of", "the", "X-ray", "focal", "spot", "to", "degrade", ".", "A", "new", "microfocus", "X-ray", "tube", "based", "on", "a", "point-like", "micro-target", "in", "which", "the", "X-ray", "target", "is", "irradiated", "with", "an", "unfocused", "electron", "beam", "was", "investigated", ".", "EGS4", "Monte", "Carlo", "simulation", "code", "was", "employed", "for", "the", "calculation", "of", "the", "X-ray", "intensity", "produced", "from", "the", "point-like", "micro-target", "and", "the", "substrate", ".", "The", "effects", "of", "several", "arrangements", "of", "the", "target", "material", ",", "target", "and", "beam", "size", "were", "studied", ".", "The", "simulation", "results", "demonstrated", "that", "if", "the", "intensity", "of", "X-rays", "generated", "at", "the", "point-like", "target", "is", "greater", "than", "half", "of", "the", "X-ray", "intensity", "produced", "on", "the", "substrate", ",", "the", "X-ray", "focal", "spot", "is", "determined", "in", "part", "by", "the", "point-like", "target", "rather", "than", "by", "the", "electron", "beam", "in", "the", "conventional", "X-ray", "tube", ".", "In", "theory", ",", "since", "it", "is", "able", "to", "reduce", "those", "unfavorable", "effects", "such", "as", "the", "electron", "beam", "trajectory", "swinging", "and", "the", "beam", "size", "changing", "for", "the", "microfocus", "X-ray", "tube", ",", "it", "could", "alleviate", "CT", "image", "artifacts", "caused", "by", "the", "X-ray", "focal", "spot", "shift", "and", "size", "change", "." ]

[ "B-Laboratory Procedure", "O", "O", "B-Spatial Concept", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Spatial Concept", "B-Medical Device", "B-Medical Device", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Spatial Concept", "B-Quantitative Concept", "O", "B-Diagnostic Procedure", "B-Intellectual Product", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "O", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Spatial Concept", "B-Medical Device", "B-Medical Device", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Temporal Concept", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Spatial Concept", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Diagnostic Procedure", "B-Functional Concept", "O", "B-Phenomenon or Process", "O", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Activity", "O", "O", "B-Diagnostic Procedure", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Functional Concept", "B-Substance", "O", "B-Functional Concept", "O", "B-Manufactured Object", "B-Spatial Concept", "O", "B-Laboratory Procedure", "O", "O", "B-Research Activity", "B-Functional Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "B-Diagnostic Procedure", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Diagnostic Procedure", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Substance", "O", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "B-Qualitative Concept", "B-Medical Device", "B-Medical Device", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Manufactured Object", "B-Spatial Concept", "B-Functional Concept", "O", "O", "B-Spatial Concept", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Qualitative Concept", "B-Diagnostic Procedure", "B-Intellectual Product", "B-Human-caused Phenomenon or Process", "B-Idea or Concept", "O", "O", "B-Diagnostic Procedure", "B-Spatial Concept", "B-Spatial Concept", "B-Finding", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O" ]

[ "How", "variation", "between", "individuals", "affects", "species", "coexistence", "Although", "the", "effects", "of", "variation", "between", "individuals", "within", "species", "are", "traditionally", "ignored", "in", "studies", "of", "species", "coexistence", ",", "the", "magnitude", "of", "intraspecific", "variation", "in", "nature", "is", "forcing", "ecologists", "to", "reconsider", ".", "Compelling", "intuitive", "arguments", "suggest", "that", "individual", "variation", "may", "provide", "a", "previously", "unrecognised", "route", "to", "diversity", "maintenance", "by", "blurring", "species", "-", "level", "competitive", "differences", "or", "substituting", "for", "species", "-", "level", "niche", "differences", ".", "These", "arguments", ",", "which", "are", "motivating", "a", "large", "body", "of", "empirical", "work", ",", "have", "rarely", "been", "evaluated", "with", "quantitative", "theory", ".", "Here", "we", "incorporate", "intraspecific", "variation", "into", "a", "common", "model", "of", "competition", "and", "identify", "three", "pathways", "by", "which", "this", "variation", "affects", "coexistence", ":", "(", "1", ")", "changes", "in", "competitive", "dynamics", "because", "of", "nonlinear", "averaging", ",", "(", "2", ")", "changes", "in", "species", "'", "mean", "interaction", "strengths", "because", "of", "variation", "in", "underlying", "traits", "(", "also", "via", "nonlinear", "averaging", ")", "and", "(", "3", ")", "effects", "on", "stochastic", "demography", ".", "As", "a", "consequence", "of", "the", "first", "two", "mechanisms", ",", "we", "find", "that", "intraspecific", "variation", "in", "competitive", "ability", "increases", "the", "dominance", "of", "superior", "competitors", ",", "and", "intraspecific", "niche", "variation", "reduces", "species", "-", "level", "niche", "differentiation", ",", "both", "of", "which", "make", "coexistence", "more", "difficult", ".", "In", "addition", ",", "individual", "variation", "can", "exacerbate", "the", "effects", "of", "demographic", "stochasticity", ",", "and", "this", "further", "destabilises", "coexistence", ".", "Our", "work", "provides", "a", "theoretical", "foundation", "for", "emerging", "empirical", "interests", "in", "the", "effects", "of", "intraspecific", "variation", "on", "species", "diversity", "." ]

[ "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Population Group", "B-Qualitative Concept", "B-Classification", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Population Group", "O", "B-Classification", "O", "B-Functional Concept", "B-Idea or Concept", "O", "B-Research Activity", "O", "B-Classification", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "B-Functional Concept", "B-Professional or Occupational Group", "O", "B-Functional Concept", "O", "O", "B-Individual Behavior", "B-Social Behavior", "B-Idea or Concept", "O", "B-Population Group", "B-Qualitative Concept", "O", "B-Activity", "O", "O", "O", "B-Spatial Concept", "O", "B-Qualitative Concept", "B-Activity", "O", "B-Qualitative Concept", "B-Classification", "O", "B-Qualitative Concept", "B-Social Behavior", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Classification", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "B-Social Behavior", "O", "O", "O", "B-Mental Process", "O", "B-Quantitative Concept", "B-Spatial Concept", "O", "B-Qualitative Concept", "B-Occupational Activity", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "B-Intellectual Product", "O", "B-Social Behavior", "O", "B-Qualitative Concept", "O", "B-Conceptual Entity", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Social Behavior", "B-Intellectual Product", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Classification", "O", "B-Quantitative Concept", "B-Functional Concept", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Organism Attribute", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Finding", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Social Behavior", "B-Organism Attribute", "B-Functional Concept", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Population Group", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Classification", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Population Group", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Qualitative Concept", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "B-Functional Concept", "B-Quantitative Concept", "O", "O", "B-Occupational Activity", "B-Activity", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "B-Mental Process", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Qualitative Concept", "O", "B-Classification", "B-Qualitative Concept", "O" ]

[ "Intracellular", "Metabolism", "of", "α", ",", "β-Unsaturated", "Carbonyl", "Compounds", ",", "Acrolein", ",", "Crotonaldehyde", "and", "Methyl", "Vinyl", "Ketone", ",", "Active", "Toxicants", "in", "Cigarette", "Smoke", ":", "Participation", "of", "Glutathione", "Conjugation", "Ability", "and", "Aldehyde-Ketone", "Sensitive", "Reductase", "Activity", "The", "major", "toxicants", "in", "cigarette", "smoke", ",", "α", ",", "β-unsaturated", "aldehydes", ",", "such", "as", "acrolein", "(", "ACR", ")", "and", "crotonaldehyde", "(", "CA", ")", ",", "and", "α", ",", "β-unsaturated", "ketone", ",", "methyl", "vinyl", "ketone", "(", "MVK", ")", ",", "are", "known", "to", "form", "Michael-type", "adducts", "with", "glutathione", "(", "GSH", ")", "and", "consequently", "cause", "intracellular", "GSH", "depletion", ",", "which", "is", "involved", "in", "cigarette", "smoke", "-", "induced", "cytotoxicity", ".", "We", "have", "previously", "clarified", "that", "exposure", "to", "cigarette", "smoke", "extract", "(", "CSE", ")", "of", "a", "mouse", "melanoma", "cell", "culture", "medium", "causes", "rapid", "reduction", "of", "intracellular", "GSH", "levels", ",", "and", "that", "the", "GSH", "-", "MVK", "adduct", "can", "be", "detected", "by", "LC/MS", "analysis", "while", "the", "GSH", "-", "CA", "adduct", "is", "hardly", "detected", ".", "In", "the", "present", "study", ",", "to", "clarify", "why", "the", "GSH", "-", "CA", "adduct", "is", "difficult", "to", "detect", "in", "the", "cell", "medium", ",", "we", "conducted", "detailed", "investigation", "of", "the", "structures", "of", "the", "reaction", "products", "of", "ACR", ",", "CA", ",", "MVK", "and", "CSE", "in", "the", "GSH", "solution", "or", "the", "cell", "culture", "medium", ".", "The", "mass", "spectra", "indicated", "that", "in", "the", "presence", "of", "the", "cells", ",", "the", "GSH", "-", "CA", "and", "GSH", "-", "ACR", "adducts", "were", "almost", "not", "detected", "while", "their", "corresponding", "alcohols", "were", "detected", ".", "On", "the", "other", "hand", ",", "both", "the", "GSH", "-", "MVK", "adducts", "and", "their", "reduced", "products", "were", "detected", ".", "In", "the", "absence", "of", "the", "cells", ",", "the", "reaction", "of", "GSH", "with", "all", "α", ",", "β-unsaturated", "carbonyls", "produced", "only", "their", "corresponding", "adducts", ".", "These", "results", "show", "that", "the", "GSH", "adducts", "of", "α", ",", "β-unsaturated", "aldehydes", ",", "CA", "and", "ACR", ",", "are", "quickly", "reduced", "by", "certain", "intracellular", "carbonyl", "reductase", "(", "s", ")", "and", "excreted", "from", "the", "cells", ",", "unlike", "the", "GSH", "adduct", "of", "α", ",", "β-unsaturated", "ketone", ",", "MVK", ".", "Such", "a", "difference", "in", "reactivity", "to", "the", "carbonyl", "reductase", "might", "be", "related", "to", "differences", "in", "the", "cytotoxicity", "of", "α", ",", "β-unsaturated", "aldehydes", "and", "ketones", "." ]

[ "B-Cell Function", "B-Cell Function", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "B-Hazardous or Poisonous Substance", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Functional Concept", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Biologically Active Substance", "B-Molecular Function", "O", "O", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "O", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "O", "O", "O", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "B-Spatial Concept", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Functional Concept", "B-Cell or Molecular Dysfunction", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "O", "O", "O", "B-Mammal", "B-Cell", "B-Cell", "B-Indicator, Reagent, or Diagnostic Aid", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Qualitative Concept", "O", "B-Spatial Concept", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Organic Chemical", "B-Chemical Viewed Structurally", "O", "O", "B-Finding", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Biologically Active Substance", "O", "B-Hazardous or Poisonous Substance", "B-Chemical Viewed Structurally", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Hazardous or Poisonous Substance", "B-Chemical Viewed Structurally", "O", "O", "O", "B-Finding", "O", "O", "B-Cell", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Spatial Concept", "O", "O", "B-Chemical Viewed Structurally", "B-Chemical Viewed Structurally", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "B-Hazardous or Poisonous Substance", "O", "B-Organic Chemical", "O", "B-Hazardous or Poisonous Substance", "O", "O", "B-Biologically Active Substance", "B-Substance", "O", "O", "B-Cell", "B-Indicator, Reagent, or Diagnostic Aid", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Cell", "O", "O", "B-Biologically Active Substance", "O", "B-Hazardous or Poisonous Substance", "O", "B-Biologically Active Substance", "O", "B-Indicator, Reagent, or Diagnostic Aid", "B-Chemical Viewed Structurally", "O", "O", "O", "B-Finding", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "B-Organic Chemical", "B-Chemical Viewed Structurally", "O", "O", "B-Entity", "B-Entity", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "B-Functional Concept", "O", "B-Biologically Active Substance", "O", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "O", "O", "O", "B-Chemical Viewed Structurally", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Biologically Active Substance", "B-Chemical Viewed Structurally", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Hazardous or Poisonous Substance", "O", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "O", "B-Natural Phenomenon or Process", "O", "O", "B-Spatial Concept", "B-Enzyme", "B-Enzyme", "B-Enzyme", "B-Enzyme", "B-Enzyme", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "B-Biologically Active Substance", "B-Chemical Viewed Structurally", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "O", "O", "O", "B-Cell or Molecular Dysfunction", "O", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O" ]

[ "Diagnostic", "utility", "of", "additional", "conventional", "techniques", "after", "endobronchial", "ultrasonography", "guidance", "during", "transbronchial", "biopsy", "Endobronchial", "ultrasonography", "with", "a", "guide", "sheath", "transbronchial", "biopsy", "(", "EBUS", "-", "GS", "TBB", ")", "has", "been", "used", "to", "diagnose", "peripheral", "pulmonary", "lesions", "(", "PPLs", ")", ".", "In", "this", "study", ",", "we", "evaluated", "the", "diagnostic", "utility", "of", "conventional", "TBB", "after", "EBUS", "-", "GS", "TBB", ".", "A", "retrospective", "analysis", "of", "patients", "who", "underwent", "conventional", "TBB", "after", "EBUS", "-", "GS", "TBB", "for", "PPL", "between", "August", "1", ",", "2012", "and", "December", "31", ",", "2014", ".", "We", "performed", "multivariate", "analysis", "to", "examine", "the", "association", "of", "various", "clinical", "factors", ",", "including", "EBUS", "probe", "distance", "and", "sample", "size", "area", ",", "with", "diagnostic", "yield", ".", "Of", "88", "eligible", "patients", ",", "57", "(", "65", "%", ")", "were", "successfully", "diagnosed", "by", "EBUS", "-", "GS", "TBB", ".", "In", "31", "patients", "not", "diagnosed", "by", "EBUS", "-", "GS", "TBB", ",", "15", "(", "48", "%", ")", "were", "successfully", "diagnosed", "by", "additional", "conventional", "TBB", ".", "Ground", "glass", "opacity", "(", "GGO", ")", "was", "a", "significant", "factor", "associated", "with", "the", "diagnostic", "yield", "of", "additional", "conventional", "TBB", "following", "EBUS", "-", "GS", "TBB", ".", "Multivariate", "analysis", "and", "receiver", "operator", "curves", "revealed", "that", "distance", "between", "the", "PPL", "and", "the", "EBUS", "probe", "of", "less", "than", "2.55", "mm", "favored", "the", "utility", "of", "conventional", "TBB", ".", "Additional", "conventional", "TBB", "after", "EBUS", "-", "GS", "TBB", "could", "be", "a", "useful", "procedure", "for", "the", "diagnosis", "of", "ground", "glass", "opacity", "PPLs", "and", "in", "cases", "of", "a", "distance", "of", "less", "than", "2.55", "mm", "between", "the", "EBUS", "probe", "and", "the", "lesion", "." ]

[ "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Health Care Activity", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Medical Device", "B-Medical Device", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "O", "B-Research Activity", "B-Research Activity", "O", "B-Patient or Disabled Group", "O", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "O", "O", "B-Diagnostic Procedure", "B-Medical Device", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Finding", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "B-Idea or Concept", "B-Functional Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "O", "B-Finding", "O", "O", "B-Diagnostic Procedure", "B-Medical Device", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "O", "B-Quantitative Concept", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "B-Medical Device", "B-Diagnostic Procedure", "O", "O", "O", "O", "B-Diagnostic Procedure", "O", "O", "B-Finding", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Medical Device", "O", "O", "B-Finding", "O" ]

[ "Strategies", "for", "Assaying", "Lysosomal", "Membrane", "Permeabilization", "Late", "endosomal", "organelles", "have", "an", "acidic", "pH", "and", "contain", "hydrolytic", "enzymes", "to", "degrade", "cargo", "delivered", "either", "from", "the", "extracellular", "environment", "by", "endocytosis", "or", "from", "within", "the", "cell", "itself", "by", "autophagy", ".", "In", "the", "event", "of", "lysosomal", "membrane", "permeabilization", "(", "LMP", ")", ",", "the", "contents", "of", "late", "endosomes", "and", "lysosomes", "can", "be", "released", "into", "the", "cytosol", "and", "then", "initiate", "apoptosis", ".", "Compounds", "that", "can", "trigger", "LMP", "are", "therefore", "candidates", "for", "the", "induction", "of", "apoptosis", ",", "in", "particular", "in", "anticancer", "therapy", ".", "Alternatively", ",", "drug-delivery", "systems", ",", "such", "as", "nanoparticles", ",", "can", "have", "side", "effects", "that", "can", "include", "LMP", ",", "which", "has", "toxic", "consequences", "for", "the", "cells", ".", "To", "determine", "when", ",", "to", "what", "extent", ",", "and", "with", "what", "consequences", "LMP", "occurs", "is", "therefore", "of", "paramount", "importance", "for", "the", "evaluation", "of", "new", "potentially", "LMP", "-", "inducing", "compounds", ".", "In", "this", "introduction", ",", "we", "provide", "an", "overview", "of", "some", "basic", "assays", "for", "assessing", "LMP", ",", "such", "as", "staining", "with", "lysosomotropic", "dyes", "and", "measurement", "of", "cysteine", "cathepsin", "activity", ",", "and", "discuss", "additional", "strategies", "for", "the", "detection", "of", "the", "release", "of", "endogenous", "lysosomal", "molecules", "or", "preloaded", "exogenous", "tracers", "into", "the", "cytosol", "." ]

[ "B-Therapeutic or Preventive Procedure", "O", "B-Laboratory Procedure", "B-Cell Component", "B-Cell Component", "B-Cell Function", "B-Cell Component", "B-Cell Component", "B-Cell Component", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Enzyme", "B-Enzyme", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Cell Component", "B-Spatial Concept", "O", "B-Cell Function", "O", "O", "O", "O", "B-Cell", "O", "O", "B-Cell Function", "O", "O", "O", "O", "O", "B-Cell Component", "B-Cell Component", "B-Cell Function", "O", "B-Cell Function", "O", "O", "O", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Cell Component", "O", "O", "O", "O", "O", "B-Cell Component", "O", "O", "O", "B-Cell Function", "O", "B-Qualitative Concept", "O", "O", "O", "B-Cell Function", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Cell Function", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Medical Device", "B-Medical Device", "O", "O", "O", "B-Manufactured Object", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell Function", "O", "O", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Cell Function", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Cell Function", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Health Care Activity", "B-Cell Function", "O", "O", "O", "O", "O", "B-Indicator, Reagent, or Diagnostic Aid", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "O", "B-Biologically Active Substance", "B-Enzyme", "B-Molecular Function", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "B-Cell Component", "B-Substance", "O", "O", "B-Functional Concept", "B-Indicator, Reagent, or Diagnostic Aid", "O", "O", "B-Cell Component", "O" ]

[ "Active", "diffusion", "and", "microtubule-based", "transport", "oppose", "myosin", "forces", "to", "position", "organelles", "in", "cells", "Even", "distribution", "of", "peroxisomes", "(", "POs", ")", "and", "lipid", "droplets", "(", "LDs", ")", "is", "critical", "to", "their", "role", "in", "lipid", "and", "reactive", "oxygen", "species", "homeostasis", ".", "How", "even", "distribution", "is", "achieved", "remains", "elusive", ",", "but", "diffusive", "motion", "and", "directed", "motility", "may", "play", "a", "role", ".", "Here", "we", "show", "that", "in", "the", "fungus", "Ustilago", "maydis", "~95", "%", "of", "POs", "and", "LDs", "undergo", "diffusive", "motions", ".", "These", "movements", "require", "ATP", "and", "involve", "bidirectional", "early", "endosome", "motility", ",", "indicating", "that", "microtubule", "-", "associated", "membrane", "trafficking", "enhances", "diffusion", "of", "organelles", ".", "When", "early", "endosome", "transport", "is", "abolished", ",", "POs", "and", "LDs", "drift", "slowly", "towards", "the", "growing", "cell", "end", ".", "This", "pole-ward", "drift", "is", "facilitated", "by", "anterograde", "delivery", "of", "secretory", "cargo", "to", "the", "cell", "tip", "by", "myosin-5", ".", "Modelling", "reveals", "that", "microtubule-based", "directed", "transport", "and", "active", "diffusion", "support", "distribution", ",", "mobility", "and", "mixing", "of", "POs", ".", "In", "mammalian", "COS-7", "cells", ",", "microtubules", "and", "F-actin", "also", "counteract", "each", "other", "to", "distribute", "POs", ".", "This", "highlights", "the", "importance", "of", "opposing", "cytoskeletal", "forces", "in", "organelle", "positioning", "in", "eukaryotes", "." ]

[ "B-Functional Concept", "B-Natural Phenomenon or Process", "O", "B-Cell Function", "B-Cell Function", "O", "B-Biologically Active Substance", "B-Phenomenon or Process", "O", "B-Spatial Concept", "B-Cell Component", "O", "B-Cell", "O", "B-Functional Concept", "O", "B-Cell Component", "O", "B-Cell Component", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Cell Component", "O", "O", "O", "O", "O", "B-Conceptual Entity", "O", "B-Organic Chemical", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Biologic Function", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Organism Function", "O", "O", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "O", "B-Fungus", "B-Fungus", "B-Fungus", "O", "O", "O", "B-Cell Component", "O", "B-Cell Component", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Organism Function", "O", "B-Biologically Active Substance", "O", "O", "B-Qualitative Concept", "O", "B-Cell Component", "B-Organism Function", "O", "O", "O", "B-Cell Component", "O", "B-Qualitative Concept", "B-Cell Component", "B-Cell Function", "B-Activity", "B-Natural Phenomenon or Process", "O", "B-Cell Component", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "O", "O", "B-Cell Component", "O", "B-Cell Component", "O", "O", "O", "O", "B-Cell Component", "B-Cell Component", "B-Cell Component", "O", "O", "B-Cell Function", "B-Cell Function", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "O", "B-Cell Component", "B-Cell Component", "O", "B-Enzyme", "O", "B-Research Activity", "O", "O", "B-Cell Function", "B-Cell Function", "B-Cell Function", "O", "B-Functional Concept", "B-Natural Phenomenon or Process", "O", "B-Functional Concept", "O", "B-Cell Function", "O", "O", "O", "B-Cell Component", "O", "O", "B-Mammal", "B-Cell", "B-Cell", "O", "B-Cell Component", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Cell Component", "O", "O", "O", "O", "O", "O", "O", "B-Cell Component", "B-Phenomenon or Process", "O", "B-Cell Component", "B-Spatial Concept", "O", "B-Eukaryote", "O" ]

[ "Stimulation", "of", "cell", "proliferation", "by", "glutathione", "monoethyl", "ester", "in", "aged", "bone", "marrow", "stromal", "cells", "is", "associated", "with", "the", "assistance", "of", "TERT", "gene", "expression", "and", "telomerase", "activity", "The", "proliferation", "and", "differentiation", "potential", "of", "aged", "bone", "marrow", "stromal", "cells", "(", "BMSCs", ")", "are", "significantly", "reduced", ".", "In", "order", "to", "improve", "the", "performance", "of", "the", "aged", "BMSCs", ",", "these", "cells", "were", "treated", "with", "2", "mM", "glutathione", "monoethyl", "ester", "(", "GSH-MEE", ")", "for", "24", "h.", "Proliferation", "rate", ",", "telomerase", "activity", ",", "telomere", "length", ",", "and", "differentiation", "to", "cholinergic", "neuron-like", "cells", "(", "CNLCs", ")", "were", "observed", "to", "increase", ".", "Though", ",", "the", "expression", "level", "of", "telomerase", "reverse", "transcriptase", "gene", "increased", ",", "but", "CTC1", "and", "TEN1", "genes", "from", "Ctc1-Stn1-Ten1", "complex", "encoding", "proteins", "with", "regulatory", "function", "significantly", "decreased", ".", "Trypan", "blue", "exclusion", "assay", "was", "used", "to", "analyze", "the", "proliferation", "and", ",", "while", "telomere", "length", ",", "its", "several", "related", "gene", "expressions", ",", "and", "telomerase", "activity", "were", "measured", "using", "the", "real", "time", "reverse", "transcription-polymerase", "chain", "reaction", "and", "polymerase", "chain", "reaction", "enzyme-linked", "immunosorbent", "assay", "techniques", ",", "respectively", ".", "CNLCs", "differentiation", "potential", "was", "evaluated", "by", "estimating", "the", "percentage", "of", "choline", "acetyltransferase", "immunereactive", "cells", ".The", "results", "suggested", "that", "GSH-MEE", "could", "improve", "aged", "rat", "BMSC", "properties", "and", "would", "be", "of", "potential", "benefit", "for", "enhancing", "the", "performance", "of", "aged", "people", "'s", "BMSCs", "." ]

[ "B-Functional Concept", "O", "B-Cell Function", "B-Cell Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Gene or Genome", "B-Genetic Function", "B-Genetic Function", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Cell Function", "O", "B-Cell Function", "B-Qualitative Concept", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "B-Organism Attribute", "B-Cell", "O", "O", "B-Cell", "O", "B-Functional Concept", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "B-Cell Function", "B-Quantitative Concept", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Cell Component", "B-Quantitative Concept", "O", "O", "B-Cell Function", "O", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Gene or Genome", "B-Functional Concept", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Cell Component", "B-Cell Component", "B-Activity", "B-Biologically Active Substance", "O", "B-Genetic Function", "B-Genetic Function", "O", "B-Quantitative Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Cell Function", "O", "O", "O", "B-Cell Component", "B-Quantitative Concept", "O", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "B-Cell", "B-Cell Function", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "B-Gene or Genome", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Finding", "O", "B-Mammal", "B-Cell", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Activity", "O", "O", "O", "B-Population Group", "B-Population Group", "B-Population Group", "B-Cell", "O" ]

[ "Wild", "food", "plants", "and", "fungi", "used", "in", "the", "mycophilous", "Tibetan", "community", "of", "Zhagana", "(", "Tewo", "County", ",", "Gansu", ",", "China", ")", "The", "aim", "of", "the", "study", "was", "to", "investigate", "knowledge", "and", "use", "of", "wild", "food", "plants", "and", "fungi", "in", "a", "highland", "valley", "in", "the", "Gannan", "Tibetan", "Autonomous", "Region", "on", "the", "north-eastern", "edges", "of", "the", "Tibetan", "Plateau", ".", "Field", "research", "was", "carried", "out", "in", "four", "neighbouring", "villages", "in", "a", "mountain", "valley", "of", "the", "Diebu", "(", "Tewo", ")", "county", ",", "surrounded", "by", "spruce", "forests", ".", "The", "study", "consisted", "of", "30", "interviews", "with", "single", "informants", ",", "or", "group", "interviews", "(", "altogether", "63", "informants", ")", ".", "Apart", "from", "collecting", "voucher", "specimens", ",", "we", "also", "identified", "fungi", "using", "DNA", "barcoding", ".", "We", "recorded", "the", "use", "of", "54", "species", "of", "vascular", "plants", ".", "We", "also", "recorded", "the", "use", "of", "22", "mushroom", "taxa", ",", "which", "made", "up", "the", "largest", "category", "of", "wild", "foods", ".", "Fruits", "formed", "the", "largest", "category", "of", "food", "plants", ",", "with", "21", "species", ",", "larger", "than", "the", "wild", "greens", "category", ",", "which", "consisted", "of", "20", "species", "eaten", "after", "boiling", "or", "frying", "and", "7", "as", "raw", "snacks", ".", "We", "also", "recorded", "the", "alimentary", "use", "of", "10", "species", "of", "edible", "flowers", "and", "3", "species", "with", "underground", "edible", "organs", ".", "On", "average", ",", "20.8", "edible", "taxa", "were", "listed", "per", "interview", "(", "median", "-", "21", ")", ".", "The", "most", "listed", "category", "of", "wild", "foods", "was", "green", "vegetables", "(", "mean", "-", "7.5", "species", ",", "median", "-", "8", "species", ")", ",", "but", "fruits", "and", "mushrooms", "were", "listed", "nearly", "as", "frequently", "(", "mean", "-", "6.3", ",", "median", "-", "6", "and", "mean", "-", "5.8", ",", "-", "median", "6", "respectively", ")", ".", "Other", "category", "lists", "were", "very", "short", ",", "e.g.", ",", "flowers", "(", "mean", "-", "1.3", ",", "median", "-", "1", ")", "and", "underground", "edible", "parts", "(", "mean", "-", "0.7", ",", "median", "-", "1", ")", ".", "Wild", "vegetables", "are", "usually", "boiled", "and/or", "fried", "and", "served", "as", "side-dishes", ",", "or", "their", "green", "parts", "are", "eaten", "as", "snacks", "during", "mountain", "treks", "(", "e.g.", ",", "peeled", "rhubarb", "shoots", ")", ".", "Wild", "fruits", "are", "mainly", "collected", "by", "children", "and", "eaten", "raw", ",", "they", "are", "not", "stored", "for", "further", "use", ".", "The", "most", "widely", "used", "wild", "staple", "foods", "are", "Potetilla", "anserina", "roots", ",", "an", "important", "ceremonial", "food", "served", "on", "such", "occasions", "as", "New", "Year", "or", "at", "funerals", ".", "They", "are", "boiled", "and", "served", "with", "sugar", "and", "butter", ".", "The", "most", "important", "famine", "plants", "remembered", "by", "people", "are", "the", "aerial", "bulbils", "of", "Persicaria", "vivipara", ".", "Flowers", "are", "used", "as", "children", "'s", "snacks", "-", "their", "nectar", "is", "sucked", ".", "The", "number", "of", "wild", "taxa", "eaten", "in", "the", "studied", "valley", "is", "similar", "to", "that", "of", "other", "Tibetan", "areas", ".", "The", "structure", "of", "wild", "food", "plant", "taxa", "is", "also", "very", "typical", "for", "Tibetan", "speaking", "areas", "(", "e.g.", ",", "the", "use", "of", "rhubarb", "shoots", ",", "Potentilla", "anserina", ",", "Persicaria", "vivipara", ")", ".", "The", "studied", "community", "show", "a", "high", "level", "of", "mycophilia", "." ]

[ "B-Food", "B-Food", "B-Food", "O", "B-Fungus", "O", "O", "O", "B-Food", "B-Geographic Area", "B-Group", "O", "B-Geographic Area", "O", "B-Geographic Area", "B-Geographic Area", "O", "B-Geographic Area", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Functional Concept", "B-Intellectual Product", "O", "O", "O", "B-Food", "B-Food", "B-Food", "O", "B-Fungus", "O", "O", "O", "B-Spatial Concept", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "O", "O", "B-Geographic Area", "B-Spatial Concept", "O", "O", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "B-Research Activity", "O", "O", "O", "B-Activity", "O", "O", "B-Functional Concept", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Substance", "O", "O", "O", "O", "B-Fungus", "O", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "B-Food", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "O", "B-Classification", "O", "O", "O", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Classification", "B-Organism Function", "O", "B-Occupational Activity", "O", "B-Occupational Activity", "O", "O", "O", "B-Qualitative Concept", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Classification", "O", "B-Plant", "B-Plant", "O", "O", "B-Classification", "O", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "O", "B-Activity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "B-Food", "B-Food", "O", "O", "O", "O", "B-Classification", "O", "O", "O", "O", "B-Classification", "O", "O", "O", "B-Food", "O", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "B-Occupational Activity", "O", "O", "O", "O", "O", "B-Plant", "B-Plant", "O", "B-Organism Function", "O", "B-Food", "O", "B-Geographic Area", "B-Daily or Recreational Activity", "O", "O", "O", "B-Plant", "B-Plant", "B-Plant", "O", "O", "B-Food", "B-Food", "O", "O", "O", "O", "B-Age Group", "O", "B-Organism Function", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Food", "B-Food", "B-Food", "O", "B-Plant", "B-Plant", "B-Plant", "O", "O", "O", "B-Food", "B-Food", "B-Occupational Activity", "O", "O", "B-Event", "O", "O", "O", "O", "O", "B-Social Behavior", "O", "O", "O", "B-Qualitative Concept", "O", "B-Occupational Activity", "O", "B-Pharmacologic Substance", "O", "B-Food", "O", "O", "O", "O", "B-Phenomenon or Process", "B-Plant", "O", "O", "B-Population Group", "O", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Plant", "O", "B-Plant", "O", "O", "O", "B-Age Group", "B-Age Group", "B-Food", "O", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "O", "B-Plant", "B-Plant", "B-Organism Function", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "B-Geographic Area", "B-Geographic Area", "O", "O", "O", "O", "B-Food", "B-Food", "B-Food", "O", "O", "O", "O", "O", "O", "B-Language", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "B-Group", "O", "O", "O", "O", "O", "B-Food", "O" ]

[ "Early", "assessment", "of", "bilateral", "inguinal", "hernia", "repair", ":", "A", "comparison", "between", "the", "laparoscopic", "total", "extraperitoneal", "and", "Stoppa", "approaches", "The", "present", "clinical", "trial", "was", "designed", "to", "compare", "the", "results", "of", "bilateral", "inguinal", "hernia", "repair", "between", "patients", "who", "underwent", "the", "conventional", "Stoppa", "technique", "and", "laparoscopic", "total", "extraperitoneal", "repair", "(", "LTE", ")", "with", "a", "single", "mesh", "and", "without", "staple", "fixation", ".", "This", "controlled", ",", "randomised", "clinical", "trial", "was", "conducted", "at", "General", "Surgery", "and", "Trauma", "of", "the", "Clinics", "Hospital", ",", "Medical", "School", ",", "the", "University", "of", "Sγo", "Paulo", "between", "September", "2010", "and", "February", "2011", ".", "Totally", ",", "50", "male", "patients", ",", "with", "a", "bilateral", "inguinal", "hernia", ",", "older", "than", "25", "years", "were", "considered", "eligible", "for", "the", "study", ".", "The", "following", "parameters", "were", "analysed", "during", "the", "early", "post-operative", "period", ":", "(", "1", ")", "The", "intensity", "of", "surgical", "trauma", ",", "operation", "time", ",", "C-reactive", "protein", "(", "CRP", ")", "levels", ",", "white", "blood", "cell", "count", ",", "bleeding", "and", "pain", "intensity", ";", "(", "2", ")", "quality", "of", "life", "assessment", ";", "and", "(", "3", ")", "post-operative", "complications", ".", "LTE", "procedure", "was", "longer", "than", "the", "Stoppa", "procedure", "(", "134.6", "min", "΁", "38.3", "vs.", "90.6", "min", "΁", "41.3", ";", "P", "<", "0.05", ")", ".", "The", "levels", "of", "CRP", "were", "higher", "in", "the", "Stoppa", "group", "(", "P", "<", "0.05", ")", "but", "the", "number", "of", "leucocytes", ",", "haematocrit", ",", "and", "haemoglobin", "were", "similar", "between", "the", "groups", "(", "P", ">", "0.05", ")", ".", "There", "was", "no", "difference", "in", "pain", "during", "the", "1", "st", "and", "7", "th", "post-operative", ",", "physical", "functioning", ",", "physical", "limitation", ",", "the", "impact", "of", "pain", "on", "daily", "activities", ",", "and", "the", "Carolinas", "Comfort", "Scale", "during", "the", "7", "th", "and", "15", "th", "post-operative", "(", "P", ">", "0.05", ")", ".", "Complications", "occurred", "in", "88", "%", "of", "Stoppa", "group", "(", "22", "patients", ")", "and", "64", "%", "in", "LTE", "group", "(", "16", "patients", ")", "(", "P", "<", "0.05", ")", ".", "The", "comparative", "study", "between", "the", "Stoppa", "and", "LTE", "approaches", "for", "the", "bilateral", "inguinal", "hernia", "repair", "demonstrated", "that", ":", "(", "1", ")", "The", "LTE", "approach", "showed", "less", "surgical", "trauma", "despite", "the", "longer", "operation", "time", ";", "(", "2", ")", "Quality", "of", "life", "during", "the", "early", "post-operative", "period", "were", "similar", ";", "and", "(", "3", ")", "Complication", "rates", "were", "higher", "in", "the", "Stoppa", "group", "." ]

[ "B-Temporal Concept", "B-Health Care Activity", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Temporal Concept", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "O", "O", "B-Functional Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Medical Device", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "B-Patient or Disabled Group", "O", "O", "O", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "B-Anatomical Abnormality", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Research Activity", "O", "O", "O", "B-Conceptual Entity", "O", "B-Research Activity", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Qualitative Concept", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Pathologic Function", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "B-Health Care Activity", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Immunologic Factor", "O", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "B-Finding", "O", "O", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Finding", "B-Finding", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "O", "B-Sign or Symptom", "O", "B-Daily or Recreational Activity", "B-Daily or Recreational Activity", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Idea or Concept", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Idea or Concept", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Qualitative Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Pathologic Function", "B-Quantitative Concept", "O", "B-Qualitative Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Idea or Concept", "O" ]

[ "The", "role", "of", "catheter", "ablation", "in", "the", "management", "of", "atrial", "fibrillation", "Atrial", "fibrillation", "is", "driven", "by", "spontaneous", "electrical", "activation", "emerging", "from", "the", "pulmonary", "veins", ".", "Catheter", "ablation", "using", "either", "radiofrequency", "or", "cryothermal", "energy", "electrically", "isolates", "these", "veins", "from", "the", "left", "atrium", ",", "both", "reducing", "the", "burden", "of", "atrial", "fibrillation", "episodes", "and", "improving", "the", "patient", "'s", "symptoms", ".", "Catheter", "ablation", "is", "superior", "to", "antiarryhthmic", "drugs", "when", "patients", "are", "carefully", "selected", ".", "Underlying", "medical", "problems", "-", "including", "obesity", ",", "hypertension", "and", "obstructive", "sleep", "apnoea", "-", "should", "be", "optimally", "treated", "before", "considering", "ablation", ".", "Although", "this", "treatment", "has", "the", "potential", "to", "cure", "patients", "of", "their", "symptoms", ",", "they", "should", "be", "aware", "of", "the", "important", "associated", "procedural", "complications", "." ]

[ "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Health Care Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Organism Function", "B-Organism Function", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Functional Concept", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "O", "B-Idea or Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Temporal Concept", "O", "O", "O", "B-Patient or Disabled Group", "B-Patient or Disabled Group", "B-Sign or Symptom", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Qualitative Concept", "O", "B-Conceptual Entity", "B-Patient or Disabled Group", "O", "O", "B-Sign or Symptom", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O" ]

[ "The", "Chinese", "Herbal", "Mixture", "Tien-Hsien", "Liquid", "Augments", "the", "Anticancer", "Immunity", "in", "Tumor", "Cell", "-", "Vaccinated", "Mice", "Background", "The", "Chinese", "herbal", "mixture", ",", "Tien-Hsien", "liquid", "(", "THL", ")", ",", "has", "been", "used", "as", "an", "anticancer", "dietary", "supplement", "for", "more", "than", "20", "years", ".", "Our", "previous", "studies", "have", "shown", "that", "THL", "can", "modulate", "immune", "response", "and", "inhibit", "tumor", "growth", ".", "In", "this", "study", ",", "we", "further", "evaluated", "the", "effect", "of", "THL", "on", "anticancer", "immune", "response", "in", "mice", "vaccinated", "with", "γ-ray", "-", "irradiated", "tumor", "cells", ".", "Methods", "The", "antitumor", "effect", "of", "THL", "was", "determined", "in", "mice", "vaccinated", "with", "low-tumorigenic", "CT-26-low", "colon", "cancer", "cells", "or", "γ-ray-irradiated", "high-tumorigenic", "CT-26-high", "colon", "cancer", "cells", ".", "The", "number", "of", "natural", "killer", "(", "NK", ")", "cells", "and", "T", "lymphocytes", "in", "the", "spleen", "was", "analyzed", "by", "flow", "cytometry", ".", "The", "tumor", "-", "killing", "activities", "of", "NK", "cells", "and", "cytotoxic", "T", "lymphocytes", "(", "CTLs", ")", "were", "analyzed", "by", "flow", "cytometry", "using", "YAC-1", "and", "CT-26-high", "cells", ",", "respectively", ",", "as", "target", "cells", ".", "The", "levels", "of", "IFN-γ", ",", "IL-2", ",", "and", "TNF-α", "were", "determined", "by", "ELISA", ".", "Results", "THL", "suppressed", "the", "growth", "of", "CT-26-high", "tumor", "in", "mice", "previously", "vaccinated", "with", "low-tumorigenic", "CT-26-low", "cells", "or", "γ-irradiated", "CT-26-high", "cells", ".", "THL", "increased", "the", "populations", "of", "NK", "cells", "and", "CD4+", "T", "lymphocytes", "in", "the", "spleen", "and", "enhanced", "the", "tumor", "-", "killing", "activities", "of", "NK", "cells", "and", "CTL", "in", "mice", "vaccinated", "with", "γ-irradiated", "CT-26-high", "cells", ".", "THL", "increased", "the", "production", "of", "IFN-γ", ",", "IL-2", ",", "and", "TNF-α", "in", "mice", "vaccinated", "with", "γ-irradiated", "CT-26-high", "cells", ".", "Conclusion", "THL", "can", "enhance", "the", "antitumor", "immune", "responses", "in", "mice", "vaccinated", "with", "killed", "tumor", "cells", ".", "These", "results", "suggest", "that", "THL", "may", "be", "used", "as", "a", "complementary", "medicine", "for", "cancer", "patients", "previously", "treated", "with", "killed", "tumor", "cell", "vaccines", ",", "radiotherapy", ",", "or", "chemotherapy", "." ]

[ "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Physiologic Function", "O", "B-Cell", "B-Cell", "O", "B-Finding", "B-Mammal", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Substance", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Food", "B-Food", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "B-Research Activity", "O", "O", "O", "B-Pharmacologic Substance", "O", "B-Spatial Concept", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "B-Activity", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Research Activity", "O", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "O", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "B-Mammal", "B-Finding", "O", "B-Natural Phenomenon or Process", "O", "B-Natural Phenomenon or Process", "B-Cell", "B-Cell", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "O", "B-Mammal", "B-Finding", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Therapeutic or Preventive Procedure", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Quantitative Concept", "O", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "B-Cell", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Research Activity", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Neoplastic Process", "O", "B-Cell Function", "B-Activity", "O", "B-Cell", "B-Cell", "O", "B-Cell", "B-Cell", "B-Cell", "O", "B-Cell", "O", "O", "B-Research Activity", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Cell", "O", "B-Cell", "B-Cell", "O", "O", "O", "O", "B-Functional Concept", "B-Cell", "O", "O", "B-Qualitative Concept", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "O", "B-Immunologic Factor", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Laboratory Procedure", "O", "O", "B-Pharmacologic Substance", "B-Functional Concept", "O", "B-Organism Function", "O", "B-Cell", "B-Cell", "O", "B-Mammal", "O", "B-Finding", "O", "B-Cell", "B-Cell", "B-Cell", "O", "B-Therapeutic or Preventive Procedure", "B-Cell", "B-Cell", "O", "B-Pharmacologic Substance", "B-Quantitative Concept", "O", "O", "O", "B-Cell", "B-Cell", "O", "B-Cell", "B-Cell", "B-Cell", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "B-Activity", "O", "B-Neoplastic Process", "O", "B-Cell Function", "B-Activity", "O", "B-Cell", "B-Cell", "O", "B-Cell", "O", "B-Mammal", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "B-Cell", "B-Cell", "O", "B-Pharmacologic Substance", "B-Quantitative Concept", "O", "B-Functional Concept", "O", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "O", "B-Immunologic Factor", "O", "B-Mammal", "B-Finding", "O", "B-Therapeutic or Preventive Procedure", "B-Cell", "B-Cell", "O", "O", "B-Pharmacologic Substance", "O", "B-Activity", "O", "B-Qualitative Concept", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "B-Mammal", "B-Finding", "O", "B-Functional Concept", "B-Cell", "B-Cell", "O", "O", "B-Functional Concept", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Biomedical Occupation or Discipline", "O", "B-Neoplastic Process", "B-Patient or Disabled Group", "B-Temporal Concept", "B-Functional Concept", "O", "B-Immunologic Factor", "B-Immunologic Factor", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "O" ]

[ "Comparison", "of", "Head", "Elevation", "Protocols", "Following", "Femoral", "Artery", "Sheath", "Removal", "After", "Coronary", "Angiography", "To", "compare", "2", "standard", "protocols", "for", "head", "elevation", "following", "removal", "of", "a", "femoral", "artery", "sheath", "after", "coronary", "angiography", "and", "their", "effects", "on", "bleeding", "complications", "and", "reported", "levels", "of", "back", "pain", ".", "One", "protocol", "involved", "flat", "supine", "bed", "rest", ";", "the", "other", "allowed", "progressive", "head", "elevation", ".", "A", "prospective", "comparative", "study", "of", "80", "adult", "patients", "undergoing", "coronary", "angiography", "via", "the", "femoral", "approach", ".", "The", "Numeric", "Rating", "Scale", "was", "used", "as", "the", "measure", "of", "reported", "pain", ".", "No", "bleeding", "complications", "occurred", "in", "either", "group", ".", "Both", "groups", "had", "very", "low", "mean", "pain", "scores", ".", "Repeated-", "measures", "analysis", "demonstrated", "that", "the", "experience", "of", "pain", "differed", "significantly", "over", "time", "by", "location", "(", "F5,70", "=", "3.864", ",", "P", "=", ".004", ")", ",", "with", "a", "notable", "decrease", "in", "pain", "scores", "more", "than", "1", "hour", "after", "sheath", "removal", "at", "the", "location", "that", "used", "the", "progressive", "head", "elevation", "protocol", ".", "Patients", "'", "satisfaction", "scores", "after", "discharge", "did", "not", "differ", "significantly", "between", "the", "2", "groups", ".", "Patients", "with", "a", "history", "of", "chronic", "back", "pain", "had", "consistently", "higher", "pain", "scores", ",", "but", "those", "pain", "scores", "did", "not", "differ", "significantly", "by", "location", "(", "or", "protocol", ")", ".", "It", "appears", "that", "using", "a", "progressive", "head", "-", "elevation", "protocol", "within", "the", "first", "3", "hours", "after", "diagnostic", "angiography", "is", "not", "associated", "with", "an", "increased", "risk", "of", "bleeding", "complications", "at", "the", "access", "site", "and", "warrants", "further", "exploration", "in", "the", "mitigation", "of", "back", "pain", "associated", "with", "prolonged", "supine", "bed", "rest", "." ]

[ "B-Activity", "O", "B-Body Location or Region", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Therapeutic or Preventive Procedure", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Activity", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Body Location or Region", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Qualitative Concept", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "B-Body Location or Region", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "O", "B-Age Group", "B-Patient or Disabled Group", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Spatial Concept", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Sign or Symptom", "O", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Idea or Concept", "O", "O", "B-Qualitative Concept", "B-Quantitative Concept", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "B-Research Activity", "O", "O", "O", "O", "O", "B-Sign or Symptom", "O", "O", "O", "B-Temporal Concept", "O", "B-Body Location or Region", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Temporal Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Body Location or Region", "O", "O", "O", "O", "B-Body Location or Region", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Patient or Disabled Group", "O", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Patient or Disabled Group", "O", "O", "B-Finding", "O", "B-Temporal Concept", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Body Location or Region", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Location or Region", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "O", "B-Temporal Concept", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O" ]

[ "Morphological", "characteristics", "regulating", "phallic", "glans", "engorgement", "in", "the", "American", "alligator", "The", "distal", "part", "of", "the", "crocodilian", "phallus", "consists", "of", "a", "bulbous", "glans", "containing", "well-developed", "vascular", "tissues", "that", "can", "inflate", "before", "or", "during", "sexual", "activity", ",", "enlarging", "and", "elaborating", "the", "glans", "into", "a", "complex", ",", "though", "still", "functionally", "undefined", ",", "copulatory", "structure", ".", "An", "enlarged", "glans", "putatively", "interacts", "with", "the", "female", "cloaca", "and", "may", "change", "the", "shape", "of", "her", "reproductive", "tract", "to", "facilitate", "insemination", "and", "increase", "the", "probability", "of", "fertilization", ".", "Here", ",", "we", "investigated", "the", "cellular-level", "properties", "of", "the", "glans", "and", "other", "inflatable", "phallic", "tissues", "associated", "with", "the", "sperm", "-conducting", "sulcus", "spermaticus", "in", "the", "American", "alligator", "(", "Alligator", "mississippiensis", ")", ".", "Using", "histochemical", "staining", ",", "we", "visualized", "and", "defined", "collagen", "and", "elastin", "fiber", "densities", "and", "orientations", "in", "these", "tissues", ".", "Extracellular", "matrix", "architectures", "provided", "insights", "about", "phallic", "glans", "material", "properties", "and", "how", "they", "may", "affect", "tissue", "strength", "and", "flexibility", "during", "inflation", "and", "in", "response", "to", "copulatory", "forces", ".", "We", "also", "investigated", "the", "potential", "sources", "of", "fluids", "that", "induce", "inflation", "in", "alligator", "phalli", ".", "Combining", "serial", "sectioning", "and", "three-dimensional", "reconstruction", ",", "we", "identified", "a", "pair", "of", "supracrucal", "plexus", "vascular", "bodies", "at", "the", "proximal", "end", "of", "the", "alligator", "phallus", "that", "extend", "distally", "adjacent", "to", "ventro-medial", "sulcus", "tissues", ".", "Together", ",", "our", "gross", "and", "histological", "examination", "of", "the", "American", "alligator", "phallic", "glans", "suggests", "that", "its", "tissues", "are", "arranged", "in", "a", "manner", "that", "would", "allow", "vascular", "inflation", "to", "expand", "the", "glans", "to", "a", "specific", "and", "repeatable", "shape", ",", "and", "potentially", "release", "secretory", "products", "into", "the", "female", "reproductive", "tract", ".", "Both", "elements", "could", "play", "roles", "in", "postcopulatory", "sexual", "selection", ",", "by", "mechanically", "and/or", "chemically", "affecting", "female", "reproductive", "physiology", "." ]

[ "B-Spatial Concept", "B-Qualitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Disease or Syndrome", "O", "O", "B-Reptile", "B-Reptile", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Reptile", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "O", "O", "O", "B-Behavior", "B-Behavior", "O", "B-Qualitative Concept", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Functional Concept", "B-Idea or Concept", "O", "B-Social Behavior", "O", "O", "O", "B-Qualitative Concept", "B-Body Part, Organ, or Organ Component", "O", "B-Functional Concept", "O", "O", "B-Organism Attribute", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Functional Concept", "O", "B-Spatial Concept", "O", "B-Body System", "B-Body System", "B-Body System", "O", "O", "B-Organ or Tissue Function", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "B-Organism Function", "O", "O", "O", "O", "O", "O", "B-Cell Function", "B-Cell Function", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Tissue", "B-Tissue", "B-Tissue", "O", "O", "O", "B-Cell", "O", "B-Body Space or Junction", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Reptile", "B-Reptile", "O", "B-Reptile", "B-Reptile", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "B-Amino Acid, Peptide, or Protein", "O", "B-Tissue", "B-Tissue", "B-Quantitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Tissue", "O", "B-Tissue", "B-Tissue", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Tissue", "B-Quantitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "B-Social Behavior", "B-Phenomenon or Process", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Substance", "O", "B-Functional Concept", "O", "O", "B-Reptile", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Cell Component", "O", "O", "O", "O", "O", "O", "B-Reptile", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Tissue", "B-Tissue", "B-Tissue", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "B-Reptile", "B-Reptile", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "B-Spatial Concept", "O", "O", "B-Qualitative Concept", "O", "B-Cell Component", "B-Cell Component", "O", "O", "B-Body System", "B-Body System", "B-Body System", "O", "O", "O", "O", "O", "O", "O", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "O", "B-Functional Concept", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "B-Physiologic Function", "B-Physiologic Function", "O" ]

[ "Heterogeneous", "Mechanisms", "of", "Primary", "and", "Acquired", "Resistance", "to", "Third-Generation", "EGFR", "Inhibitors", "To", "identify", "novel", "mechanisms", "of", "resistance", "to", "third-generation", "EGFR", "inhibitors", "in", "patients", "with", "lung", "adenocarcinoma", "that", "progressed", "under", "therapy", "with", "either", "AZD9291", "or", "rociletinib", "(", "CO-1686", ")", ".", "We", "analyzed", "tumor", "biopsies", "from", "seven", "patients", "obtained", "before", ",", "during", ",", "and/or", "after", "treatment", "with", "AZD9291", "or", "rociletinib", "(", "CO-1686", ")", ".", "Targeted", "sequencing", "and", "FISH", "analyses", "were", "performed", ",", "and", "the", "relevance", "of", "candidate", "genes", "was", "functionally", "assessed", "in", "in", "vitro", "models", ".", "We", "found", "recurrent", "amplification", "of", "either", "MET", "or", "ERBB2", "in", "tumors", "that", "were", "resistant", "or", "developed", "resistance", "to", "third-generation", "EGFR", "inhibitors", "and", "show", "that", "ERBB2", "and", "MET", "activation", "can", "confer", "resistance", "to", "these", "compounds", ".", "Furthermore", ",", "we", "identified", "a", "KRAS", "(", "G12S", ")", "mutation", "in", "a", "patient", "with", "acquired", "resistance", "to", "AZD9291", "as", "a", "potential", "driver", "of", "acquired", "resistance", ".", "Finally", ",", "we", "show", "that", "dual", "inhibition", "of", "EGFR", "/MEK", "might", "be", "a", "viable", "strategy", "to", "overcome", "resistance", "in", "EGFR-mutant", "cells", "expressing", "mutant", "KRAS", "CONCLUSIONS", ":", "Our", "data", "suggest", "that", "heterogeneous", "mechanisms", "of", "resistance", "can", "drive", "primary", "and", "acquired", "resistance", "to", "third-generation", "EGFR", "inhibitors", "and", "provide", "a", "rationale", "for", "potential", "combination", "strategies", ".", "Clin", "Cancer", "Res", ";", "1-11", ".", "©2016", "AACR", "." ]

[ "B-Functional Concept", "B-Functional Concept", "O", "B-Biologic Function", "B-Biologic Function", "B-Biologic Function", "B-Biologic Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "I-Biologic Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Patient or Disabled Group", "O", "B-Neoplastic Process", "B-Neoplastic Process", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Research Activity", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Quantitative Concept", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Gene or Genome", "B-Gene or Genome", "O", "B-Activity", "B-Activity", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Neoplastic Process", "O", "O", "B-Biologic Function", "O", "B-Biologic Function", "B-Biologic Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "O", "B-Genetic Function", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Biologic Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Patient or Disabled Group", "O", "B-Biologic Function", "B-Biologic Function", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Biologic Function", "B-Biologic Function", "O", "O", "O", "O", "O", "O", "B-Activity", "B-Activity", "O", "I-Enzyme", "B-Enzyme", "O", "O", "O", "B-Mental Process", "B-Mental Process", "O", "O", "B-Biologic Function", "O", "B-Cell", "B-Cell", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Idea or Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "I-Biologic Function", "O", "O", "B-Biologic Function", "B-Biologic Function", "B-Biologic Function", "B-Biologic Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Nax", "signaling", "evoked", "by", "an", "increase", "in", "[", "Na+", "]", "in", "CSF", "induces", "water", "intake", "via", "EET", "-mediated", "TRPV4", "activation", "Water-intake", "behavior", "is", "under", "the", "control", "of", "brain", "systems", "that", "sense", "body-fluid", "conditions", "at", "sensory", "circumventricular", "organs", "(", "sCVOs", ")", ";", "however", ",", "the", "underlying", "mechanisms", "have", "not", "yet", "been", "elucidated", "in", "detail", ".", "Nax", "is", "a", "sodium", "(", "Na", "(", "+", ")", ")", "level", "sensor", "in", "the", "brain", ",", "and", "the", "transient", "receptor", "potential", "vanilloid", "(", "TRPV", ")", "channels", ",", "TRPV1", "and", "TRPV4", ",", "have", "been", "proposed", "to", "function", "as", "osmosensors", ".", "We", "herein", "investigated", "voluntary", "water", "intake", "immediately", "induced", "after", "an", "intracerebroventricular", "(", "icv", ")", "administration", "of", "a", "hypertonic", "NaCl", "solution", "in", "TRPV1-", ",", "TRPV4-", ",", "Nax-", ",", "and", "their", "double-gene", "knockout", "(", "KO", ")", "mice", ".", "The", "induction", "of", "water", "intake", "by", "TRPV1", "-", "KO", "mice", "was", "normal", ",", "whereas", "that", "by", "TRPV4", "-", "KO", "and", "Nax", "-", "KO", "mice", "was", "significantly", "less", "than", "that", "by", "WT", "mice", ".", "Water", "intake", "by", "Nax", "/", "TRPV4", "-", "double", "KO", "mice", "was", "similar", "to", "that", "by", "the", "respective", "single", "KO", "mice", ".", "When", "TRPV4", "activity", "was", "blocked", "with", "a", "specific", "antagonist", "HC-067047", ",", "water", "intake", "by", "WT", "mice", "was", "significantly", "reduced", ",", "whereas", "that", "by", "TRPV4", "-", "KO", "and", "Nax", "-", "KO", "mice", "was", "not", ".", "Similar", "results", "were", "obtained", "with", "the", "administration", "of", "miconazole", ",", "which", "inhibits", "the", "biosynthesis", "of", "epoxyeicosatrienoic", "acids", "(", "EETs", ")", ",", "endogenous", "agonists", "for", "TRPV4", ",", "from", "arachidonic", "acid", "(", "AA", ")", ".", "Icv", "injection", "of", "hypertonic", "NaCl", "with", "AA", "or", "5,6-EET", "restored", "water", "intake", "by", "Nax", "-", "KO", "mice", "to", "the", "WT", "level", ",", "but", "not", "that", "by", "TRPV4", "-", "KO", "mice", ".", "These", "results", "suggest", "that", "the", "Na", "(", "+", ")", "signal", "generated", "in", "Nax", "-", "positive", "glial", "cells", "leads", "to", "the", "activation", "of", "TRPV4", "-", "positive", "neurons", "in", "sCVOs", "in", "order", "to", "stimulate", "water", "intake", "by", "using", "EETs", "as", "gliotransmitters", "." ]

[ "B-Biologically Active Substance", "B-Cell Function", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "B-Element, Ion, or Isotope", "O", "O", "B-Body Substance", "B-Functional Concept", "B-Organism Function", "B-Organism Function", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "B-Genetic Function", "B-Organism Function", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Body Substance", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Biologically Active Substance", "O", "O", "B-Element, Ion, or Isotope", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "O", "B-Qualitative Concept", "B-Molecular Function", "O", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Receptor", "B-Receptor", "B-Receptor", "B-Receptor", "B-Receptor", "B-Receptor", "B-Receptor", "B-Receptor", "O", "B-Receptor", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Molecular Function", "O", "O", "O", "B-Functional Concept", "B-Individual Behavior", "B-Organism Function", "B-Organism Function", "O", "B-Functional Concept", "O", "O", "B-Spatial Concept", "O", "B-Spatial Concept", "O", "B-Therapeutic or Preventive Procedure", "O", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "B-Inorganic Chemical", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "O", "O", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "B-Mammal", "O", "O", "B-Functional Concept", "O", "B-Organism Function", "B-Organism Function", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "O", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Mammal", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Mammal", "B-Mammal", "O", "B-Organism Function", "B-Organism Function", "O", "B-Gene or Genome", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "B-Mammal", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Mammal", "B-Mammal", "O", "O", "B-Biologically Active Substance", "B-Molecular Function", "O", "B-Functional Concept", "O", "O", "B-Chemical Viewed Functionally", "B-Chemical Viewed Functionally", "B-Pharmacologic Substance", "O", "B-Organism Function", "B-Organism Function", "O", "B-Mammal", "B-Mammal", "O", "B-Idea or Concept", "B-Qualitative Concept", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Mammal", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "O", "O", "O", "B-Qualitative Concept", "B-Finding", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Pharmacologic Substance", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "B-Functional Concept", "B-Pharmacologic Substance", "O", "B-Biologically Active Substance", "O", "O", "B-Organic Chemical", "B-Organic Chemical", "O", "B-Organic Chemical", "O", "O", "B-Spatial Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Inorganic Chemical", "B-Inorganic Chemical", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "O", "B-Organism Function", "B-Organism Function", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "O", "O", "B-Gene or Genome", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Gene or Genome", "O", "B-Mammal", "B-Mammal", "O", "O", "B-Finding", "O", "O", "O", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Element, Ion, or Isotope", "B-Phenomenon or Process", "O", "O", "B-Biologically Active Substance", "O", "B-Finding", "B-Cell", "B-Cell", "O", "O", "O", "B-Genetic Function", "O", "B-Biologically Active Substance", "O", "B-Finding", "B-Cell", "O", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Organism Function", "B-Organism Function", "O", "O", "B-Organic Chemical", "O", "B-Biologically Active Substance", "O" ]

[ "Timing", "of", "False", "Ring", "Formation", "in", "Pinus", "halepensis", "and", "Arbutus", "unedo", "in", "Southern", "Italy", ":", "Outlook", "from", "an", "Analysis", "of", "Xylogenesis", "and", "Tree-Ring", "Chronologies", "Mediterranean", "tree", "rings", "are", "characterized", "by", "intra-annual", "density", "fluctuations", "(", "IADFs", ")", "due", "to", "partly", "climate-driven", "cambial", "activity", ".", "IADFs", "are", "used", "as", "structural", "signals", "to", "gain", "information", "on", "relations", "between", "environmental", "conditions", "and", "eco-physiological", "processes", "during", "xylogenesis", ",", "with", "intra-annual", "resolution", ".", "To", "reach", "an", "unbiased", "synchronization", "of", "the", "IADF", "position", "within", "tree", "rings", "and", "seasonal", "fluctuations", "in", "environmental", "conditions", ",", "it", "is", "necessary", "to", "know", "the", "timing", "of", "cambial", "activity", "and", "wood", "formation", ",", "which", "are", "species-", "and", "site-specific", "processes", ".", "We", "applied", "the", "microcoring", "technique", "to", "analyze", "xylogenesis", "in", "Pinus", "halepensis", "and", "Arbutus", "unedo", ".", "To", "the", "best", "of", "our", "knowledge", ",", "this", "is", "the", "first", "attempt", "to", "study", "xylogenesis", "in", "a", "hardwood", "species", "forming", "frequent", "IADFs", ".", "Both", "species", "co-occur", "at", "a", "site", "in", "southern", "Italy", "characterized", "by", "a", "Mediterranean", "climate", ".", "To", "facilitate", "tree-ring", "dating", "and", "identification", "of", "IADFs", ",", "we", "performed", "traditional", "dendroecological", "analysis", ".", "We", "analyzed", "xylogenesis", "during", "summer", ",", "which", "is", "considered", "a", "constraint", "for", "xylogenesis", "and", "a", "trigger", "for", "IADF", "formation", ".", "We", "followed", "the", "different", "phases", "of", "cell", "development", "in", "the", "current", "wood", "increment", "with", "the", "aim", "of", "evaluating", "whether", "and", "which", "type", "of", "IADFs", "were", "formed", ".", "We", "additionally", "analyzed", "the", "same", "phases", "again", "in", "September", "and", "in", "winter", "to", "verify", "the", "possible", "formation", "of", "IADFs", "in", "fall", "and", "whether", "cell", "production", "and", "differentiation", "was", "completed", "by", "the", "end", "of", "the", "calendar", "year", ".", "Both", "species", "formed", "the", "same", "type", "of", "IADFs", "(", "earlywood", "-like", "cells", "within", "latewood", ")", ",", "due", "to", "temporary", "growth", "restoration", "triggered", "by", "rain", "events", "during", "the", "period", "of", "summer", "drought", ".", "At", "the", "end", "of", "the", "calendar", "year", ",", "no", "cells", "in", "the", "phases", "of", "enlargement", "and", "secondary", "cell", "wall", "deposition", "occurred", ".", "A.", "unedo", "was", "more", "sensitive", "than", "P.", "halepensis", "because", "IADF", "s", "were", "formed", "earlier", "in", "the", "season", "and", "were", "more", "frequent", "in", "the", "tree-ring", "series", ".", "The", "dendro-anatomical", "approach", ",", "combining", "analysis", "of", "tree-ring", "series", "and", "of", "xylogenesis", ",", "helped", "to", "detect", "the", "period", "of", "IADF", "formation", "in", "the", "two", "species", ".", "Results", "are", "discussed", "in", "functional", "terms", ",", "highlighting", "the", "environmental", "conditions", "triggering", "IADFs", ",", "and", "also", "in", "methodological", "terms", ",", "evaluating", "the", "applicability", "of", "xylogenesis", "analysis", "in", "Mediterranean", "woods", ",", "especially", "when", "the", "formation", "of", "IADFs", "is", "not", "uniform", "around", "the", "stem", "." ]

[ "B-Temporal Concept", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Plant", "O", "B-Spatial Concept", "B-Geographic Area", "O", "B-Clinical Attribute", "O", "O", "B-Research Activity", "O", "B-Physiologic Function", "O", "B-Plant", "B-Intellectual Product", "B-Geographic Area", "B-Plant", "B-Plant", "O", "B-Activity", "O", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Temporal Concept", "O", "O", "O", "B-Spatial Concept", "B-Idea or Concept", "O", "O", "B-Idea or Concept", "O", "B-Qualitative Concept", "B-Spatial Concept", "B-Spatial Concept", "B-Qualitative Concept", "O", "B-Physiologic Function", "B-Phenomenon or Process", "B-Temporal Concept", "B-Physiologic Function", "O", "O", "B-Temporal Concept", "B-Conceptual Entity", "O", "O", "O", "O", "B-Research Activity", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "B-Spatial Concept", "O", "B-Plant", "B-Spatial Concept", "O", "B-Temporal Concept", "B-Sign or Symptom", "O", "B-Spatial Concept", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Substance", "B-Functional Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "O", "B-Functional Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Research Activity", "B-Physiologic Function", "O", "B-Plant", "B-Plant", "O", "B-Plant", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Event", "O", "B-Research Activity", "B-Physiologic Function", "O", "O", "B-Substance", "B-Classification", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "B-Classification", "B-Activity", "O", "O", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Geographic Area", "B-Activity", "O", "O", "B-Geographic Area", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "B-Qualitative Concept", "O", "B-Temporal Concept", "O", "O", "B-Functional Concept", "B-Functional Concept", "B-Qualitative Concept", "B-Research Activity", "O", "O", "B-Research Activity", "B-Physiologic Function", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "B-Idea or Concept", "O", "B-Functional Concept", "O", "B-Physiologic Function", "O", "O", "O", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "B-Temporal Concept", "O", "B-Cell Function", "B-Cell Function", "O", "O", "B-Temporal Concept", "B-Substance", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Research Activity", "O", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "O", "B-Finding", "B-Functional Concept", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "O", "B-Cell", "B-Physiologic Function", "O", "B-Cell Function", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "B-Classification", "B-Functional Concept", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Substance", "O", "B-Cell", "O", "B-Substance", "O", "O", "O", "O", "B-Temporal Concept", "B-Phenomenon or Process", "B-Finding", "B-Qualitative Concept", "B-Qualitative Concept", "B-Natural Phenomenon or Process", "B-Event", "B-Temporal Concept", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "B-Cell", "O", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "B-Cell Component", "B-Cell Component", "B-Cell Component", "B-Functional Concept", "B-Activity", "O", "B-Plant", "B-Plant", "O", "O", "B-Functional Concept", "O", "B-Plant", "B-Plant", "O", "B-Temporal Concept", "O", "O", "B-Functional Concept", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Plant", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Research Activity", "O", "B-Plant", "O", "O", "O", "B-Physiologic Function", "O", "O", "O", "B-Finding", "O", "B-Temporal Concept", "O", "B-Temporal Concept", "B-Functional Concept", "O", "O", "O", "B-Classification", "O", "B-Functional Concept", "O", "O", "O", "B-Functional Concept", "B-Idea or Concept", "O", "O", "O", "B-Spatial Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Functional Concept", "O", "B-Physiologic Function", "B-Research Activity", "O", "B-Geographic Area", "B-Substance", "O", "O", "O", "O", "B-Functional Concept", "O", "B-Temporal Concept", "O", "O", "B-Qualitative Concept", "O", "O", "B-Plant", "O" ]

[ "An", "Accessible", "and", "Pragmatic", "Experimental", "Model", "of", "Nonalcoholic", "Fatty", "Liver", "Disease", "BACKGROUND", "There", "is", "no", "convenient", "cheap", "pragmatic", "experimental", "model", "for", "Nonalcoholic", "Fatty", "Liver", "Disease", "(", "NAFLD", ")", "/", "Nonalcoholic", "Steatohepatitis", "(", "NASH", ")", ".", "Our", "objective", "was", "to", "create", "a", "pragmatic", "model", "of", "NAFLD", "/", "NASH", ".", "METHODS", "Sprague-Dawley", "rats", "were", "fed", "a", "high-fat", ",", "high", "sugar", "homemade", "diet", "ad", "libitum", "for", "seven", "weeks", ".", "The", "high-fat", ",", "high", "sugar", "diet", "included", "59", "%", "of", "energy", "derived", "from", "fat", ",", "30", "%", "from", "carbohydrates", ",", "and", "11", "%", "from", "protein", ".", "Serum", "levels", "of", "fasting", "glucose", ",", "triglyceride", ",", "cholesterol", ",", "liver", "enzymes", ",", "insulin", ",", "and", "hepatic", "tumor", "necrosis", "factor-alpha", "(", "TNF-α", ")", "gene", "expression", "were", "determined", ".", "Hepatic", "histology", "was", "examined", "by", "H", "&", "E", "stain", ".", "RESULTS", "Rats", "fed", "the", "high-fat", ",", "high", "sugar", "diet", "developed", "hepatic", "steatosis", ",", "and", "a", "moderate", "inflammation", ",", "which", "was", "associated", "with", "increased", "serum", "levels", "of", "liver", "enzymes", ",", "glucose", ",", "insulin", ",", "triglyceride", ",", "cholesterol", ",", "and", "hepatic", "TNF-α", "gene", "expression", ".", "CONCLUSION", "This", "rat", "model", "resembles", "the", "key", "features", "of", "human", "NAFLD", "/", "NASH", "and", "provides", "a", "simple", "pragmatic", "experimental", "model", "for", "elucidating", "the", "disease", "prevention", "and", "treatment", "." ]

[ "O", "O", "O", "B-Animal", "B-Animal", "B-Animal", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Animal", "B-Animal", "B-Animal", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "O", "O", "B-Animal", "B-Animal", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "B-Mammal", "B-Mammal", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Quantitative Concept", "O", "O", "B-Food", "O", "O", "O", "O", "B-Food", "O", "O", "O", "O", "O", "B-Food", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "B-Laboratory Procedure", "O", "O", "B-Body Location or Region", "B-Immunologic Factor", "B-Immunologic Factor", "B-Immunologic Factor", "O", "B-Immunologic Factor", "O", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "B-Body Location or Region", "B-Laboratory Procedure", "O", "O", "O", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "B-Laboratory Procedure", "O", "O", "B-Mammal", "O", "O", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "B-Laboratory or Test Result", "O", "B-Laboratory or Test Result", "O", "B-Laboratory or Test Result", "O", "B-Laboratory or Test Result", "O", "O", "B-Body Location or Region", "B-Immunologic Factor", "B-Genetic Function", "B-Genetic Function", "O", "O", "O", "B-Mammal", "B-Animal", "O", "O", "O", "O", "O", "B-Human", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Animal", "B-Animal", "B-Animal", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "O" ]

[ "Comparison", "of", "the", "Effects", "of", "Subcutaneous", "Versus", "Continuous", "Infusion", "of", "Heparin", "on", "Key", "Inflammatory", "Parameters", "Following", "Sepsis", "Sepsis", "is", "the", "result", "of", "the", "interaction", "between", "inflammatory", "mediators", "and", "coagulation", "pathway", ".", "Unfractionated", "heparin", "may", "play", "a", "role", "as", "an", "anti-inflammatory", "agent", "beyond", "its", "anticoagulatory", "effect", "in", "sepsis", ".", "As", "a", "result", ",", "it", "may", "cause", "reduction", "in", "organ", "failure", "rate", "in", "patients", "with", "sepsis", "due", "to", "its", "impact", "on", "both", "inflammatory", "and", "coagulation", "process", ".", "The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "anti-inflammatory", "effects", "of", "heparin", "in", "sepsis", ".", "Plasma", "plasminogen", "activator", "inhibitor-1", "(", "PAI-1", ")", "as", "an", "inflammatory", "mediator", "and", "urinary", "necoutrophil", "gelatinase-associated", "lipocalin", "(", "NGAL", ")", "as", "a", "marker", "of", "kidney", "injury", "were", "investigated", ".", "This", "prospective", ",", "randomized", "controlled", "trial", "was", "conducted", "in", "a", "32-", "bed", "intensive", "care", "unit", ".", "Thirty", "patients", "with", "sepsis", "were", "randomized", "to", "receive", "heparin", "infusion", "of", "500", "units/hour", "or", "5000", "units", "of", "heparin", "three", "times", "a", "day", ",", "subcutaneously", ".", "The", "plasma", "level", "of", "PAI-1", "and", "urinary", "level", "of", "NGAL", "were", "determined", "at", "day", "0", ",", "2", "and", "7", ".", "The", "infusion", "group", "had", "a", "lower", "plasma", "PAI-1", "level", "compared", "to", "the", "subcutaneous", "group", "at", "day", "7", "(", "11.3", "±", "1.6", "vs.", "16.5", "±", "4.2", ";", "P", "=", "0.003", ")", ".", "The", "urinary", "NGAL", "level", "was", "lower", "in", "the", "infusion", "group", "at", "day", "2", "(", "131.3", "±", "11.9", "vs.", "151.2", "±", "20.6", ";", "P", "=", "0.014", ")", ";", "however", ",", "at", "day", "7", "the", "NGAL", "level", "was", "decreased", "in", "the", "subcutaneous", "group", "as", "much", "as", "the", "infusion", "group", "and", "there", "was", "no", "significant", "difference", "between", "the", "two", "groups", ".", "There", "was", "no", "significant", "difference", "in", "the", "acute", "physiology", "and", "chronic", "health", "evaluation", "(", "APACHE", ")", "II", "and", "sequential", "organ", "failure", "assessment", "(", "SOFA", ")", "scores", "between", "the", "two", "groups", "at", "day", "0", ",", "2", "and", "7", ".", "Low-dose", "heparin", "infusion", "compared", "to", "subcutaneous", "heparin", "can", "decrease", "the", "plasma", "PAI-1", "and", "urinary", "NGAL", "levels", "more", "rapidly", ".", "It", "can", "be", "related", "to", "anti-inflammatory", "effects", "of", "heparin", ",", "which", "may", "be", "more", "prominent", "in", "infusion", "route", "." ]

[ "B-Activity", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Therapeutic or Preventive Procedure", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "B-Biologically Active Substance", "O", "B-Functional Concept", "B-Functional Concept", "B-Conceptual Entity", "B-Temporal Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "B-Functional Concept", "O", "O", "B-Functional Concept", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Molecular Function", "B-Molecular Function", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "O", "B-Conceptual Entity", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Pathologic Function", "B-Pathologic Function", "B-Quantitative Concept", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Qualitative Concept", "O", "O", "B-Functional Concept", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "B-Idea or Concept", "O", "O", "B-Research Activity", "O", "O", "B-Health Care Activity", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Disease or Syndrome", "O", "B-Body Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Biologically Active Substance", "B-Biologically Active Substance", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Clinical Attribute", "O", "B-Injury or Poisoning", "B-Injury or Poisoning", "O", "B-Functional Concept", "O", "O", "B-Research Activity", "O", "B-Research Activity", "B-Research Activity", "B-Research Activity", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "B-Research Activity", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Biologically Active Substance", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Finding", "O", "O", "B-Body Substance", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "O", "O", "B-Functional Concept", "B-Idea or Concept", "O", "O", "B-Spatial Concept", "B-Body Substance", "B-Biologically Active Substance", "B-Qualitative Concept", "B-Activity", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Spatial Concept", "O", "O", "B-Functional Concept", "B-Idea or Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Quantitative Concept", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Functional Concept", "B-Idea or Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "O", "B-Idea or Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "B-Finding", "O", "O", "O", "B-Idea or Concept", "O", "B-Finding", "B-Finding", "O", "B-Finding", "O", "B-Finding", "O", "B-Quantitative Concept", "B-Biologically Active Substance", "B-Functional Concept", "B-Activity", "O", "B-Spatial Concept", "B-Biologically Active Substance", "O", "B-Quantitative Concept", "O", "B-Body Substance", "B-Biologically Active Substance", "O", "B-Qualitative Concept", "B-Biologically Active Substance", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Biologically Active Substance", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O" ]

[ "The", "Spreading", "of", "Social", "Energy", ":", "How", "Exposure", "to", "Positive", "and", "Negative", "Social", "News", "Affects", "Behavior", "Social", "news", ",", "unlike", "video", "games", "or", "TV", "programs", ",", "conveys", "real-life", "interactions", ".", "Theoretically", ",", "social", "news", "in", "which", "people", "help", "or", "harm", "each", "other", "and", "violate", "rules", "should", "influence", "both", "prosocial", "and", "violation", "behaviors", ".", "In", "two", "experiments", ",", "we", "demonstrated", "the", "spreading", "effects", "of", "social", "news", "in", "a", "social", "interaction", "context", "emphasizing", "social", "conventions", "and", "a", "nonsocial", "interaction", "context", "emphasizing", "moral", "norms", ".", "Across", "the", "two", "studies", ",", "the", "results", "showed", "that", "positive", "social", "news", "increased", "cooperation", "(", "decreased", "defection", ")", "but", "had", "no", "effect", "on", "cheating", ",", "whereas", "negative", "social", "news", "increased", "cheating", "but", "with", "no", "change", "in", "cooperation", "(", "or", "defection", ")", ".", "We", "conclude", "that", "there", "is", "a", "spreading", "impact", "of", "positive", "social", "news", "in", "the", "conventional", "norm", "domain", "and", "of", "negative", "social", "news", "in", "the", "moral", "norm", "domain", "." ]

[ "O", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Finding", "O", "B-Finding", "B-Functional Concept", "B-Intellectual Product", "O", "B-Behavior", "B-Functional Concept", "B-Intellectual Product", "O", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Finding", "O", "O", "O", "B-Functional Concept", "B-Intellectual Product", "O", "O", "B-Population Group", "B-Qualitative Concept", "O", "B-Social Behavior", "B-Social Behavior", "B-Social Behavior", "O", "B-Individual Behavior", "B-Regulation or Law", "O", "O", "O", "B-Social Behavior", "O", "B-Individual Behavior", "B-Individual Behavior", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Intellectual Product", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Functional Concept", "B-Human-caused Phenomenon or Process", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Finding", "B-Functional Concept", "B-Intellectual Product", "O", "B-Social Behavior", "O", "O", "B-Social Behavior", "O", "O", "O", "B-Finding", "B-Qualitative Concept", "O", "B-Individual Behavior", "O", "O", "B-Finding", "B-Functional Concept", "B-Intellectual Product", "O", "B-Individual Behavior", "O", "O", "B-Finding", "B-Functional Concept", "O", "B-Social Behavior", "O", "O", "B-Social Behavior", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Finding", "B-Functional Concept", "B-Intellectual Product", "O", "O", "B-Qualitative Concept", "B-Idea or Concept", "B-Idea or Concept", "O", "O", "B-Finding", "B-Functional Concept", "B-Intellectual Product", "O", "O", "B-Idea or Concept", "B-Idea or Concept", "B-Idea or Concept", "O" ]

[ "Using", "Evolutionary", "Theory", "to", "Guide", "Mental", "Health", "Research", "Evolutionary", "approaches", "to", "medicine", "can", "shed", "light", "on", "the", "origins", "and", "etiology", "of", "disease", ".", "Such", "an", "approach", "may", "be", "especially", "useful", "in", "psychiatry", ",", "which", "frequently", "addresses", "conditions", "with", "heterogeneous", "presentation", "and", "unknown", "causes", ".", "We", "review", "several", "previous", "applications", "of", "evolutionary", "theory", "that", "highlight", "the", "ways", "in", "which", "psychiatric", "conditions", "may", "persist", "despite", "and", "because", "of", "natural", "selection", ".", "One", "lesson", "from", "the", "evolutionary", "approach", "is", "that", "some", "conditions", "currently", "classified", "as", "disorders", "(", "because", "they", "cause", "distress", "and", "impairment", ")", "may", "actually", "be", "caused", "by", "functioning", "adaptations", "operating", "``", "normally", "``", "(", "as", "designed", "by", "natural", "selection", ")", ".", "Such", "conditions", "suggest", "an", "alternative", "illness", "model", "that", "may", "generate", "alternative", "intervention", "strategies", ".", "Thus", ",", "the", "evolutionary", "approach", "suggests", "that", "psychiatry", "should", "sometimes", "think", "differently", "about", "distress", "and", "impairment", ".", "The", "complexity", "of", "the", "human", "brain", ",", "including", "normal", "functioning", "and", "potential", "for", "dysfunctions", ",", "has", "developed", "over", "evolutionary", "time", "and", "has", "been", "shaped", "by", "natural", "selection", ".", "Understanding", "the", "evolutionary", "origins", "of", "psychiatric", "conditions", "is", "therefore", "a", "crucial", "component", "to", "a", "complete", "understanding", "of", "etiology", "." ]

[ "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "B-Mental Process", "B-Mental Process", "B-Research Activity", "B-Spatial Concept", "B-Spatial Concept", "O", "B-Biomedical Occupation or Discipline", "O", "B-Activity", "B-Activity", "O", "O", "B-Temporal Concept", "O", "B-Functional Concept", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "O", "B-Finding", "B-Finding", "O", "O", "B-Idea or Concept", "O", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "B-Qualitative Concept", "O", "B-Classification", "O", "B-Mental or Behavioral Dysfunction", "O", "O", "O", "O", "B-Finding", "O", "B-Pathologic Function", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Biologic Function", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "B-Experimental Model of Disease", "B-Experimental Model of Disease", "O", "O", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "B-Health Care Activity", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "O", "B-Pathologic Function", "O", "O", "B-Qualitative Concept", "O", "O", "B-Human", "B-Body Part, Organ, or Organ Component", "O", "O", "B-Qualitative Concept", "B-Organ or Tissue Function", "O", "B-Qualitative Concept", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "O", "O", "B-Temporal Concept", "B-Temporal Concept", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Qualitative Concept", "B-Conceptual Entity", "O", "O", "O", "O", "O", "B-Functional Concept", "O" ]

[ "Transcriptomic", "and", "Physiological", "Responses", "of", "the", "Green", "Microalga", "Chlamydomonas", "reinhardtii", "during", "Short-Term", "Exposure", "to", "Subnanomolar", "Methylmercury", "Concentrations", "The", "effects", "of", "short-term", "exposure", "to", "subnanomolar", "methyl-mercury", "(", "MeHg", ")", "concentrations", ",", "representative", "of", "contaminated", "environments", ",", "on", "the", "microalga", "Chlamydomonas", "reinhardtii", "were", "assessed", "using", "both", "physiological", "end", "points", "and", "gene", "expression", "analysis", ".", "MeHg", "bioaccumulated", "and", "induced", "significant", "increase", "of", "the", "photosynthesis", "efficiency", ",", "while", "the", "algal", "growth", ",", "oxidative", "stress", ",", "and", "chlorophyll", "fluorescence", "were", "unaffected", ".", "At", "the", "molecular", "level", ",", "MeHg", "significantly", "dysregulated", "the", "expression", "of", "genes", "involved", "in", "motility", ",", "energy", "metabolism", ",", "lipid", "metabolism", ",", "metal", "transport", ",", "and", "antioxidant", "enzymes", ".", "Data", "suggest", "that", "the", "cells", "were", "able", "to", "cope", "with", "subnanomolar", "MeHg", "exposure", ",", "but", "this", "tolerance", "resulted", "in", "a", "significant", "cost", "to", "the", "cell", "energy", "and", "reserve", "metabolism", "as", "well", "as", "ample", "changes", "in", "the", "nutrition", "and", "motility", "of", "C.", "reinhardtii", ".", "The", "present", "results", "allowed", "gaining", "new", "insights", "on", "the", "effects", "and", "uptake", "mechanisms", "of", "MeHg", "at", "subnanomolar", "concentrations", "in", "aquatic", "primary", "producers", "." ]

[ "B-Genetic Function", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "O", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "B-Hazardous or Poisonous Substance", "B-Quantitative Concept", "O", "O", "O", "B-Temporal Concept", "B-Qualitative Concept", "B-Qualitative Concept", "B-Quantitative Concept", "B-Hazardous or Poisonous Substance", "O", "B-Hazardous or Poisonous Substance", "O", "B-Quantitative Concept", "O", "O", "O", "B-Functional Concept", "B-Spatial Concept", "O", "O", "O", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "O", "B-Activity", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "B-Molecular Biology Research Technique", "O", "B-Hazardous or Poisonous Substance", "B-Organ or Tissue Function", "O", "O", "B-Idea or Concept", "B-Functional Concept", "O", "O", "B-Natural Phenomenon or Process", "B-Quantitative Concept", "O", "O", "O", "B-Phenomenon or Process", "B-Phenomenon or Process", "O", "B-Cell or Molecular Dysfunction", "B-Cell or Molecular Dysfunction", "O", "O", "B-Cell Function", "B-Cell Function", "O", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "B-Hazardous or Poisonous Substance", "O", "B-Genetic Function", "O", "B-Genetic Function", "B-Genetic Function", "B-Genetic Function", "O", "O", "B-Organism Function", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Molecular Function", "B-Molecular Function", "O", "B-Cell Function", "B-Cell Function", "O", "O", "B-Pharmacologic Substance", "B-Enzyme", "O", "B-Idea or Concept", "O", "O", "O", "B-Cell", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Quantitative Concept", "B-Hazardous or Poisonous Substance", "B-Qualitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "B-Molecular Function", "O", "O", "O", "O", "O", "O", "O", "B-Organism Function", "O", "B-Organism Function", "O", "B-Eukaryote", "B-Eukaryote", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Hazardous or Poisonous Substance", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Eukaryote", "B-Eukaryote", "B-Eukaryote", "O" ]

[ "Emergence", "of", "family", "medicine", "in", "Ethiopia", "[", "corrected", "]", ":", "an", "international", "collaborative", "education", "model", "Family", "Medicine", "(", "FM", ")", "is", "a", "new", "specialty", "in", "Ethiopia", ".", "The", "first", "seven", "family", "physicians", "graduated", "in", "February", "2016", "from", "the", "inaugural", "residency", "programme", "at", "Addis", "Ababa", "University", ".", "Cooperation", "amongst", "Ethiopian", "and", "expatriate", "decision-makers", "and", "physicians", "was", "needed", "to", "begin", "the", "programme", ".", "Intentional", "replacement", "of", "expatriates", "with", "Ethiopian", "family", "physicians", "has", "begun", ".", "Barriers", "include", "lack", "of", "understanding", "of", "FM", "and", "the", "human", "and", "financial", "resources", "needed", "for", "scaling", "up", "the", "programme", ".", "Regular", "programme", "review", "with", "resident", "physician", "involvement", "has", "allowed", "the", "FM", "training", "programme", "to", "adapt", "and", "fit", "the", "Ethiopian", "context", ".", "Further", "successes", "will", "result", "from", "ongoing", "support", "and", "advocacy", "from", "the", "Federal", "Ministry", "of", "Health", "and", "other", "Ethiopian", ",", "African", ",", "and", "international", "primary", "care", "organisations", "." ]

[ "B-Qualitative Concept", "O", "B-Biomedical Occupation or Discipline", "B-Biomedical Occupation or Discipline", "O", "B-Geographic Area", "O", "O", "O", "O", "O", "B-Idea or Concept", "B-Social Behavior", "B-Intellectual Product", "B-Intellectual Product", "B-Biomedical Occupation or Discipline", "B-Biomedical Occupation or Discipline", "O", "B-Biomedical Occupation or Discipline", "O", "O", "O", "O", "B-Biomedical Occupation or Discipline", "O", "B-Geographic Area", "O", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Population Group", "O", "B-Qualitative Concept", "O", "O", "O", "O", "B-Educational Activity", "B-Intellectual Product", "O", "B-Organization", "B-Organization", "B-Organization", "O", "B-Social Behavior", "O", "B-Population Group", "O", "B-Finding", "B-Professional or Occupational Group", "O", "B-Professional or Occupational Group", "O", "O", "O", "B-Temporal Concept", "O", "B-Intellectual Product", "O", "B-Idea or Concept", "B-Functional Concept", "O", "B-Finding", "O", "B-Population Group", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "O", "B-Temporal Concept", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Mental Process", "O", "B-Biomedical Occupation or Discipline", "O", "O", "B-Functional Concept", "O", "B-Finding", "B-Finding", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Intellectual Product", "O", "B-Qualitative Concept", "B-Intellectual Product", "B-Qualitative Concept", "O", "B-Professional or Occupational Group", "B-Professional or Occupational Group", "B-Social Behavior", "O", "O", "O", "B-Biomedical Occupation or Discipline", "B-Educational Activity", "B-Educational Activity", "O", "B-Qualitative Concept", "O", "B-Activity", "O", "B-Population Group", "B-Idea or Concept", "O", "O", "B-Social Behavior", "O", "B-Functional Concept", "O", "O", "B-Social Behavior", "O", "B-Social Behavior", "O", "O", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "B-Occupational Activity", "O", "O", "B-Population Group", "O", "B-Population Group", "O", "O", "I-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "B-Health Care Related Organization", "O" ]

[ "Hierarchical", "Targeting", "Strategy", "for", "Enhanced", "Tumor", "Tissue", "Accumulation", "/", "Retention", "and", "Cellular", "Internalization", "Targeted", "delivery", "of", "therapeutic", "agents", "is", "an", "important", "way", "to", "improve", "the", "therapeutic", "index", "and", "reduce", "side", "effects", ".", "To", "design", "nanoparticles", "for", "targeted", "delivery", ",", "both", "enhanced", "tumor", "tissue", "accumulation", "/", "retention", "and", "enhanced", "cellular", "internalization", "should", "be", "considered", "simultaneously", ".", "So", "far", ",", "there", "have", "been", "very", "few", "nanoparticles", "with", "immutable", "structures", "that", "can", "achieve", "this", "goal", "efficiently", ".", "Hierarchical", "targeting", ",", "a", "novel", "targeting", "strategy", "based", "on", "stimuli", "responsiveness", ",", "shows", "good", "potential", "to", "enhance", "both", "tumor", "tissue", "accumulation", "/", "retention", "and", "cellular", "internalization", ".", "Here", ",", "the", "recent", "design", "and", "development", "of", "hierarchical", "targeting", "nanoplatforms", ",", "based", "on", "changeable", "particle", "sizes", ",", "switchable", "surface", "charges", "and", "activatable", "surface", "ligands", ",", "will", "be", "introduced", ".", "In", "general", ",", "the", "targeting", "moieties", "in", "these", "nanoplatforms", "are", "not", "activated", "during", "blood", "circulation", "for", "efficient", "tumor", "tissue", "accumulation", ",", "but", "re-activated", "by", "certain", "internal", "or", "external", "stimuli", "in", "the", "tumor", "microenvironment", "for", "enhanced", "cellular", "internalization", "." ]

[ "B-Functional Concept", "B-Functional Concept", "B-Research Activity", "O", "B-Functional Concept", "B-Tissue", "B-Tissue", "O", "O", "B-Physiologic Function", "O", "B-Cell Function", "B-Cell Function", "B-Functional Concept", "B-Phenomenon or Process", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "O", "B-Qualitative Concept", "B-Phenomenon or Process", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Qualitative Concept", "B-Pathologic Function", "B-Pathologic Function", "O", "O", "B-Activity", "B-Manufactured Object", "O", "B-Functional Concept", "B-Phenomenon or Process", "O", "O", "B-Functional Concept", "B-Tissue", "B-Tissue", "O", "O", "B-Physiologic Function", "O", "B-Functional Concept", "B-Cell Function", "B-Cell Function", "O", "O", "B-Idea or Concept", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Manufactured Object", "O", "O", "B-Spatial Concept", "O", "O", "O", "O", "B-Idea or Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "B-Qualitative Concept", "B-Functional Concept", "B-Research Activity", "O", "O", "B-Phenomenon or Process", "B-Organism Attribute", "O", "O", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "B-Tissue", "B-Tissue", "O", "O", "B-Physiologic Function", "O", "B-Cell Function", "B-Cell Function", "O", "O", "O", "O", "O", "B-Activity", "O", "B-Functional Concept", "O", "B-Functional Concept", "B-Functional Concept", "O", "O", "O", "O", "B-Functional Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Functional Concept", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Spatial Concept", "B-Chemical", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Conceptual Entity", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "B-Physiologic Function", "B-Physiologic Function", "O", "B-Qualitative Concept", "B-Tissue", "B-Tissue", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Spatial Concept", "O", "B-Spatial Concept", "B-Phenomenon or Process", "O", "O", "B-Natural Phenomenon or Process", "B-Natural Phenomenon or Process", "O", "B-Functional Concept", "B-Cell Function", "B-Cell Function", "O" ]

[ "Subsolid", "pulmonary", "nodule", "morphology", "and", "associated", "patient", "characteristics", "in", "a", "routine", "clinical", "population", "To", "determine", "the", "presence", "and", "morphology", "of", "subsolid", "pulmonary", "nodules", "(", "SSNs", ")", "in", "a", "non-screening", "setting", "and", "relate", "them", "to", "clinical", "and", "patient", "characteristics", ".", "A", "total", "of", "16,890", "reports", "of", "clinically", "obtained", "chest", "CT", "(", "06/2011", "to", "11/2014", ",", "single-centre", ")", "were", "searched", "describing", "an", "SSN", ".", "Subjects", "with", "a", "visually", "confirmed", "SSN", "and", "at", "least", "two", "thin-slice", "CTs", "were", "included", ".", "Nodule", "volumes", "were", "measured", ".", "Progression", "was", "defined", "as", "volume", "increase", "exceeding", "the", "software", "interscan", "variation", ".", "Nodule", "morphology", ",", "location", ",", "and", "patient", "characteristics", "were", "evaluated", ".", "Fifteen", "transient", "and", "74", "persistent", "SSNs", "were", "included", "(", "median", "follow-up", "19.6", "[", "8.3-36.8", "]", "months", ")", ".", "Subjects", "with", "an", "SSN", "were", "slightly", "older", "than", "those", "without", "(", "62", "vs.", "58", "years", ";", "p", "=", "0.01", ")", ",", "but", "no", "gender", "predilection", "was", "found", ".", "SSNs", "were", "mostly", "located", "in", "the", "upper", "lobes", ".", "Women", "showed", "significantly", "more", "often", "persistent", "lesions", "than", "men", "(", "94", "%", "vs.", "69", "%", ";", "p", "=", "0.002", ")", ".", "Part-solid", "lesions", "were", "larger", "(", "1638", "vs.", "383", "mm", "(", "3", ")", ";", "p", "<", "0.001", ")", "and", "more", "often", "progressive", "(", "68", "%", "vs.", "38", "%", ";", "p", "=", "0.02", ")", ",", "compared", "to", "pure", "ground-glass", "nodules", ".", "Progressive", "SSNs", "were", "rare", "under", "the", "age", "of", "50", "years", ".", "Logistic", "regression", "analysis", "did", "not", "identify", "additional", "nodule", "parameters", "of", "future", "progression", ",", "apart", "from", "part-solid", "nature", ".", "This", "study", "confirms", "previously", "reported", "characteristics", "of", "SSNs", "and", "associated", "factors", "in", "a", "European", ",", "routine", "clinical", "population", ".", "•", "SSNs", "in", "women", "are", "significantly", "more", "often", "persistent", "compared", "to", "men", ".", "•", "SSN", "persistence", "is", "not", "associated", "with", "age", "or", "prior", "malignancy", ".", "•", "The", "majority", "of", "(", "persistent", ")", "SSNs", "are", "located", "in", "the", "upper", "lung", "lobes", ".", "•", "A", "part-solid", "nature", "is", "associated", "with", "future", "nodule", "growth", ".", "•", "Progressive", "solitary", "SSNs", "are", "rare", "under", "the", "age", "of", "50", "years", "." ]

[ "B-Finding", "B-Finding", "B-Finding", "B-Qualitative Concept", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Population Group", "O", "O", "O", "B-Qualitative Concept", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "B-Finding", "O", "B-Finding", "O", "O", "O", "B-Spatial Concept", "B-Spatial Concept", "O", "O", "O", "O", "B-Clinical Attribute", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "O", "O", "O", "O", "B-Intellectual Product", "O", "B-Qualitative Concept", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "O", "B-Population Group", "O", "O", "B-Functional Concept", "O", "B-Finding", "O", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Acquired Abnormality", "B-Quantitative Concept", "O", "B-Qualitative Concept", "O", "B-Functional Concept", "O", "O", "O", "B-Quantitative Concept", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Qualitative Concept", "O", "B-Acquired Abnormality", "B-Qualitative Concept", "O", "B-Body Location or Region", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Health Care Activity", "O", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "B-Finding", "O", "O", "O", "O", "B-Health Care Activity", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Population Group", "O", "O", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism Attribute", "B-Idea or Concept", "O", "O", "O", "B-Finding", "O", "O", "B-Spatial Concept", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "B-Population Group", "O", "B-Idea or Concept", "O", "O", "B-Temporal Concept", "B-Finding", "O", "B-Population Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Finding", "B-Finding", "O", "B-Functional Concept", "B-Finding", "O", "O", "O", "O", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O", "O", "O", "O", "O", "O", "O", "O", "B-Acquired Abnormality", "B-Finding", "O", "O", "B-Functional Concept", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "O", "B-Research Activity", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "O", "O", "B-Functional Concept", "O", "O", "B-Population Group", "O", "B-Qualitative Concept", "B-Qualitative Concept", "B-Population Group", "O", "O", "B-Finding", "O", "B-Population Group", "O", "B-Idea or Concept", "O", "O", "B-Temporal Concept", "O", "O", "B-Population Group", "O", "O", "B-Finding", "B-Temporal Concept", "O", "O", "O", "O", "B-Organism Attribute", "O", "B-Temporal Concept", "B-Neoplastic Process", "O", "O", "O", "O", "O", "O", "B-Temporal Concept", "O", "B-Finding", "O", "O", "O", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "O", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Acquired Abnormality", "B-Organ or Tissue Function", "O", "O", "B-Functional Concept", "B-Neoplastic Process", "B-Neoplastic Process", "O", "B-Qualitative Concept", "O", "O", "B-Organism Attribute", "O", "O", "B-Temporal Concept", "O" ]

[ "Dynamic", "CT", "myocardial", "perfusion", "imaging", "identifies", "early", "perfusion", "abnormalities", "in", "diabetes", "and", "hypertension", ":", "Insights", "from", "a", "multicenter", "registry", "To", "identify", "patients", "with", "early", "signs", "of", "myocardial", "perfusion", "reduction", ",", "a", "reference", "base", "for", "perfusion", "measures", "is", "needed", ".", "To", "analyze", "perfusion", "parameters", "derived", "from", "dynamic", "computed", "tomography", "perfusion", "imaging", "(", "CTPI", ")", "in", "patients", "with", "suspected", "coronary", "artery", "disease", "(", "CAD", ")", ",", "and", "relationship", "with", "risk", "factors", ".", "In", "this", "multicenter", "study", ",", "coronary", "CT", "angiography", "(", "cCTA", ")", "and", "dynamic", "CTPI", "were", "performed", "by", "second-generation", "dual-source", "CT", "in", "patients", "suspected", "of", "CAD", ".", "Risk", "factors", "were", "collected", "from", "hospital", "records", ".", "Patients", "with", "visual", "perfusion", "defects", "on", "CTPI", ",", "previous", "coronary", "intervention", ",", "or", "missing", "risk", "factor", "details", "were", "excluded", ".", "This", "analysis", "included", "98", "patients", "(", "mean", "age", "±", "standard", "deviation", "[", "SD", "]", ",", "59.0", "±", "8.6yrs", ";", "73", "male", ")", ".", "Global", "measures", "of", "left", "ventricular", "myocardial", "blood", "flow", "(", "MBF", ")", ",", "myocardial", "blood", "volume", "(", "MBV", ")", "and", "volume", "transfer", "constant", "(", "K", "(", "trans", ")", ")", "were", "calculated", ".", "Mean", "MBF", "was", "139.3", "±", "31.4", "mL/100", "mL/min", ",", "MBV", "19.1", "±", "2.7", "mL/100", "mL", ",", "and", "Ktrans", "85.0", "±", "17.5", "mL/100", "mL/min", ".", "No", "significant", "differences", "in", "perfusion", "parameters", "were", "found", "by", "gender", "or", "age", "category", ".", "Hypertension", "and", "diabetes", "mellitus", "resulted", "in", "lower", "perfusion", "parameters", "(", "hypertension", "vs", "normotension", ":", "MBV", "18.5", "±", "3.0", "vs", "19.7", "±", "2.3", "mL/100", "mL", "and", "K", "(", "trans", ")", "82.0", "±", "18.0", "vs", "89.0", "±", "16.0", ",", "p", "<", "0.05", ";", "diabetes", "vs", "no", "diabetes", ":", "MBF", "128.5", "±", "31.5", "vs", "144.0", "±", "30.5", "mL/100", "mL/min", "and", "MBV", "17.9", "±", "2.4", "vs", "19.4", "±", "2.8", "mL/100", "mL", ",", "p", "<", "0.05", ")", ".", "In", "patients", "with", "hyperlipidemia", ",", "MBF", "was", "higher", "(", "146.8", "±", "34.4", "vs", "130.7", "±", "24.3", "mL/100", "mL/min", ",", "p", "<", "0.05", ")", ".", "Smoking", "and", "family", "history", "did", "not", "show", "perfusion", "parameter", "differences", ".", "Dynamic", "CTPI", "identifies", "early", "perfusion", "disturbances", "in", "conditions", "like", "diabetes", "and", "hypertension", ".", "With", "further", "standardization", ",", "absolute", "perfusion", "measures", "may", "improve", "CAD", "risk", "stratification", "in", "patients", "without", "visual", "perfusion", "defects", "." ]

[ "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Temporal Concept", "B-Organ or Tissue Function", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "O", "B-Research Activity", "B-Intellectual Product", "O", "O", "B-Patient or Disabled Group", "O", "B-Sign or Symptom", "B-Sign or Symptom", "O", "B-Organism Attribute", "I-Organ or Tissue Function", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Organ or Tissue Function", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Organ or Tissue Function", "B-Finding", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "I-Organ or Tissue Function", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Qualitative Concept", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Research Activity", "B-Research Activity", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Diagnostic Procedure", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Patient or Disabled Group", "O", "O", "B-Disease or Syndrome", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Intellectual Product", "B-Intellectual Product", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "B-Organ or Tissue Function", "B-Functional Concept", "O", "B-Diagnostic Procedure", "O", "O", "B-Therapeutic or Preventive Procedure", "B-Therapeutic or Preventive Procedure", "O", "O", "O", "B-Finding", "B-Finding", "O", "O", "O", "O", "O", "B-Research Activity", "O", "O", "B-Patient or Disabled Group", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Population Group", "O", "O", "O", "B-Quantitative Concept", "O", "B-Body Part, Organ, or Organ Component", "B-Body Part, Organ, or Organ Component", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "B-Organ or Tissue Function", "O", "B-Organ or Tissue Function", "O", "O", "B-Clinical Attribute", "B-Clinical Attribute", "B-Clinical Attribute", "O", "B-Clinical Attribute", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Organ or Tissue Function", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ or Tissue Function", "B-Finding", "O", "O", "O", "B-Organism Attribute", "O", "B-Organism Attribute", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "O", "O", "B-Organ or Tissue Function", "B-Finding", "O", "B-Disease or Syndrome", "O", "B-Finding", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Finding", "B-Finding", "O", "B-Organ or Tissue Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Clinical Attribute", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Patient or Disabled Group", "O", "B-Disease or Syndrome", "O", "B-Organ or Tissue Function", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual Behavior", "O", "B-Finding", "B-Finding", "O", "O", "O", "B-Organ or Tissue Function", "B-Finding", "O", "O", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "O", "B-Organ or Tissue Function", "B-Qualitative Concept", "O", "O", "O", "B-Disease or Syndrome", "O", "B-Disease or Syndrome", "O", "O", "O", "B-Research Activity", "O", "O", "B-Organ or Tissue Function", "B-Quantitative Concept", "O", "O", "B-Disease or Syndrome", "B-Idea or Concept", "B-Research Activity", "O", "B-Patient or Disabled Group", "O", "B-Functional Concept", "B-Organ or Tissue Function", "B-Functional Concept", "O" ]

[ "Cognition", "Enhancing", "Activity", "of", "Sulforaphane", "Against", "Scopolamine", "Induced", "Cognitive", "Impairment", "in", "Zebra", "Fish", "(", "Danio", "rerio", ")", "Several", "epidemiological", "studies", "have", "shown", "that", "consumption", "of", "large", "quantities", "of", "vegetables", "especially", "cruciferous", "vegetables", "(", "Broccoli", "and", "Brussels", "sprouts", ")", "can", "protect", "against", "chronic", "diseases", ".", "Sulforaphane", ",", "an", "isothiocynate", "found", "in", "cruciferous", "vegetables", "has", "been", "demonstrated", "to", "have", "neuroprotective", "effects", "in", "several", "experimental", "paradigms", ".", "This", "study", "was", "undertaken", "to", "examine", "the", "effect", "of", "sulforaphane", "on", "cognitive", "impairment", "in", "zebra", "fish", "model", "using", "a", "novel", "method", "of", "fear", "conditioning", ".", "Initially", ",", "the", "normal", "behaviour", "of", "zebra", "fishes", "was", "studied", "in", "light-dark", "tank", "for", "10", "min", "daily", "for", "10", "days", ".", "Fishes", "were", "then", "divided", "into", "seven", "groups", "of", "twelve", "in", "each", ".", "Group", "I", "served", "as", "normal", ",", "group", "II", "served", "as", "fear", "conditioned", "control", ",", "group", "III", "and", "group", "IV", "were", "sulforaphane", "(", "25", "µM/L", ")", "and", "piracetam", "(", "200", "mg/L", ")", "treated", "respectively", ".", "Group", "V", "served", "as", "scopolamine", "(", "400", "µM/L", ")", "induced", "memory", "impairment", "fishes", ".", "Group", "VI", "and", "VII", "were", "sulforaphane", "(", "25", "µM/L", ")", "and", "piracetam", "(", "200", "mg/L", ")", "treated", "scopolamine", "induced", "memory", "impairment", "groups", "respectively", ".", "In", "normal", "behavioural", "analysis", ",", "fishes", "preferred", "to", "stay", "in", "dark", "compartment", ".", "The", "average", "number", "of", "entries", "into", "the", "dark", "and", "time", "spent", "in", "dark", "were", "significantly", "more", ".", "Fishes", "in", "group", "II", "to", "VII", "were", "individually", "subjected", "to", "fear", "conditioning", "passive", "avoidance", "task", "and", "evaluated", "for", "learned", "task", "memory", ".", "It", "was", "observed", "that", "the", "average", "number", "of", "entries", "into", "dark", "and", "time", "spent", "in", "dark", "were", "significantly", "decreased", ".", "After", "exposure", "to", "respective", "treatment", "fishes", "in", "group", "III", "to", "VII", "were", "subjected", "to", "cognitive", "evaluation", ".", "There", "was", "no", "significant", "difference", "in", "cognition", "of", "group", "III", "and", "IV", "fishes", "exposed", "to", "sulforaphane", "and", "piracetam", "alone", "respectively", ".", "Fishes", "exposed", "to", "scopolamine", "showed", "a", "significant", "cognitive", "impairment", ".", "Sulforaphane", "exposure", "prior", "to", "scopolamine", "significantly", "retained", "the", "memory", "of", "learned", "task", ".", "These", "findings", "suggest", "that", "sulforaphane", "might", "be", "a", "promising", "therapeutic", "agent", "for", "cognitive", "enhancement", "in", "Alzheimer", "'s", "disease", "." ]

[ "B-Mental Process", "B-Activity", "B-Idea or Concept", "O", "B-Pharmacologic Substance", "B-Qualitative Concept", "B-Pharmacologic Substance", "B-Functional Concept", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Fish", "B-Fish", "O", "B-Fish", "B-Fish", "O", "B-Quantitative Concept", "B-Research Activity", "B-Research Activity", "O", "O", "O", "B-Activity", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Food", "O", "B-Food", "B-Food", "O", "B-Food", "O", "B-Food", "B-Food", "O", "O", "O", "B-Qualitative Concept", "B-Disease or Syndrome", "B-Disease or Syndrome", "O", "B-Pharmacologic Substance", "O", "O", "B-Organic Chemical", "B-Finding", "O", "B-Food", "B-Food", "O", "O", "O", "O", "O", "B-Functional Concept", "B-Functional Concept", "O", "B-Quantitative Concept", "B-Research Activity", "B-Research Activity", "O", "O", "B-Research Activity", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "B-Pharmacologic Substance", "O", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Fish", "B-Fish", "B-Experimental Model of Disease", "O", "O", "B-Qualitative Concept", "B-Intellectual Product", "O", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "B-Qualitative Concept", "B-Behavior", "O", "B-Fish", "B-Fish", "O", "B-Research Activity", "O", "B-Manufactured Object", "B-Manufactured Object", "O", "O", "O", "B-Temporal Concept", "O", "O", "B-Temporal Concept", "O", "B-Fish", "O", "O", "B-Functional Concept", "O", "B-Quantitative Concept", "O", "O", "B-Quantitative Concept", "O", "B-Quantitative Concept", "O", "O", "O", "O", "O", "B-Qualitative Concept", "O", "O", "O", "O", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "B-Functional Concept", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "B-Functional Concept", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "B-Fish", "O", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "B-Functional Concept", "B-Pharmacologic Substance", "B-Functional Concept", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "O", "O", "O", "B-Qualitative Concept", "B-Health Care Activity", "B-Health Care Activity", "O", "B-Fish", "O", "O", "O", "O", "B-Qualitative Concept", "B-Spatial Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Entity", "O", "O", "B-Qualitative Concept", "O", "B-Temporal Concept", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Fish", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Mental Process", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "B-Diagnostic Procedure", "O", "B-Health Care Activity", "O", "B-Mental Process", "B-Mental Process", "B-Mental Process", "O", "O", "O", "B-Functional Concept", "O", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "B-Entity", "O", "B-Qualitative Concept", "O", "B-Temporal Concept", "O", "O", "B-Qualitative Concept", "O", "B-Quantitative Concept", "B-Quantitative Concept", "O", "O", "B-Qualitative Concept", "B-Qualitative Concept", "O", "B-Functional Concept", "B-Fish", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mental Process", "B-Health Care Activity", "O", "O", "O", "B-Finding", "B-Finding", "B-Qualitative Concept", "O", "B-Mental Process", "O", "O", "O", "O", "O", "B-Fish", "B-Qualitative Concept", "B-Qualitative Concept", "B-Pharmacologic Substance", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Fish", "B-Qualitative Concept", "B-Qualitative Concept", "B-Pharmacologic Substance", "O", "O", "B-Quantitative Concept", "B-Mental or Behavioral Dysfunction", "B-Mental or Behavioral Dysfunction", "O", "B-Pharmacologic Substance", "O", "O", "O", "B-Pharmacologic Substance", "B-Quantitative Concept", "O", "O", "B-Mental Process", "O", "B-Mental Process", "B-Functional Concept", "O", "O", "B-Finding", "B-Idea or Concept", "O", "B-Pharmacologic Substance", "O", "O", "O", "O", "B-Pharmacologic Substance", "B-Pharmacologic Substance", "O", "B-Mental Process", "B-Activity", "O", "B-Disease or Syndrome", "B-Disease or Syndrome", "B-Disease or Syndrome", "O" ]